Evolution of the concept of corporate social responsibility and ways of its development in modern Russia by A. N. Kurayev, I. G. Morozova, A. A. Grunina, N. M. Suray, M. V. Shatokhin

“…It is found that the introduction of ESG-practices in Russian business is in its infancy. The growth of digital technologies and the involvement of employees in the dissemination of ESG practices will help to accelerate the process of ESG-strategy implementation in the activities of the organization. …”
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Development, optimization and application of a universal fluorescence multiplex PCR-based assay to detect BCOR genetic alterations in pediatric tumors by Meng Zhang, Xingfeng Yao, Nan Zhang, Yongbo Yu, Chao Jia, Xiaoxing Guan, Wenjian Xu, Xin Ni, Yongli Guo, Lejian He

“…Abstract Background A number of genetic aberrations are associated with the BCL6-correpresor gene (BCOR), including internal tandem duplications (ITDs) and gene fusions (BCOR::CCNB3 and BCOR::MAML3), as well as YWHAE::NUTM2, which are found in clear cell sarcoma of the kidney (CCSK), sarcoma with BCOR genetic alterations, primitive myxoid mesenchymal tumor of infancy, and high-grade neuroepithelial tumors in children. …”
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Clinical spectrum, treatment and outcomes of the m.10197G>A mutation in MT-ND3: a case report, systematic review and meta-analysis by YuZhi Shi, Bin Chen, SongTao Niu, XinGao Wang, ZaiQiang Zhang

“…A negative linear correlation was observed between mutation load and age of onset in patients who presented with LS/LS+ (R2 = 0.592, P < 0.001), with the age of onset ranging from infancy to adulthood. Patients with an older age at onset [OR (95% CI), 1.46 (1.12–1.91), P = 0.005] or higher mutation loads [OR (95% CI), 1.14 (1.03–1.26), P = 0.011] were more likely to present with LHON/LHON+ than with LS/LS+. …”
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Ferroptosis Transcriptional Regulation and Prognostic Impact in Medulloblastoma Subtypes Revealed by RNA-Seq by Christophe Desterke, Yuanji Fu, Jenny Bonifacio-Mundaca, Claudia Monge, Pascal Pineau, Jorge Mata-Garrido, Raquel Francés

“…Medulloblastoma (MB) is the most common malignant brain tumor in children, typically arising during infancy and childhood. Despite multimodal therapies achieving a response rate of 70% in children older than 3 years, treatment remains challenging. …”
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The maturation of infant and toddler visual cortex neural activity and associations with fine motor performance by Katharina Otten, J. Christopher Edgar, Heather L. Green, Kylie Mol, Marybeth McNamee, Emily S. Kuschner, Mina Kim, Song Liu, Hao Huang, Marisa Nordt, Kerstin Konrad, Yuhan Chen

“…Our understanding of how visual cortex neural processes mature during infancy and toddlerhood is limited. Using magnetoencephalography (MEG), the present study investigated the development of visual evoked responses (VERs) in cross-sectional and longitudinal samples of infants and toddlers 2 months to 3 years. …”
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SMRT sequencing and ddPCR reveal the complexity of developmental trajectories and temporal dynamics of gut bifidobacterial communities in infants by Xu Gao, Tao Zhang, Xiaoye Bai, Qiannan Wen, Dongyu Li, Lai-Yu Kwok, Heping Zhang, Zhihong Sun

“…The results of ddPCR confirmed large variations in quantities of bifidobacteria between infants and suggested discordances in temporal dynamics of bifidobacterial communities during the first half year of infancy. In conclusion, our results suggested that the early infant gut bifidobacterial microbiota was highly complex and temporal dynamics, with individualized developmental trajectories, which should be considered in future research of infant gut microbiota.…”
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Advances and Prospects in Smart Border Studies Based on a Bibliometric Analysis by Yang Danxuan, Li Cansong, Hu Wei, Lai Zulan, Ge Xurui

“…The results of the study revealed that smart border research is still very much in its infancy, and although there has been a general upward trend in the number of published articles, the volume of relevant research is still comparatively low. …”
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Severe neonatal hypotonia due to SLC30A5 variant affecting function of ZnT5 zinc transporter by Vadim Dolgin, Pauline Chabosseau, Jacob Bistritzer, Iris Noyman, Orna Staretz‐Chacham, Ohad Wormser, Noam Hadar, Marina Eskin‐Schwartz, Bibi Kanengisser‐Pines, Ginat Narkis, Ramy Abramsky, Eilon Shany, Guy A. Rutter, Kyla Marks, Ohad S. Birk

