Dexamethasone Provides Effective Immunosuppression for Improved Survival of Retinal Organoids after Epiretinal Transplantation by Bikun Xian, Ziming Luo, Kaijing Li, Kang Li, Mingjun Tang, Runcai Yang, Shoutao Lu, Haijun Zhang, Jian Ge

“…Retinal organoids were then seeded onto poly(lactic-co-glycolic) acid (PLGA) scaffolds and implanted into rhesus monkey eyes (including a healthy individual and three monkeys with chronic ocular hypertension (OHT) induction) and subjected to different post-operative immunosuppressant treatments; 8 weeks after the experiment, histological examinations were carried out to assess the success of the different treatments. …”
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PPARγ Antagonizes Hypoxia-Induced Activation of Hepatic Stellate Cell through Cross Mediating PI3K/AKT and cGMP/PKG Signaling by Qinghui Zhang, Shihao Xiang, Qingqian Liu, Tao Gu, Yongliang Yao, Xiaojie Lu

“…Hypoxia promoted the induction and progress of hepatic fibrosis and HSCs activation. …”
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Phase II Study of Personalized Peptide Vaccination with Both a Hepatitis C Virus-Derived Peptide and Peptides from Tumor-Associated Antigens for the Treatment of HCV-Positive Advan... by Shigeru Yutani, Kazuomi Ueshima, Kazumichi Abe, Atsushi Ishiguro, Junichi Eguchi, Satoko Matsueda, Nobukazu Komatsu, Shigeki Shichijo, Akira Yamada, Kyogo Itoh, Tetsuro Sasada, Masatoshi Kudo, Masanori Noguchi

“…Further clinical study of PPV would be warranted for HCV-positive advanced HCC, based on the safety and strong immune induction.…”
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Studies on the Dual Cytotoxicity and Antioxidant Properties of Berberis vulgaris Extracts and Its Main Constituent Berberine by Lamyae El khalki, Mounir Tilaoui, Abdeslam Jaafari, Hassan Ait Mouse, Abdelmajid Zyad

“…The observed cytotoxicity was related to apoptosis induction as demonstrated by the annexin-V-streptavidin FITC-staining analysis.…”
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Intradermal DNA Electroporation Induces Cellular and Humoral Immune Response and Confers Protection against HER2/neu Tumor by Alessia Lamolinara, Lorenzo Stramucci, Albana Hysi, Manuela Iezzi, Cristina Marchini, Marianna Mariotti, Augusto Amici, Claudia Curcio

“…Moreover, we tested the efficacy of intradermal vaccination against Her2/neu antigen in cellular and humoral response induction and consequent protection from a Her2/neu tumor challenge in Her2/neu nontolerant and tolerant mice. …”
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Renal Transplantation in Hepatitis C Positive Patients: A Single Centre Experience by P. R. Shah, A. V. Vanikar, M. R. Gumber, H. V. Patel, V. B. Kute, S. M. Godara, H. L. Trivedi

“…We analyzed 132 HCV-positive RTx patients (group A) transplanted under tolerance induction protocol (TIP) and compared them with 79 controls (group B) transplanted using standard triple drugs. …”
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Hypoxia Promotes Vascular Smooth Muscle Cell (VSMC) Differentiation of Adipose-Derived Stem Cell (ADSC) by Regulating Mettl3 and Paracrine Factors by Jiaying Lin, Qianqian Zhu, Jialyu Huang, Renfei Cai, Yanping Kuang

“…Herein, we investigated the expression of N6-adenosine methyltransferases (Mettl3) and demethylases (Fto and Alkbh5) and found that Mettl3 was upregulated in ADSCs undergoing vascular smooth muscle differentiation induction. Moreover, silence of Mettle3 reduced the expression level of VSMC-specific markers, including α-SMA, SM22α, calponin, and SM-MHC. …”
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Effectiveness of Phytomining of Vanadium (V) and Chromium (Cr) Using Cymbopogon citratus and Portulaca grandiflora in Red Mud with Manure Addition by Fitranto Irwan, Voijant Tangahu Bieby, Yulikasari Andriyan, Mashudi, Sulistyaning Titah Harmin, Najib Rizal Moh., Salsabilla Faiza, Ming Lam Yeng, Wang Yamin, In Hurun, Maryanawati Soesilo Mery

“…The phytomining capacity of the plants was determined by measuring the concentration of vanadium (V) and chromium (Cr) in the plant extractions using inductively coupled plasma-optical emission spectroscopy (ICP-OES) equipment. …”
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Characterization and Expression of Senescence Marker in Prolonged Passages of Rat Bone Marrow-Derived Mesenchymal Stem Cells by Noridzzaida Ridzuan, Akram Al Abbar, Wai Kien Yip, Maryam Maqbool, Rajesh Ramasamy

“…Mesenchymal stem cells were successfully generated and characterized as delineated by the expressions of CD90.1, CD44H, CD29, and CD71 and lack of CD11b/c and CD45 markers. Upon induction, rBM-MSCs differentiated into osteocytes and adipocytes and expressed osteocytes and adipocytes genes. …”
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Exogenous Interleukin-37 Alleviates Hepatitis with Reduced Dendritic Cells and Induced Regulatory T Cells in Acute Murine Cytomegalovirus Infection by Yufei Ruan, Zhengwang Wen, Ke Chen, Jianan Xi, Bo Wu, Zhiyong Xu, Minzhi Jiang, Junling Zhang, Yiping Chen, Qi Liu

