Vedolizumab for inflammatory bowel diseasesI by Igor L. Khalif, M. V. Shapina

“…Similar efficacy was demonstrated for Crohn's disease (GEMINI-2) study in remission induction (clinical response rate - 31,4% of patients, clinical remission - 14,5%) and remission maintenance (percentage of patient in clinical remission by 52nd week at injection of the drug every 4 weeks - 39%). …”
Get full text

Deep Learning-Based Waste Classification with Transfer Learning Using EfficientNet-B0 Model by Risfendra Risfendra, Gheri Febri Ananda, Herlin Setyawan

“…Conventional techniques that use inductive and capacitive proximity sensors exhibit limitations in accuracy and flexibility for the detection of various types of waste. …”
Get full text

Suvorexant, a Novel Dual Orexin Receptor Antagonist, for the Management of Insomnia by Andrew H. Han, Caroline R. Burroughs, Evan P. Falgoust, Jamal Hasoon, Grace Hunt, Juyeon Kakazu, Tim Lee, Adam M. Kaye, Alan D. Kaye, Latha Ganti

“…While there are existing treatments that target different receptors and pathways of normal sleep induction and maintenance, Suvorexant is a novel drug that targets dual orexin receptors. …”
Get full text

A SIMPLIFIED MODEL OF THREE-PHASE BANK OF CURRENT TRANSFORMERS IN THE DYNAMIC SIMULATION SYSTEM by I. V. Novash, Yu. V. Rumiantsev

“…An elaborated user-friendly graphic interface provides a means of visual assigning the CT nominal parameters, the residual magnetic induction, and the method of the transformer iron magnetization curve approximation. …”
Get full text

Acute Lymphoblastic Leukemia following Lenalidomide Maintenance for Multiple Myeloma: Two Cases with Unexpected Presentation and Good Prognostic Features by Abdullah M. Khan, Jameel Muzaffar, Hermant Murthy, John R. Wingard, Jan S. Moreb

“…Herein, we describe two patients with MM treated with induction therapy, ASCT, and lenalidomide maintenance that experienced cytopenias while on maintenance. …”
Get full text

Photobiomodulation: An Effective Approach to Enhance Proliferation and Differentiation of Adipose-Derived Stem Cells into Osteoblasts by Daniella Da Silva, Anine Crous, Heidi Abrahamse

“…In this article, the potential for differentiating ADSCs into osteoblasts and the various methods used, including biological induction, chemical induction, and PBM, will be addressed. …”
Get full text

Sequential Treatment with Activin and Hepatocyte Growth Factor Induces FOXM1 to Promote Colorectal Cancer Liver Metastasis by Hong Peng, Ting Ye, Lei Deng, Xiaofang Yang, Zheng Jiang, Jinjun Guo

“…SMAD2 was required for activin-mediated FOXM1 induction. FOXM1 transactivated CXCR4 by directly binding to the promoter of CXCR4. …”
Get full text

Metabolic Basis for Thyroid Hormone Liver Preconditioning: Upregulation of AMP-Activated Protein Kinase Signaling by Luis A. Videla, Virginia Fernández, Pamela Cornejo, Romina Vargas

“…Data discussed in this work suggest that T3-induced liver activation of AMPK may be of importance in the promotion of metabolic processes favouring energy supply for the induction and operation of preconditioning mechanisms. …”
Get full text

Calcium levels modulate embryo yield in Brassica napus microspore embryogenesis by Antonio Calabuig-Serna, Ricardo Mir, Daniel Sancho-Oviedo, Paloma Arjona-Mudarra, Jose M. Seguí-Simarro

“…This study shows that Ca2+ increase can be considered as an early marker of induction of microspore embryogenesis. Besides, Ca2+ levels are highly dynamic during microspore embryogenesis, influencing the final embryo yield. …”
Get full text

Inhibition of Autophagy in Heat-Stressed Sperm of Adult Mice: A Possible Role of Catsper1, 2 Channel Proteins by Malihe Soltani, Majid Rahmati, Mohammad Reza Nikravesh, Shahin Saeedi Nejat, Mahdi Jalali

“…The current study aimed to assess the autophagy-related proteins along with the activity of sperm calcium channel (CatSper) proteins following the induction of heat stress (HS). Methods. The study sample includes two groups of adult mice: sham and HS groups. …”
Get full text

Synthesis and Comparison of Soft-Switched Operating Modes of a Series Resonant Balancing Converter for Bipolar DC Grids by Sachin Yadav, Pavol Bauer, Zian Qin

“…It is shown that the converter can be operated in both the capacitive and inductive regions with respect to the resonant frequency of the <italic>LC</italic> tank. …”
Get full text

Clopidogrel Protects Endothelium by Hindering TNFα-Induced VCAM-1 Expression through CaMKKβ/AMPK/Nrf2 Pathway by Huabing Yang, Pengjun Zhao, Shiliu Tian

“…Our data suggest that INN diminishes TNFα-stimulated VCAM-1 expression at least in part via HO-1 induction, which is CaMKKβ/AMPK pathway-dependent.…”
Get full text

Accurate Determination of Boron Content in Halite by ICP-OES and ICP-MS by Zhang-kuang Peng, Zhi-na Liu

