Downregulation of PGC-1α Prevents the Beneficial Effect of EET-Heme Oxygenase-1 on Mitochondrial Integrity and Associated Metabolic Function in Obese Mice by Shailendra P. Singh, Lars Bellner, Luca Vanella, Jian Cao, John R. Falck, Attallah Kappas, Nader G. Abraham

“…We postulate that EETs attenuate adiposity by stimulating mitochondrial function and induction of HO-1 via activation of PGC-1α in adipose and hepatic tissue. …”
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Systems science and systems thinking for public health: a systematic review of the field by Gemma Carey, Brad Crammond, Eleanor Malbon, Nicole Carey, Andrew Joyce, Alan Carey

“…The objectives were to: (1) explore how systems methodologies are being applied within public health and (2) identify fruitful areas of activity.Design A systematic review was conducted from existing literature that draws on or uses systems science (in its various forms) and relates to key public health areas of action and concern, including tobacco, alcohol, obesity and the social determinants of health.Data analysis 117 articles were included in the review. An inductive qualitative content analysis was used for data extraction. …”
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Intervention to systematize fall risk assessment and prevention in older hospitalized adults: a mixed methods study by Johann Stuby, Pascal Leist, Noël Hauri, Sanjana Jeevanji, Marie Méan, Carole E. Aubert

“…Quantitative data were analyzed descriptively and qualitative data with a mixed deductive and inductive approach. Results were integrated through meta-inferences. …”
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Successful Antiviral Treatment with Direct-Acting Antivirals for Hepatitis C Virus Infection during Peritransplant Period in a Kidney Transplant Recipient by Giovanni Varotti, Ferdinando Dodi, Ernesto Paoletti, Andrea Bruno, Iris Fontana

“…Immunosuppression included thymoglobulin and prednisone for induction and tacrolimus and mycophenolate for maintenance. …”
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Resveratrol, Acetyl-Resveratrol, and Polydatin Exhibit Antigrowth Activity against 3D Cell Aggregates of the SKOV-3 and OVCAR-8 Ovarian Cancer Cell Lines by Simon J. Hogg, Kenny Chitcholtan, Wafaa Hassan, Peter H. Sykes, Ashley Garrill

“…The growth reduction was mediated by the induction of apoptosis via the cleavage of poly(ADP-ribose) polymerase (PARP-1). …”
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MicroRNA-29b Suppresses Inflammation and Protects Blood-Brain Barrier Integrity in Ischemic Stroke by Xiaoqing Ma, Ho Jun Yun, Kenneth Elkin, Yunliang Guo, Yuchuan Ding, Guangwen Li

“…This study investigates the underlying mechanism and implications of miR-29b in leukocyte induction. Methods. miR-29b from stroke patients and rats with middle cerebral artery occlusion (MCAO) were assessed using real-time polymerase chain reaction (PCR). miR-29b agomir was used to increase miR-29b expression in leukocytes via intravenous injection. …”
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A scoping review of information provided within degenerative cervical myelopathy education resources: Towards enhancing shared decision making. by Rishi Umeria, Oliver Mowforth, Ben Grodzinski, Zahabiya Karimi, Iwan Sadler, Helen Wood, Irina Sangeorzan, Petrea Fagan, Rory Murphy, Angus McNair, Benjamin Davies

“…Resources were then further arranged into a hierarchical framework of domains and subdomains, formed through inductive analysis. Frequency statistics were employed to capture relative popularity as a surrogate marker of potential significance.…”
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Community interventions for pandemic preparedness: A scoping review of pandemic preparedness lessons from HIV, COVID-19, and other public health emergencies of international concer... by Sali Hafez, Sharif A Ismail, Zandile Zibwowa, Nadin Alhamshary, Reem Elsayed, Mandeep Dhaliwal, Fiona Samuels, Ade Fakoya

“…Following screening and extraction, key themes were identified using a combined inductive/deductive approach. 130 papers met the criteria for inclusion. …”
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Integrated analysis of cellulose structure and properties using solid-state low-field H-NMR and photoacoustic spectroscopy by Levente Csóka, Worakan Csoka, Ella Tirronen, Ekaterina Nikolskaya, Yrjö Hiltunen, Bunsho Ohtani

“…Solid-state low-field H-NMR spectroscopy aids in characterizing the crystallinity degrees and amorphous regions within cellulose, revealing time-dependent changes in free induction decay (FID) signals. Complementing this, we investigate the photo-absorption properties of cellulose fibers under both continuous and modulated irradiation using reversed double-beam photoacoustic spectroscopy (RDB-PAS). …”
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Assessment of Angiography-Based Renal Quantitative Flow Ratio Measurement in Patients with Atherosclerotic Renal Artery Stenosis by Xiang Huang, Xiao-Lan Li, Heng Zhou, Xiao-Mei Li

