‘It takes a village’: patient lived experiences of residential treatment for an eating disorder by Rebekah Rankin, Janet Conti, Lucie Ramjan, Phillipa Hay

“…Data were analysed with inductive reflexive thematic analysis. Results Three main themes were generated from the data that included participants’ journeys to treatment, experiences of treatment and the transitions associated with and following discharge. …”
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Adipose Tissue-Derived Stem Cells Differentiate into Carcinoma-Associated Fibroblast-Like Cells under the Influence of Tumor-Derived Factors by Constantin Jotzu, Eckhard Alt, Gabriel Welte, Jie Li, Bryan T. Hennessy, Eswaran Devarajan, Srinivasalu Krishnappa, Severin Pinilla, Lilly Droll, Yao-Hua Song

“…The conditioned medium from MDAMB231 and MCF7 contains significant amounts of transforming growth factor-beta 1 (TGFβ1) and the differentiation of hASCs towards CAFs is dependent on TGFβ1 signaling via Smad3 in hASCs. The induction of CAFs can be abolished using a neutralizing antibody to TGFβ1 as well as by pretreatment of the hASCs with SB431542, a TGFβ1 receptor kinase inhibitor. …”
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A Prospective Randomized Comparison of Postoperative Pain and Complications after Thyroidectomy under Different Anesthetic Techniques: Volatile Anesthesia versus Total Intravenous... by Jun-Young Jo, Yeon Ju Kim, Seong-Soo Choi, Jihoon Park, Han Park, Kyung-Don Hahm

“…Patients were randomly assigned to undergo either total intravenous anesthesia with remifentanil and propofol (TIVA, n = 35) or propofol induction and maintenance with desflurane and nitrous oxide (volatile anesthesia [VA], n = 37). …”
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Probing the Catalytic Efficiency of Supported Heteropoly Acids for Esterification: Effect of Weak Catalyst Support Interactions by Ali Alsalme, Aliyah A. Alsharif, Hamda Al-Enizi, Mujeeb Khan, Saad G. Alshammari, Mshari A. Alotaibi, Rais Ahmad Khan, Mohammed Rafiq H. Siddiqui

“…Besides, the effect of leaching of active sites on the catalysts performance for biodiesel production was also evaluated by inductively coupled plasma studies (ICP). The kaolinite-supported catalyst (25% HPW/kaolinite) demonstrated higher amount of leaching which is also confirmed by the significant decrease in its catalytic activity when it is used for the second time. …”
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The Continental Divide: Anti-TNF Use in Pediatric IBD Is Different in North America Compared to Other Parts of the World by Peter C. Church, Jeffrey Hyams, Frank Ruemmele, Lissy de Ridder, Dan Turner, Anne M. Griffiths

“…North Americans more often continued immunomodulator indefinitely and less often adhered to standard infliximab induction dosing. Access limitations were more common outside North America and Europe for both CD (67% vs. 31%, p<0.001) and UC (62% vs. 33%, p<0.001). …”
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Knights in shining armour and (M)others in life jackets: Women’s experiences of advocating for care alone when suffering recurrent early pregnancy loss during the SARS-CoV-2 pandem... by Flora E. Kent-Nye, Kayleigh S. Sheen, Karen Burgess, Munira Oza, Laura A. Magee, Davor Jurković, Sergio A. Silverio

“…Results Iterative and inductive analysis generated the theory ‘Knights in Shining Armour and (M)others in Life Jackets’, which describes women’s experience of advocating for care alone, when suffering rEPL during the pandemic. …”
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Metabolic conversion of phenol to polyhydroxyalkanoate (PHA) for addressing dual environmental challenges: A review by Izzati Sabri, Mohd Zulkhairi Mohd Yusoff, Nor Azlan Nor Muhammad, Li Sim Ho, Norhayati Ramli

