Light Chain Escape in 3 Cases: Evidence of Intraclonal Heterogeneity in Multiple Myeloma from a Single Institution in Poland by Maria Kraj, Barbara Kruk, Kelly Endean, Krzysztof Warzocha, Katarzyna Budziszewska, Monika Dąbrowska

“…We report three cases of light chain escape (LCE) at a single institution in Poland, including an interesting case of biclonal monoclonal gammopathy of undetermined significance (MGUS) that satisfied the criteria for progression to light chain multiple myeloma (LCMM) with a rapid rise in serum free light chain (FLC) levels, following steroidal treatment for simultaneous temporal artery inflammation and polymyalgia rheumatica (PMR). In the three cases discussed, progression of the disease by light chain escape was associated with rapid and severe renal impairment, highlighting the necessity for prompt detection of such free light chain-only producing clones in order to prevent the possible development of irreversible end-organ damage. …”
Get full text

Current Status of the Immunomodulation and Immunomediated Therapeutic Strategies for Multiple Sclerosis by Shyi-Jou Chen, Yen-Ling Wang, Hueng-Chuen Fan, Wen-Tsung Lo, Chih-Chien Wang, Huey-Kang Sytwu

“…Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, and CD4+ T cells form the core immunopathogenic cascade leading to chronic inflammation. Traditionally, Th1 cells (interferon-γ-producing CD4+ T cells) driven by interleukin 12 (IL12) were considered to be the encephalitogenic T cells in MS and experimental autoimmune encephalomyelitis (EAE), an animal model of MS. …”
Get full text

Prevalence of Fluoroquinolone-Resistant Campylobacter Species in Iran: A Systematic Review and Meta-Analysis by Farzad Khademi, Amirhossein Sahebkar

Get full text

Serum Analysis in Patients with Temporomandibular Disorders: A Controlled Cross-Sectional Study in Norway by Kordian Staniszewski, Henning Lygre, Trond Berge, Annika Rosén

“…Our findings could not associate any severe systemic disease, malnutrition, or systemic inflammation with the TMD. Results from our study suggest that serum analyses should neither be used as a biomarker of TMD nor a diagnostic tool for an individual subject with TMD.…”
Get full text

Infrared thermography in clinical practice: a literature review by Qian Liu, Mingzhu Li, Wenping Wang, Shengbo Jin, Haozhe Piao, Yuxin Jiang, Ningxin Li, Huini Yao

“…The application of infrared thermography has been demonstrated in oncology, painful diseases, inflammation, rheumatism, and vascular-related diseases. …”
Get full text

Transformation of brain myeloid cell populations by SIV in rhesus macaques revealed by multiomics by Xiaoke Xu, Meng Niu, Benjamin G. Lamberty, Katy Emanuel, Moses Jedd Facun Apostol, Howard S. Fox

“…In SIVE, microglia-like cells express high levels of chemoattractants capable of recruiting highly activated CAM-like cells to the site of infection/inflammation. A unique population of microglia-like cells is found in which the chromatin accessibility of genes diverges from their RNA expression. …”
Get full text

Morphological features of chronic virus-associated gastritis and duodenitis by S. Yu. Yermak, S. A. Lyalikov, M. G. Zubritsky

“…Presence of HSV-1 infection alters of the severity and activity of chronic inflammation in stomach mucosa in children and adults.…”
Get full text

Herbal remedies as a potential alternative therapy for arthritis by Disha Trivedi, Riya Jayapal Roja, Eva Künnemann

“…Arthritis forms a vicious cycle, where upon overuse of a joint or an autoimmune reaction inflammation and pain occur. These are marked by specific molecular patterns and immunological pathways that lead to chondrolysis and destruction of cartilage. …”
Get full text

A Rare Cause of Ascites-Disseminated TB with Peritonitis in a Middle-Aged Female by Sahathevan Vithoosan, Ponnudurai Shanjeeban, Joseph Philip Anpalahan, Paramarajan Piranavan, Harindra Karunatilake, Ananda Jayanaga

“…Diagnostic laparoscopy was in favour of miliary TB and the peritoneal biopsy revealed granulomatous inflammation with caseous necrosis, suggestive of TB. …”
Get full text

Optimization of the Coupling Coefficient of the Inductive Link for Wireless Power Transfer to Biomedical Implants by Jiarui Bao, Shuyan Hu, Zibin Xie, Guangxi Hu, Ye Lu, Lirong Zheng

