PTEN suppresses renal cell carcinoma proliferation and migration via inhibition of the PI3K/AKT pathway by Xu Xu, Yuan-Yue Tang, Xiaohong Liang, Wen Luo, Dong-Mei Jiang, Jie Chen

“…In 786-O cells with low PTEN expression, further induction of PTEN overexpression significantly inhibited PI3K/AKT signaling activity (p < 0.01), accompanied by decreased cell viability and migration ability. …”
Get full text

De Novo Acute Myeloid Leukemia with Combined CBFB-MYH11 and BCR-ABL1 Gene Rearrangements: A Case Report and Review of Literature by Venkata Rakesh Sethapati, Ra’ed Jabr, Leyla Shune, Wissam El Atrouni, Patrick R. Gonzales, Wei Cui, Shivani Golem

“…The patient was initially treated with standard induction regimen; 7 daily doses of cytarabine from day 1–day 7, 3 daily doses of daunorubicin from day 1–day 3, and 1 dose of Mylotarg (gemtuzumab ozogamicin) on day 1. …”
Get full text

“Listening to understand,” exploring postpartum women’s perceptions of their social networks and social support in relation to their health behaviors and weight: A qualitative expl... by Jacqueline Kent-Marvick, Kristin G Cloyes, Ana Clark, Monica Angulo, Kayla de la Haye, Michelle Precourt Debbink, Cristina Creal, Bob Wong, Sara E Simonsen

“…Qualitative analysis used content and thematic analysis in stages of deductive coding applying codes derived from social-network and support theories, followed by inductive coding. Results: Thirty-eight participants (38.4%) returned to or weighed less than pre-pregnancy weight. …”
Get full text

Application of core functions and forms in complex health intervention research: a scoping review protocol by Eunyoung Kang, Maria E Fernández, Jessica D Austin, Monica Perez Jolles, Katelyn Fox, Debbie Passey, Laura Zeigen, Erin Kenzie, Rachel J Meadows

“…One researcher will extract the data and a second will review it for any omissions or errors. An inductive content analysis will be used to categorise the nature of how studies define and operationalise core functions and forms. …”
Get full text

Developing and validation of religious education curriculum in preschool by Zeinab Ashrafi Soltan-Ahmadi, Sadegh Maleki Avarsin, Javad Keyhan, jahangir yari

“…The data obtained from the interviews were analyzed using Nvivo version 8 software in the form of thematic analysis-based, inductively on the "theme network" technique, and during the stages of coding (open, central and selected), and the proposed model of religious education for preschool children was compiled and its assumptions were used to prepare a survey questionnaire in the quantitative stage and evaluate its validity. …”
Get full text

Designing a professional development model for technical teachers in order to teach entrepreneurship in technical schools by hosein hasankhani, Niloufar Mortazanejad, maryam sameri

“…Data analysis using qualitative content analysis method is of inductive type. To validate the findings, the four criteria of "reliability", "credibility", "verifiability" and "transferability" of qualitative studies have been used. …”
Get full text

Designing and explaining the political behavior model of managers in government organizations by Mehdi Izadi, Amir Hoshang Nazarpuri, Reza Sepahvand, Hojat Vahdati, Mohammad Hakak

“…The research method is applicable in terms of purpose, qualitative in terms of execution method, and inductive-deductive in terms of the logic of data collection. …”
Get full text

The contextual adaptation and educational impacts of the mhGAP-IG to address child mental and behavioral disorder treatment gap in China: A mixed-method study by Meng Zheng, Yi Zhang, Feng Chen, Ang Chen, Di Kong, Kun Xie, Jie Li, Brian James Hall, Andre M.N. Renzaho, Jian-hui Gao, Dao-meng Cheng, Qing Zou, Xin-yuan Zhong, Qi-mei Yu, Wen Chen