“…Affected infants required nasogastric tube or gastrostomy feeding, suffered from various degrees of respiratory compromise and failure to thrive and died in infancy. Thus, a biallelic variant in SLC30A5 (ZnT5), affecting cytosolic zinc concentrations, causes a severe hypotonia syndrome with respiratory insufficiency and failure to thrive, lethal by 1 year of age.…”
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First-year dynamics of the anaerobic microbiome and archaeome in infants’ oral and gastrointestinal systems by Charlotte J. Neumann, Rokhsareh Mohammadzadeh, Pei Yee Woh, Tanja Kobal, Manuela-Raluca Pausan, Tejus Shinde, Victoria Haid, Polona Mertelj, Eva-Christine Weiss, Vassiliki Kolovetsiou-Kreiner, Alexander Mahnert, Christina Kumpitsch, Evelyn Jantscher-Krenn, Christine Moissl-Eichinger

“…We demonstrated the presence of archaea in the infant oral cavity and GIT microbiome from early infancy, with Methanobrevibacter being the predominant genus. …”
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Modified neuroimmune processes and emotional behaviour in weaned and late adolescent male and female mice born via caesarean section by Mathieu Di Miceli, Moïra Rossitto, Maud Martinat, Flore Marchaland, Sarah Kharbouche, Marion Graland, Farah Younes, Alexandra Séré, Agnès Aubert, Lydia Rabbaa Khabbaz, Charlotte Madore, Jean-Christophe Delpech, Rebeca Martín, Sophie Layé

“…The latter is essential for adequate neuro-immune processes to take place during infancy. In this study, we used a validated model of mice born by C-section (CSD), which mimics clinical observations of dysregulated gut microbiota. …”
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Identification of a novel heterozygous GPD1 missense variant in a Chinese adult patient with recurrent HTG-AP consuming a high-fat diet and heavy smoking by Xiao-Yao Li, Bei-Yuan Zhang, Xin-Ran Liang, Yan-Yu Han, Min-Hua Cheng, Mei Wei, Ke Cao, Xian-Cheng Chen, Ming Chen, Jian-Feng Duan, Wen-Kui Yu

“…Additionally, 36 patients with GPD1 variants found in previous studies showed significant transient HTG in infancy. The proband carrying the GDP1 variant was the first reported adult with recurrent HTG-AP. …”
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Bifidobacterium fermentation with infant formulas is associated with benefits for gut and brain barrier function by Emily G. Knox, Paula Sánchez-Díaz, Colin Buttimer, Sarah-Jane Leigh, Klara Vlckova, Colin Hill, Elaine Kennedy, Jonathan O’Regan, Seamus McSweeney, David Goulding, Maria Rodriguez Aburto, Caitriona M. O’Driscoll, John F. Cryan, Eoin Gunnigle, Gerard Clarke

“…The gut and blood-brain barrier are essential components of the microbiota-gut-brain axis and are influenced by diet, particularly in infancy. Breast milk supports gut and brain barrier function, but infant formulas often lack key protective components. …”
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Results from an Australopithecus africanus dental enamel fragment confirm the potential of palaeoproteomics for South African Plio-Pleistocene fossil sites by Palesa P. Madupe, Fazeelah Munir, Marc Dickinson, Alberto J. Taurozzi, Meaghan Mackie, Mirriam Tawane, Catherine Mollereau, Nomawethu Hlazo, Kirsty Penkman, Lauren Schroeder, Clément Zanolli, Jesper V. Olsen, Rebecca R. Ackermann, Enrico Cappellini

“…Although it is still in its infancy for Plio-Pleistocene hominin fossils, palaeoproteomics has the potential to help unravel the causes of observed morphological variation. …”
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Exploring the potential mediating role of systemic antibiotics in the association between early-life lower respiratory tract infections and asthma at age 5 in the CHILD study by Maria V. Medeleanu, Maria V. Medeleanu, Myrtha E. Reyna, Myrtha E. Reyna, Darlene L. Y. Dai, Geoffrey L. Winsor, Fiona S. L. Brinkman, Rahul Verma, Ella Nugent, Nashita Riaz, Elinor Simons, Piushkumar J. Mandhane, Piushkumar J. Mandhane, Meghan B. Azad, Meghan B. Azad, Stuart E. Turvey, Stuart E. Turvey, Theo J. Moraes, Theo J. Moraes, Padmaja Subbarao, Padmaja Subbarao, Padmaja Subbarao, Padmaja Subbarao, Padmaja Subbarao, Padmaja Subbarao

