Meckel's diverticulum as a cause of mechanical intestinal obstruction in an adult. A case report by Indira Noa Lores, Yodanky Ochoa Rodríguez, Yolexi Laborí Columbié

“…There are three most common complications: hemorrhage, inflammation, and occlusion. The last one occurs more frequently in children. …”
Get full text

The Endotoxin-Induced Neuroinflammation Model of Parkinson's Disease by Kemal Ugur Tufekci, Sermin Genc, Kursad Genc

“…A bacterial endotoxin-based experimental model of PD has been established, representing a purely inflammation-driven animal model for the induction of nigrostriatal dopaminergic neurodegeneration. …”
Get full text

Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin by Yinka K. Davies, Cynthia J. Tsay, Dario V. Caccamo, Kathleen M. Cox, Ricardo O. Castillo, Kenneth L. Cox

“…Primary sclerosing cholangitis (PSC) is a progressive, cholestatic disease of the liver that is marked by inflammation of the bile ducts and damage to the hepatic biliary tree. …”
Get full text

Bilateral Ampiginous Choroiditis following Presumed SARS-CoV-2 Infection by Elysse S. Tom, K. Matthew McKay, Steven S. Saraf

“…This report suggests that SARS-CoV-2 infection may trigger chorioretinal inflammation in susceptible hosts.…”
Get full text

Post corona virus Disease-19 (COVID-19): Hyper inflammatory syndrome-associated bilateral anterior uveitis and multifocal serous retinopathy secondary to steroids by Srinivasan Sanjay, Vijay K R. Rao, Deepashri Mutalik, Padmamalini Mahendradas, Ankush Kawali, Rohit Shetty

“…Anterior chamber showed inflammation in the LE, a day later in the right eye. …”
Get full text

Local Drug Delivery Systems for Vital Pulp Therapy: A New Hope by Ardavan Parhizkar, Saeed Asgary

“…However, to succeed in VPT, specific biomaterials are used to cover and/or dress the exposed pulp, lower the inflammation, heal the dental pulp, provoke the remaining odontoblastic cells, and induce the formation of a hard tissue, i.e., the dentinal bridge. …”
Get full text

Profile of STING agonist and inhibitor research: a bibliometric analysis by Xuemei Wang, Qian Wang, Yidan Gao, Lijuan Jiang, Lingli Tang

“…Application of STING agonists primarily focuses on cancer immunotherapy, while STING inhibitors target inflammation, particularly neuroinflammation and acute lung injury.ConclusionCurrent research emphasizes optimizing STING agonists for permeability, efficacy, and safety, with nanotechnology and lipid nanoparticles being prominent delivery techniques. …”
Get full text

Mirtazapine Treatment of a Severe Depressive Episode and Resolution of Elevated Inflammatory Markers by Shahzad M. Alikhan, Jessica A. Lee, Luiz Dratcu

“…This report describes an association between a clinical antidepressant response and a decrease in markers of systemic inflammation observed during pharmacotherapy with mirtazapine in a severely depressed but physically well patient. …”
Get full text

Kidney and Urinary Tract Involvement in Kawasaki Disease by Toru Watanabe

“…TIN with AKI and renal tubular abnormalities probably result from renal parenchymal inflammation caused by T-cell activation. HUS and renal artery lesions are caused by vascular endothelial injuries resulting from vasculitis. …”
Get full text

Guanylate-Binding Protein 1 Promotes Migration and Invasion of Human Periodontal Ligament Stem Cells by Shi Bai, Tao Chen, Xia Deng

“…Mesenchymal stem/stromal cells (MSCs) are capable of migrating to sites of injury and inflammation in response to various cytokines to improve tissue repair. …”
Get full text

A Comprehensive Updated Review of Pharmaceutical and Nonpharmaceutical Treatment for NAFLD by Newaz Hossain, Pushpjeet Kanwar, Smruti R. Mohanty

“…On the contrary, nonalcoholic steatohepatitis (NASH) consists of steatosis, inflammation, and ballooning degeneration and can progress to cirrhosis. …”
Get full text

Phosphate, Calcification in Blood, and Mineral Stress: The Physiologic Blood Mineral Buffering System and Its Association with Cardiovascular Risk by Andreas Pasch, Willi Jahnen-Dechent, Edward R. Smith

