PathoGD: an integrative genomics approach to primer and guide RNA design for CRISPR-based diagnostics by Soo Jen Low, Matthew O’Neill, William J. Kerry, Natasha Wild, Marcelina Krysiak, Yi Nong, Francesca Azzato, Eileen Hor, Lewis Williams, George Taiaroa, Eike Steinig, Shivani Pasricha, Deborah A. Williamson

Get full text

Hepatitis C pada Anak by Yusri Dianne Jurnalis, Yorva Sayoeti, Adria Russelly

“…Acute HCV infection may end up with cirrhosis and hepatocellular carcinoma after the third decade (around 20%), due to a slower progression of HCV infection of hepatitis B virus infection. …”
Get full text

Sequence Analysis of Long-Term Readmissions among High-Impact Users of Cerebrovascular Patients by Ahsan Rao, Alex Bottle, Ara Darzi, Paul Aylin

“…Common discriminating subsequences in chronic high-impact users (n=2863) of ischaemic stroke (n=34208) were “urological conditions-chest infection,” “chest infection-urological conditions,” “injury-urological conditions,” “chest infection-ambulatory condition,” and “ambulatory condition-chest infection” (p<0.01). …”
Get full text

Interaction between Th17 and central nervous system in multiple sclerosis by Shixin Lai, Xiaomin Wu, Yue Liu, Bo Liu, Haiqi Wu, Kongyang Ma

Get full text

The Impact of Serum Vancomycin Levels and Minimum Inhibitory Concentrations of Methicillin-Resistant Staphylococcus aureus on Mortality in Patients with Nosocomial Pneumonia by Denise Pires Machado, Luciano Z Goldani, Rodrigo Minuto Paiva, Valério Rodrigues Aquino, Fernanda de-Paris, Thiago Lisboa, Bruno Jung, Rodrigo Pires dos Santos

“…BACKGROUND: Vancomycin is the treatment of choice for methicillin-resistant Staphylococcus aureus (MRSA) infections; however, treatment failure is not uncommon, even when the minimum inhibitory concentration (MIC) of the MRSA strain is within the susceptible range for vancomycin.…”
Get full text

Novel oral adjuvant to enhance cytotoxic memory like NK cell responses in HIV vaccine platform by Mario Alles, Manuja Gunasena, Christina Isckarus, Ilmini De Silva, Sarah Board, Will Mulhern, Patrick L. Collins, Thorsten Demberg, Namal P. M. Liyanage

“…Our study underscores the potential of incorporating I3C as an oral adjuvant to HIV vaccine platforms to enhance antigen-specific cytotoxicity of NK cells against HIV-infected cells. This approach may contribute to enhancing the protective efficacy of HIV preventive vaccines against HIV acquisition.…”
Get full text

Still No Substantial Evidence to Use Prophylactic Antibiotic at Operative Vaginal Delivery: Systematic Review and Meta-Analysis by Yifru Berhan, Sisay Kirba, Achamyelesh Gebre

“…Postpartum maternal infection is still a common problem worldwide, mainly due to obstetric risk factors. …”
Get full text

A case–control study based on the National Health and Nutrition Examination Survey to evaluate the effects of human papilloma virus on bone health in women by Xiang Li, Guangjun Jiao, Yunzhen Chen

“…Abstract Background Human papillomavirus (HPV) infection and osteoporosis (OP) are global health concerns, with higher prevalence observed in women compared to men. …”
Get full text

The Central Role and Possible Mechanisms of Bacterial DNAs in Sepsis Development by Zhenxing Cheng, Simon T. Abrams, James Austin, Julien Toh, Susan Siyu Wang, Zhi Wang, Qian Yu, Weiping Yu, Cheng Hock Toh, Guozheng Wang

Get full text

Glutamine-glutamate centered metabolism as the potential therapeutic target against Japanese encephalitis virus-induced encephalitis by Mengyuan Li, Hang Yuan, Xiaofei Yang, Yingfeng Lei, Jianqi Lian

“…Given that viruses are obligate intracellular parasites, cellular metabolic reprogramming triggered by viral infection is intricately related to the establishment of infection and progression of disease. …”
Get full text

Progression of the faecal microbiome in preweaning dairy calves that develop cryptosporidiosis by M. F. Hares, B. E. Griffiths, L. Barningham, E. E. Vamos, R. Gregory, J. S. Duncan, G. Oikonomou, C. J. Stewart, J. L. Coombes

“…The causative agent, Cryptosporidium parvum, has been associated with the abundance of specific taxa in the faecal microbiome during active infection. However, the long-term impact of these microbiome shifts, and potential effects on calf growth and health have not yet been explored in depth. …”
Get full text

