Impact of Bone Marrow Aspirate Tregs on the Response Rate of Younger Newly Diagnosed Acute Myeloid Leukemia Patients by Mario Delia, Paola Carluccio, Anna Mestice, Claudia Brunetti, Francesco Albano, Giorgina Specchia

“…We studied 23 AML young patients, all treated with standard induction chemotherapy: OR (complete remission (CR) + CR incomplete (CRi)) was documented in 10 of 23 patients (44%); there were two partial responder patients. …”
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Therapeutic potential and mechanisms of umbilical cord mesenchymal stem cells differentiating into tendon cells and promotion of rotator cuff tendon-bone healing by Youliang Shen, Yuelei Wang, Yidan Xu, Jie Wang, Chuqiang Yin, Zengshuai Han, Feng Shen, Ting Wang

“…CTGF was the optimal factor for inducing the differentiation of UCMSCs into tendon cells. With increasing induction time, UCMSCs exhibited obvious tendon cell characteristics, such as changes in cell morphology and increased expression of tendon-specific proteins (MKX, SCX, and TNC). …”
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How does community health feature in Global Financing Facility planning documents to support reproductive, maternal, newborn, child and adolescent health and nutrition (RMNAH-N)? i... by Joël Arthur Kiendrébéogo, Orokia Sory, Issa Kaboré, Yamba Kafando, Rosie Steege, Asha S. George, Meghan Bruce Kumar

“…We applied an iterative hybrid inductive-deductive approach to identify themes for data coding and extraction. …”
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Anti-HER2 biparatopic antibody KJ015 has near-native structure, functional balanced high affinity, and synergistic efficacy with anti-PD-1 treatment in vivo by Zheng Wang, Yu Liu, Yunxia Xu, Lin Lu, Zhen Zhu, Baojie Lv, Xin Fang, Yao Tang, Jinhua Wang, Yu Cheng, Ying Hu, Junwen Lou, Peican Wu, Chendan Liu, Yanjun Liu, Xin Zeng, Qing Xu

“…BpAbs bind two independent epitopes on the same antigen, which allows fine-tuning of mechanisms of action, including enhancement of on-target specificity and induction of strong antigen clustering due to the unique binding mode. …”
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Essential Roles of PKA, iNOS, CD95/CD95L, and Terminal Caspases in Suppression of Eosinopoiesis by PGE2 and Other cAMP-Elevating Agents by Bianca de Luca, Pedro Xavier-Elsas, Mônica Barradas, Ricardo A. Luz, Túlio Queto, Carla Jones, Maria Augusta Arruda, Thiago Mattar Cunha, Fernando Queiroz Cunha, Maria Ignez Gaspar-Elsas

“…This effect was (a) paralleled by induction of iNOS in eosinophils; (b) duplicated by sodium nitroprusside, isoproterenol, and cAMP-inducing/mimetic agents; (c) prevented by protein kinase A inhibition. …”
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Navigating ethics in HIV data and biomaterial management within Black, African, and Caribbean communities in Canada by Rusty Souleymanov, Bolaji Akinyele-Akanbi, Chinyere Njeze, Patricia Ukoli, Paula Migliardi, Linda Larcombe, Gayle Restall, Laurie Ringaert, Michael Payne, John Kim, Wangari Tharao, Ayn Wilcox

“…The study employed iterative inductive thematic data analysis. Findings Participants expressed significant concerns about the collection, sharing, and use of HIV data from healthcare encounters, revealing mistrust towards institutions like police, child welfare, and immigration accessing their health information. …”
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Advanced progress in the genetic modification of the oncolytic HSV-1 virus by Mi Zhou, Mi Zhou, Mi Zhou, Zhenyu Shen, Zhenyu Shen, Zhenyu Shen

“…The HSV-1 genome can be modified through genetic engineering in two main ways: first, by reducing infectivity and toxicity to normal cells via limited replication and assembly, altered protein-virus receptor binding, and minimized immune evasion; second, by enhancing anticancer activity through disruption of tumor cell metabolism, induction of autophagy, improved immune recognition, and modification of the tumor microenvironment. …”
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Light and dark biofilm adaptation impacts larval settlement in diverse coral species by Paul A. O’Brien, Sara C. Bell, Laura Rix, Abigail C. Turnlund, Shannon R. Kjeldsen, Nicole S. Webster, Andrew P. Negri, Muhammad A. Abdul Wahab, Inka Vanwonterghem

