HDAC Inhibition Modulates Cardiac PPARs and Fatty Acid Metabolism in Diabetic Cardiomyopathy by Ting-I Lee, Yu-Hsun Kao, Wen-Chin Tsai, Cheng-Chih Chung, Yao-Chang Chen, Yi-Jen Chen

“…The aim of this study was to investigate whether HDAC inhibitor, MPT0E014, can modulate myocardial PPARs, inflammation, and fatty acid metabolism in diabetes mellitus (DM) cardiomyopathy. …”
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Methylcobalamin protects against liver failure via engaging gasdermin E by Wanfeng Xu, Yun Wang, Shuang Cui, Qiuling Zheng, Yanghao Lin, Qingqing Cui, Yuxin Xie, Yuming Zeng, Chuan Zhang, Yujie Li, Xin Jin, Minna Qin, Huiyong Sun, Haiping Hao, Lijuan Cao

“…In cholestasis-, cisplatin- or concanavalin A (Con A)-induced male mouse models, MeCbl significantly suppresses liver transaminase activities and inflammation, alleviates hepatocyte death, and reduces mortality of mice by blocking GSDME cleavage. …”
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Comparative Outcomes of Standard Perioperative Eye Drops, Intravitreal Triamcinolone Acetonide-Moxifloxacin, and Intracameral Dexamethasone-Moxifloxacin-Ketorolac in Cataract Surge... by Robin K. Kuriakose, Soungmin Cho, Saman Nassiri, Frank S. Hwang

“…The purpose of this study is to compare the effectiveness of intravitreal triamcinolone acetonide-moxifloxacin and intracameral dexamethasone-moxifloxacin-ketorolac to a standard eye drop regimen in controlling postoperative inflammation, corneal edema, and intraocular pressure (IOP) among cataract patients. …”
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Effect of Antrodia camphorata on Inflammatory Arterial Thrombosis-Mediated Platelet Activation: The Pivotal Role of Protein Kinase C by Wan-Jung Lu, Shih-Chang Lin, Chang-Chou Lan, Tzu-Yin Lee, Chih-Hsuan Hsia, Yung-Kai Huang, Hsiu-Chuan Lee, Joen-Rong Sheu

“…Critical vascular inflammation leads to vascular dysfunction and cardiovascular diseases, including abdominal aortic aneurysms, hypertension, and atherosclerosis. …”
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Metabolic consequences of erastin-induced ferroptosis in human ovarian cancer cells: an untargeted metabolomics study by Kaylie I. Kirkwood-Donelson, Alan K. Jarmusch, Carl D. Bortner, Bruce Alex Merrick, Birandra K. Sinha

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Immunomodulation effects of collagen hydrogel encapsulating extracellular vesicles derived from calcium silicate stimulated-adipose mesenchymal stem cells for diabetic healing by Yen-Hong Lin, Yeh Chen, En-Wei Liu, Mei-Chih Chen, Min-Hua Yu, Cheng-Yu Chen, Chia-Che Ho, Tai-Yi Hsu-Jiang, Jian-Jr Lee, Der-Yang Cho, Ming-You Shie

“…Abstract Diabetic wounds are characterized by chronic inflammation, reduced angiogenesis, and insufficient collagen deposition, leading to impaired healing. …”
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Plasma-derived extracellular vesicles prime alveolar macrophages for autophagy and ferroptosis in sepsis-induced acute lung injury by Rongzong Ye, Yating Wei, Jingwen Li, Yu Zhong, Xiukai Chen, Chaoqian Li

“…In vivo, the inhibition of miR-223-3p effectively mitigated LPS-EV-induced inflammation and AM death in the lungs, as well as histological lesions. …”
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Synergic Renoprotective Effects of Combined ASC Therapy with RAAS Blockade in Experimental Advanced CKD by Marina P. C. Maires, Krislley R. Pereira, Everidiene K. V. B. Silva, Victor H. R. Souza, Flavio Teles, Paulyana F. Barbosa, Margoth R. Garnica, Felipe M. Ornellas, Irene L. Noronha, Camilla Fanelli

“…Overactivity of the renin-angiotensin-aldosterone system (RAAS), associated to renal inflammation and fibrosis, contributes to its evolution. …”
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The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with age-related hearing impairment in a Taiwanese population: a case control study by Ning-Chia Chang, Hua-Ling Yang, Chia-Yen Dai, Wen-Yi Lin, Hsun-Mo Wang, Chen-Yu Chien, Kuen-Yao Ho

“…Abstract Background Age-related hearing impairment (ARHI) is a major disability among the elder population. Chronic inflammation is an important factor in the development of ARHI. …”
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Comparison of the impact of intermittent fasting diet alone or in conjunction with probiotic supplementation versus calorie-restricted diet on inflammatory, oxidative stress, and a... by Sepide Talebi, Sakineh Shab-Bidar, Gholamreza Askari, Hamed Mohammadi, Ashraf Moini, Kurosh Djafarian

