Mast Cell Degranulation Decreases Lipopolysaccharide-Induced Aortic Gene Expression and Systemic Levels of Interleukin-6 In Vivo by Jason M. Springer, Vineesh V. Raveendran, Mingcai Zhang, Ryan Funk, Donald D. Smith, Mehrdad Maz, Kottarappat N. Dileepan

“…The results revealed that induction of mast cell degranulation significantly lowers serum IL-6 levels and aortic expression of IL-6 in LPS-treated mice. …”
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Providing a General Model for the Successful Implementation of Digital Transformation in Organizations by Haidar Ahmadi, Najme Parsaei, Seyyed Hamed Hashemi, Hamidreza Nematollahi

“…Methods This study adopts an interpretive and inductive approach and is practical in its objectives. …”
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Search for biocontrol agents among endophytic lipopeptidesynthesizing bacteria <i>Bacillus</i> spp. to protect wheat plants against Greenbug aphid (<i>Schizaphis graminum</i>) by S. D. Rumyantsev, V. Y. Alekseev, A. V. Sorokan, G. F. Burkhanova, E. A. Cherepanova, I. V. Maksimov, S. V. Veselova

“…Beneficial endophytic bacteria can suppress the development of insect pests through direct antagonism, with the help of metabolites, or indirectly by the induction of systemic resistance through the regulation of hormonal signaling pathways. …”
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Effective control of southern blight and root rot of Aconitum carmichaelii Debeaux by endophytic Bacillus velezensis YN-2-6S by Qian Wang, Yujie Qiu, Siyu Wang, Yumei Gou, Hongji Hou, Tianwei Su, Lan Zou, Jing Huang

“…Taken together, this study proved that YN-2-6S was a promising biocontrol agent against southern blight and root rot of A. carmichaelii and the underline mechanism may involve the production of antifungal lipopeptides, polyketides, volatile compounds, hydrolysis and induction of host systemic resistance.…”
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Phosphate-modified CpG oligonucleotides induce in vitro maturation of human myeloid dendritic cells by A. A. Ostanin, O. Y. Leplina, E. A. Burakova, T. V. Tyrinova, A. A. Fokina, A. S. Proskurina, S. S. Bogachev, D. A. Stetsenko, E. R. Chernykh

“…The enhancement of DC allostimulatory activity in the presence of CpG-ODNs was associated with the induction of final DC maturation, which was confirmed by a significant decrease in the number of CD14+DC, an increase in mature CD83+DC and a trend towards an increase in CD86+DC. …”
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Factors Influencing Telemedicine Adoption Among Health Care Professionals: Qualitative Interview Study by Fiona Schürmann, Daniel Westmattelmann, Gerhard Schewe

“…The interview data were analyzed with deductive and inductive coding based on the EVF. Two coders conducted the coding process independently, achieving an intercoder reliability of 86.14%. …”
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MSCs with upregulated lipid metabolism block hematopoietic stem cell differentiation via exosomal CTP-1A in MDS by Chunlai Yin, Xue Yan, Jinyi Ren, Cheng Zhang, Jiaqing Liu, Zilong Wang, Jing Liu, Weiping Li, Xia Li

“…The proliferation, apoptosis, differentiation and support for hematopoiesis of these cells were analyzed using CCK-8 assay, FC and induction medium and CFU (colony forming units) assay, respectively. …”
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Evaluation of the needs assessment process of the training courses for the staff of the general sports and youth departments by Shahin Hayati, Haleh Fazel, Lora Chapari

“…The research method is applicable in terms of its purpose, and qualitative in terms of implementation, based on the inductive approach. The statistical population of the research includes all professors of sports management, managers, deputy general departments of sports and youth; and sampling was done intentionally or judgmentally; and 15 people in this research were interviewed, and based on the selection of this sample method; sampling done by the researcher was based on personal judgment and study objectives and the nature of the research. …”
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Presenting the internal evaluation model on the performance of the banking industry based on the data theory method of the foundation by Zahra Ramzanpour Osmavandani, mehdi Rouholamini, Shahrbanoo Gholipour