“…Quantitative flow ratio (QFR) is an angiography-based fractional flow reserve measurement without pressure wire or induction of hyperemia. A recent innovation that uses combined geometrical data and hemodynamic boundary conditions to measure QFR from a single angiographic view has shown the potential to measure QFR of the renal artery-renal QFR (rQFR). …”
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Comparative Chemical Profiling and Biological Potential of Essential Oils of Petal, Choke, and Heart Parts of Cynara scolymus L. Head by Sana Razhan M. Alsubaiei, Hanan A. Alfawaz, Musarat Amina, Nawal M. Al Musayeib, Afaf El-Ansary, Syed Rizwan Ahamad, Omar M. Noman, Jaber A. Maini

“…The essential oil and macroelemental composition of different parts of flower bud (petal, choke, and heart) of Cynara scolymus L. were explored and compared using gas chromatography mass spectrometry (GC-MS) and inductively coupled plasma mass spectrometry (ICP-MS). …”
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Transcriptional Activity of PGC-1α and NT-PGC-1α Is Differentially Regulated by Twist-1 in Brown Fat Metabolism by Hee-Jin Jun, Thomas W. Gettys, Ji Suk Chang

“…In contrast, NT-PGC-1α-mediated induction of these genes is unaffected by Twist-1. …”
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Exploring the macro-level, meso-level and micro-level barriers and facilitators to the provision of good quality early inflammatory arthritis (EIA) care in England and Wales by Sam Norton, Cath Taylor, James Galloway, Magdalena Zasada, Mark Yates, Nicola Ayers, Zoë Ide

“…Data from semi-structured interviews with staff (1–5 from each unit, 56 in total) and an online questionnaire (n=14/16 units) were integrated and analysed using the framework method for thematic analysis using a combined inductive and deductive approach (underpinned by an evidence-based framework of healthcare team effectiveness), and constant comparison of data within and between units and its relationship with the quality criteria.Findings Quality of care was influenced by an interplay between macro, meso and micro domains. …”
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Patient autonomy and metabolic bariatric surgery: an empirical perspective by Shelly Kamin-Friedman, Nili Karako-Eyal, Galya Hildesheimer

“…The conclusions were drawn from an inductive analysis of the interview data conducted using a grounded theory approach, and by applying theories of autonomy to the empirical findings. …”
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Measurement tools and indicators for assessing nurturing care for early childhood development: A scoping review. by Joshua Jeong, Lilia Bliznashka, Eileen Sullivan, Elizabeth Hentschel, Youngkwang Jeon, Kathleen L Strong, Bernadette Daelmans

“…We first classified outcomes to their respective nurturing care component, and then applied an inductive approach to organize key constructs within each nurturing care component and the specific measures and indicators used across studies. …”
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Best Evidence Summary for the Improvement and Management of Disorders of Consciousness in Patients With Severe Brain Injury by Miaoyuan Lin, Qiongna Lu, Sheng Yu, Wenjuan Lin

“…The 26 best pieces of evidence were recommended by inducting and integrating the evidence from these articles, covering the following seven aspects: consciousness assessment, multidisciplinary team, intervention in facilitating arousal, sensory stimulation programs, drug administration, rehabilitation program, and prevention of complications. …”
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Building Responsive Intersectoral Initiatives for Newcomers in Toronto: Learning from Service Providers’ Experiences in the Context of COVID-19 by Carly Jackson, Shinjini Mondal, Erica Di Ruggiero, Lara Gautier

“…The data were analyzed thematically with an inductive approach. Findings: The analysis covers four key themes: (1) vulnerable newcomers’ circumstances regarding accessing the social determinants of health during COVID-19; (2) the process of designing specific interventions to target these populations’ needs and service access challenges in the context of COVID-19; (3) the implementation phase of the initiatives, including any associated challenges and lessons learned; and finally, (4) long-term potential sustainability of the initiatives. …”
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Curcumin Relieves Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior through the PGC-1α/FNDC5/BDNF Pathway by Yanqin Wu, Fusheng Sun, Yujin Guo, Yumao Zhang, Li Li, Ruili Dang, Pei Jiang

“…The PGC-1α inhibitor SR18292 was used to explore the role of PGC-1α in the induction of BDNF by CUR. Results. Daily gavage of 100 mg/kg CUR successfully attenuated the abnormal behaviors induced by CUMS and effectively prevented CUMS-induced reduction of PGC-1α, ERRα, FNDC5, and BDNF expressions. …”
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α-Lipoic Acid Inhibits Helicobacter pylori-Induced Oncogene Expression and Hyperproliferation by Suppressing the Activation of NADPH Oxidase in Gastric Epithelial Cells by Eunyoung Byun, Joo Weon Lim, Jung Mogg Kim, Hyeyoung Kim

“…As a result, α-LA inhibited the activation of NADPH oxidase and, thus, reduced ROS production, resulting in inhibition on activation of NF-κB and AP-1, induction of oncogenes, nuclear translocation of β-catenin, and hyperproliferation in H. pylori-infected AGS cells. …”
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Promoting critical reading instruction in higher education: a three-step training scheme facilitated by using corpus technology by Yang Jing, Mei Fang

“…This study examines the development of students’ cognitive skills through hands-on concordancing, also known as the inductive Data-driven learning (DDL) method (Cobb, T. 1997. …”
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