Inflammatory Signalling Associated with Brain Dead Organ Donation: From Brain Injury to Brain Stem Death and Posttransplant Ischaemia Reperfusion Injury by Ryan P. Watts, Ogilvie Thom, John F. Fraser

“…Activation of deleterious immunological pathways in organ grafts occurs, priming them for further inflammation after engraftment. Finally, posttransplantation ischaemia reperfusion injury leads to further generation of inflammatory mediators and consequent activation of the recipient’s immune system. …”
Get full text

Glucocorticosteroids and the Risk of NAFLD in Inflammatory Bowel Disease by Sara Jarmakiewicz-Czaja, Aneta Sokal, Piotr Pardak, Rafał Filip

“…Certain groups of drugs also increase the risk of developing inflammation, liver fibrosis, and cirrhosis. Particularly important in the development of NAFLD are steroids, which are used in the treatment of many diseases, for example, IBD. …”
Get full text

Recurrent Silent Thyroiditis as a Sequela of Postpartum Thyroiditis by Preaw Hanseree, Vincent Bryan Salvador, Issac Sachmechi, Paul Kim

“…Thyroiditis encompasses a group of disorders characterized by thyroid inflammation. Though clinically indistinguishable from silent thyroiditis, postpartum thyroiditis occurs in women within 12 months after delivery. …”
Get full text

Role of the Gastrointestinal Tract Microbiome in the Pathophysiology of Diabetes Mellitus by Muhammad U. Sohail, Asmaa Althani, Haseeb Anwar, Roberto Rizzi, Hany E. Marei

“…A change in microbial diversity, referred as microbial dysbiosis, alters the gut fermentation profile and intestinal wall integrity and causes metabolic endotoxemia, low-grade inflammation, autoimmunity, and other affiliated metabolic disorders. …”
Get full text

Castleman's Disease and Neutropenic Enterocolitis Presenting as Crohn’s Disease by Kelly W Burak, Ronald J Bridges, Walter B Blahey

“…Colonoscopy confirmed ulcerations in the terminal ileum and cecum, with biopsies showing necrosis and inflammation. Treatment was initiated with prednisone, 5-aminosalicylate and granulocyte colony-stimulating factor for neutropenia. …”
Get full text

The hypoglycemic potential of phenolics from functional foods and their mechanisms by Oksana Golovinskaia, Chin-Kun Wang

“…Chronic hyperglycemia induces the glycation of proteins, oxidative stress, inflammation and increases plasma insulin and lipid concentrations. …”
Get full text

Zinc in Keratinocytes and Langerhans Cells: Relevance to the Epidermal Homeostasis by Youichi Ogawa, Manao Kinoshita, Shinji Shimada, Tatsuyoshi Kawamura

“…Disruption of the epidermal barrier allows external substances and stimuli to invade or stimulate the epidermal cells, leading to the elicitation of skin inflammation. The major components of the epidermal barrier are the stratum corneum (SC) and tight junctions (TJs). …”
Get full text

Microflora species and population analysis for feline sepsis treatment efficiency control by P. A. Rudenko

“…Sepsis diagnostics demonstrated a significant (by 37.7%) prevalence of gram-negative microorganisms compared to gram-positive ones as well as the presence of Candida species which is indicative of severe purulent inflammation in experimental cats. The provided data also suggest that in the course of sepsis treatment intestinal microbe ecosystem stabilizes more effectively and tends towards healthy cat parameters in B3 group animals. …”
Get full text

Biomarkers for Risk Stratification of Neoplastic Progression in Barrett Esophagus by Marjon Kerkhof, Johannes G. Kusters, Herman van Dekken, Ernst J. Kuipers, Peter D. Siersema

“…In this review, we will summarize the most promising tissue biomarkers, i.e. proliferation/cell cycle proteins, tumor suppressor genes, adhesion molecules, DNA ploidy status and inflammation associated markers, that can be used for risk stratification in BE, and discuss their respective clinical application.…”
Get full text

The Spectrum of Fundus Autofluorescence Findings in Birdshot Chorioretinopathy by GianPaolo Giuliari, David M. Hinkle, C. Stephen Foster

“…Four eyes presented with active inflammation. Correspondence of the lesions noted in the colour fundus photograph was observed in 3 eyes which were more easily identified with the FAF. …”
Get full text