“…The research method is applicable in terms of the purpose, and qualitative in terms of the implementation method, based on the inductive approach. The statistical population of the research includes 8 experts of the banking industry, and the sampling was done in a targeted manner and the interviews continued until reaching theoretical saturation. …”
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Ten pressure points in primary care during COVID-19: findings from an international narrative review by Sally Hall Dykgraaf, Anne Parkinson, Michael Wright, William C. W. Wong, Jane Desborough, Lauren Ball, Elizabeth Sturgiss, Garang M. Dut, Katelyn Barnes, Danielle Butler, Steph Davis, Kirsty Douglas, Candan Kendir, Danielle Martin, Robert Marten, Katherine Rouleau, Shannon Barkley, Lucas de Toca, Michael Kidd

“…Narrative data regarding impacts on PC services and challenges experienced by PCPs were extracted and analysed using inductive coding and thematic analysis. Results From 1745 screened papers 108, representing 90 countries, were included. …”
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Regional disparities in the use of intensive chemotherapy for AML in the Netherlands: does it influence survival? by Hester F Lingsma, David van Klaveren, Arjan A van de Loosdrecht, Anna van Rhenen, Otto Visser, Valery E P P Lemmens, Nikki van Leeuwen, Gerwin Huls, Z L Rana Kaplan, Eduardus F M Posthuma, Danielle van Lammeren-Venema, Tjeerd J F Snijders, Catharina H M J van Elssen, Peter A von dem Borne, Nicole M A Blijlevens, Jan J Cornelissen, Marc H G P Raaijmakers, Avinash G Dinmohamed

“…Objective Acute myeloid leukaemia (AML) prognosis is enhanced with intensive remission induction chemotherapy (ICT) in eligible patients. …”
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Improving NGOs’ participation in implementing HIV preventive interventions: a case of adolescents with high-risk behaviors in Iran by Haniye Sadat Sajadi, Laleh Ghadirian, Azadeh Sayarifard, Fatemeh Rajabi, Maryam Nazari, Narges Rostamigooran, Nina Loori, Haniyeh Haji Abolhasan Memar, Mojgan Farshadi, Parvin Afsar Kazerooni, Maryam Sargolzaeemoghaddam, Reza Majdzadeh

“…Data from interviews and FGDs were audio-recorded, transcribed, and analyzed using an inductive content analysis. Second, a scoping review was performed, utilizing databases such as PubMed, Web of Science, ProQuest, and Google Scholar. …”
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Selective expression and significance of ACKR2 in lung aerocytes by Alberto Mantovani, Gianluigi Condorelli, Raffaella Bonecchi, Massimo Locati, Marina Sironi, Roberta Carriero, Francesca Albano, Valeria Mollica Poeta, Lucia Zotti, Alessandra Castagna, Arianna Felicetta, Alessandro Mesaglio, Elisa Zaghen, Arianna Capucetti, Rachele Di Donato, Mattia Laffranchi, Matteo Massara, Silvano Sozzani

“…In vivo models of lung metastasis and inflammation were performed in wild-type (WT) and conditional KO mice by intravenous injection of melanoma and colon cancer cell lines; the induction of acute lung injury model was done by intranasal injection of lipopolysaccharide (LPS). …”
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Pharmacological interventions for the management of anesthesia and sedation in patients with Duchenne muscular dystrophy: a systematic review and meta-analysis by Xianghong Lian, Xianghong Lian, Xianghong Lian, Yang Jing, Yang Jing, Yang Jing, Ting Luo, Ting Luo, Ting Luo, Yixin Guo, Yixin Guo, Yixin Guo, Yunzhu Lin, Yunzhu Lin, Yunzhu Lin

“…In addition, general anesthesia and central neuraxial blockade in patients with severe DMD are unsafe because respiratory depression and myocardial complications may occur after the administration of volatile anesthetics and depolarizing muscle relaxants (succinylcholine) during the induction of anesthesia.ConclusionsPatients with DMD are more sensitive to NMBAs with delayed onset times and prolonged recovery times. …”
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Proteomic Analysis of Hypoxia-Induced Senescence of Human Bone Marrow Mesenchymal Stem Cells by Liping Mai, Guodong He, Jing Chen, Jiening Zhu, Shaoxian Chen, Xinghua Hou, Hui Yang, Mengzhen Zhang, Yueheng Wu, Qiuxiong Lin, Min Yang, Xiaohong Li

