Discovery of Evolutionary Loss of the Ubiquitin-like Autophagy-Related ATG12 System in a Lineage of Apicomplexa by Xiaoxia X. Lin, Yun D. Bai, Sichang T. Wang, Akira Nozawa, Tatsuya Sawasaki, Tatsunori Masatani, Kenji Hikosaka, Masahito Asada, Hirokazu Sakamoto

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The disappearing COVID-Naïve Population and comparative Roche vs. Abbott Test sensitivity: evidence from antibody seroprevalence in Milwaukee County, Wisconsin by Lorenzo Franchi, Vladimir Atanasov, Mark Stake, Garrett Bates, Kristen Osinski, John R Meurer, Bernard Black

“…Positive tests for spike protein antibodies were very high (86%; 19/22) even among unvaccinated persons who reported no knowledge of prior infection. Thus, by mid-2022, almost all persons were no longer COVID-naïve, defined as vaccination, infection (often without symptoms), or both. …”
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Justified Suspicion: Symptomatic Syphilitic Alopecia in a Patient with Well-Controlled HIV by Robert Jame, Yousif Al-Saeigh, Leo L. Wang, Kevin Wang

“…An estimated 25% of primary and secondary syphilis, a sexually transmitted infection caused by the spirochete bacterium Treponema pallidum, occurs in patients coinfected with human immunodeficiency virus (HIV) (Chesson et al., 2005). …”
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Immune Dysfunction in HIV: A Possible Role for Pro- and Anti-Inflammatory Cytokines in HIV Staging by Iorhen Ephraim Akase, Bolanle O. P. Musa, Reginald Onyedumarakwe Obiako, Abdurrahman Ahmad Elfulatiy, Abdullahi Asara Mohammed

“…HIV infection is a chronic infection that almost inevitably progresses to AIDS. …”
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Prevalence and Predictors of Maternal Anemia during Pregnancy in Gondar, Northwest Ethiopia: An Institutional Based Cross-Sectional Study by Mulugeta Melku, Zelalem Addis, Meseret Alem, Bamlaku Enawgaw

“…Low income, large family size, hookworm infection, and HIV infection were associated with anemia. …”
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Intraoperative Disinfection by Pulse Irrigation with Povidone-Iodine Solution in Spine Surgery by Vincenzo De Luna, Federico Mancini, Fernando De Maio, Gabriele Bernardi, Ernesto Ippolito, Roberto Caterini

“…Background. Deep wound infection in spine surgery is a debilitating complication for patients and increases costs. …”
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Maxillary Fungal Osteomyelitis Mimicking and Treated as Endodontic Pathosis by Sarang Suresh Hotchandani, Feroze Ali Kalhoro, Priya Rani Harjani, Mahwish Memon

“…Fungal osteomyelitis is a lethal opportunistic infection that affects only a small percentage of patients present to endodontists. …”
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Cryptococcal Meningitis in an Immunocompetent Patient with a Ventriculo-Pleural Shunt by Raynieri Fernandez, Jose Henao, Catherine Creticos

“…Cryptococcal meningitis is the most common form of infection caused by Cryptococcus yeast species, followed by pulmonary infection. …”
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Haematologic and Urologic Manifestations of Cryptococcus neoformans by Jessica Morgan, John Vardanega, Mimi Yue, Ian Gassiep

“…Cryptococcus neoformans classically causes pulmonary and central nervous system (CNS) infection in immunocompromised hosts and can lead to disseminated disease. …”
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Cladophialophora bantiana Brain Abscess in an Immunocompetent Patient by Sanjay G. Revankar

“…Additional studies to understand the pathogenesis of this infection and to improve outcomes are needed.…”
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Single‐cell sequencing reveals the features of adaptive immune responses in the liver of a mouse model of dengue fever by Yizhen Yuan, Qian Chen, Zhe Li, Fangzhou Cai, Dan Li, Wei Wang

“…Methods We used single‐cell sequencing to examine the liver tissues of mild or severe dengue mice model to analyze the changes in immune response of T cells in the liver after dengue virus infection, and the immune interaction between macrophages and T cells. …”
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Visual Mapping of Operating Theater Team Dynamics and Communication for Reflexive Feedback and Surgical Practice Optimization by Surya Surendran, MA, Candice Bonaconsa, MSc, Vrinda Nampoothiri, PharmD, Oluchi Mbamalu, PhD, Anu George, PGDip, Swetha Mallick, MCh, Sudheer OV, MCh, Alison Holmes, MD, Marc Mendelson, PhD, Sanjeev Singh, PhD, Gabriel Birgand, PhD, Esmita Charani, PhD