“…Meanwhile, PHA can be synthesized through the acetoacetyl-CoA (pathway I), de novo fatty acids synthesis (pathway II), β-oxidation (pathway III), and the tricarboxylic acid (TCA) cycle, with the induction of these pathways are highly dependent on the substrate. …”
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Bredemolic Acid Ameliorates Selected Liver Function Biomarkers in a Diet-Induced Prediabetic Rat Model by Akinjide Moses Akinnuga, Angezwa Siboto, Bongiwe Khumalo, Ntethelelo Hopewell Sibiya, Phikelelani Ngubane, Andile Khathi

“…After 12 weeks, blood samples and the liver were collected for biochemical analysis. Results. The induction of prediabetes resulted in increased release of liver enzymes (AST and ALT), increased liver glycogen and triglyceride, lipid peroxidation, and decreased sterol regulatory element-binding protein (SREBP1c) and antioxidant enzymes. …”
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After Treatment Decrease of Bone Marrow Tregs and Outcome in Younger Patients with Newly Diagnosed Acute Myeloid Leukemia by Mario Delia, Paola Carluccio, Anna Mestice, Roberta Frappampina, Francesco Albano, Giorgina Specchia, Pellegrino Musto

“…We studied 39 AML younger patients (<65 years), all treated with standard induction chemotherapy. ORR (complete remission (CR)+CR with incomplete hematologic recovery (CRi)) was documented in 21 out of 39 patients (54%); two partial responder patients were also recorded. …”
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Inhibiting ATP6V0D2 Aggravates Liver Ischemia-Reperfusion Injury by Promoting NLRP3 Activation via Impairing Autophagic Flux Independent of Notch1/Hes1 by Ziyi Wang, Hao Wang, Xuejiao Chen, Sheng Han, Yulin Zhu, Hanhua Wang, Feng Cheng, Liyong Pu

“…We first found that the expression of specific ATP6V0D2 in liver macrophages was upregulated with the induction of inflammatory cascade after liver IR surgery, and knockdown of ATP6V0D2 resulted in increased secretion of proinflammatory factors and chemokines, which enhanced activation of NLRP3 and aggravation of liver injury. …”
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Thyroid Hormone Activation Regulates the Crosstalk between Breast Cancer and Mesenchymal Stem Cells by Annarita Nappi, Vittoria D’Esposito, Caterina Miro, Alessia Parascandolo, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Sepehr Torabinejad, Federica Restolfer, Maddalena Raia, Melania Murolo, Emery Di Cicco, Pietro Formisano, Monica Dentice

“…D2 inactivation reduced the invasiveness of MCF7 cells and their responsiveness to the pro-tumorigenic induction via MSCs, both in vivo and in vitro. …”
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Intracellular iron accumulation throughout the progression of sepsis influences the phenotype and function of activated macrophages in renal tissue damage by Mira Hanna, Ahmed M. A. Akabawy, Mohamed Mansour Khalifa, Mohamed Mansour Khalifa, Marawan Abd Elbaset, Reda Abdelnasser Imam, Hanan Seddiek

“…We tackled the relationship between intracellular iron overload and macrophage polarization within 6, 24, and 72 h of sepsis induction. In our study, sepsis-induced kidney injury was caused by using the cecal ligation and puncture (CLP) model. …”
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Study protocol of the METAPANC trial - intensified treatment in patients with local operable but oligometastatic pancreatic cancer - multimodal surgical treatment versus chemothera... by Michael Ghadimi, Uwe Pelzer, Marc G. Besselink, Jens Siveke, Ralph Telgmann, Rickmer Braren, Hanneke Wilmink, Marie Crede, Alexander Koenig, Ute Koenig, Sven Thorsten Liffers, Kai Antweiler, Bas Uijterwijk, Hanna Seppanen, Arno Nordin, Pauli Puolakkainen, Olav F. Dajani, Knut Jørgen Labori, Mia Johansson, Svein Olav Bratlie, Tim Friede, Peter Jo

