3D-Printed Tablets of Nifurtimox: In Vitro and In Vivo Anti-<i>Trypanosoma cruzi</i> Studies by Giselle R. Bedogni, Ana Luiza Lima, Idejan P. Gross, Tatiana Prata Menezes, Andre Talvani, Marcilio Cunha-Filho, Claudio J. Salomon

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Deoxycholic Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Exacerbates DSS-Induced Colitis through Promoting Cathepsin B Release by Shengnan Zhao, Zizhen Gong, Xixi Du, Chunyan Tian, Lingyu Wang, Jiefei Zhou, Congfeng Xu, Yingwei Chen, Wei Cai, Jin Wu

“…DCA enema significantly aggravated DSS-induced colitis in mice and S1PR2 inhibitor as well as inflammasome inhibition by cathepsin B antagonist substantially reducing the mature IL-1β production and alleviated colonic inflammation superimposed by DCA. Therefore, our findings suggest that S1PR2/ERK1/2/cathepsin B signaling plays a critical role in triggering inflammasome activation by DCA and S1PR2 may represent a new potential therapeutic target for the management of intestinal inflammation in individuals on a high-fat diet.…”
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Hematemesis as Initial Presentation in a 10-Week-Old Infant with Eosinophilic Gastroenteritis by Varun Shetty, Kayla E. Daniel, Anil Kesavan

“…Eosinophilic gastroenteritis is a rare condition characterized by eosinophilic inflammation in the gastrointestinal tract resulting in a variety of gastrointestinal symptoms. …”
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Activation and Regulation of Cellular Eicosanoid Biosynthesis by Thomas G. Brock, Marc Peters-Golden

“…However, the various eicosanoids are synthesized by a wide variety of cell types by distinct enzymatic pathways, and have diverse roles in immunity and inflammation. In this review, the major pathways involved in the synthesis of eicosanoids, as well as key points of regulation, are presented.…”
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Presence of Autoimmune Antibody in Chikungunya Infection by Wirach Maek-a-nantawat, Udomsak Silachamroon

“…During the investigation to exclude autoimmune muscular inflammation, high titers of antinuclear antibody were detected. …”
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Evaluation of In Vitro Anti-inflammatory Activity of Azomethines of Aryl Oxazoles by V. Niraimathi, A. Jerad Suresh, T. Latha

“…Azomethines of aryl oxazoles were evaluated for anti-inflammatory by in vitro hemolytic membrane stabilising study. The effect of inflammation condition was studied on erythrocyte exposed to hypotonic solution. …”
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PPARγ in Inflammatory Bowel Disease by Vito Annese, Francesca Rogai, Alessia Settesoldi, Siro Bagnoli

“…The colon is a major tissue which expresses PPARγ in epithelial cells and, to a lesser degree, in macrophages and lymphocytes and plays a role in the regulation of intestinal inflammation. Indeed, both natural and synthetic PPARγ ligands have beneficial effects in different models of experimental colitis, with possible implication in the therapy of inflammatory bowel disease (IBD). …”
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Fluticasone Propionate in Inflammatory Bowel Disease by Marta Carpani de Kaski, Humphery JF Hodgson

“…In particular, fluitcasone propionate is a fluorinated glucocorticoid, in which systemic side effects are absent or minimal due to its relatively low absorption and rapid first pass metabolism In an open trial in 12 patients with mild and moderately active Crohn's disease, administration of 20 mg fluitcasone propionate orally was associated with a significant fall in the Crohn's disease activity index and improvement in other parameters of inflammation, without change in either plasma cortisol levels or responsiveness to adrenocorticotropic hormone, suggesting that this drug is a promising therapy for Crohn's disease meriting evaluation against conventional corticosteroids.…”
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Mesenteric Panniculitis Presenting as Fever of Unknown Etiology in a Patient with History of Abdominal Surgery by Christopher P. Irwin, Joo B. Lee, Andrew Kim, Ijagha Eme, Christina Schofield, George Mount