“…We mapped the OT team dynamics and infection control practices using visual methods to guide reflexive feedback and optimize perioperative practices. …”
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Confronting needlestick and sharp injuries in healthcare: a decade of struggle and progress in a university teaching hospital by Shuk-Ching Wong, Lithia Lai-Ha Yuen, Germaine Kit-Ming Lam, Monica Oi-Tung Kwok, Crystal Yuen-Ki Siu, Bella Hong-Yan Li, Jonathan Hon-Kwan Chen, Simon Yung-Chun So, Kelvin Hei-Yeung Chiu, Vincent Chi-Chung Cheng

“…Abstract Background Needlestick and sharp injuries (NSIs) among healthcare workers (HCWs) are a significant concern in infection prevention. This study analyzes the incidence and characteristics of NSIs at Queen Mary Hospital and assesses the effectiveness of targeted training programs for interns. …”
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Invariant Natural Killer T Cells as Key Players in Host Resistance against Paracoccidioides brasiliensis by Joes Nogueira-Neto, Flavio V. Loures, Alessandra S. Schanoski, David A. G. Andrade, Michelangelo B. Gonzatti, Tania A. Costa, Bruno C. Vivanco, Patrícia Xander, Daniela S. Rosa, Vera L. G. Calich, Alexandre C. Keller

“…Invariant Natural Killer T (iNKT) cells are key players in the immunity to several pathogens; however, their involvement in the resistance to Paracoccidioides brasiliensis infection remains unknown. Using splenocytes from CD1d (CD1d-/-) and iNKT-deficient (Jα18-/-) mice, we found that iNKT cells are the innate source of IFN-γ after P. brasiliensis infection and are required to potentiate macrophage oxidative burst and control fungal growth. …”
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The Rickettsia actin-based motility effectors RickA and Sca2 contribute differently to cell-to-cell spread and pathogenicity by Cuong J. Tran, Zahra Zubair-Nizami, Ingeborg M. Langohr, Matthew D. Welch

“…We further compared the roles of RickA and Sca2 in vivo following intradermal (i.d.) infection of Ifnar1−/−; Ifngr1−/− mice carrying knockout mutations in the genes encoding the receptors for IFN-I (Ifnar1) and IFN-γ (Ifngr1), which exhibit eschars and succumb to infection with wild-type (WT) R. parkeri. …”
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Staphylococcus aureus nt5 gene mutation through CRISPR RNA-guided base editing weakens bacterial virulence and immune evasion by Xinpeng Liu, Lan Huang, Yang Ye, Haiyi Wang, Min Tang, Fuqiang He, Zijing Xia, Shi Deng, Peng Zhang, Ruiwu Dai, Shufang Liang

“…The resistance of commonly used clinical antibiotics, such as daptomycin (DAP), has become increasingly serious in the fight against Staphylococcus aureus (S. aureus) infection. It is essential to explore key pathogenicity-driven genes/proteins in bacterial infection and antibiotics resistance, which contributes to develop novel therapeutic strategies against S. aureus infections. …”
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Canine distemper outbreak and laryngeal paralysis in captive tigers (Panthera tigris) by Sarin Suwanpakdee, Anuwat Wiratsudakul, Nattarun Chaisilp, Luxsana Prasittichai, Anurux Skulpong, Patarapol Maneeorn, Benjaporn Bhusri, Chalisa Mongkolpan, Ruangrat Buddhirongawatr, Jarupa Taowan, Peerawat Wongluechai, Nlin Arya, Parin Suwannaprapha, Natharin Ngamwongsatit, Witthawat Wiriyarat, Nareerat Sangkachai

“…Abstract The canine distemper virus (CDV) could infect various wildlife species worldwide. The viral infection in large felids directly impacts wildlife conservation. …”
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Delivery determinants of an Acinetobacter baumannii type VI secretion system bifunctional peptidoglycan hydrolase by Valeriya Bezkorovayna, Brooke K. Hayes, Francesca N. Gillett, Amy Wright, David I. Roper, Marina Harper, Sheena McGowan, John D. Boyce

“…ABSTRACT Acinetobacter baumannii is a Gram-negative opportunistic pathogen and is a common cause of nosocomial infections. The increasing development of antibiotic resistance in this organism is a global health concern. …”
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Hepatitis C Virus Evasion from RIG-I-Dependent Hepatic Innate Immunity by Helene Minyi Liu, Michael Gale

“…Exposure to hepatitis C virus (HCV) usually results in persistent infection that often develops into chronic liver disease. …”
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Necrotizing Epididymo-Orchitis: A Rare Manifestation of COVID-19 by Ali Tavoosian, Sana Ahmadi, Seyed Mohammad Kazem Aghamir

“…Epididymo-orchitis is an infection of the epididymis and testis, one of the most common urogenital infections. …”
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