Phenotypic and transcriptomic analyses reveal major differences between apple and pear scab nonhost resistance by Vergne, Emilie, Chevreau, Elisabeth, Ravon, Elisa, Gaillard, Sylvain, Pelletier, Sandra, Bahut, Muriel, Perchepied, Laure

“…In addition, a comparative analysis between pear scab host and nonhost interactions indicated that, although specificities were observed, two major defense lines seems to be shared in these resistances: cell wall and cuticle potential modifications and phenylpropanoid pathway induction. This first deciphering of the molecular mechanisms underlying a nonhost scab resistance in pear offers new possibilities for the genetic engineering of sustainable scab resistance in this species. …”
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LRP1 involvement in FHIT-regulated HER2 signaling in non-small cell lung cancer by Théophile Ponchel, Emma Loeffler, Julien Ancel, Audrey Brisebarre, Nathalie Lalun, Véronique Dalstein, Anne Durlach, Gaëtan Deslée, Stéphane Dedieu, Myriam Polette, Béatrice Nawrocki-Raby

“…In addition, we found that the induction of vimentin upon FHIT inactivation was counteracted by LRP1 silencing. …”
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Diagnostics and treatment of Clostridium difficile-associated disease: Guidelines of the Russian gastroenterological association by V. T. Ivashkin, N. D. Yushchuk, I. V. Mayev, Tatyana L Lapina, Ye. A. Poluektova, O. S. Shifrin, A. S. Tertychny, A. S. Trukhmanov, A. A. Sheptulin, Ye. K. Baranskaya, O. S. Lyashenko, K. V. Ivashkin

“…C. difficile toxins A and B are major virulence factors causing damage of intestinal wall and inflammation due to damage of intestinal epithelial barrier, induction of proinflammatory cytokines, apoptosis and a necrosis of epithelial cells. …”
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TGF-β3 Induces Autophagic Activity by Increasing ROS Generation in a NOX4-Dependent Pathway by Yun Zhang, Hong-Mei Tang, Chun-Feng Liu, Xie-Fang Yuan, Xiao-Yun Wang, Ning Ma, Guo-Feng Xu, Song-Ping Wang, Jun Deng, Xing Wang

“…The following study examined whether ROS act as upstream of autophagy activation in response to TGF-β3 induction. Using an allergic inflammation mouse model induced by house dust mite (HDM), we observed elevated lung amounts of TGF-β3 accompanied by increased ROS levels. …”
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Transferability of bioprocessing modes for recombinant protease production: from fed-batch to continuous cultivation with Bacillus licheniformis by Stefan Kittler, Fabian Müller, Mohamed Elshazly, Georg Benjamin Wandrey, Tobias Klein, Andreas Daub, Oliver Spadiut, Julian Kopp

“…Results Therefore, this study aimed to explore the potential of chemostat cultivations for producing a protease from Bacillus licheniformis utilizing a derepressed induction system, and comparing specific productivities and space-time yields to fed-batch cultivations. …”
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Bindarit attenuates neuroinflammation after subarachnoid hemorrhage by regulating the CCL2/CCR2/NF-κB pathway by Yanting Yao, Qiaowei Wu, Kaikun Yuan, Pei Wu, Chao Xu, Zhiyong Ji, Weishi Xu, Hongli Yu, Anyu Xu, Yanchen Liu, Huaizhang Shi

“…Recombinant CCL2 protein was administered via the lateral ventricle one hour before SAH induction. HT22 cells were cultured and stimulated by oxyhemoglobin to establish an in vitro model of SAH. …”
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Perceived effectiveness and recommendations from a childbirth quality assurance and improvement programme in India’s private sector: a qualitative evaluation using the RE-AIM frame... by Katherine Semrau, Meghna Desai, Lauren Spigel, Somesh Kumar, Megan Marx Delaney, Lauren Bobanski, Suranjeen Pallipamula, Natalie Henrich, Tapas Sadasivan Nair, Hema Divakar, Rajat Chabba, Shweta Jindal, Gulnoza Usmanova, Sukanya Dutta, Aarushi Gupta, Sucheta Kinjawadekar, Priti Kumar, Priyanka Kumari, Prerna Mukharya, Hrishikesh Pai, Ameya Purandare, Pompy Sridhar

“…Data were coded and analysed using a deductive and inductive process. Codes were mapped to the Reach, Effectiveness, Adoption, Implementation and Maintenance (RE-AIM) framework, which we expanded to include scale.Results We interviewed 185 programme participants. …”
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Molecular Characterization of the Tumor Suppressor Candidate 5 Gene: Regulation by PPARγ and Identification of TUSC5 Coding Variants in Lean and Obese Humans by Trina A. Knotts, Hyun Woo Lee, Jae Bum Kim, Pieter J. Oort, Ruth McPherson, Robert Dent, Keisuke Tachibana, Takefumi Doi, Songtao Yu, Janardan K. Reddy, Kenji Uno, Hideki Katagiri, Magdalena Pasarica, Steven R. Smith, Dorothy D. Sears, Michel Grino, Sean H. Adams

“…We tested the hypothesis that the TUSC5 gene is a bona fide PPARγ target and evaluated whether its WAT expression or single-nucleotide polymorphisms (SNPs) in the TUSC5 coding region are associated with human obesity. Induction of Tusc5 mRNA levels in 3T3-L1 adipocytes by troglitazone and GW1929 followed a dose-response consistent with these agents' binding affinities for PPARγ. …”
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The enigmatical manipulators in the capsule synthesis of pasteurella multocida: iron acquisition proteins by Asli Balevi, Aysegul Ilban, Ali Uslu, Zafer Sayin, Ayten Gok, Beatriz Padron, Eda Toslak, Osman Erganis