“…However, a significant direct effect of moderate-to-severe LRTIs on asthma risk remained in adjusted mediation models (p = .014).ConclusionThrough mediation modeling we estimate that the increased risk of asthma at age 5 that is associated with moderate-severe LRTIs in infancy may be partially mediated by systemic antibiotics taken during the first 18 months of life. …”
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Child mortality in England after national lockdowns for COVID-19: An analysis of childhood deaths, 2019-2023. by David Odd, Sylvia Stoianova, Tom Williams, Peter Fleming, Karen Luyt

“…Rates of death from preterm birth, trauma and sudden unexpected deaths in infancy and childhood (SUDIC), increased across the entire 4-year-study period (preterm birth, IRR 1.03 (95% CI 1.00-1.07); trauma IRR 1.12 (95% CI 1.06-1.20); SUDIC IRR 1.09 (95% CI 1.04-1.13)), and there was no change in the rate of death from Malignancy (IRR 1.01 (95% CI 0.95-1.06)). …”
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Atacama Large Aperture Submillimeter Telescope (AtLAST) science: Probing the transient and time-variable sky [version 2; peer review: 1 approved, 2 approved with reservations] by Pamela Klaassen, Mark Booth, Thomas Stanke, Evanthia Hatziminaoglou, Claudia Cicone, Martin Cordiner, Tony Mroczkowski, Doug Johnstone, Luca Di Mascolo, Minju Lee, Eelco van Kampen, Thomas Maccarone, Daizhong Liu, Matthew Smith, Amélie Saintonge, Sven Wedemeyer, Alexander Thelen, John Orlowski-Scherer, Tomasz Kamiński, Joe Bright, Atul Mohan, Michael Koss, Sigurd Næss, Francisco Miguel Montenegro-Montes, Paola Severgnini, Claudio Ricci, Jochen Greiner, Cristian Vignali

“…The study of such events in the millimeter and submillimeter is, however, still in its infancy. Submillimeter observations probe a variety of materials, such as optically thick dust, which are hard to study in other wavelengths. …”
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Selected Abstracts of the 20th International Workshop on Neonatology and Pediatrics; Cagliari (Italy); October 23-26, 2024 by --- Various Authors

“…Selected Abstracts of the 20th International Workshop on Neonatology and Pediatrics; Cagliari (Italy); October 23rd-26th, 2024 CHILDREN’S HEALTH: MESSAGES FROM THE FUTURE   The Workshop has been organized with the patronage of Autonomous Region of Sardinia, City of Cagliari, Azienda Ospedaliera di Cagliari, University of Cagliari, Board of Physicians of the Province of Cagliari, Italian-Albanian Pediatric Society, AMBO (Alleanza per un Ambiente a misura di Bambino: alliance for a child-friendly environment), European Project Better4u, European Project Life Milch, National Confederation of Pediatrics Heads (CONAPP), Italian Federation of Family Pediatricians (FIMP), Italian-Arabian Pediatric Society (IAPS), Italian-Romanian Pediatric Society (IRPS), Norman Group of Neonatal and Pediatric Nephrology, International Academy of Perinatal Medicine, Italian Society of Pediatric Allergology and Immunology (SIAIP), Italian Society of Clinical Biochemistry (SIBioC), Italian Society of Gynecology of Infancy and Adolescence (SIGIA), Italian Society of Neonatology (SIN), Italian Society of Hospital Pediatricians (SIPO), Association SIPO in the World, Italian Society of Developmental Origins of Health and Disease (SI-DOHaD), Alfred Nobel International Study Center Sanremo, Italian Society of Pediatricians (SIMPE), Italian Society of Pediatric Psychology (S.I.P.Ped.), Romanian Society of Pediatrics, Italian Society for Research on Essential Oils (SIROE), Italian Society of Neonatal Nursing (SIN INF), Union of European Neonatal and Perinatal Societies (UENPS).   …”
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