Hypericum Perforatum-Derived Exosomes-Like Nanovesicles: A Novel Natural Photosensitizer for Effective Tumor Photodynamic Therapy by Ma X, Chen N, Zeng P, He Y, Zhang T, Lu Y, Li Z, Xu J, You J, Zheng Y, Wang L, Luo M, Wu J

“…In vitro, HPDENs showed light dose-dependent cytotoxicity against human melanoma cells, characterized by elevated ROS production and apoptosis induction. In vivo, HPDEN-mediated PDT significantly suppressed tumor growth and induced extensive tumor necrosis, with no observable toxicity to major organs.Conclusion: HPDENs represent a novel plant-derived photosensitizer with dual ROS generation pathways and significant therapeutic efficacy, providing a promising platform for enhancing photodynamic therapy.Keywords: Hypericum perforatum-derived exosomes-like nanovesicles, photosensitizer, photodynamic therapy, reactive oxygen species, apoptosis…”
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The Synergistic Effect of TRPV1 on Oxidative Stress-Induced Autophagy and Apoptosis in Microglia by Tingting Huang, Yao Lin, Qiongyi Pang, Weimin Shen, Xiang Chen, Fengxia Tu

“…A high amount of reactive oxygen species (ROS) is involved in oxidative stress induction. Transient receptor potential vanilloid 1 (TRPV1) has been shown to regulate oxidative stress and apoptosis in microglia; however, the detailed mechanisms remain unclear. …”
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Conditional knockdown of hepatic PCSK9 ameliorates high-fat diet-induced liver inflammation in mice by Xue-Ying Zhang, Qing-Qing Lu, Yan-Jie Li, Shan-Rui Shi, Chao-Nan Ma, Miao Miao, Shou-Dong Guo

“…These findings confirmed that conditional knockdown of hepatic PCSK9 attenuates liver inflammation following hyperlipidemia induction by modulating multiple signaling pathways; this suggests that targeting PCSK9 knockdown/inhibition with appropriate agents is useful not only for treating hyperlipidemia but also for ameliorating hyperlipidemia-induced liver inflammation.…”
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Terminalia catappa Extract Palliates Redox Imbalance and Inflammation in Diabetic Rats by Upregulating Nrf-2 Gene by Franklyn Nonso Iheagwam, Gaber El-Saber Batiha, Olubanke Olujoke Ogunlana, Shalom Nwodo Chinedu

“…Molecular docking and prediction of major TCA phytoconstituents’ biological activity related to T2DM-induced oxidative stress were evaluated in silico. Induction of diabetes significantly (p<0.05) reduced superoxide dismutase, glutathione-S-transferase, and peroxidase activities. …”
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Acceptability of donor funding for clinical trials in the UK: a qualitative empirical ethics study using focus groups to elicit the views of research patient public involvement gro... by Simon Bowman, Heather Draper, Alexander Masters, Dominic Nutt, Kirstie Shearman

“…Data were analysed using inductive thematic approach informed by the study aims and ethical analysis.Participants 22 participants were recruited: 8 research patient public involvement group members, 7 REC chairs and 7 clinical researchers. …”
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An Open‐Label Phase II Trial of Pembrolizumab, an Immune Checkpoint Inhibitor Alone or in Combination With Oral Azacitidine as Second‐Line Therapy for Advanced Head and Neck Squamo... by Vinod K. Ramani, Srimonta Gayen, Radheshyam Naik

“…To evaluate the clinical effectiveness endpoints and toxicity of oral azacytidine when combined with pembrolizumab. ii. To assess the induction of a T‐cell response among the study subjects. iii. …”
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The impact of the Lesotho health reform in the re-structuring of the village health workers program by Afom T. Andom, Hannah N. Gilbert, Courtney M. Yuen, Mapoho Mokoroane, Melino Ndayizigiye, Mpopo Tsoele, Masebeo Koto, Retsepile Tlali, Makena Ratsiu, Joia S. Mukherjee

“…Methods In 2018, we conducted a qualitative research study with an inductive content analysis approach in the four pilot health reform districts of Lesotho. …”
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APPLICATION OF MODIFYING ALLOYING ALLOY CONTAINING NANOSIZED POWDERS OF ACTIVE ELEMENTS IN PRODUCTION OF HIGH-STRENGTH CAST IRON WITH GLOBULAR GRAPHITE by A. S. Kalinichenko, A. G. Slutsky, V. A. Sheinert

“…Melting of iron in laboratory conditions was performed in crucible induction furnace IST-006 with an acid lining held. …”
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Development of Vegetative Propagation Strategies for Balanites aegyptiaca in the Sahel, Niger by Moussa Massaoudou, Rabiou Habou, Zounon Christian Serge Félix, Abasse Tougiani, Patrick Van Damme

“…We then tested seed germination success, and suckering induction, air-layering, and stem cuttings were carried out to determine the techniques best suited for the propagation of B. aegyptiaca. …”
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Barriers and facilitators to implementation of non-medical independent prescribing in primary care in the UK: a qualitative systematic review by Nicola Carey, Judith Edwards, Melaine Coward