“…Mesenteric panniculitis is characterized by nonspecific fibrous inflammation of the small bowel mesentery, appendix, and mesoappendix. …”
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Cytokines and Liver Diseases by Herbert Tilg

“…There is increasing evidence that several cytokines mediate hepatic inflammation, apoptosis and necrosis of liver cells, cholestasis and fibrosis. …”
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Orofacial Granulomatosis in a Child by Reena Razdan, Maxwell D. Newby, Michele M. Carr

“…Full-thickness mucosal biopsy reveals noncaseating granulomatous inflammation, similar to Crohn’s disease and sarcoidosis. …”
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PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia by Sarawin Harnchoowong, Poonkiat Suchonwanit

“…Disruption of PPAR-γ is believed to be one of the mechanisms of primary cicatricial alopecia (PCA) pathogenesis, causing pilosebaceous dysfunction leading to follicular inflammation. In this review article, we discuss the pathogenesis of PCA with a focus on PPAR-γ involvement in pathogenesis of lichen planopilaris (LPP), the most common lymphocytic form of PCA. …”
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ERYTHROCYTE SEDEMENTATION RATE:A USEFUL TOOL IN DIAGNOSTIC APPROACH by Muhammad Usman

“…Although it doesn’t enjoy the status of being called a diagnostic test,even then it is in continuous use as a good indicator in conditions like infections and inflammations; for screening and prognosis of certain diseases and also for monitoring the course of an existing disease.It is a good indicator to estimate the quantitative change in plasma that may occur in a lot of clinical conditions ranging from simple to much serious disorders such as inflammation, infection, pregnancy, obesity and even malignancies. …”
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Cytokine-Leukotriene Receptor Interactions by Marek Rola-Pleszczynski, Jana Stankova

“…A privileged interaction exists between these lipid mediators and another group of molecules essential for inflammation and immune modulation, namely, cytokines. …”
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Modulation of gut microbiota by dietary macronutrients in type 2 diabetes: a review by Hong Jing Wang, Oumaima Battousse, Amutha Ramadas

“…Literature suggests macronutrients impose significant impacts on the gut microbiome related to glucose tolerance, insulin resistance and inflammation. Although there is insufficient literature on gut microbiota modulation via dietary macronutrient management, this area of study has been gradually gaining interest amongst researchers. …”
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Neuroinflammatory Mechanisms of Mitochondrial Dysfunction and Neurodegeneration in Glaucoma by Joao N. Duarte

“…Recent evidence shows that, in conditions where mitochondria are damaged, a sustained inflammatory response and downstream pathological inflammation may ensue. Mitochondrial damage has been linked to the accumulation of age-related mitochondrial DNA mutations and mitochondrial dysfunction, possibly through aberrant reactive oxygen species production and defective mitophagy. …”
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Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity by Barry Sears, Camillo Ricordi

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Steroids and/or Cytotoxic Agents Should Be Used Early in the Management of Patients with IPF -- The Pro Argument by Sat Sharma

“…These disorders present with similar clinical features of shortness of breath, diffuse pulmonary infiltrates on chest radiograph, and histologically, a varying combination of inflammation and fibrosis. However, the natural history and response to therapy differs substantially, as some categories have more favourable prognoses than others (2). …”
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Crohn’s Disease – The Pathogenesis of a Granulomatous Vasculitis: A Hypothesis by Andrew J Wakefield

“…The virus was detected in foci of granulomatous and lymphocytic inflammation. Recent epidemiological data from Sweden support the idea that early exposure to measles virus is a risk factor for the later development of Crohn’s disease. …”
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Orbital Pseudotumor as an Extrahepatic Complication of Chronic HCV Infection by Owen Huang, Tina Shah, Divya Sundarapandiyan, Matthew J. Akiyama

“…We present a patient who was admitted for eye swelling, pain, and discharge, with CT orbits with contrast demonstrating inflammation and enlargement of the lacrimal glands and surrounding tissue. …”
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