GV1001, hTERT Peptide Fragment, Prevents Doxorubicin-Induced Endothelial-to-Mesenchymal Transition in Human Endothelial Cells and Atherosclerosis in Mice by Wei Chen, Seojin Kim, Sharon Y. Kim, Cheyenne Beheshtian, Naryung Kim, Ki-Hyuk Shin, Reuben H. Kim, Sangjae Kim, No-Hee Park

“…Additionally, GV1001 reduced systemic and vascular inflammation, lipid accumulation, and monocyte/macrophage infiltration within arterial walls in mice. …”
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Immune-endocrine crossroads: the impact of nuclear receptors in Tuberculosis and Chagas disease by Ana R. Pérez, Ana R. Pérez, Oscar A. Bottasso, Oscar A. Bottasso, Oscar A. Bottasso, Natalia E. Santucci, Natalia E. Santucci

“…Chronic infectious diseases, characterized by pathogen persistence, are particularly notable for an exaggerated inflammatory process. Unlike acute inflammation, which helps the host respond to pathogens, chronic inflammation leads to metabolic disorders and a dysregulated neuro-immuno-endocrine response. …”
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T-cell immune status in patients with acute exacerbation of chronic obstructive pulmonary disease: a case-control study by Xiao-feng Xiong, Xiao-feng Xiong, Min Zhu, Min Zhu, Hong-xia Wu, Zuo-hong Wu, Li-li Fan, De-yun Cheng

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The role of homogenization cycles and Poloxamer 188 on the quality of mitochondria isolated for use in mitochondrial transplantation therapy by Ryosuke Takegawa, Kei Hayashida, Atsushi Murao, Yusuke Endo, Cyrus E. Kuschner, Jacob Kazmi, Eriko Nakamura, Ping Wang, Lance B. Becker

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Epithelial NSD2 maintains FMO‐mediated taurine biosynthesis to prevent intestinal barrier disruption by Yue Xu, Xiuying Xiao, Chunxiao Ma, Ziyi Wang, Wenxin Feng, Hanyu Rao, Wei Zhang, Ningyuan Liu, Rebiguli Aji, Xiangjun Meng, Wei‐Qiang Gao, Li Li

“…These data suggest that maintenance of NSD2‐mediated taurine biosynthesis is vital for preserving the intestinal barrier and attenuating inflammation.…”
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Therapeutic role of miR-26a on cardiorenal injury in a mice model of angiotensin-II induced chronic kidney disease through inhibition of LIMS1/ILK pathway by Weijie Ni, Yajie Zhao, Jinxin Shen, Qing Yin, Yao Wang, Zuolin Li, Taotao Tang, Yi Wen, Yilin Zhang, Wei Jiang, Liangyunzi Jiang, Jinxuan Wei, Weihua Gan, Aiqing Zhang, Xiaoyu Zhou, Bin Wang, Bi-Cheng Liu, Yuanyuan Ji

“…Chronic kidney disease (CKD) is associated with common pathophysiological processes, such as inflammation and fibrosis, in both the heart and the kidney. …”
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Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy by James Dooley, Bart Neyns, Elizabeth Allen, Frank Tacke, Louis Boon, Damya Laoui, Julia Katharina Schwarze, Helena Van Damme, Bruno Dombrecht, Máté Kiss, Heleen Roose, Eva Van Overmeire, Daliya Kancheva, Liesbet Martens, Aleksandar Murgaski, Pauline Madeleine Rachel Bardet, Gillian Blancke, Maude Jans, Evangelia Bolli, Maria Solange Martins, Yvon Elkrim, Kiavash Movahedi, Niels Vandamme, Sebahat Ocak, Isabelle Scheyltjens, Lars Vereecke, Frank Aboubakar Nana, Pascal Merchiers, Jo Agnes Van Ginderachter

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An Overall Glance of Evidence Supportive of One-Hour and Two-Hour Postload Plasma Glucose Levels as Predictors of Long-Term Cardiovascular Events by Baldeep K. Mann, Janpreet S. Bhandohal, Jungrak Hong

“…Many molecular studies also supported this fact by illustrating that postchallenge hyperglycemia is associated with elevated biomarkers of systemic inflammation in the plasma and thus increasing the chances of vascular damage. …”
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Helicobacter pylori: Genomic Insight into the Host-Pathogen Interaction by Kathryn P. Haley, Jennifer A. Gaddy