“…The frequencies of MHC-Ⅱ, CD40, CD80, and CD86 positive DCs in the liver and spleen were decreased significantly at 7 days postinfection (dpi) in MCMV-infected mice with IL-37 pretreatment when compared with those without the pretreatment, while the total number of DCs in the liver was reduced in IL-37-pretreated mice. The induction of Tregs in the spleen was enhanced at dpi 3 with IL-37 pretreatment in MCMV-infected mice. …”
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Histopathological investigation of the effect of coenzyme q10 on intestinal mucosa and tight junction proteins in experimental colitis model by Saadet Ozen Akarca Dizakar, Murside Ayse Demirel

“…One day after colitis induction, CoQ10 was administered to the Colitis+CoQ10 group by gavage (30 mg/kg/day) for 10 days. …”
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Methodical approaches in experimental modelling of non-alcoholic fatty liver disease by N. V. Bivalkevich, Yu. K. Denisenko, T. P. Novgorodtseva

“…Today‘s methods of NAFLD modelling can be divided into two extensive groups: induction of liver disease by genetic mutation, and phenotypic development of NAFLD due to alimentary factor. …”
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Facilitators and barriers for the implementation of a transmural fall-prevention care pathway for older adults in the emergency department. by W M Charmant, B A M Snoeker, H P J van Hout, I N Nauta, F Boonstra, E Geleijn, C Veenhof, P W B Nanayakkara

“…Two researchers independently coded the transcripts using inductive thematic analysis.<h4>Results</h4>We revealed facilitators and barriers on three key themes: 1) Communication, 2) organisation & execution, and 3) personal factors, and thereunder 12 subthemes. …”
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Modelling Euphrates river water quality index based on field measured data in Al-Diwaniyah City, Iraq by Marwah M. Al-Khuzaie, Khairul Nizam Abdul Maulud, Wan Hanna Melini Wan Mohtar, Zaher Mundher Yaseen

“…The study established using 40 water sampling stations and incorporates Inductively Coupled Plasma Atomic Emission Spectrometry (ICP-OES) to assess HM levels. …”
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Fault Diagnosis of Planetary Gearbox Based on Motor Current Signal Analysis by Ziyuan Jiang, Qinkai Han, Xueping Xu

“…Once it breaks down, it can lead to serious accidents and economic loss. Induction motor current signal analysis (MCSA) is a noninvasive method that uses current to detect faults. …”
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The effect of Garcinia livingstonei aqueous leaf extract on hyperglycaemic-induced human sperm cell: An in-vitro study by Murendeni Nethengwe, Kunle Okaiyeto, Chinyerum S. Opuwari, Oluwafemi O. Oguntibeju

“…Hyperglycaemia was induced using sperm media supplemented with 100 mM D-glucose over 24 h. Hyperglycaemia induction led to a significant (P<0.05) decline in sperm motility, vitality, DNA integrity, mitochondrial membrane potential (MMP), and acrosome integrity. …”
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Can Melatonin Act as an Antioxidant in Hydrogen Peroxide-Induced Oxidative Stress Model in Human Peripheral Blood Mononuclear Cells? by Solaleh Emamgholipour, Arash Hossein-Nezhad, Mohammad Ansari

“…Moreover, melatonin could promote inductive effect of H2O2 on catalase mRNA expression.…”
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Performance of Nile tilapia juvenile fed diet containing different dosages ofrecombinant common carpgrowth hormone by Dian Hardiantho, . Alimuddin, Arief Eko Prasetiyo, Dwi Hany Yanti, Komar Sumantadinata

“…RT-PCR analysisshowedthat expression level of IGF-1 gene in juvenile liver was increased in parallel with the increasing of rCcGH dosages supplemented in diet.This suggestedthatIGF-1 plays an important rolein the induction ofgrowth,andfeed conversionefficiencyof tilapiafed diet containing rCcGH. …”
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A comprehensive analysis of in vitro and in vivo genetic fitness of Pseudomonas aeruginosa using high-throughput sequencing of transposon libraries. by David Skurnik, Damien Roux, Hugues Aschard, Vincent Cattoir, Deborah Yoder-Himes, Stephen Lory, Gerald B Pier

“…In vitro growth in LB provided a baseline for comparison with the survival of the Tn insertion strains following 6 days of colonization of the murine gastrointestinal tract as well as a comparison with Tn-inserts subsequently able to systemically disseminate to the spleen following induction of neutropenia. Sequencing was performed following DNA extraction from the recovered bacteria, digestion with the MmeI restriction enzyme that hydrolyzes DNA 16 bp away from the end of the Tn insert, and fractionation into oligonucleotides of 1,200-1,500 bp that were prepared for high-throughput sequencing. …”
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Factors involved in the recruitment and retention of voluntary blood donors in South Kivu (Democratic Republic of Congo), results from a qualitative study by Susanne Mbaka Ngunza, Isabelle Aujoulat

“…The data was analysed inductively within these predefined units of analysis to generate possible factors of motivation that were then presented and further discussed during the focus-groups discussions with donors and non-donors. …”
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