Silica Induces Changes in Cytosolic Free Calcium, Cytosolic pH, and Plasma Membrane Potential in Bovine Alveolar Macrophages by Attila Tárnok, Thomas Schlüter, Ingeborg Berg, Günther Gercken

“…The mineral‐dust induced activation of pulmonary phagocytes is thought to be involved in the induction of severe lung diseases. The activation of bovine alveolar macrophages (BAM) by silica was investigated by flow cytometry. …”
Get full text

Mechanism of Cytosolic Phospholipase A2 Activation in Ghrelin Protection of Salivary Gland Acinar Cells against Ethanol Cytotoxicity by Bronislaw L. Slomiany, Amalia Slomiany

“…Thus, ghrelin protection of salivary gland cells against ethanol involves cNOS-derived NO induction of cPLA2 activation through S-nitrosylation for the increase in AA release at the site of COX-1 action for PGE2 synthesis.…”
Get full text

Mechanisms Underlying Aggressive Behavior Induced by Antiepileptic Drugs: Focus on Topiramate, Levetiracetam, and Perampanel by Cerine C. Hansen, Hanna Ljung, Eylert Brodtkorb, Arne Reimers

“…Information to patients, relatives, and caregivers, as well as sufficient clinical follow-up, is crucial, and there is a need for further research to understand the complex relationship between AED mechanisms of action and the induction/worsening of AB.…”
Get full text

Chidamide Suppresses the Growth of Cholangiocarcinoma by Inhibiting HDAC3 and Promoting FOXO1 Acetylation by Yongpan Li, Jujia Zheng, Qiang Huo, Zhongchao Chen, Jun Chen, Xiangwei Xu

“…Additionally, CDM inhibited tumor growth in vivo via HDAC3 downregulation and FOXO1 acetylation induction. Overall, this study reveals that CDM can exhibit antitumor effects against CCA by promoting HDAC3-mediated FOXO1 acetylation, thus identifying a new therapeutic avenue for the treatment of CCA.…”
Get full text

SOCIAL ENTREPRENEURSHIP AS AN INCLUSIVE CLUSTER CONCEPT OF SUSTAINABLE DEVELOPMENT OF THE COUNTRY by Andriy Braunagel

“…The relationship between the components of the cluster system of social entrepreneurship and process management tools to achieve the effectiveness of ideas regarding social impact, effects, values, and benefits is highlighted. The map of the inductive analysis of the narrative interview according to F. …”
Get full text

Correlations between Endothelial Functions and ROS Detection in Diabetic Microvascular Wall: Early and Late Ascorbic Acid Supplementation by Pattarin Sridulyakul, Natchaya Wongeak-in, Suthiluk Patumraj

“…The correlation between endothelial function and reactive oxygen species detecting from diabetic microvascular wall and the antioxidant effect of ascorbic acid (AA) during early and late phases of diabetic induction were determined. Male Spraque-Dawley rats were divided into four groups: control, diabetes rats (DM, using iv.injection of 55 mg/kg BW streptozotocin, (STZ)), and two groups of DM rats treated with AA (1 g/L, (STZ)) starting on day 2 (DM + AAday2) and week 6th (DM + AA6wk). …”
Get full text

Effects of salbutamol on serum potassium level and electrocardiography in experimental hyperkalemia in rabbits by Ramazan Bal, Ramazan Durgut, Sefa Çelik

“…In this study 12 New Zealand Rabbits were used, which were divided into 2 groups, positive control and salbutamol. For induction of hyperkalemia, 300 mM KCI solution (in isotonic NaCI) was infused at 0.5 ml/kg/min for 15 minutes via v.auricularis. …”
Get full text

Network meta-analysis of efficacy and safety of drugs for the treatment of moderate to severe ulcerative colitis by Wenkai Zhang, Wenkai Zhang, Songbo Zhao, Songbo Zhao, Jipin Li, Jipin Li, Yihua Sun, Yihua Sun, Xiang Wang, Xiang Wang

“…Moreover, the Stata17.0 software was employed for statistical analysis and results were reported as relative risk (RR) and 95% confidence interval (CI).ResultsFor the efficacy of induction, upadacitinib ranked first in clinical response, clinical remission, and endoscopic improvement rates, with cumulative probabilities of 96.0%, 99.3%, and 99.0%, respectively. …”
Get full text

Effect of physiochemical parameters on yield and biological efficiency of Volvariella volvacea cultivated on empty fruit bunch pellets by Nur Fariha Amir, Aslizah Mohd-Aris, Tuan Norhafizah Tuan-Zakaria, Noor Azrimi Umor, Azhar Mohamad, Nornadiah Mohd Razali, Farida Zuraina Mohd Yusof, Sumaiyah Abdullah

“…However, the formulation media showed a significant contribution that could help in the induction of fruiting bodies. According to the results, the culture medium with a mixture of EFB substrate and black soil showed the highest BE percentage of 17.75 % (at optimised substrate weights = 2 kg). …”
Get full text

Genetically Modified Lactococcus lactis for Delivery of Human Interleukin-10 to Dendritic Cells by Inge L. Huibregtse, Sebatian A. Zaat, Martien L. Kapsenberg, Maria A. Sartori da Silva, Maikel P. Peppelenbosch, Sander J. H. van Deventer, Henri Braat

“…lactisIL-10-derived suppressor Th-cells with allogenic Th-cells in a transwell system prevented the induction of suppressor Th-cells. Only 130 pg/mL of bacterial-derived IL-10 and 40 times more exogenously added recombinant human IL-10 were needed during DC priming for the generation of suppressor Th-cells. …”
Get full text