“…A qualitative analysis utilizing deductive and inductive thematic coding was applied. The educational impacts of a two-day training based on the adapted CMBDs-mhGAP-IG were assessed using a pre-post design among 89 participants, including kindergarten teachers or doctors and GPs. …”
Get full text

VCP regulates early tau seed amplification via specific cofactors by Sushobhna Batra, Jaime Vaquer-Alicea, Clarissa Valdez, Skyler P. Taylor, Victor A. Manon, Anthony R. Vega, Omar M. Kashmer, Sourav Kolay, Andrew Lemoff, Nigel J. Cairns, Charles L. White, Marc I. Diamond

“…We exposed cells to fibrils or brain homogenates in cell culture media and measured effects on uptake and induction of intracellular tau aggregation following various genetic and pharmacological manipulations of VCP. …”
Get full text

Support in digital health skill development for vulnerable groups in a public library setting: perspectives of trainers by Lucille M. B. Standaar, Lucille M. B. Standaar, Lucille M. B. Standaar, Adriana M. C. Israel, Rosalie van der Vaart, Brigitta Keij, Roland D. Friele, Roland D. Friele, Mariëlle A. Beenackers, L. H. D. van Tuyl

“…A deductive analysis based upon the interview guide topics was performed. A second inductive analysis was applied to identify underlying patterns. …”
Get full text

Children with autoimmune hepatitis receiving standard-of-care therapy demonstrate long-term obesity and linear growth delay by Or Steg Saban, Shannon M. Vandriel, Syeda Aiman Fatima, Celine Bourdon, Amrita Mundh, Vicky L. Ng, Simon C. Ling, Robert H.J. Bandsma, Binita M. Kamath

“…Standard-of-care therapy in children with autoimmune hepatitis (AIH) includes induction with prednisone 1–2 mg/kg daily with gradual weaning of the dose. …”
Get full text

Lipopolymers as the Basis of Non-Viral Delivery of Therapeutic siRNA Nanoparticles in a Leukemia (MOLM-13) Model by Panadda Yotsomnuk, Amarnath Praphakar Rajendran, Daniel Nisakar Meenakshi Sundaram, Luis Carlos Morales, Cezary Kucharski, Mohammad Nasrullah, Wanwisa Skolpap, Xiaoyan Jiang, Spencer B. Gibson, Joseph Brandwein, Hasan Uludağ

“…The desired inhibition of cell growth was attained with both FLT3 and KMT2A::MLLT3 siRNAs, and the combination provided more potent effects in both cell growth and colony formation assays. Induction of apoptosis was confirmed after specific siRNA treatments using the Annexin V assay. …”
Get full text

Humanizing processes after harm part 1: patient safety incident investigations, litigation and the experiences of those affected by Lauren Ramsey, Laura Sheard, Justin Waring, Siobhan McHugh, Ruth Simms-Ellis, Ruth Simms-Ellis, Gemma Louch, Katherine Ludwin, Jane K. O’Hara

“…Data were analyzed using an inductive reflexive thematic approach.Findings42 people with personal or professional experience of safety incident investigations participated, comprising patients and families (n = 18), healthcare staff (n = 7), legal staff (n = 1), and investigators (n = 16). …”
Get full text

<i>Sambucus nigra</i>-Lyophilized Fruit Extract Attenuated Acute Redox–Homeostatic Imbalance via Mutagenic and Oxidative Stress Modulation in Mice Model on Gentamicin-Induced Nephr... by Kamelia Petkova-Parlapanska, Ivaylo Stefanov, Julian Ananiev, Tsvetelin Georgiev, Petya Hadzhibozheva, Veselina Petrova-Tacheva, Nikolay Kaloyanov, Ekaterina Georgieva, Galina Nikolova, Yanka Karamalakova

“…<b>Background:</b> Gentamicin (GM) administration is associated with decreased metabolism, increased oxidative stress, and induction of nephrotoxicity. <i>Sambucus nigra</i> L., containing flavonoids, anthocyanins, and phytosterols, possesses antioxidant and anti-inflammatory potential. …”
Get full text