“…Biofilms were characterised using 16S rRNA gene sequencing to identify the taxa associated with settlement induction and/or inhibition. Results We show that light and biofilm age are critical factors in the development of settlement inducing biofilms, where different biofilm compositions impacted larval settlement behaviour. …”
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Tracing the Origin of Oxide Inclusions in Vacuum Arc Remelted Steel Ingots Using Trace Element Profiles and Strontium Isotope Ratios by Christoph Walkner, Gulnaz Mukhametzianova, Stefan Wagner, Jörg C. Korp, Andreas Graf, Johanna Irrgeher, Thomas C. Meisel, Thomas Prohaska

“…In this study, the potential of elemental and isotopic fingerprinting to trace the sources of macroscopic oxide NMIs found in VAR-treated steel ingots using SEM-EDX, inductively coupled plasma mass spectrometry (ICP-MS), laser ablation ICP-MS (LA-ICP-MS), and laser ablation multicollector ICP-MS (LA-MC-ICP-MS) were exploited. …”
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Eliminating Postoperative Nausea and Vomiting in Outpatient Surgery with Multimodal Strategies including Low Doses of Nonsedating, Off-Patent Antiemetics: Is “Zero Tolerance“ Achie... by Susan J. Skledar, Brian A. Williams, Manuel C. Vallejo, Patricia L. Dalby, Jonathan H. Waters, Ronald Glick, Michael L. Kentor

“…Routine oral administration (immediately on arrival to the ambulatory surgery suite) of perphenazine 8 mg (antidopaminergic) or cyclizine 50 mg (antihistamine), is followed by dexamethasone 4 mg i.v. after anesthesia induction (dexamethasone is avoided in diabetic patients). …”
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Effect of icatibant on sweating-induced dermal pain by Shunsuke Takahagi, Shunsuke Takahagi, Daiki Matsubara, Emi Murakami, Yumi Aoyama, Shinya Imamura, Atsushi Fukunaga, Atsushi Fukunaga, Yoshiko Oda, Hiroyuki Murota, Michihiro Hide, Michihiro Hide

“…Icatibant did not affect the changes in whole blood and plasma histamine, and serum angiotensin-converting enzyme levels after the induction of the dermal pain. A safety profile showed injection site pain associated with icatibant.ConclusionBlockade of bradykinin B2 receptor signaling by icatibant contributed to the reduction of dermal pain during sweating stimuli in one patient but not in two others. …”
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Adsorptive Removal of Copper by Using Surfactant Modified Laterite Soil by Tien Duc Pham, Hoang Hiep Nguyen, Ngoc Viet Nguyen, Thanh Tu Vu, Thi Ngoc Mai Pham, Thi Hai Yen Doan, Manh Ha Nguyen, Thi Mai Viet Ngo

“…Characterizations of laterite were examined by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), inductively coupled plasma mass spectrometry (ICP-MS), and total carbon analysis. …”
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Endogenous IL-33 Deficiency Exacerbates Liver Injury and Increases Hepatic Influx of Neutrophils in Acute Murine Viral Hepatitis by Virginie Carrière, Muhammad Imran Arshad, Jacques Le Seyec, Benjamin Lefevre, Muhammad Farooq, Aurélien Jan, Christelle Manuel, Laurence Touami-Bernard, Catherine Lucas-Clerc, Valentine Genet, Hugues Gascan, Jean-Philippe Girard, Frédéric Chalmel, Lucie Lamontagne, Claire Piquet-Pellorce, Michel Samson

“…In conclusion, we demonstrated that endogenous IL-33 had multifaceted immunoregulatory effect during viral hepatitis via induction of IFNγ, survival effect on immune cells, and infiltration of neutrophils in the liver.…”
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Conjugated Linoleic Acid Treatment Attenuates Cancerous features in Hepatocellular Carcinoma Cells by Zohre Miri-Lavasani, Shukoofeh Torabi, Roya Solhi, Bahareh Shokouhian, Parvaneh Afsharian, Zahra Heydari, Abbas Piryaei, Zahra Farzaneh, Nikoo Hossein-khannazer, Hamidreza Aboulkheyr Es, Ensieh Zahmatkesh, Andreas Nussler, Moustapha Hassan, Mustapha Najimi, Massoud Vosough

