Rational strategies for designing next-generation oncolytic viruses based on transcriptome analysis of tumor cells infected with oncolytic herpes simplex virus-1 by Naeme Javid, Shahriyar Abdoli, Majid Shahbazi, Majid Shahbazi

“…Subsequently, the expression of hub genes was verified by real-time polymerase chain reaction (qRT-PCR) in MDA-MB-231 (a breast cancer cell line) infected with oHSV-1 and non-infected cells.ResultsThe results of our data analysis indicated notable disparities in the genes associated with the proteasome pathway between infected and non-infected cells. …”
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Vitamin D and Tinospora cordifolia modulate TLR3 and TLR4 pathways, reduce inflammation, and maintain antimicrobial peptide levels in infected mice by Jamil Ahmad Shobrun, Widyarti Sri, Setiawan Meddy, Rifa’i Muhaimin

“…The activation of Toll-Like Receptor-3 (TLR3) and Toll-Like Receptor-4 (TLR4) signalling pathways is a regular pathway for immune system activation during infection. This study aimed to investigate the effects of vitamin D (VD) and Tinospora cordifolia ethanol extract (TC) on TLR3 and TLR4 receptor protein expression, proinflammatory cytokine (IL1 and IL-6) production, and antimicrobial peptide cathelicidin (CAP) production in CD11b+ cells of mice infected with Escherichia coli. …”
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Increases in the susceptibility of human endometrial CD4+ T cells to HIV-1 infection post-menopause are not dependent on greater viral receptor expression frequency by Landon G. vom Steeg, Zheng Shen, Jane Collins, Mickey V. Patel, Fiona D. Barr, Daniel C. Hopkins, Christina Ochsenbauer, Charles R. Wira

“…Here, we evaluated how menopause-associated changes in CD4+ T cell numbers and subsets as well as HIV coreceptor expression, particularly CCR5, in the endometrium (EM), endocervix (CX), and ectocervix (ECX) may alter HIV infection susceptibility. Using a tissue-specific mixed cell infection model, we demonstrate that while no changes in CD14+ macrophage infection susceptibility were observed, CD4+ T cell HIV-1 infection frequency increases following menopause in the EM, but not CX nor ECX. …”
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Specific immune response to M. tuberculosis and ability to in vitro control mycobacterial replication are not impaired in subjects with immune-mediated inflammatory disease and tuberculosis infection by Chiara Farroni, Anna Maria Gerarda Altera, Andrea Salmi, Valentina Vanini, Valentina Vanini, Gilda Cuzzi, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Giovanni Delogu, Giovanni Delogu, Ivana Palucci, Settimia Sbarra, Alessandra Aiello, Andrea Picchianti-Diamanti, Gina Gualano, Fabrizio Palmieri, Delia Goletti, Elisa Petruccioli

“…BackgroundSubjects with immune-mediated inflammatory diseases (IMID), such as rheumatoid arthritis, with tuberculosis infection (TBI), have a high probability of progressing to tuberculosis disease (TB). …”
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Unique North American isolates of severe metastatic hypervirulent Klebsiella pneumoniae strain infections with hepatic abscesses seen in young patients within Texas. by Junaid M Alam, Eric N Riha, Haris Ahmed, Hong M Thai, Kevin Garnepudi, Ramesh B Kesavan, Gnananandh Jayaraman, Anna Sangster, Dylan Curry, Heidi A Butz, Lori Smith, Maureen Vowles, Kelly F Oakeson, Erin L Young, Siva T Sarva

“…<h4>Rationale</h4>Hypervirulent Klebsiella pneumoniae (hvKp) infections have principally been identified in Asia. …”
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Updating the Antimicrobial Resistance Pattern among Critical Priority Pathogens in the Intensive Care Unit in Northern Iran Post COVID-19 Pandemic by Golnar Rahimzadeh, Nadia Ghezljai, Shaghayegh Rezai, Raha Rezai, Mohammad Reza Navaiefar, Mohammad Sadegh Rezai, Masoud Moradi, Mostafa Shakeri