“…Moreover, the CCND1, UQCRH, and COX7C expressions were verified by PRM. Hypoxia induction for 12 hours in hBMSCs reduced CCND1 expression but promoted ROS production and cell apoptosis. …”
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Investigating the neuroprotective effects of Dracocephalum moldavica extract and its effect on metabolomic profile of rat model of sporadic Alzheimer's disease by Marjan Talebi, Seyed Abdulmajid Ayatollahi, Mohammad Ali As’Habi, Farzad Kobarfard, Mona Khoramjouy, Farzaneh Niki Boroujeni, Mehrdad Faizi, Alireza Ghassempour

“…Male Wistar rats were injected with STZ (3 mg/kg, single dose, bilateral ICV) to induce a sporadic AD (sAD) model. Following model induction, rats were orally administered with DM extract (100, 200, and 400 mg/kg/day) or donepezil (5 mg/kg/day) for 21 days. …”
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Ligilactobacillus salivarius LZZAY01 accelerated autophagy and apoptosis in colon cancer cells and improved gut microbiota in CAC mice by Wenhong Yang, Tao Li, Shixiang An, Rong Chen, Yuxin Zhao, Jiaxian Cui, Mingyu Zhang, Jingkun Lu, Yunpeng Tian, Lili Bao, Pengwei Zhao

“…A model of colitis-associated cancer (CAC) was established in C57BL/6j mice following induction with AOM/DSS. The levels of autophagy and apoptosis proteins, tight junction proteins, and inflammatory factors were detected by western blotting, immunofluorescence assay, and enzyme-linked immunosorbent assay. …”
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PATHOLOGICAL CHANGES IN MICE TREATED WITH CYCLOPHOSPHAMIDE AND EXOGENOUS DNA by E. V. Dolgova, V. P. Nikolin, N. A. Popova, A. S. Proskurina, K. E. Orishchenko, E. A. Alyamkina, Ya. R. Efremov, S. I. Baiborodin, E. R. Chernykh, A. A. Ostanin, S. S. Bogachev, T. S. Gvozdeva, E. M. Malkova, O. S. Taranov, V. A. Rogachev, A. S. Panov, S. N. Zagrebelnyi, M. A. Shurdov

“…Plasmid DNA has the greatest effect on apoptosis induction.The analysis of reduction and restoration of BMC subpopulations as the mice progressed to death revealed a virtually complete loss of the 12–20-mkm fraction of the cell population (about 3–4 % vs. 35–40 % in the control), which corresponds to the maximum leukopenia on day 3 after CP treatment. …”
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NLRP3 activation maintains intestinal epithelial barrier and reduces liver injury in alcoholic liver disease mice by Shi‐Qing Li, Ya‐Ru Wang, Zhong‐Liang Xie, Yan Wang, Zi‐Han Feng, Jian‐Hao Xu, Bing Yuan, Yi‐Tong Zhang, Guan Yang, Jing‐Lin Wang, Yuan Yuan

“…Methods We established ALD mice models of WT, Nlrp3−/− and Gsdmd−/− through chronic alcohol consumption feeding and acute alcohol induction. We compared alterations in gut microbiota, ileitis, and adhesion protein expression, to analyze the role and potential mechanism of NLRP3 in the early onset of ALD. …”
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Characterisation of <i>Staphylococcus aureus</i> Strains and Their Prophages That Carry Horse-Specific Leukocidin Genes <i>lukP/Q</i> by Stefan Monecke, Sindy Burgold-Voigt, Andrea T. Feßler, Martina Krapf, Igor Loncaric, Elisabeth M. Liebler-Tenorio, Sascha D. Braun, Celia Diezel, Elke Müller, Martin Reinicke, Annett Reissig, Adriana Cabal Rosel, Werner Ruppitsch, Helmut Hotzel, Dennis Hanke, Christiane Cuny, Wolfgang Witte, Stefan Schwarz, Ralf Ehricht

“…In addition to sequencing, phages were characterised by mitomycin C induction and transmission electron microscopy (TEM). …”
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