“…The presence of the ompA gene in these strains was secondly a induction on these strains. Other genes were not effective in capsule synthesis in these strains.…”
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Eucalyptus grandis WRKY genes provide insight into the role of arbuscular mycorrhizal symbiosis in defense against Ralstonia solanacearum by Jianlang Zhang, Xinzhu Yang, Chunyu Huo, Xinyi Fan, Qiutong Liu, Zhihong Liu, Yu Su, Zujing Chen, Zujing Chen

“…All subfamilies (except for group IV-b and IV-c) contain AW-boxes, which are related to mycorrhizal induction. Furthermore, transcriptomic analysis revealed that 21 EgWRKYs were responsive to the AMF Ri, with 13 and 8 genes strongly up- and downregulated, respectively. …”
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Inhibition of Matrix Metalloproteinase with BB-94 Protects against Caerulein-Induced Pancreatitis via Modulating Neutrophil and Macrophage Activation by Zengkai Wu, Tunike Mulatibieke, Mengya Niu, Bin Li, Juanjuan Dai, Xin Ye, Yan He, Congying Chen, Li Wen, Guoyong Hu

“…The MMP inhibitor, BB-94 (20 mg/kg) was intraperitoneally administered 30 min before AP induction. Pancreatitis was confirmed by histology and serum amylase and lipase. …”
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The Application of Traditional Chinese Medicine-Derived Formulations in Cancer Immunotherapy: A Review by Li Y, Li C, Fan J, Liu Y, Xu Y, Pang G

“…The mechanisms through which these formulations enhance anti-tumor immunity are multifaceted, involving modulation of immune cell activity, apoptosis induction, and suppression of tumor progression. As cancer immunotherapy evolves, the integration of TCM into conventional treatment regimens may offer enhanced therapeutic efficacy, reduced side effects, and improved overall outcomes for cancer patients. …”
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The phytoplasma SAP54 effector acts as a molecular matchmaker for leafhopper vectors by targeting plant MADS-box factor SVP by Zigmunds Orlovskis, Archana Singh, Adi Kliot, Weijie Huang, Saskia A Hogenhout

“…SAP54 is responsible for the induction of leaf-like flowers in phytoplasma-infected plants. …”
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Lactate Ameliorates Kainic Acid-Induced Neuroinflammation and Cognitive Impairment via the Chemokine Signaling Pathway in Mice by Chu X, Ge Y, Geng C, Cao P, Wei P, Fu B, Deng Z, Li Y, Zhao G

“…An acute epilepsy model was established in mice by kainic acid induction. The neuronal damage, microglial activation, inflammatory responses, and functional changes were determined by TUNEL assays, immunohistochemistry, quantitative real-time polymerase chain reaction and behavioral tests. …”
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Exploring the Needs and Preferences of Users and Parents to Design a Mobile App to Deliver Mental Health Peer Support to Adolescents With Type 1 Diabetes: Qualitative Study by Titilola I Yakubu, Poonamdeep Jhajj, Samantha Pawer, Nicholas C West, Shazhan Amed, Tricia S Tang, Matthias Görges

“…A thematic analysis following an inductive and iterative process was performed to develop themes and subthemes from the collected information. …”
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Personality Differences of Brain Networks in Placebo Analgesia and Nocebo Hyperalgesia: A Psychophysiological Interaction (PPI) Approach in fMRI by Yu Shi, Shimin Huang, Hongrui Zhan, Yaping Wang, Yanyan Zeng, Guiyuan Cai, Jianming Yang, Wen Wu

“…We designed this study to explore the personality differences of functional magnetic resonance imaging (fMRI) signals in placebo response and nocebo response by using psychophysiological interaction (PPI) analysis. 30 healthy subjects underwent conditioning induction training to establish expectations of placebo effect and nocebo effect, and then, all subjects completed the following experimental procedures: (1) baseline scanning, (2) acute pain model establishment, (3) pain status scanning, and (4) pseudorandom scanning of block design of placebo response or nocebo response. …”
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The Role of Dendritic Cells in Adaptive Immune Response Induced by OVA/PDDA Nanoparticles by Daniele R. Pereira, Yunys Pérez-Betancourt, Bianca C. L. F. Távora, Geraldo S. Magalhães, Ana Maria Carmona-Ribeiro, Eliana L. Faquim-Mauro

“…<b>Conclusions</b>: The data showed the central role of DCs in the induction of antigen-specific immune response by OVA-PDDA-NPs, thus proving that these NPs are a potent adjuvant for subunit vaccine design.…”
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Barriers and Facilitators to User Engagement and Moderation for Web-Based Peer Support Among Young People: Qualitative Study Using the Behavior Change Wheel Framework by Ananya Ananya, Janina Tuuli, Rachel Perowne, Leslie Morrison Gutman

“…ResultsThematic analysis revealed a total of 20 inductive themes within 10 TDF domains—9 (45%) for engagement and 11 (55%) for moderation. …”
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Barriers and enablers to young people accessing sexual and reproductive health services in Pacific Island Countries and Territories: A scoping review. by Maggie Ikinue Baigry, Robin Ray, Daniel Lindsay, Angela Kelly-Hanku, Michelle Redman-MacLaren

“…Text data from published articles were charted inductively using thematic analysis with no predetermined codes and themes.…”
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Mycosynthesis of chitosan-selenium nanocomposite and its activity as an insecticide against the cotton leafworm Spodoptera littoralis by Sohila A. Ibrahiem, Fifi M. Reda, Eman M. Abd-ElAzeem, Mostafa S. Hashem, Hala A. Ammar

“…The biosynthesized nanomaterials were fully characterized by UV–visible spectroscopy, transmission electron microscopy, dynamic light scattering, energy dispersive X-ray, inductively coupled plasma spectroscopy, and Fourier transform infrared. …”
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