“…This could be as a result of HNF4a induction and EMT inhibition.…”
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Heterologous cAd3-Ebola and MVA-EbolaZ vaccines are safe and immunogenic in US and Uganda phase 1/1b trials by Myra Happe, Amelia R. Hofstetter, Jing Wang, Galina V. Yamshchikov, LaSonji A. Holman, Laura Novik, Larisa Strom, Francis Kiweewa, Salim Wakabi, Monica Millard, Colleen F. Kelley, Sarah Kabbani, Srilatha Edupuganti, Allison Beck, Florence Kaltovich, Tamar Murray, Susanna Tsukerman, Derick Carr, Carl Ashman, Daphne A. Stanley, Aurélie Ploquin, Robert T. Bailer, Richard Schwartz, Fatim Cham, Allan Tindikahwa, Zonghui Hu, Ingelise J. Gordon, Nadine Rouphael, Katherine V. Houser, Emily E. Coates, Barney S. Graham, Richard A. Koup, John R. Mascola, Nancy J. Sullivan, Merlin L. Robb, Julie A. Ake, Kirsten E. Lyke, Mark J. Mulligan, Julie E. Ledgerwood, Hannah Kibuuka, the VRC 208 and RV 422 study team

“…The heterologous prime-boost regimen was immunogenic, including induction of durable antibody responses which peaked as early as two weeks and persisted up to one year after each vaccination. …”
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Scaling up of parenting support to prevent violence against children in Tanzania: insights from policymakers and service providers by Sabine van Tuyll van Serooskereken Rakotomalala, Kija Nyalali, Joyce Wamoyi, Onduru Gervas Onduru, Gerry Mshana, F. Marijn Stok, Mara A. Yerkes, John B. F. De Wit

“…The interview data were analysed using inductive and deductive coding and analysis. Results The most prominent enabling factors noted for the scale-up of parenting support interventions in Tanzania include the existing supportive political commitment, the interventions currently on offer at the programmatic level, and the perceived understanding of Tanzanian caregivers of the importance of parenting and, thereby, a willingness to change. …”
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Anti-IL-22 Antibody Attenuates Acute Graft-versus-Host Disease via Increasing Foxp3+ T Cell through Modulation of CD11b+ Cell Function by Jianbo Wu, Jian Gu, Shun Zhou, Hao Lu, Yunjie Lu, Ling Lu, Xuehao Wang

“…In the presence of Tregs and donor CD11b+ cells, IL-22Ab protected against aGVHD. In vitro Treg induction was more efficient when CD4+CD25− T cells differentiated in the presence of CD11b+ cells obtained from IL-22Ab-treated GVHD mice, compared with cocultured untreated control cells. …”
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Lipid nephrotoxicity mediated by HIF-1α activation accelerates tubular injury in diabetic nephropathy by Zebo Hu, Qianwen Zhu, Ying Wang, Xue Deng, Hui Yang, Mingjun Zhou, Jiyuan Zhang, Hao Wang, Haosen Wang, Lin Wang, Cui Zhang, Shu Li

“…Our findings demonstrate that the activation of HIF-1α contributed to interstitial injury in a rat model of diabetic nephropathy and that the underlying mechanism involved the induction of lipid accumulation.…”
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Palmitic Acid Induces Production of Proinflammatory Cytokines Interleukin-6, Interleukin-1β, and Tumor Necrosis Factor-α via a NF-κB-Dependent Mechanism in HaCaT Keratinocytes by Bing-rong Zhou, Jia-an Zhang, Qian Zhang, Felicia Permatasari, Yang Xu, Di Wu, Zhi-qiang Yin, Dan Luo

“…To investigate whether palmitic acid can be responsible for the induction of inflammatory processes, HaCaT keratinocytes were treated with palmitic acid at pathophysiologically relevant concentrations. …”
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Hypoxia-induced CTCF mediates alternative splicing via coupling chromatin looping and RNA Pol II pause to promote EMT in breast cancer by Parik Kakani, Shruti Ganesh Dhamdhere, Deepak Pant, Rushikesh Joshi, Sachin Mishra, Anchala Pandey, Dimple Notani, Sanjeev Shukla

“…Hypoxia drives CCCTC-binding factor (CTCF) induction through hypoxia-inducible factor 1-alpha (HIF1α), which promotes EMT, although the underlying mechanisms remain unclear. …”
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