Acquired vulnerability against EGF receptor inhibition in gastric cancer promoted by class I histone deacetylase inhibitor entinostat by Tamara Zenz, Robert Jenke, Denys Oliinyk, Sandra Noske, René Thieme, Tim Kahl, Ines Gockel, Florian Meier-Rosar, Achim Aigner, Thomas RH Büch

“…Results: Proteomics analyses in gastric cancer cells treated with entinostat revealed a marked upregulation of EGFR in the majority of cell lines and an even more robust induction of the EGFR ligand AREG. This was confirmed in a panel of different cell lines in vitro, in tumor tissue-slice cultures ex vivo and in cell line- or patient-derived tumor xenografts in mice. …”
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Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles in ischemic stroke: A meta-analysis of preclinical studies by Xiaoming Zhang, Yibing Guo, Kun Fang, Xiangqian Huang, Duo Lan, Mengqi Wang, Lina Jia, Xunming Ji, Ran Meng, Da Zhou

“…Treatment within 24 hours and beyond 24 hours of stroke induction both demonstrated substantial reductions in infarct volume/ratio compared to controls. …”
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P53 and Expression of Immunological Markers May Identify Early Stage Thyroid Tumors by Marjory Alana Marcello, Elaine Cristina Morari, Lucas Leite Cunha, Aline Carolina De Nadai Silva, Dirce Maria Carraro, André Lopes Carvalho, Fernando Augusto Soares, José Vassallo, Laura Sterian Ward

“…Besides its major role in cell proliferation, DNA repair, and apoptosis, functional p53 protein is involved in the induction of antitumor cytotoxic-T-cell activity against carcinoma cells. …”
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Lipid-Rich Extract from Mexican Avocado Seed (Persea americana var. drymifolia) Reduces Staphylococcus aureus Internalization and Regulates Innate Immune Response in Bovine Mammary... by Marisol Báez-Magaña, Alejandra Ochoa-Zarzosa, Nayeli Alva-Murillo, Rafael Salgado-Garciglia, Joel Edmundo López-Meza

“…This effect correlated with NO production and the induction of the gene expression of IL-10, while the expression of the proinflammatory cytokine TNF-α was reduced. …”
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Safety and Efficacy of Epithelium-On Corneal Collagen Cross-Linking Using a Multifactorial Approach to Achieve Proper Stromal Riboflavin Saturation by Aleksandar Stojanovic, Xiangjun Chen, Nan Jin, Ting Zhang, Filip Stojanovic, Sten Raeder, Tor Paaske Utheim

“…Chemical epithelial penetration enhancement (benzalkonium chloride-containing local medication and hypotonic riboflavin solution), mechanical disruption of the superficial epithelium, and prolongation of the riboflavin-induction time until verification of stromal saturation were used before the UVA irradiation. …”
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Chloroplast Vesiculation and Induced Chloroplast Vesiculation and Senescence‐Associated Gene 12 Expression During Tomato Flower Pedicel Abscission by Magda Tušek Žnidarič, Maja Zagorščak, Živa Ramšak, Katja Stare, Marko Chersicola, Maruša Pompe Novak, Aleš Kladnik, Marina Dermastia

“…Significant changes in chloroplast structure and vesicle formation were observed 8 and 14 h after abscission induction, coinciding with the differential expression of vesiculation‐related genes, particularly with upregulation of Senescence‐Associated Gene 12 (SAG12) and Chloroplast Vesiculation (CV). …”
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Understanding the formation of a low-pressure pedestal in the presence of a strong internal transport barrier in DIII-D high βp plasmas by X.R. Zhang, X. Jian, Y.R. Zhu, Y.P. Zou, Z.Y. Li, Y.J. Zhou, L.Z. Liu, S. Zheng, Z.X. Wang, W. Chen, S.Y. Ding, A.M. Garofalo, V.S. Chan, G.Q. Li

“…As a promising scenario for fusion reactors, the high poloidal-beta ( ${\beta _{\text{P}}}$ ) scenario is characterized by a strong large radius internal transport barrier (ITB), which significantly enhances the overall confinement quality and the bootstrap current fraction for fully non-inductive operation. It is frequently observed that in the presence of a strong ITB, the pedestal height is lower and is accompanied by small edge localized modes (ELMs), which further improves the compatibility of a high performance core with an edge solution. …”
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Decellularized Liver Matrices for Expanding the Donor Pool—An Evaluation of Existing Protocols and Future Trends by Marcin Morawski, Maciej Krasnodębski, Jakub Rochoń, Hubert Kubiszewski, Michał Marzęcki, Dominik Topyła, Kacper Murat, Mikołaj Staszewski, Jacek Szczytko, Marek Maleszewski, Michał Grąt