Biochemical and antioxidant responses of common carp (Cyprinus carpio) exposed to sublethal concentrations of the antiepileptic and analgesic drug gabapentin by J Blahova, P Mikula, P Marsalek, Z Svobodova

“…Our research shows that subchronic exposure to gabapentin may pose a significant risk to non-target aquatic organisms, such as disruption of metabolic pathways or induction of oxidative stress, even at environmentally relevant concentrations.…”
Get full text

Perspectives from parents and clinicians on an ecology-focused approach to a group well-child care by Ishaan T. Shah, Nina D. Ham, Hassan Lubega, Christopher L. Boswell, Esther Kim Liu, Renée D. Boynton-Jarrett

“…One-on-one interviews were conducted via videoconference, transcribed, and analyzed using an inductive approach. Parent and clinician thematic analyses were independently conducted to construct shared domains. …”
Get full text

The Role of AChE in Swimming Behavior of Daphnia magna: Correlation Analysis of Both Parameters Affected by Deltamethrin and Methomyl Exposure by Qing Ren, Ruibin Zhao, Cheng Wang, Shangge Li, Tingting Zhang, Zongming Ren, Meiyi Yang, Hongwei Pan, Shiguo Xu, Jianping Zhu, Xun Wang

“…Even though the de novo synthesis of AChE in D. magna might help it recover, the AChE inhibition in different treatments could be observed. Some induction effects on AChE activity at the beginning of exposure occurred, and a 50% decrease may cause toxic effects on behavior. …”
Get full text

Effect of Coenzyme-Q10 on Doxorubicin-Induced Nephrotoxicity in Rats by Azza A. K. El-Sheikh, Mohamed A. Morsy, Marwa M. Mahmoud, Rehab A. Rifaai, Aly M. Abdelrahman

“…Interestingly, the high dose of CoQ10 alone significantly decreased renal GSH level as well as catalase activity and caused a mild induction of caspase 3 expression compared to control, probably due to a prooxidant effect at this dose of CoQ10. …”
Get full text

Toll-Like Receptor 4 in Bone Marrow-Derived Cells Contributes to the Progression of Diabetic Retinopathy by Hui Wang, Haojun Shi, Jing Zhang, Guoliang Wang, Jinxiang Zhang, Fagang Jiang, Qing Xiao

“…To further elucidate the mechanism of DR, we used bone marrow transplantation to establish reciprocal chimeric animals of TLR4 mutant mice and TLR4 WT mice combined with diabetes mellitus (DM) induction by streptozotocin (STZ) treatment to identify the role of TLR4 in different cell types in the development of the proinflammatory state during DR. …”
Get full text

Huoxiang Zhengqi dropping pills alleviate exertional heat stroke–induced multiple organ injury through sustaining intestinal homeostasis via regulating MAPK/NF-κB pathway and gut m... by Lei Li, Lei Li, Lei Li, Jun Ma, Jun Ma, Zeshi Li, Zeshi Li, Juelin Chen, Jiawei Zhou, Yawei Wang, Yankun Pei, Yitong Gong, Jianyao You, Yangyang Cao, Man Wang, Jikuai Chen, Wenjun Chang, Weiyi Ma, Hanyu Zhu, Chuhan Xiang, Shuogui Xu, Qing Song, Qing Song

“…HXZQD was administered via oral gavage at low, medium, and high doses, followed by EHS induction through exercise under high-temperature and high-humidity conditions. …”
Get full text

Characterization of Ti6Al4V powders produced by different methods for selective electron beam melting by Liu Z., Huang C., Gao C., Liu R., Chen J., Xiao Z.

“…Three different types of Ti6Al4V powders produced by electrode induction melting gas atomization (EIGA), plasma rotating electrode process (PREP), and plasma atomization (PA) were compared from these aspects: particle size distribution, particle shape, and microstructure. …”
Get full text

Expression of Otx Genes in Müller Cells Using an In Vitro Experimental Model of Retinal Hypoxia by Claudio Azzolini, Simone Donati, Giovanni Micheloni, Vittoria Moretti, Roberto Valli, Francesco Acquati, Lucy Costantino, Fulvio Ferrara, Davide Borroni, Elias Premi, Francesco Testa, Francesca Simonelli, Giovanni Porta

“…The HIF-1α protein and VEGF-A gene expression were quantified to verify the induction of a hypoxia-like state. Results. Among the genes under study, we did not observe any difference in the expression levels of Otx1 and Otx2 during treatment; conversely, Otx1 was overexpressed during recovery steps. …”
Get full text

Primary Stability of Self-Drilling and Self-Tapping Mini-Implant in Tibia of Diabetes-Induced Rabbits by Jea-Beom Park, Eun-Young Kim, Janghyun Paek, Yoon-Ah Kook, Do-Min Jeong, Il-Sik Cho, Gerald Nelson

“…After 4 weeks of diabetic induction, 48 mini-implants (24 self-tapping and 24 self-drilling implants) were placed on the tibia of 6 diabetic and 6 normal rabbits. …”
Get full text

Impairment of Hepatic and Renal Functions by 2,5-Hexanedione Is Accompanied by Oxidative Stress in Rats by Isaac A. Adedara, Amos O. Abolaji, Blessing E. Odion, Isioma J. Okwudi, Abiola A. Omoloja, Ebenezer O. Farombi

“…These findings suggest that undue exposure to 2,5-HD at environmentally relevant levels may impair liver and kidney functions through induction of oxidative stress.…”
Get full text