“…Background: The objective of this study was to compare the effects of early time-restricted eating (eTRE) and eTRE plus probiotic supplementation to daily caloric restriction (DCR) alone in terms of biomarkers of oxidative stress (OS), antioxidant capacity, inflammation, and blood pressure (BP) in obese women with polycystic ovary syndrome (PCOS). …”
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NLRP3 is a BMI-independent mediator of stable COPD by Yonca Gungor, Selin Ercan, Saliha Selin Özuygur Ermiş, Yiğit Kozalı, Gizem Kursunluoglu, Ceyda Sahan, Aylin Ozgen Alpaydin, Hulya Ayar Kayali

“…Smoking may trigger NLRP3-mediated inflammation in stable COPD patients. The expression levels of NLRP3 inflammasome molecules did not differ in terms of disease severity or BMI. …”
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The correlation of the forkhead transcription factor foxo1 expression and histopathological pancreatic lesions in dogs by Firas M. Abed, Ahmed N. Abduljawaad, Omar A. Al-Mahmood, Karam H. Yehia, Hana Kh. Ismail

“…In dogs, pancreatic lesions can range from mild inflammation (pancreatitis) to more severe conditions such as pancreatic cancer. …”
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Deficiency of Dietary Fiber in Slc5a8-Null Mice Promotes Bacterial Dysbiosis and Alters Colonic Epithelial Transcriptome towards Proinflammatory Milieu by Sathish Sivaprakasam, Pramodh K. Ganapathy, Mohd Omar Faruk Sikder, Moamen Elmassry, Sabarish Ramachandran, Kameswara Rao Kottapalli, Vadivel Ganapathy

“…Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the intestinal tract due to disruption of the symbiotic relationship between the host immune system and microbiota. …”
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Circulating miR-574–5p shows diagnostic and prognostic significance and regulates oxygen-glucose deprivation (OGD)-induced inflammatory activation of microglia by targeting ATP2B2... by Xia Yin, Chunlei Zhang

“…The regulation of inflammation, oxidative stress, and proliferation of microglia by miR-574–5p were assessed by cell transfection. …”
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Clinicopathological Features and Increased Expression of Toll-Like Receptor 4 of Gastric Cardia Cancer in a High-Risk Chinese Population by Guangcan Chen, Muming Xu, Jingyao Chen, Liangli Hong, Wenting Lin, Shukun Zhao, Guohong Zhang, Guo Dan, Shuhui Liu

“…Immunohistochemistry for TLR4 was performed in 201 histological samples of normal gastric cardia mucosa (n=11), gastric cardia inflammation (n=87), and GCC (n=103). We included 84 patients with EC and 99 with GCC. …”
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Arterial Hypertension and Interleukins: Potential Therapeutic Target or Future Diagnostic Marker? by Daniela Maria Tanase, Evelina Maria Gosav, Smaranda Radu, Anca Ouatu, Ciprian Rezus, Manuela Ciocoiu, Claudia Florida Costea, Mariana Floria

“…Increased vascular permeability, thrombogenesis, and fibrosis, effects that are associated with sustained hypertension, could be attributed to chronic inflammation. Chronic inflammation triggers endothelial dysfunction via increased production of ROS through proinflammatory cytokines. …”
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Associates of an Elevated Natriuretic Peptide Level in Stable Heart Failure Patients: Implications for Targeted Management by Aftab Jan, Ian Dawkins, Niamh Murphy, Patrick Collier, John Baugh, Mark Ledwidge, Kenneth McDonald, Chris J. Watson

“…Among the potential stimuli for NP in clinically stable patients are persistent occult fluid overload, wall stress, inflammation, fibrosis, and ischemia. The purpose of this study was to identify associates of B-type natriuretic peptide (BNP) in a stable HF population. …”
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Effects of POPs-induced SIRT6 alteration on intestinal mucosal barrier function: A comprehensive review by Guangcan Chen, Tengyang Huang, Yifeng Dai, Xia Huo, Xijin Xu

“…Sirtuin 6 (SIRT6), a sirtuin family member, is pivotal in genome and telomere stability, inflammation regulation, and metabolic processes. Result shows POPs have been implicated in the intestinal diseases, particularly in intestinal barrier dysfunction, through mechanisms such as cellular damage, epigenetic alterations, inflammation, microbiota changes, and metabolic disruptions. …”
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Vascular Protective Effects of Morinda citrifolia Leaf Extract on Postmenopausal Rats Fed with Thermoxidized Palm Oil Diet: Evidence at Microscopic Level by C. L. G. Chong, Faizah Othman, Farida Hussan

“…Atherosclerosis is now well understood as an inflammatory disease instead of lipid storage disorder; however, the conventional treatment is not targeted on treating the inflammation. Morinda citrifolia L. (Rubiaceae) leaf or noni leaf, which is a medicinal food (ulam) used in Traditional Malay Medicine to prevent chronic diseases, may have the potential to be formulated into a functional antiatherosclerotic agent. …”
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Investigation of the Molecular Mechanism of Asthma in Meishan Pigs Using Multi-Omics Analysis by Weilong Tu, Hongyang Wang, Yingying Zhang, Ji Huang, Yuduan Diao, Jieke Zhou, Yongsong Tan, Xin Li

“…Asthma in Meishan pigs is related to inflammation, mitochondrial oxidative phosphorylation, and tricarboxylic acid (TCA) cycle disorders. …”
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