Wharton’s Jelly Mesenchymal Stem Cell Conditioned Medium Ameliorates Diabetes-Induced Testicular Damage and Sperm Abnormalities by Mitigating Oxidative Stress, Apoptosis, and Infla... by Mojtaba Sargazi, Narges Karbalaei, Saied Karbalay-Doust, Sara Keshtgar, Zohre Aghaei

“…In the early treatment groups, insulin (3 U/day, subcutaneously) and WJMSCs-CM (10 mg/week, intraperitoneally) were administered immediately after diabetes induction; in the late treatment groups, these interventions began 30 days postinduction. …”
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Promoting Immortalized Adipose-Derived Stem Cell Transdifferentiation and Proliferation into Neuronal-Like Cells through Consecutive 525 nm and 825 nm Photobiomodulation by Madeleen Jansen van Rensburg, Anine Crous, Heidi Abrahamse

“…Cells were exposed to induction type 1 (IT1): 3-isobutyl-1-methylxanthine (IBMX) (0.5 mM)+indomethacin (200 μM)+insulin (5 μg/ml) for 14 days, preinduced with β-mercaptoethanol (BME) (1 mM) for two days, and then incubated with IT2: β-hydroxyanisole (BHA) (100 μM)+retinoic acid (RA) (10-6 M)+epidermal growth factor (EGF) (10 ng/ml)+basic fibroblast growth factor (bFGF) (10 ng/ml) for 14 days and preinduced with β-mercaptoethanol (BME) (1 mM) for two days and then incubated with indomethacin (200 μM)+RA (1 μM)+forskolin (10 μM) for 14 days. …”
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Hypericum Perforatum-Derived Exosomes-Like Nanovesicles: A Novel Natural Photosensitizer for Effective Tumor Photodynamic Therapy by Ma X, Chen N, Zeng P, He Y, Zhang T, Lu Y, Li Z, Xu J, You J, Zheng Y, Wang L, Luo M, Wu J

“…In vitro, HPDENs showed light dose-dependent cytotoxicity against human melanoma cells, characterized by elevated ROS production and apoptosis induction. In vivo, HPDEN-mediated PDT significantly suppressed tumor growth and induced extensive tumor necrosis, with no observable toxicity to major organs.Conclusion: HPDENs represent a novel plant-derived photosensitizer with dual ROS generation pathways and significant therapeutic efficacy, providing a promising platform for enhancing photodynamic therapy.Keywords: Hypericum perforatum-derived exosomes-like nanovesicles, photosensitizer, photodynamic therapy, reactive oxygen species, apoptosis…”
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EGFR-targeting RNase A-cetuximab antibody-drug conjugate induces ROS-mediated apoptosis to overcome drug resistance in KRAS mutant cancer cells by Bita Jafary, Mostafa Akbarzadeh-Khiavi, Hamed Farzi-Khajeh, Azam Safary, Khosro Adibkia

“…These findings emphasize the potential of RN-PEG-Cet as a novel therapeutic approach for KRAS mutant CRC, offering superior apoptosis induction and targeted cytotoxicity compared to conventional therapies. …”
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The effect of plasma nitriding duration on the tribological performance of Ni-B-Gr self-lubricant composite coatings on AISI 4140 steel by Vahid Niksefat, Farzad Mahboubi

“…The Ni-B-Gr coatings were characterized using various techniques, including X-ray diffraction, field emission scanning electron microscopy, inductively coupled plasma optical emission spectroscopy, microhardness testing, and tribological assessments. …”
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The Synergistic Effect of TRPV1 on Oxidative Stress-Induced Autophagy and Apoptosis in Microglia by Tingting Huang, Yao Lin, Qiongyi Pang, Weimin Shen, Xiang Chen, Fengxia Tu

“…A high amount of reactive oxygen species (ROS) is involved in oxidative stress induction. Transient receptor potential vanilloid 1 (TRPV1) has been shown to regulate oxidative stress and apoptosis in microglia; however, the detailed mechanisms remain unclear. …”
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Conditional knockdown of hepatic PCSK9 ameliorates high-fat diet-induced liver inflammation in mice by Xue-Ying Zhang, Qing-Qing Lu, Yan-Jie Li, Shan-Rui Shi, Chao-Nan Ma, Miao Miao, Shou-Dong Guo

“…These findings confirmed that conditional knockdown of hepatic PCSK9 attenuates liver inflammation following hyperlipidemia induction by modulating multiple signaling pathways; this suggests that targeting PCSK9 knockdown/inhibition with appropriate agents is useful not only for treating hyperlipidemia but also for ameliorating hyperlipidemia-induced liver inflammation.…”
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Terminalia catappa Extract Palliates Redox Imbalance and Inflammation in Diabetic Rats by Upregulating Nrf-2 Gene by Franklyn Nonso Iheagwam, Gaber El-Saber Batiha, Olubanke Olujoke Ogunlana, Shalom Nwodo Chinedu

“…Molecular docking and prediction of major TCA phytoconstituents’ biological activity related to T2DM-induced oxidative stress were evaluated in silico. Induction of diabetes significantly (p<0.05) reduced superoxide dismutase, glutathione-S-transferase, and peroxidase activities. …”
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Acceptability of donor funding for clinical trials in the UK: a qualitative empirical ethics study using focus groups to elicit the views of research patient public involvement gro... by Simon Bowman, Heather Draper, Alexander Masters, Dominic Nutt, Kirstie Shearman