Primary biliary cirrhosis: clinical and laboratory criteria of diagnostics and up-to-date treatment by L. Yu. Il’chenko, V. I. Reshetn’yak

“…PBC is organ-specific autoimmune liver disease affecting predominantly women that is characterized by chronic progressing destruction of intrahepatic bile ducts with portal inflammation, resulting in development of liver cirrhosis (LC). …”
Get full text

Pannus Is the New Prepuce? Penile Cancer in a Buried Phallus by Jared Manwaring, Srinivas Vourganti, Dmitriy Nikolavsky, Alfredo L. Valente, Timothy Byler

“…Buried penis represents a difficulty in early detection of suspicious lesions but may also provide an environment susceptible to poor hygiene and subsequent chronic inflammation. Patients with buried penis may be at a higher risk for development of invasive penile cancer and may benefit from regular and thorough genital exams.…”
Get full text

Acquired Vulvar Lymphangioma Circumscriptum by Derya Uçmak, Sema Aytekin, Bilal Sula, Zeynep Meltem Akkurt, Gül Türkçü, Elif Ağaçayak

“…Here, two uncommon cases with giant lymphangioma circumscriptum mimicking genital warts will be presented: a 55-year-old female patient with extensive lymphangiectasic lesions and genital wart-like papular lesions in the vulva secondary to diffuse scrofuloderma scars and a 60-year-old female patient with verruca-like lesions secondary to chronic inflammation.…”
Get full text

Inflammatory Acute Response. Biochemical and Cellular Considerations by Milagros Lisset León Regal, Ania Alvarado Borges, José Omar de Armas García, Luciano Miranda Alvarado, Javier Antonio Varens Cedeño, José Ángel Cuesta del Sol

“…The acute inflammation constitutes a natural, protective-character response that intends to free the organism of the initial cause of the cell lesion and of the consequences that it provokes. …”
Get full text

Invariant NKT Cells as Novel Targets for Immunotherapy in Solid Tumors by Karsten A. Pilones, Joseph Aryankalayil, Sandra Demaria

“…They are uniquely poised to respond rapidly to infection and inflammation and produce cytokines that critically shape the ensuing adaptive cellular response. …”
Get full text

Basal Cell Carcinoma Masked in Rhinophyma by Daniele De Seta, Francesca Yoshie Russo, Elio De Seta, Roberto Filipo

“…The anatomical distortion produced by the chronic inflammation and fibrous scarring makes the BCC diagnosis difficult and uncertain. …”
Get full text

Anesthetic Management of an Obstetric Patient with Behçet’s Disease Complicated by Transverse Myelitis by Sara Alwatban, Etedal AlAamri, Abdullah Alraffa, Mona Alkhawajah

“…Transverse myelitis is an acute inflammation of the spinal cord. Its annual incidence is 1–8 per million. …”
Get full text

PATHOGENETIC ROLE OF THROMBOCYTES IN THE DEVELOPMENT OF AUTOIMMUNE PATHOLOGY OF THE THYROID GLAND by I. Yu. Bahmut, O. O. Halmyz, S. М. Hramatiuk, A. V. Titkova

“…Taking into account the importance of platelets in the mechanisms of inflammation and the autoimmune process, the aim of this study was to experimentally answer a simple question: whether platelets in people with autoimmune euthyroidism, hyperthyroidism and hypothyroidism exhibit the characteristics of high activity. …”
Get full text

Peroxisome Proliferator-Activated Receptor-γ-Mediated Polarization of Macrophages in Leishmania Infection by Marion M. Chan, Nagasuresh Adapala, Cui Chen

“…This ligand-activated nuclear factor curbs inflammation to protect the host from excessive injuries by setting a limit to its destructive force. …”
Get full text

Functional Properties and Molecular Architecture of Leukotriene A4 Hydrolase, a Pivotal Catalyst of Chemotactic Leukotriene Formation by Jesper Z. Haeggström, Pär Nordlund, Marjolein M.G.M. Thunnissen

“…The leukotrienes are a family of lipid mediators involved in inflammation and allergy. Leukotriene B4 is a classical chemoattractant, which triggers adherence and aggregation of leukocytes to the endothelium at only nM concentrations. …”
Get full text