Subjects: “…gram-negative bacterial infection…”
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Forecasting the development of antimicrobial resistance of S. aureus by Oleh Shemetov, Mariia Faustova, Tetiana Perepelova, Hennadii Balia, Ihor Pavlish, Galina Loban'

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Impact of discontinuation of cephazolin prophylaxis on the incidence of postoperative adverse events in cataract surgery by Kazutaka Uchida, Keita Takahama, Kenshiro Higashi, Yuki Kusano, Koki Matsumoto, Yoshihiro Nakagawa, Kazutaka Oda

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From Cure to Crisis: Understanding the Evolution of Antibiotic-Resistant Bacteria in Human Microbiota by Hamed Tahmasebi, Neda Arjmand, Marzieh Monemi, Ali Babaeizad, Farnaz Alibabaei, Negar Alibabaei, Aisa Bahar, Valentyn Oksenych, Majid Eslami

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À propos de deux cas de brucellose dans le sud de la France aux époques médiévale et moderne (Abbaye Saint-Sauveur, Aniane ; La Closeraie, Aix-en-Provence) by Avril Meffray, Philippe Biagini, Catherine Rigeade, Michel Panuel, Laurent Schneider, Yann Ardagna

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Syphilis and Urogenital Diseases during Pregnancy and Developmental Defects of Enamel: A Brazilian Prenatal Cohort (BRISA) by Elisa Miranda Costa, Judith Rafaelle Oliveira Pinho, Maria da Conceição Pereira Saraiva, Cecília Cláudia Costa Ribeiro, Claudia Maria Coêlho Alves, Erika Barbara Abreu Fonseca Thomaz

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Lidocaine Shows Significant Antimicrobial Effects Against <i>Staphylococcus</i> Species: An In-Vitro Study Comparing Different Combinations of Lidocaine and Clinically Used Injecta... by Stephan Heller, Ricarda Johanna Seemann, Rainer Burgkart, Andreas Obermeier, Hermann Locher

Subjects: “…periprosthetic joint infections…”
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Evidence based use of antibiotics in epidemic keratoconjunctivitis to prevent development of microbial resistance by Shalini Kumari, Imsensenba Longkumer, Mamta Sharma, Shashank Tripathi

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Feasibility of Early Definitive Internal Fixation of Pelvic Bone Fractures in Therapeutic Open Abdomen by Kyunghak Choi, Kwang-Hwan Jung, Min Ae Keum, Sungjeep Kim, Jihoon T Kim, Kyu-Hyouck Kyoung

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Plasma mcfDNA Sequencing May Improve Usual Care Diagnostics to Detect HHV-8 Among Outpatient People with Advanced HIV by Sarah Park, Brian Epling, Morgan Richey, Daniel Lupu, Mona Mughar, Irini Sereti

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The Role of Plain Radiography in Diagnosing Brodie's Abscess: Clinical Image by Ujjwal Prakash Khanal, Mitu Sadashankar, Siddhartha Bhandari

Subjects: “…bone infections…”
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MANAGEMENT OF DENTO-ALVEOLAR SURGICAL EMERGENCIES IN PEDIATRIC PATIENTS by Mircea Rivis, Alexandra Roi, Cristina Fuior, Cosmin Sinescu, Ciprian Roi

Subjects: “…dento-alveolar emergencies; pediatric patiens; trauma; odontogenic infections…”
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Etiological Aspects of Infectious Endocarditis in a Tertiary Hospital in Northeastern Romania by Isabela Ioana Loghin, Amelia Elena Surdu, Șerban Alin Rusu, Ion Cecan, Victor Daniel Dorobăț, Amelia Andreea Mihăescu, Carmen Mihaela Dorobăţ

Subjects: “…infective endocarditis…”
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The effect of azithromycin treatment on respiratory morbidity in children with down syndrome by Inbal Golan-Tripto, Omer Dor, Noga Arwas, Itai Hazan, Guy Hazan, Aviv Goldbart

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Exploring the anticandida potentials of nanoparticles fabricated from tea leaf (Camellia sinensis) extracts: a systematic review by Naheem Adekilekun Tijani, Abdullateef Opeyemi Afolabi, Fred Mutanule, Sujithkumar Ganesh Moorthy, Danladi Makeri

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