Multivalent Neuroprotective Activity of <i>Elettaria cardamomum</i> (Cardamom) and <i>Foeniculum vulgare</i> (Fennel) in H₂O₂-Induced Oxidative Stress in SH-S... by Himadri Sharma, Hyewon Yang, Niti Sharma, Seong Soo A. An

“…Hydrogen peroxide was used for the induction of oxidative stress, and evaluation was done based on neuroprotection, reduced reactive oxygen species, and restoration of mitochondrial membrane potential (MMP). …”
Get full text

Do community-based digital health inclusion programmes contribute to tackling health inequalities in disadvantaged population groups?: a qualitative study of experiences of a city-... by Shoba Poduval, Lily Arnold, Emma Carta, Danielle Nimmons, Irene Stratton, Michael Shaw, Katherine Bradbury, Fiona Stevenson

“…Methods We used qualitative semi-structured interviews to explore the experiences of service-users receiving digital support, and perspectives of staff working for organisations coordinating or providing digital support (n = 30). Results Inductive thematic analysis was used to identify four major themes and mapped to ‘Consolidated Framework for Implementation Research’ constructs. …”
Get full text

UV-fs-LA-ICP-MS Analysis of CO2-Rich Fluid Inclusions in a Frozen State: Example from the Dahu Au-Mo Deposit, Xiaoqinling Region, Central China by Wei Jian, Moritz Albrecht, Bernd Lehmann, Jingwen Mao, Ingo Horn, Yanhe Li, Huishou Ye, Zongyan Li, Guanguan Fang, Yongsheng Xue

“…The recently developed technique of ultraviolet femtosecond laser ablation inductively coupled plasma mass spectrometry (UV-fs-LA-ICP-MS) combined with a freezing cell is expected to improve the analysis of CO2-rich fluid inclusions by decreasing their internal pressure and avoiding the common problem of uncontrolled explosive fluid release on ablation. …”
Get full text

Source distribution, ecological risks, and controlling factors of heavy metals in river sediments: Receptor model-based study in a transboundary river basin by Abu Reza Md Towfiqul Islam, Abu Hena Md Fazla Rabbi, Amit Hasan Anik, Rahat Khan, Md Abdullah Al Masud, Grara Nedjoud, Abubakr M. Idris, Md Naimur Rahman, Venkatramanan Senapathi

“…The current investigation encompasses the analysis of twenty-seven sediment samples, utilizing inductively coupled plasma mass spectrometry, in the transboundary river basin of Bangladesh, specifically the Teesta River. …”
Get full text

Modulation of Innate Immunity by G-CSF and Inflammatory Response by LBPK95A Improves the Outcome of Sepsis in a Rat Model by Haoshu Fang, Chuanfeng Hua, Stefanie Weiss, Anding Liu, Wenhui Cheng, Ralf Claus, Jürgen Rödel, Olaf Dirsch, Uta Dahmen

“…Bacterial clearance, neutrophil infiltration, tissue damage, and the induction of hepatic and systemic inflammatory responses were determined 2 h and 12 h after the septic insult. …”
Get full text

Hepatitis associated with immune checkpoint inhibitors-based combinations of other therapies: A real-world pharmacovigilance analysis based on the FDA adverse event reporting syste... by Zhaohui Li, Zixiang Zhou, Nan Zhang, Binhe Tian, Xiangqi Chen, Haitao Zhao, Hanping Wang

“…Conclusion We confirmed that combination treatment of ICI and TT is associated with the amplified risk of hepatitis, which is partly due to the interaction between ICI and TT, and the KRAS-targeted drugs may harbor the highest potential for hepatitis induction among TT drugs when combined with ICI. Besides, the combination treatment of ICI- and KRAS-targeted drugs also increases the incidence of colitis, pulmonary embolism and dehydration.…”
Get full text