Neural Mechanisms of Temporomandibular Joint and Masticatory Muscle Pain: A Possible Role for Peripheral Glutamate Receptor Mechanisms by David K Lam, Barry J Sessle, Brian E Cairns, James W Hu

“…A peripheral mechanism involving autocrine and/or paracrine regulation of nociceptive neuronal excitability via injury or inflammation-induced release of glutamate into peripheral tissues that may contribute to the development of craniofacial pain is proposed.…”
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Mathematical modeling of liver fibrosis by Avner Friedman, Wenrui Hao

“…Fibrosis is the formation of excessive fibrous connective tissue in an organ or tissue, which occurs in reparative process or in response to inflammation. Fibrotic diseases are characterized by abnormal excessive deposition of fibrous proteins, such as collagen, and the disease is most commonly progressive, leading to organ disfunction and failure. …”
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Biological Functions and Health Benefits of Flavonoids in Fruits and Vegetables: A Contemporary Review by Xiaoyuan Zheng, Xuejiao Zhang, Fankui Zeng

“…In relation to human health, flavonoids are recognized for their ability to combat aging, mitigate inflammation, safeguard the nervous system, and promote overall well-being. …”
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The Role of Peroxisome Proliferator-Activated Receptors in Pulmonary Vascular Disease by Rachel E. Nisbet, Roy L. Sutliff, C. Michael Hart

“…Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily that regulate diverse physiological processes ranging from lipogenesis to inflammation. Recent evidence has established potential roles of PPARs in both systemic and pulmonary vascular disease and function. …”
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The Renoprotective Actions of Peroxisome Proliferator-Activated Receptors Agonists in Diabetes by M. C. Thomas, K. A. Jandeleit-Dahm, C. Tikellis

“…Over and above action on metabolic control and effects on blood pressure, PPAR agonists also appear to have independent effects on a number of critical pathways that are implicated in the development and progression of diabetic kidney disease, including oxidative stress, inflammation, hypertrophy, and podocyte function. This review will examine these direct and indirect actions of PPAR agonists in the diabetic kidney and explore recent findings of clinical trials of PPAR agonists in patients with diabetes.…”
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Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease by Sheetal Verma, Tamisha Vaughan, Kevin D. Bunting

“…In addition, Gabs participate in hematopoiesis and regulation of immune response which can be aberrantly activated in cancer and inflammation. The multifunctionality of Gab adapters might suggest that they would be too difficult to consider as candidates for “targeted” therapy. …”
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Biological therapy for inflammatory bowel disease: cyclical rather than lifelong treatment? by Christian Philipp Selinger, Konstantina Rosiou, Marco V Lenti

“…Treatment guidelines highlight the need for effective control of inflammation and early escalation to advanced therapies to avoid long-term complications. …”
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The Pain System in Oesophageal Disorders: Mechanisms, Clinical Characteristics, and Treatment by Christian Lottrup, Søren Schou Olesen, Asbjørn Mohr Drewes

“…The pain stimulus is further processed and modulated in specific pain centres in the brain, which may undergo plastic alterations. Hence, tissue inflammation and long-term exposure to pain can cause sensitisation and hypersensitivity. …”
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The impact of obesity on disease activity and other health outcome measures in rheumatoid arthritis by Ankur Dalal, Rizwan Rajak

“…It is believed to be a state of low-grade inflammation. Rheumatoid arthritis (RA) is the most prevalent chronic inflammatory arthritis, and obesity is thought to influence its development through adipokines. …”
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Stimulators and Activators of Soluble Guanylate Cyclase: Review and Potential Therapeutic Indications by Bobby Nossaman, Edward Pankey, Philip Kadowitz