“…The receiving (Rx) coil is implanted in the body and set as a circular coil with a radius of 5 millimeters for reducing the risk of tissue inflammation. The inductive link under misalignment scenarios is optimized to improve k. …”
Get full text

Henoch-Schonlein Purpura—A Case Report and Review of the Literature by Amit B. Sohagia, Srinivas Guptha Gunturu, Tommy R. Tong, Hilary I. Hertan

“…It is a systemic disease where antigen-antibody (IgA) complexes activate the alternate complement pathway, resulting in inflammation and small vessel vasculitis. Mild disease resolves spontaneously, and symptomatic treatment alone is sufficient. …”
Get full text

Dexmedetomidine Mitigates Microglial Activation Associated with Postoperative Cognitive Dysfunction by Modulating the MicroRNA-103a-3p/VAMP1 Axis by Zhichao Wu, Han Wang, Zuan Shi, Yalan Li

“…Dexmedetomidine treatment markedly inhibited LPS-induced inflammation and the expression of VAMP1, and miR-103a-3p expression reversed this inhibition. …”
Get full text

Longitudinal Analysis of Adiponectin through 20-Year Type 1 Diabetes Duration by Tamara J. LeCaire, Mari Palta

“…Little information exists on the trajectory and determinants of adiponectin, a possible insulin sensitizer and marker for inflammation and endothelial function, across the duration of type 1 diabetes. …”
Get full text

Helicobacter pylori and gastric cancer: mechanisms and new perspectives by Yantao Duan, Yonghu Xu, Yi Dou, Dazhi Xu

“…Furthermore, we highlight the role of H. pylori in inducing oxidative stress, DNA damage, chronic inflammation, and cell apoptosis—key cellular events that pave the way for carcinogenesis. …”
Get full text

Cardiac Magnetic Resonance Imaging in Diagnostics and Cardiovascular Risk Assessment by Patrycja S. Matusik, Katarzyna Mikrut, Amira Bryll, Tadeusz J. Popiela, Paweł T. Matusik

“…Novel CMR techniques, such as T1 and T2 mapping, may be used for the longitudinal follow-up of myocardial fibrosis and myocardial edema or inflammation in different groups of patients, including patients with systemic sclerosis, myocarditis, cardiac sarcoidosis, amyloidosis, and both ischemic and non-ischemic cardiomyopathy, among others. …”
Get full text

A new computational framework for simulating airway resistance, fraction of exhaled nitric oxide, and diffusing capacity for nitric oxide. by Benoit Haut, Cyril Karamaoun, Clément Rigaut

“…In addition, a geometry can be easily modified to simulate various abnormalities, local or global (constriction, inflammation, perfusion defect). The natural variability of the lungs at constant body mass is also considered. …”
Get full text

Roles of Brain Angiotensin II in Cognitive Function and Dementia by Masaki Mogi, Jun Iwanami, Masatsugu Horiuchi

“…A direct AT2 receptor agonist is now available and is expected to reduce inflammation and oxidative stress and enhance cell differentiation. …”
Get full text

Antitumoral and Anti-inflammatory Roles of Somatostatin and Its Analogs in Hepatocellular Carcinoma by Argyrios Periferakis, Georgios Tsigas, Aristodemos-Theodoros Periferakis, Ioana Anca Badarau, Andreea-Elena Scheau, Mircea Tampa, Simona Roxana Georgescu, Andreea Cristiana Didilescu, Cristian Scheau, Constantin Caruntu

“…The complexity of the treatment is also justified by the unique pathogenesis of HCC that involves intricate processes such as chronic inflammation, fibrosis, and multiple molecular carcinogenesis events. …”
Get full text

Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor 𝜅B Is a Steady Feature of Urinary Bladder Carcinogenesis by Stylianos Kontos, Georgia Sotiropoulou-Bonikou, Athina Kominea, Maria Melachrinou, Eleni Balampani, Dionysis Bonikos

“…The inescapable relationship between chronic inflammation and carcinogenesis has long been established. …”
Get full text

The Expression of miR-34a in Gingival Crevicular Fluid of Chronic Periodontitis and Its Connection with the TLR/NF-κB Signaling Pathway by Jiaxin Pan, Jue Liu, Lu Zhao

“…Its expression is associated with the degree of periodontal inflammation, periodontal tissue damage, and the activation of the TLR/NF-κB signaling pathway and could be used as a potential index for auxiliary diagnosis and severity of the disease.…”
Get full text