“…This multicentre, randomized, controlled phase III trial is planned to evaluate whether resection of the primary tumor and liver metastases can improve overall survival in patients with PDAC with hepatic oligometastases in a multimodal treatment setting. Methods After an induction therapy with eight cyles of mFOLFIRINOX and a response assessment after four and eight cycles, patients will be randomized to either Arm 1 (perioperative mFOFIRINOX plus resection of the primary tumor with resection or ablation of all hepatic metastases) or Arm 2 (continuation of 4 cycles of the standard-of-care mFOLFIRINOX chemotherapy). …”
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Delta-Like-1 Changes the Immunomodulatory Property of OP9 Cells by Lei Zhang, Rui-Jie Dang, Yan-Mei Yang, Dian-Chao Cui, Ping Li, Yan-Li Ni, Tong Hao, Changyong Wang, Xiao-Xia Jiang, Nan-Zhu Fang

“…Compared with OP9, OP9DL1 displayed more osteogenesis and less adipogenesis when cultured in the respective induction media. Both OP9 and OP9DL1 inhibited mature B and T cell proliferation. …”
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Resiquimod induces a mixed Th1 and Th2 response via STAT1 and STAT3 signalling in chickens by Deepthi Kappala, Saravanan Ramakrishnan, Patel Nikunjkumar Prakashbhai, Abinaya Kaliappan, Prasad Thomas, Jörg Linde, Mithilesh Singh, Sohini Dey, Madhan Mohan Chellappa

“…These results align with transcriptomic findings and highlight the upregulation of STAT1 and STAT3 as potential contributors to the induction of Th1 and Th2 immune responses by R-848 in chickens. …”
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3D printed magnesium silicate/β-tricalcium phosphate scaffolds promote coupled osteogenesis and angiogenesis by Lulu Wang, Mingkui Shen, Zhongxin Tang, Jun Tan, Kuankuan Li, Haijun Ma

“…In summary, 3D printed MS/β-TCP scaffolds with effectively osteogenic and angiogenic induction will be an ideal bone substitute applied in bone defect repair for clinical application in the future.…”
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Isolation and characterization of a novel highly efficient bacterium Lysinibacillus boronitolerans QD4 for quantum dot biosynthesis by Xingyu Gu, Xingyu Gu, Xiaoju Li, Ruijia Zhang, Ruijia Zhang, Ruoli Zheng, Ruoli Zheng, Mingrui Li, Mingrui Li, Rong Huang, Xin Pang

“…The distinctive yellow fluorescence from CdS quantum dots is visible after only a short induction time (a few hours). Moreover, the properties of the CdS quantum dots are characterized by fluorescence spectroscopy, UV-absorption spectroscopy, TEM, XRD, XPS, and infrared spectroscopy. …”
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Analysis of Argonaute Complex Bound mRNAs in DU145 Prostate Carcinoma Cells Reveals New miRNA Target Genes by Jaroslaw Szczyrba, Volker Jung, Michaela Beitzinger, Elke Nolte, Sven Wach, Martin Hart, Sandra Sapich, Marc Wiesehöfer, Helge Taubert, Gunther Wennemuth, Norbert Eichner, Thomas Stempfl, Bernd Wullich, Gunter Meister, Friedrich A. Grässer

“…Posttranscriptional gene regulation by microRNAs (miRNAs) contributes to the induction and maintenance of prostate carcinoma (PCa). …”
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Levels of Pathogenic Th17 and Th22 Cells in Patients with Rheumatoid Arthritis by Marlen Vitales-Noyola, Berenice Hernández-Castro, Diana Alvarado-Hernández, Lourdes Baranda, Sofía Bernal-Silva, Carlos Abud-Mendoza, Perla Niño-Moreno, Roberto González-Amaro

“…However, the in vitro induction/differentiation of pathogenic Th17 cells showed similar results in controls and patients with RA. …”
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From research to practice: bridging the implementation gap on the use of tranexamic acid in total knee arthroplasty by Robin M. Pfister, Benjamin F. Pfister, Ronald L. Hager, Nathan Sandholtz, Daniel Abulafia, David Bradshaw

“…Primary outcome measure was use of TXA at operative induction. Secondary outcome measures were post-operative blood transfusion, haemoglobin levels and in-hospital length of stay. …”
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