Colchicine Does Not Reduce Abdominal Aortic Aneurysm Growth in a Mouse Model by James Phie, Shivshankar Thanigaimani, Pacific Huynh, Raghuveeran Anbalagan, Corey S. Moran, Robert Kinobe, Joseph V. Moxon, Matt A. Field, Smriti M. Krishna, Jonathan Golledge

“…For aim two, 3 weeks after AAA induction, mice were randomly allocated to receive colchicine (n=28, 0.2 mg/kg/d) or vehicle control (n=29). …”
Get full text

Radiation-induced impacts on mitochondrial DNA and the transgenerational genomic instability by Ryosuke Seino, Haruka Kubo, Kai Nishikubo, Hisanori Fukunaga

“…Discussion: We found the delayed induction of mtDNA damage in human cancer and noncancerous cells after irradiation, as well as the same trend in mice. …”
Get full text

Venetoclax added to CLAG regimen might improve the outcome of patients with relapsed/refractory acute myeloid leukemia by Yu Zhang, Zhao Yin, Zurong Yao, Dan Xu, Xuejie Jiang, Xiaqi Nie, Dandan Chen, Hongsheng Zhou, Pengcheng Shi, Hui Liu, Qifa Liu, Guopan Yu

“…Subgroup analysis showed that patients without response after two courses of induction therapy, or patients with FLT3 mutations seemed to benefit more from CLAG ± Ida/Mito + Ven than CLAG ± Ida/Mito in acquiring CRc. …”
Get full text

Lactococcus lactis D4 Restores Gut Microbiota Balance in Azoxymethane and Dextran Sulfate Sodium-induced Colorectal Cancer Rat Model by Rini Suswita, Muhammad Iqbal Rivai, Muhammad Iqbal, Irwan Irwan, Avit Suchitra

“…METHODS: This experimental study involved Sprague Dawley rats that were separated into untreated control (CO group), CRC-induced (CA group), and L. lactis D4-treated CRC-induced (LLD group). The CRC induction was performed by giving azoxymethane (AOM) and dextran sulfate sodium (DDS). …”
Get full text

What made people (more) positive toward the COVID-19 vaccine? Exploring positive and negative deviance perspectives by Mitchell A. M. Matthijssen, Mariëlle Cloin, Florian van Leeuwen, Ien van de Goor, Peter Achterberg

“…The data were analyzed via semi-inductive coding with Atlas.ti.23. Results Positive deviants got vaccinated because they perceived COVID-19 as a threat, wanted to protect (vulnerable) others, or wanted to regain their freedom. …”
Get full text

Endosperm culture-based allotriploid hybrid production from an interspecific cross of Haemanthus spp.: new insights into polyploidization and hybridization by Arisa Nakano, Masahiro Mii, Yoichiro Hoshino

“…MS medium supplemented with 4-amino-3,5,6-trichloropicolinic acid (picloram) and 6-benzylaminopurine (BAP), or 2,4-dichloro phenoxy acetic acid (2,4-D) and BAP were used for callus induction, and callus formation rates were measured. …”
Get full text

“The big topic is COVID”: A qualitative study about changes in HPV vaccine conversations between parents and primary care team members throughout the COVID-19 pandemic by Josheili Y. Llavona-Ortiz, Lauren J. Van Scoy, Benjamin Fogel, Casey Pinto, Jamelia Graham, William A. Calo

“…Verbatim transcriptions were analyzed using both inductive and deductive approaches to thematic analysis. …”
Get full text

Board of Governors’ roles and students’ academic Performance in Secondary Schools in Kikagate Sub-County, Isingiro District. by Wilson Mukombe, Bagarukayo

“…The study recommended that the Ministry of Education should establish a mandatory training course, conferences, seminars, inductions and workshops for all the Board of Governors to increase their knowledge and skills like financial, human resource management, planning, conceptual, technical skills in efficient management of schools.…”
Get full text

Staff Training Programmes and Teachers’ Job Performance in Selected Secondary Schools of Kanungu Town Council, Kanungu District by Richard Bens, Agaba

Get full text

Transcriptome analysis and cytochrome P450 monooxygenase reveal the molecular mechanism of Bisphenol A degradation by Pseudomonas putida strain YC-AE1 by Adel, Eltoukhy, Yang, Jia, Imane, Lamraoui, M. A., Abo‑Kadoum, Omar, Mohammad Atta, Ruth, Nahurira, Junhuan, Wang, Yanchun, Yan

“…Results: We employed RNA sequencing to analyze the differentially expressed genes (DEGs) in the YC‑AE1 strain upon BPA induction. Out of 1229 differentially expressed genes, 725 genes were positively regulated, and 504 genes were down‑regulated. …”
Get full text

Pharmacological and non-pharmacological interventions in patients undergoing nasal surgeries for prevention of emergence agitation: a systematic review and network meta-analysis by Gustavo R.M. Wegner, Bruno F.M. Wegner, Henrik G. Oliveira, Luis A. Costa, Luigi W. Spagnol, Valentine W. Spagnol, Gilberto T.F. de Oliveira Filho

“…The best ranked treatments identified were intraoperative dexmedetomidine (1 μg.kg-1 for 10 minutes as a bolus, followed by 0.4 μg.kg-1.h-1), bilateral nasociliary and maxillary nerve block, ketamine (0.5 mg.kg-1 administered 20 minutes before the end of surgery), nasal compression for 40 minutes before anesthesia induction, and suction above the cuff of the endotracheal tube. …”
Get full text