“…However there is no good method to accurately measure the boron content in halite, which is mainly because Inductively Coupled Plasma Optical Emission Spectrometer (ICP-OES) and Inductively Coupled Plasma Mass Spectrometer (ICP-MS) are limited by the high salt matrix interference and the instrument detection limit. …”
Get full text

Effects of Patterned Sound Deprivation on Short- and Long-Term Plasticity in the Rat Thalamocortical Auditory System In Vivo by Chloe N. Soutar, Laura G. Rosen, Simon G. Rodier, Hans C. Dringenberg

“…Further, the enhanced PPD following LTP induction provides novel evidence that presynaptic mechanisms contribute to thalamocortical LTP in A1 under in vivo conditions.…”
Get full text

Protection of Liver as a Remote Organ after Renal Ischemia-Reperfusion Injury by Renal Ischemic Postconditioning by Behjat Seifi, Mehri Kadkhodaee, Atefeh Najafi, Atefeh Mahmoudi

“…They underwent a right nephrectomy before induction of 45 minutes of left kidney ischemia or sham operation. …”
Get full text

The expression of different gene constructs in Escherichia coli SM lux biosensor after exposure to drugs by Grażyna Łaska, Marzena Matejczyk, Urszula Dauksza

“…The highest increase express gene construct was found for micF:luxCDABE in E. coli SM343 lux biosensor, where the micF promoter induction relative to the control at a concentration of 0.625 µg/mL is 73.9%.…”
Get full text

Fluoxetine attenuates stress-induced depression-like behavior due to decrease in pro-inflammatory cytokines in male rats. by Nabirumbi, Ritah, Onohuean, Hope, Kato, Charles Drago, Alagbonsi, Abdullateef Isiaka, Adedeji1, Ahmed A.

“…The purpose of the study was to investigate the cytokine levels in serum and hippocampus following induction of depression-like behaviors (DLB) by either force. swimming test (FST) or ethanol-induced DLB (EID). …”
Get full text

Antimalarial Combination Therapies Increase Gastric Ulcers Through an Imbalance of Basic Antioxidative‑Oxidative Enzymes in Male Wistar Rats. by Kalange, Muhamudu, Nansunga, Miriam, Keneth Iceland, Kasozi, Kasolo, Josephine, Namulema, Jackline, Kasande Atusiimirwe, Jovile, Tiyo Ayikobua, Emanuel, Ssempijja, Fred, Munanura, Edson Ireeta, Matama, Kevin, Semuyaba, Ibrahim, Zirintunda, Gerald Gerald, Okpanachi, Alfred Omachonu

“…The aim of this study was to investigate the effects of Artesunate-Amodiaquine and Artemether-Lumefantrine on ulcer induction. Malondialdehyde (MDA), reduced glutathione (GSH) and major histological changes in male Wistar rats following ulcer induction using Indomethacin were investigated. …”
Get full text

Safety and Efficacy of Subcutaneous Rituximab in Previously Untreated Patients with CD20+ Diffuse Large B-Cell Lymphoma or Follicular Lymphoma: Results from an Italian Phase IIIb S... by Mario Petrini, Gianluca Gaidano, Andrea Mengarelli, Ugo Consoli, Armando Santoro, Anna Maria Liberati, Marco Ladetto, Vincenzo Fraticelli, Attilio Guarini, Donato Mannina, Paola Ferrando, Paolo Corradini, Pellegrino Musto, Caterina Stelitano, Dario Marino, Andrea Camera, Marco Murineddu, Roberta Battistini, Giuseppe Caparrotti, Mauro Turrini, Luca Arcaini, Simone Santini, Manuela Cerqueti, Andres J. M. Ferreri, Nicola Cantore, Alessandro Inzoli, Giovanni Cardinale, Benedetto Ronci, Giorgio La Nasa, Stefano Massimi, Gianfranco Gaglione, Valentina Barbiero, Maurizio Martelli

“…The study included adult patients with CD20+ DLBCL or FL having received at least one full dose of IV RTX 375 mg/m2 during induction or maintenance. Patients on induction received ≥4 cycles of RTX SC 1400 mg plus standard chemotherapy and FL patients on maintenance received ≥6 cycles of RTX SC. …”
Get full text

Approaches for difficult-to-induce-seizures electroconvulsive therapy cases (DEC): a Japanese expert consensus by Yoshiteru Takekita, Taro Suwa, Kazuyuki Yasuda, Hirotsugu Kawashima, Wataru Omori, Naoki Kurimoto, Takashi Tsuboi, Takamasa Noda, Nobuatsu Aoki, Ken Wada, Ken Inada, Minoru Takebayash, Expert Consensus Development Working Group, Electroconvulsive Therapy Committee, Japanese Society of General Hospital Psychiatry

“…Results To avoid difficult seizure induction, dose reduction of benzodiazepine receptor agonist (BZRA) (8.33 ± 1.25), dose reduction or discontinuation of antiepileptic drugs (AEDs) or other drugs that may make seizure induction difficult (8.16 ± 1.18), and ensure hyperventilation (7.95 ± 1.47) were classified as treatments of choice. …”
Get full text