“…The bacterial pathogen, Helicobacter pylori, has been recognized as a class 1 carcinogen and contributes to chronic inflammation within the gastric niche. Genomic analyses have uncovered remarkable coevolution between the human host and H. pylori. …”
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Orbital cellulitis secondary to sinusitis. Case presentation by Oslaymi Yero Lorente, Miriellis Rodriguez Benítez, Manuel Enrique Rodríguez Valdés, Yelenis Abreu Jáuregui

“…Orbital cellulitis is the most frequent cause of acute swelling of the orbit and is a relatively frequent ophthalmological emergency and potentially serious in the pediatric population. The inflammation may extend to post septal region, and affect the orbit content. …”
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Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis: Getting to Know the Unknown by Susan Yung, Tak Mao Chan

“…Accumulating evidence shows that anti-dsDNA antibodies play a critical role in the pathogenesis of lupus nephritis through their binding to cell surface proteins of resident kidney cells, thereby triggering the downstream activation of signaling pathways and the release of mediators of inflammation and fibrosis. This paper describes the mechanisms through which autoantibodies interact with resident renal cells and how this interaction plays a part in disease pathogenesis that ultimately leads to structural and functional alterations in lupus nephritis.…”
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A transcriptional profile of aging in the human kidney. by Graham E J Rodwell, Rebecca Sonu, Jacob M Zahn, James Lund, Julie Wilhelmy, Lingli Wang, Wenzhong Xiao, Michael Mindrinos, Emily Crane, Eran Segal, Bryan D Myers, James D Brooks, Ronald W Davis, John Higgins, Art B Owen, Stuart K Kim

“…Some of the genes whose transcripts increase in abundance with age are known to be specifically expressed in immune cells, suggesting that immune surveillance or inflammation increases with age. The age-regulated genes show a similar aging profile in the cortex and the medulla, suggesting a common underlying mechanism for aging. …”
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PPARs in Calorie Restricted and Genetically Long-Lived Mice by Michal M. Masternak, Andrzej Bartke

“…These transcription factors regulate different physiological functions such as energy metabolism (including lipid and carbohydrate metabolism), insulin action, and immunity and inflammation, and apparently also act as important mediators of longevity and aging. …”
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Clinical Practice Guideline for the Treatment of Percarditis by René Mick Cabrera Núñez, Lázaro de la Cruz Avilés

“…This is a clinical practice guide for the treatment of acute pericarditis, defined as a syndrome caused by inflammation of the pericardium due to various etiologies. …”
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ER Stress and Lipid Metabolism in Adipocytes by Beth S. Zha, Huiping Zhou

“…In addition, we touch upon the interaction of ER stress and autophagy as well as inflammation. Inhibition of ER stress has the potential of decreasing the pathology in adipose tissue that is seen with energy overbalance.…”
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Diagnostic and Prognostic Role of Procalcitonin in Infections by Maria Hatzistilianou

“…The problems with sepsis definitions and diagnoses are indications of the need to focus on biochemical mediators capable not only of distinguishing the inflammatory response to infection from other types of inflammation, but also of indicating the severity and prognosis of the disease. …”
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Clinical and Histopathological Findings in a Patient of Darier–White Disease with Acrokertasosis Verruciformis of Hopf by Vikash Paudel, Manish Bhakta Pradhan, Brijesh Shrestha, Sumit Paudel

“…Although there are no curative treatments for DD, topical corticosteroids and systemic retinoids may be used to control inflammation and hyperkeratosis. We are reporting a rare case with clinical and histological findings of DD with AKVH in a 17-year-old boy with keratotic papules, presented on the hands and feet, nose, and ears without mucosal involvement.…”
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Primary Lymphoepithelioma-Like Carcinoma of Lung by Alejandro Guerrero, Michael Laflamme, S Nicholas Agoff, William M Williams, Riyad Karmy-Jones

“…The lesion was further notable because of the presence of necrotizing granulomatous inflammation. The patient was treated with surgical resection. …”
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Pediatric optic neuritis: literature review by S. Bubnytė, J. Andrulionytė

“… Pediatric optic neuritis is an optic nerve inflammation occuring in 1 to 5 children out of 100,000 per year. …”
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The Impact of Sulforaphane on Sex-Specific Conditions and Hormone Balance: A Comprehensive Review by Jed W. Fahey, Mirran Raphaely

“…SF is the most potent naturally occurring inducer of the Keap1/Nrf2 pathway, which is most well-known for its upregulation of antioxidant and detoxification mechanisms and activation of pathways resulting in the inhibition of inflammation. Much of this regulation involves the various hormonal axes of the body. …”
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