“…Stimulation of sGC mediates physiologic responses including smooth muscle relaxation, inhibition of inflammation, and thrombosis. In pathophysiologic states, NO formation and bioavailability can be impaired by oxidative stress and that tolerance to NO donors develops with continuous use. …”
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Small Bowel Obstruction due to Mesodiverticular Band of Meckel's Diverticulum: A Case Report by Aziz Sumer, Ozgur Kemik, Aydemir Olmez, A. Cumhur Dulger, Ismail Hasirci, Umit Iliklerden, Erol Kisli, Cetin Kotan

“…Common complications related to a Meckel's diverticulum include haemorrhage, intestinal obstruction, and inflammation. Small bowel obstruction due to mesodiverticular band of Meckel's diverticulum is a rare complication. …”
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A Possible Change Process of Inflammatory Cytokines in the Prolonged Chronic Stress and Its Ultimate Implications for Health by Rui Tian, Gonglin Hou, Dan Li, Ti-Fei Yuan

“…At the same time, the inflammation related transcription pathway, such as nuclear-factor kappa-B (NF-κB) signaling, may be inhibited. …”
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Clinical and Biochemical Manifestations of Depression: Relation to the Neurobiology of Stress by Phillip W. Gold, Rodrigo Machado-Vieira, Maria G. Pavlatou

“…Aspects such as depression subtypes, inflammation, insulin resistance, oxidative stress, and prothrombotic states in critical brain circuits and periphery are critically appraised. …”
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Delirium after Deep Brain Stimulation in Parkinson’s Disease by Hanyi Li, Shunchang Han, Juan Feng

“…Neurotransmitters such as acetylcholine and dopamine may be involved in the occurrence of delirium. Furthermore, inflammation, the effects of microlesioning of local nuclei, and brain atrophy may also play roles in the onset of delirium. …”
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Case Study: Colibacillosis and Coccidiosis in Broiler Chicken Farm by Tyagita Tyagita Hartady, Reza Taufik Subagio, Shafia Khairani

“…The results of this study showed that colibacillosis causes pathological changes including peritonitis which is characterized by the formation of fibrinous exudate in the peritoneum, and inflammation of the air sacs. Coccidiosis causes hemorrhagic lesions in the small intestine and cecum. …”
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Receptor for Advanced Glycation Endproducts (RAGE), Its Ligands, and Soluble RAGE: Potential Biomarkers for Diagnosis and Therapeutic Targets for Human Renal Diseases by Eun Ji Lee, Jong Hoon Park

“…Its interaction is engaged in critical cellular processes, such as inflammation, proliferation, apoptosis, autophagy, and migration, and dysregulation of RAGE and its ligands leads to the development of numerous human diseases. …”
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Low Reactive Level Laser Therapy for Mesenchymal Stromal Cells Therapies by Toshihiro Kushibiki, Takeshi Hirasawa, Shinpei Okawa, Miya Ishihara

“…Over the past forty years, it was realized that the laser therapy had the potential to improve wound healing and reduce pain and inflammation. In recent years, the term LLLT has become widely recognized in the field of regenerative medicine. …”
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Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes by John Winkler, Sanjoy Ghosh

“…A promising avenue might involve the attenuation of underlying inflammation through natural health products (NHPs). …”
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The crucial role of 5hmC in neuroprotection and repair after cerebrovascular injury by Yanina Tsenkina

“…The discussion delves into the dynamic interaction between hydroxymethylation and important pathways in neuroprotection, such as the modulation of excitotoxicity and cellular metabolism, resolution of inflammation, and mitigation of oxidative stress. Additionally, it explores emerging evidence suggesting that 5hmC contributes to neurorepair by promoting neurogenesis, axonal regeneration, angiogenesis, and synaptic plasticity. …”
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Fatal Hepatic Decompensation in a Patient with Hepatitis B Cirrhosis Following Famciclovir Withdrawal by Robert P Myers, Rabindra Chaudhary, Kevin Fonseca, Samuel S Lee

“…Clinicians should consider the risk of inducing serious flares in hepatic inflammation as a result of abrupt nucleoside analogue withdrawal. …”
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