“…The relative abundance and biological activity of these particles are a matter of intense research, because they can cause oxidative stress, inflammation, and calcification in cellular assay. Therapeutically reducing this endogenous stressor by prolonging crystal formation time might improve patient outcome. …”
Get full text

Neuroendocrine Tumour as a Diagnostic and Prognostic Criterion for Autoimmune Gastritis by S. I. Mozgovoi, M. A. Livzan, T. S. Krolevets, A. G. Shimanskaya

“…The autoimmune genesis of the chronic inflammation of the gastric mucosa may serve as a background for the development of neuroendocrine tumours of the stomach, which determines the management tactics in such conditions.…”
Get full text

Ketogenic Diet: A Review of Composition Diversity, Mechanism of Action and Clinical Application by Dominika Malinowska, Małgorzata Żendzian-Piotrowska

“…The beneficial effects of the KD on neurological diseases are related to the reconstruction of myelin sheaths of neurons, reduction of neuron inflammation, decreased production of reactive oxygen species, support of dopamine production, repair of damaged mitochondria and formation of new ones. …”
Get full text

Unusual Presentation of Phacolytic Glaucoma: Simulating Microbial Keratitis by Srikant Kumar Sahu, Siddharth Keswarwani, Ruchi Mittal

“…Histological confirmation of inflammation, histiocytic response, and giant cells around the lens material confirmed the ongoing phacolytic process. …”
Get full text

Mechanisms of liver disease in patients infected with HIV by Matthew B Kaspar, Richard K Sterling

“…A thorough understanding of the mechanisms driving the development of liver disease in these patients is essential when evaluating and caring for these patients.Methods The literature regarding mechanisms of liver disease by which different disease entities may cause hepatic injury and fibrosis was reviewed and synthesised.Results A number of discrete mechanisms of injury were identified, to include: oxidative stress, mitochondrial injury, lipotoxicity, immune-mediated injury, cytotoxicity, toxic metabolite accumulation, gut microbial translocation, systemic inflammation, senescence and nodular regenerative hyperplasia. …”
Get full text

Dual targeting carbonic anhydrase inhibitors as promising therapeutic approach: a structural overview by Katia D’Ambrosio, Anna Di Fiore, Emma Langella

“…It can enhance therapeutic outcomes, reduce side effects and avoid the emergence of drug resistance, particularly in conditions like cancer, inflammation and neurological disorders, where multiple pathways contribute to disease progression. …”
Get full text

COVID-19 Pandemic and Irritable Bowel Syndrome — is there a Relationship? by V. A. Akhmedov

“…It has been noted that the COVID-19 may contribute to the formation of post-infectious functional gastrointestinal diseases, given that angiotensin-converting enzyme-2 (ACE-2) receptors, the site of binding of the SARS-CoV-2 virus to human cells, are also present in epithelial intestinal cells; virus was found in feces in about half of patients, gastrointestinal symptoms, including diarrhea occur in about one fifth of patients, fecal calprotectin, a marker of GI inflammation is elevated in patients with COVID-19, macroscopically as well as histologically, patients show signs of damage mucous membrane of the gastrointestinal tract, and also, as noted above, they have a dysbiosis of the intestinal microbiota.Conclusion. …”
Get full text

Metabolomic analysis of murine tissues infected with Brucella melitensis. by Bárbara Ponzilacqua-Silva, Alexis S Dadelahi, Charles R Moley, Mostafa F N Abushahba, Jerod A Skyberg

“…In summary, these results indicate that Brucella infection alters host tissue metabolism and that these changes could have effects on inflammation and the outcome of infection.…”
Get full text

Unravelling the prognostic and operative role of intratumoural microbiota in non‐small cell lung cancer: Insights from 16S rRNA and RNA sequencing by Fuling Mao, Zixuan Hu, Ruifeng Shi, Hongbing Zhang, Zihe Zhang, Yongwen Li, Xuanguang Li, Penghu Gao, Jinhui Li, Minghui Liu, Hongyu Liu, Jun Chen

“…Protective microbiota primarily exerted metabolic functions, whereas harmful microbiota were mainly implicated in infection, inflammation and immune modulation. Furthermore, Peptococcus may be significant in adverse NSCLC prognoses and serve as a potential biomarker for patient management and cancer screening. …”
Get full text