“…Data were analysed using inductive thematic approach informed by the study aims and ethical analysis.Participants 22 participants were recruited: 8 research patient public involvement group members, 7 REC chairs and 7 clinical researchers. …”
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An Open‐Label Phase II Trial of Pembrolizumab, an Immune Checkpoint Inhibitor Alone or in Combination With Oral Azacitidine as Second‐Line Therapy for Advanced Head and Neck Squamo... by Vinod K. Ramani, Srimonta Gayen, Radheshyam Naik

“…To evaluate the clinical effectiveness endpoints and toxicity of oral azacytidine when combined with pembrolizumab. ii. To assess the induction of a T‐cell response among the study subjects. iii. …”
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The impact of the Lesotho health reform in the re-structuring of the village health workers program by Afom T. Andom, Hannah N. Gilbert, Courtney M. Yuen, Mapoho Mokoroane, Melino Ndayizigiye, Mpopo Tsoele, Masebeo Koto, Retsepile Tlali, Makena Ratsiu, Joia S. Mukherjee

“…Methods In 2018, we conducted a qualitative research study with an inductive content analysis approach in the four pilot health reform districts of Lesotho. …”
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Study of the effect of azithromycin on airway remodeling in asthma via the SAPK/JNK pathway by Dannv Ma, Huaqing Du, Yi Huang, Aiwu Pan, Lu Gan

“…Methods Simulated asthmatic AR mouse model was developed by induction with ovalbumin (OVA) and intervened with AZM or dexamethasone (DEX) and anisomycin (JNK activator). …”
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APPLICATION OF MODIFYING ALLOYING ALLOY CONTAINING NANOSIZED POWDERS OF ACTIVE ELEMENTS IN PRODUCTION OF HIGH-STRENGTH CAST IRON WITH GLOBULAR GRAPHITE by A. S. Kalinichenko, A. G. Slutsky, V. A. Sheinert

“…Melting of iron in laboratory conditions was performed in crucible induction furnace IST-006 with an acid lining held. …”
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Development of Vegetative Propagation Strategies for Balanites aegyptiaca in the Sahel, Niger by Moussa Massaoudou, Rabiou Habou, Zounon Christian Serge Félix, Abasse Tougiani, Patrick Van Damme

“…We then tested seed germination success, and suckering induction, air-layering, and stem cuttings were carried out to determine the techniques best suited for the propagation of B. aegyptiaca. …”
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Barriers and facilitators to implementation of non-medical independent prescribing in primary care in the UK: a qualitative systematic review by Nicola Carey, Judith Edwards, Melaine Coward

“…Study data were extracted to a bespoke table and two reviewers used NVivo software to code study findings. An inductive thematic synthesis was undertaken to identify descriptive themes and interpret these into higher order analytical themes. …”
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Filterable PM2.5, Metallic Elements, and Organic Carbon Emissions from the Exhausts of Diesel Vehicles by Yuan-Chung Lin, Ya-Ching Li, Kassian T. T. Amesho, Feng-Chih Chou, Pei-Cheng Cheng

“…To assess the risks from this pollutant, we characterized and quantified the PM2.5 exhausted by 15 diesel vehicles ranging from 28,306 to 883,374 km (an average of 525,854 km) in total mileage and varying in manufacturer and model year (1988–2005). We applied inductively coupled plasma optical emission spectroscopy (ICP-OES) to analyze the metallic element constituents, among which Ca composed the largest fraction, followed by Zn, Al, K, Fe, Mg, and Cr. …”
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Endometrial Regenerative Cell-Derived Conditioned Medium Alleviates Experimental Colitis by Chenglu Sun, Jingpeng Hao, Hong Qin, Yanglin Zhu, Xiang Li, Baoren Zhang, Yafei Qin, Guangming Li, Hongda Wang, Hao Wang

“…Acute colitis was induced by 3% dextran sodium sulfate (DSS), and ERC-CM was injected on days 4, 6, and 8, respectively, after induction. The disease activity index was calculated through the record of weight change, bleeding, and fecal viscosity during the treatment process. …”
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An Investigation of the Relationship Between the Chronotypes of Mothers Who Had Normal Delivery and Various Characteristics of Them and Their Babies by H. Bayram Yılmaz, Eda Baytaş, Dilek Erdem

“…Participants were selected among the mothers who gave a normal birth, did not have labor induction, whose birth started with spontaneous contractions, and had a healthy pregnancy. …”
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Beneficial mutualistic fungus Suillus luteus provided excellent buffering insurance in Scots pine defense responses under pathogen challenge at transcriptome level by Zilan Wen, Minna J. Manninen, Fred O. Asiegbu

“…The co-inoculated plants did not equally enhance the induction of PR genes, chalcone/stilbene biosynthesis, however genes related to cell wall growth, water and nutrient transporters, phenylpropanoid/lignin biosynthesis/flavonoid biosynthesis, and hormone signaling were induced. …”
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Comparison of inhaled versus intravenous anesthesia for laryngoscopy and laryngeal electromyography in a rat model by M. Gazzaz, J. Saini, S. Pagliardini, B. Tsui, C. Jeffery, H. El-Hakim

“…Three mortalities were encountered, one of which was due to lidocaine toxicity and two were during anesthetic induction. Respiratory related morbidity was encountered in two rats, all seen with TIVA. …”
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