Role of macrophage in intervertebral disc degeneration by Yiming Dou, Yiming Zhang, Yang Liu, Xun Sun, Xinyu Liu, Bin Li, Qiang Yang

“…Abstract Intervertebral disc degeneration is a degenerative disease where inflammation and immune responses play significant roles. …”
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Atypical Endobronchial Carcinoid with Postobstructive Pneumonia Obscuring the Diagnosis of Granulomatosis with Polyangiitis by Robert Ali, Candice Baldeo, Jesse Onyenekwe, Roshan Lala, Cristian Landa, Anwer Siddiqi

“…Diagnosis hinges on identifying a combination of clinical features of systemic vasculitis, positive ANCA serology, and histological evidence of necrotizing vasculitis, necrotizing glomerulonephritis, or granulomatous inflammation from a relevant organ biopsy. The American College of Rheumatology has also developed a classification criteria focusing specifically on nasal or oral inflammation, abnormal chest radiograph, and abnormal urinary sediment, along with granulomatous inflammation, which helps to distinguish GPA from other forms of systemic vasculitis. …”
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Multiple Factors Determine the Oncolytic or Carcinogenic Effects of TLRs Activation in Cancer by Yingxiang Yang, Chengyue Jin, Anthony Yeo, Bo Jin

“…In this context of a variety of proinflammtory cytokines being produced, chronic inflammation may result. Inflammation is an important protective mechanism. …”
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C-Reactive Protein and Breast Cancer: New Insights from Old Molecule by Shilpa Balaji Asegaonkar, Balaji Narayanrao Asegaonkar, Unmesh Vidyadhar Takalkar, Suresh Advani, Anand Pandurang Thorat

“…Recently an association between breast cancer and inflammation has emerged as the seventh hallmark of cancer. …”
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Single-Cell Transcriptome Analysis Profile of Meniscal Tissue Macrophages in Human Osteoarthritis by Jingbin Zhou, Zhihong Zhao, Chen He, Feng Gao, Yu Guo, Feng Qu, Yujie Liu

“…Osteoarthritis (OA) has long been considered as a degenerative disease, but growing evidence suggests that inflammation plays a vital role in its pathogenesis. …”
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VANGL2 alleviates inflammatory bowel disease by recruiting the ubiquitin ligase MARCH8 to limit NLRP3 inflammasome activation through OPTN-mediated selective autophagy. by Huaji Jiang, Yingchao Xie, Zhiqiang Hu, Jiansen Lu, Jiahuan Zhang, Hongyu Li, Ke Zeng, Wenqiang Peng, Cheng Yang, Junsheng Huang, Zelong Han, Xiaochun Bai, Xiao Yu

“…Inflammatory bowel disease (IBD) is a chronic and potentially life-threatening inflammatory disease of gastroenteric tissue characterized by episodes of intestinal inflammation, but the underlying mechanisms remain elusive. …”
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Eyelid edema in relapsing polychondritis by Anshul Goel, Arun Gogna

“…Eyelid edema is a recognized manifestation of this disease frequently in association with inflammation in other parts of eyes. This case highlights eyelid edema in a patient who presented primarily with chondritis of the pinna, which subsided with steroids.…”
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Simultaneous Pulmonary Embolism and Carotid Thrombosis as a Presenting Manifestation of COVID-19 by Leon Smith, Brian Zeman

“…Although COVID-19 was initially described predominantly as a respiratory infection, subsequent reports noted that it can produce generalised inflammation with effects on multiple organ systems. …”
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Periodontal diseases in Down syndrome during childhood: a scoping review by Valentin Vergier, Anne-Margaux Collignon, Marjolaine Gosset, Anne-Laure Bonnet

“…Conclusions DS children seem to have higher periodontal inflammation than other children, but no periodontal bone loss. …”
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Dangerous Liaison: Helicobacter pylori, Ganglionitis, and Myenteric Gastric Neurons: A Histopathological Study by Liana Sticlaru, Florica Stăniceanu, Mirela Cioplea, Luciana Nichita, Alexandra Bastian, Gianina Micu, Cristiana Popp