Genomic interrogation of invasive group A Streptococcus (iGAS) epidemiology and COVID-19 impacts in Victoria, Australia: a 6-year retrospective studyResearch in context by Jacqueline M. Morris, Jake A. Lacey, Kerrie Stevens, Lamali Sadeesh Kumar, Mathilda Wilmot, Janet Strachan, Marion Easton, Daneeta Hennessy, Tony M. Korman, Andrew J. Daley, Katherine B. Gibney, Adam W.J. Jenney, Steven Y.C. Tong, Benjamin P. Howden, Norelle L. Sherry

Get full text

Innate Immunity and Neuroinflammation by Abhishek Shastri, Domenico Marco Bonifati, Uday Kishore

“…Inflammation of central nervous system (CNS) is usually associated with trauma and infection. Neuroinflammation occurs in close relation to trauma, infection, and neurodegenerative diseases. …”
Get full text

Restoration of Type 17 immune signaling is not sufficient for protection during influenza-associated pulmonary aspergillosis by Aijaz Ahmad, Ravineel B. Singh, Kara L. Nickolich, Matthew J. Pilewski, Caden Ngeow, Kwame Frempong-Manso, Keven M. Robinson

“…IntroductionInfluenza-associated pulmonary aspergillosis (IAPA) is a severe complication of influenza infection that occurs in critically ill patients and results in higher mortality compared to influenza infection alone. …”
Get full text

Transmission Risk on a Neonatal Intensive Care Unit: Escherichia coli versus Klebsiella pneumoniae by Tanja Artelt, Martin Kaase, Ivonne Bley, Helmut Eiffert, Alexander Mellmann, Helmut Küster, Martina Lange, Simone Scheithauer

“…Isolation precautions required for neonatal intensive care units are part of a bundle with the aim to prevent transmission, colonization, and infection with multidrug-resistant gram-negative pathogens as neonates face an increased risk of mortality and morbidity in case of infection. …”
Get full text

Molecular investigation of Hepatozoon canis in dogs in Mosul city by Zeena D. Zaki, Wasan A. Alobaidii

“…The total positive sample was 33 dogs out of 120 dogs (27.5%) the relationship between the infection with the parasite and the age of animals recorded a high prevalence of infection in dogs less than 6 months while the lowest prevalence of infection in animals more than 2 years old, The male dogs showed a high prevalence of infection when compared with female dog, The large breeds dogs recorded high prevalence of infection than small breeds dogs, The outdoor dogs showed a high prevalence of infection Animals which suffer from paleness in mucous membrane showed high prevalence, while healthy animals recorded lowest prevalence of infection, gene sequence showed there were only three isolates out of the total samples sent for genetic sequencing.…”
Get full text

The clinical-stage drug BTZ-043 accumulates in murine tuberculosis lesions and efficiently acts against Mycobacterium tuberculosis by Andreas Römpp, Axel Treu, Julia Kokesch-Himmelreich, Franziska Marwitz, Julia Dreisbach, Nadine Aboutara, Doris Hillemann, Moritz Garrelts, Paul J. Converse, Sandeep Tyagi, Sina Gerbach, Luzia Gyr, Ann-Kathrin Lemm, Johanna Volz, Alexandra Hölscher, Leon Gröschel, Eva-Maria Stemp, Norbert Heinrich, Florian Kloss, Eric L. Nuermberger, Dominik Schwudke, Michael Hoelscher, Christoph Hölscher, Kerstin Walter

Get full text

Effect of Hepatitis E Virus on the Male Reproductive System: A Review of Current Evidence by Ahmed A. Kotb, Mohamed A. El-Mokhtar, Ibrahim M. Sayed

“…However, the effect of HEV infection on male infertility is not confirmed. One study including human samples showed male infertility associated with HEV genotype 4 infection. …”
Get full text

Modulation of Leishmania (L.) amazonensis Growth in Cultured Mouse Macrophages by Prostaglandins and Platelet Activating Factor by M. V. C. Lonardoni, C. L. Barbieri, M. Russo, S. Jancar

“…These results suggested that the infection of macrophages by leisbmanla is inhibited by PAF and enhanced by prostaglandins and that these mediators are produced by macrophages during this infection. …”
Get full text

Candida auris screening of high-risk patients: a descriptive comparison of 2 strategies by Laura Pedersen, Aldo Barajas-Ochoa, Kaila Cooper, Jenna Price, Kathryn Hannum, Yvette Major, Patrick R. Ching, Barry Rittmann, Alexandra Bryson, Christoper Doern, Michelle Doll

Get full text