Soft computing approaches of direct torque control for DFIM Motor's by Zakariae Sakhri, El-Houssine Bekkour, Badre Bossoufi, Nicu Bizon, Mishari Metab Almalki, Thamer A.H. Alghamdi, Mohammed Alenezi

“…Conventional Direct Torque Control (DTC) is widely used for torque and speed control in doubly-fed induction machines (DFIM). However, it has notable drawbacks, including high torque and flux ripples, which generate acoustic noise and reduce system performance. …”
Get full text

Prognostic Value of PSMB5 and Correlations with LC3II and Reactive Oxygen Species Levels in the Bone Marrow Mononuclear Cells of Bortezomib-Resistant Multiple Myeloma Patients by Eva Plakoula, Georgios Kalampounias, Spyridon Alexis, Evgenia Verigou, Alexandra Kourakli, Kalliopi Zafeiropoulou, Argiris Symeonidis

“…Proteasome inhibitors (PIs) constitute the most common type of induction treatment for multiple myeloma. Interactions between the proteasome, autophagy, and reactive oxygen species (ROS) have been shown in the past, thus emphasizing the need for a better understanding of the underlying pathophysiology. …”
Get full text

Pharmacological Modulation of the Unfolded Protein Response as a Therapeutic Approach in Cutaneous T-Cell Lymphoma by Nadia St. Thomas, Benjamin N. Christopher, Leticia Reyes, Reeder M. Robinson, Lena Golick, Xiaoyi Zhu, Eli Chapman, Nathan G. Dolloff

“…The CTCL response was dominated by the induction of the HSP70 family member <i>HSPA6</i> (HSP70B’) and, to a lesser extent, <i>HSPA5</i> (BiP/GRP78). …”
Get full text

Effect of intraoperative noise isolation on postoperative nausea and vomiting in patients undergoing gynecological laparoscopic surgery: protocol for a randomized controlled trial by Chong Fu, Fan Xia, Zihan Yan, Han-bing Xu, Wei-ming Zhao, Yi-shan Lei, Chang Xu, Wen-wen Huo, Duo-duo Tao, Juan Wang, Xi-sheng Shan, Ke Peng, Hong Liu, Fu-hai Ji, Hua-yue Liu

“…Patients will be randomly assigned in a 1:1 ratio and stratified by age into either the control group (Group C), without noise-cancelling headphones, or a noise reduction group (Group NR), using noise-cancelling headphones from anesthesia induction until the end of surgery. All patients will receive intraoperative dexamethasone and ondansetron prophylaxis. …”
Get full text

Computer-Aided Construction and Evaluation of Poly-L-Lysine/Hyodeoxycholic Acid Nanoparticles for Hemorrhage and Infection Therapy by Qin Qin, Wenxing Wu, Ling Che, Xing Zhou, Diedie Wu, Xiaohui Li, Yumin Yang, Jie Lou

“…<b>Results:</b> PLL-HDCA NPs demonstrated effective induction of platelet aggregation and significantly reduced bleeding time and blood loss in mouse models, including tail vein, femoral vein, artery, and liver bleeding. …”
Get full text

Gaining Insight into Operative Performance: Analysis of an Automated 360-Degree Feedback Tool Among Perioperative Staff by Stefanie J. Soelling, MD, MPH, Robert D. Sinyard, MD, Lauren Spigel, MPH, Max Riley, MD, Paul Gregory, PhD, Nick Perdomo, MS, Yves Sonnay, MScPH, Steven Yule, PhD, Steven J. Fishman, MD, Douglas S. Smink, MD, MPH, FACS

“…We performed semi-structured interviews with 10 surgeons and 5 surgical leaders. Combined inductive and deductive coding was used to determine their perceptions regarding the utility of and barriers to the i360. …”
Get full text

Acute oral toxicity study of novel polyherbal formulations by using wistar rats and Swiss albino mice as per OECD 425 TG by Ramkishan Jatoth, S.P Dhanabal, V. Senthil, T. Ganesh, Jubie Selvaraj, P.S. Venkatesan

“…Mice and rats are normally used in safety studies because of their susceptibility to toxic challenges, tumor induction, and carcinogenicity. Material and Methods: 1 % CMC, Hydaljss08, Immunoboost-Tab polyherbal formulations, female rats, and albino mice. …”
Get full text

Glyphosate treatment mediates the accumulation of small discrete 5^′ and 3^′-terminal fragments of 18S rRNA in plant cells by A. V. Zhigailov, A. S. Nizkorodova, K. O. Sharipov, N. S. Polimbetova, B. K. Iskakov

“…In the present work, we studied the induction of 18S rRNA discrete fragmentation and phosphorylation of the α-subunit of eukaryotic initiation factor 2 (eIF2α) in germinated wheat embryos in the presence of glyphosate, which imitates the condition of amino acid starvation. …”
Get full text

Experiences of ‘traditional’ and ‘one-stop’ MRI-based prostate cancer diagnostic pathways in England: a qualitative study with patients and GPs by Fiona M Walter, Stephanie Archer, Willie Hamilton, Samuel William David Merriel, John McGrath, Alice S Forster, Hashim Uddin Ahmed, David Eldred-Evans

“…Objectives This study aimed to understand and explore patient and general practitioner (GP) experiences of ‘traditional’ and ‘one-stop’ prostate cancer diagnostic pathways in England.Design Qualitative study using semi-structured interviews, analysed using inductive thematic analysisSetting Patients were recruited from National Health Service (NHS) Trusts in London and in Devon; GPs were recruited via National Institute for Health Research (NIHR) Clinical Research Networks. …”
Get full text