“…Chronic inflammation induced by Helicobacter pylori (H. pylori) infection plays a major role in development of gastric cancer. …”
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Microglia Play a Major Role in Direct Viral-Induced Demyelination by Dhriti Chatterjee, Kaushiki Biswas, Soma Nag, S. G. Ramachandra, Jayasri Das Sarma

“…Our results suggest that MHV can directly infect and activate microglia during acute inflammation, which in turn during chronic inflammation stage causes phagocytosis of myelin sheath leading to chronic inflammatory demyelination.…”
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TNF Tolerance in Monocytes and Macrophages: Characteristics and Molecular Mechanisms by René Huber, Rolf Bikker, Bastian Welz, Martin Christmann, Korbinian Brand

“…We conclude that TNF tolerance may represent a protective mechanism involved in the termination of inflammation and preventing excessive or prolonged inflammation. …”
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Ventral Prostate Fibrosis in the Akita Mouse Is Associated with Macrophage and Fibrocyte Infiltration by Sanghee Lee, Guang Yang, William Mulligan, Jerry Gipp, Wade Bushman

“…Recently, prostate inflammation and fibrosis have been implicated as major contributing factors to bladder outlet obstruction and LUTS. …”
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Thrombotic Complications in Inflammatory Bowel Disease by A. V. Borota, A. A. Borota, E. V. Onishchenko

“…In the сonditions under study, the presence of chronic inflammation and increased bleeding of the intestinal wall is shown to activate the coagulation system, impair the fibrinolysis system and reduce the activity of natural anticoagulation mechanisms. …”
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Tributyrin Supplementation Protects Immune Responses and Vasculature and Reduces Oxidative Stress in the Proximal Colon of Mice Exposed to Chronic-Binge Ethanol Feeding by B. Glueck, Y. Han, G. A. M. Cresci

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A Novel Paramagnetic Substrate for Detecting Myeloperoxidase Activity in Vivo by Mohammed S. Shazeeb, Yang Xie, Suresh Gupta, Alexei A. Bogdanov

“…Specifically, gadolinium chelates of bis-5-hydroxytryptamide-DTPA (bis-5HT-DTPA(Gd)) have been used to image localized inflammation in animal models by detecting neutrophil-derived myeloperoxidase (MPO) activity at the inflammation site. …”
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Convergent evolution of oxidized sugar metabolism in commensal and pathogenic microbes in the inflamed gut by Sophia Levy, Angela K. Jiang, Maggie R. Grant, Gabriela Arp, Glory Minabou Ndjite, Xiaofang Jiang, Brantley Hall

“…Abstract Inflammation-associated perturbations of the gut microbiome are well characterized, but poorly understood. …”
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Adipokines as Drug Targets in Diabetes and Underlying Disturbances by Vinícius Andrade-Oliveira, Niels O.S. Câmara, Pedro M. Moraes-Vieira

“…We describe how adipokines regulate inflammation in these diseases and their therapeutic implications. …”
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Features of the Atrophic Corpus Mucosa in Three Cases of Autoimmune Gastritis Revealed by Magnifying Endoscopy by Kazuyoshi Yagi, Atsuo Nakamura, Atsuo Sekine, David Graham

“…We speculate that this reflects differences in inflammation between the two types of gastritis. In autoimmune gastritis the inflammation is directed primarily against gastric glands, whereas in H. pylori infection the inflammation is directed against the bacteria on or near the surface and the damage initially affects the surface epithelium. …”
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Low-dose radiation ameliorates PM2.5-induced lung injury through non-canonical TLR1/TLR2-like receptor pathways modulated by Akkermansia muciniphila by Li Wang, Zhipeng Li, Huan He, Lijing Qin, Weiqiang Xu, Hongyuan Tian, Rongrong Liu, Xinru Lian, Wen Li, Yali Qi, Zhicheng Wang

“…Additionally, gut microbiota and inflammation are crucial in lung injury and the health benefits of LDR through gut microbiota need further exploration. …”
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