“…Study data were extracted to a bespoke table and two reviewers used NVivo software to code study findings. An inductive thematic synthesis was undertaken to identify descriptive themes and interpret these into higher order analytical themes. …”
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Filterable PM2.5, Metallic Elements, and Organic Carbon Emissions from the Exhausts of Diesel Vehicles by Yuan-Chung Lin, Ya-Ching Li, Kassian T. T. Amesho, Feng-Chih Chou, Pei-Cheng Cheng

“…To assess the risks from this pollutant, we characterized and quantified the PM2.5 exhausted by 15 diesel vehicles ranging from 28,306 to 883,374 km (an average of 525,854 km) in total mileage and varying in manufacturer and model year (1988–2005). We applied inductively coupled plasma optical emission spectroscopy (ICP-OES) to analyze the metallic element constituents, among which Ca composed the largest fraction, followed by Zn, Al, K, Fe, Mg, and Cr. …”
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Endometrial Regenerative Cell-Derived Conditioned Medium Alleviates Experimental Colitis by Chenglu Sun, Jingpeng Hao, Hong Qin, Yanglin Zhu, Xiang Li, Baoren Zhang, Yafei Qin, Guangming Li, Hongda Wang, Hao Wang

“…Acute colitis was induced by 3% dextran sodium sulfate (DSS), and ERC-CM was injected on days 4, 6, and 8, respectively, after induction. The disease activity index was calculated through the record of weight change, bleeding, and fecal viscosity during the treatment process. …”
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Comparison of inhaled versus intravenous anesthesia for laryngoscopy and laryngeal electromyography in a rat model by M. Gazzaz, J. Saini, S. Pagliardini, B. Tsui, C. Jeffery, H. El-Hakim

“…Three mortalities were encountered, one of which was due to lidocaine toxicity and two were during anesthetic induction. Respiratory related morbidity was encountered in two rats, all seen with TIVA. …”
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Characteristics of self-management among patients with complex health needs: a thematic analysis review by Catherine Hudon, Maud-Christine Chouinard, Annie-Pier Gobeil-Lavoie, Alya Danish

“…A mixed thematic analysis, deductive and inductive, was performed by three evaluators as described by Mileset al.Results Twenty-one articles were included. …”
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Loss of BRCA1 Spontaneously Induces the Tumorigenesis in Lacrimal Gland by Sun Eui Kim, Hye Jung Baek, Eun Jung Park, Sung Chul Lim, Sang Soo Kim

“…In general, mutations of BRCA1 are closely associated with induction of breast and ovarian cancers but are also known to contribute to the incidence of other cancers at a low frequency. …”
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Designing and validating an adaptation tool for endometriosis: an exploratory mixed method study protocol by Sanaz Mollazadeh, Nahid Marvi, Talat Khadivzadeh

“…Tool design will involve an inductive approach (informed by qualitative findings) and a comparative method (based on literature review) to develop and refine tool items. …”
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DETERMINATION OF HEAVY METALS AND ENVIRONMENTAL HEALTH STATUS OF AGRO SOILS IN IKOT ABASI, NIGER DELTA, NIGERIA by Usoro M. Etesin, Iniobong J. Ogbonna

“…The soil samples were air-dried and subjected to heavy metal determination (iron, Fe; cadmium, Cd; lead, Pb; zinc, Zn; copper, Cu; vanadium, V; nickel , Ni; chromium, Cr ; mercury, Hg ) by inductively coupled plasma– optical emission spectrometer (AGILENT 720 ICP-OES). …”
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Mycobacterium bovis BCG Surface Antigens Expressed under the Granuloma-Like Conditions as Potential Inducers of the Protective Immunity by Yingyu Chen, Lia Danelishvili, Sasha J. Rose, Luiz E. Bermudez

“…We also examined the immunogenicity of purified recombinant proteins and tested M. smegmatis overexpressing these surface antigens for the induction of protective immunity in mice. Significantly high levels of specific IgA and IgG antibodies were observed in recombinant protein immunized groups by both inhalation and intraperitoneal (IP) routes, but only IP delivery induced high total IgA and IgG levels. …”
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“If somebody wants an abortion, nobody should override their decision”: Modern Canadian perspectives on abortion in relation to artificial womb technology by Srishti Hukku, Lisa L. Wynn, Angel M. Foster

“…We analyzed the survey data using descriptive statistics and the interviews for content and themes using inductive and deductive techniques. Our study found that when assessing the potentiality of AWT, participants centered reproductive choice, bodily autonomy, and family planning in decision-making. …”
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The Sequence of Prostaglandin-Endoperoxide Synthase 2 Gene in Women with Cervicitis by Maha A. Ahlial, Nazar Sh. Mohammed, Maysara S. Khalaf

“…Prostaglandin endo peroxide synthase2 (Cyclooxygenase-2) is a key enzyme in prostaglandin synthesis, which is coded by the PTGS2 gene, and recognized as the master switch that activates the inflammatory response; its induction leads to the biosynthesis of prostaglandins. …”
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