“…The introduction of apoptosis induction in the field of organ engineering may provide a valuable alternative to existing long perfusion protocols, which lead to significant matrix damage. …”
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Metallothioneins 1 and 2 Modulate Inflammation and Support Remodeling in Ischemic Cardiomyopathy in Mice by Georg D. Duerr, Daniela Dewald, Eva J. Schmitz, Luise Verfuerth, Katharina Keppel, Christine Peigney, Alexander Ghanem, Armin Welz, Oliver Dewald

“…Despite their postponed chemokine induction we found a higher total neutrophil density and macrophage infiltration in small infarctions in MT-/--hearts. …”
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Unusual open-system behaviour revealed by LA-MC-ICP-MS U–Th dating of coral and coralline algae bio-carbonates by Condomines, Michel, Bruguier, Olivier, Hajji, Inès, Zaara-Ben Mosbah, Chedia

“…This paper presents new U–Th ages obtained by LA-MC-CP-MS (laser ablation - multi-collector - inductively coupled plasma - mass spectrometry) on coral samples from a sedimentary core of the Tunis lagoon. …”
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Proteomic Identification of Heat Shock-Induced Danger Signals in a Melanoma Cell Lysate Used in Dendritic Cell-Based Cancer Immunotherapy by Fermín E. González, Alexey Chernobrovkin, Cristián Pereda, Tamara García-Salum, Andrés Tittarelli, Mercedes N. López, Flavio Salazar-Onfray, Roman A. Zubarev

“…TRIMEL provides not only a broad spectrum of potential melanoma-associated antigens but also danger signals that are crucial in the induction of a committed mature DC phenotype. However, potential changes induced by heat conditioning on the proteome of TRIMEL are still unknown. …”
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Inhibition of A2B Adenosine Receptor Attenuates Intestinal Injury in a Rat Model of Necrotizing Enterocolitis by Lie Huang, Juan Fan, Yan-Xiang Chen, Jian-Hui Wang

“…Collectively, our study suggested that the inhibition of A2BR attenuates NEC in the neonatal rat, at least partially through the modulation of inflammation and the induction of epithelial cell proliferation.…”
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Dexamethasone Provides Effective Immunosuppression for Improved Survival of Retinal Organoids after Epiretinal Transplantation by Bikun Xian, Ziming Luo, Kaijing Li, Kang Li, Mingjun Tang, Runcai Yang, Shoutao Lu, Haijun Zhang, Jian Ge

“…Retinal organoids were then seeded onto poly(lactic-co-glycolic) acid (PLGA) scaffolds and implanted into rhesus monkey eyes (including a healthy individual and three monkeys with chronic ocular hypertension (OHT) induction) and subjected to different post-operative immunosuppressant treatments; 8 weeks after the experiment, histological examinations were carried out to assess the success of the different treatments. …”
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PPARγ Antagonizes Hypoxia-Induced Activation of Hepatic Stellate Cell through Cross Mediating PI3K/AKT and cGMP/PKG Signaling by Qinghui Zhang, Shihao Xiang, Qingqian Liu, Tao Gu, Yongliang Yao, Xiaojie Lu

“…Hypoxia promoted the induction and progress of hepatic fibrosis and HSCs activation. …”
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Phase II Study of Personalized Peptide Vaccination with Both a Hepatitis C Virus-Derived Peptide and Peptides from Tumor-Associated Antigens for the Treatment of HCV-Positive Advan... by Shigeru Yutani, Kazuomi Ueshima, Kazumichi Abe, Atsushi Ishiguro, Junichi Eguchi, Satoko Matsueda, Nobukazu Komatsu, Shigeki Shichijo, Akira Yamada, Kyogo Itoh, Tetsuro Sasada, Masatoshi Kudo, Masanori Noguchi

“…Further clinical study of PPV would be warranted for HCV-positive advanced HCC, based on the safety and strong immune induction.…”
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Studies on the Dual Cytotoxicity and Antioxidant Properties of Berberis vulgaris Extracts and Its Main Constituent Berberine by Lamyae El khalki, Mounir Tilaoui, Abdeslam Jaafari, Hassan Ait Mouse, Abdelmajid Zyad

“…The observed cytotoxicity was related to apoptosis induction as demonstrated by the annexin-V-streptavidin FITC-staining analysis.…”
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Intradermal DNA Electroporation Induces Cellular and Humoral Immune Response and Confers Protection against HER2/neu Tumor by Alessia Lamolinara, Lorenzo Stramucci, Albana Hysi, Manuela Iezzi, Cristina Marchini, Marianna Mariotti, Augusto Amici, Claudia Curcio

“…Moreover, we tested the efficacy of intradermal vaccination against Her2/neu antigen in cellular and humoral response induction and consequent protection from a Her2/neu tumor challenge in Her2/neu nontolerant and tolerant mice. …”
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Renal Transplantation in Hepatitis C Positive Patients: A Single Centre Experience by P. R. Shah, A. V. Vanikar, M. R. Gumber, H. V. Patel, V. B. Kute, S. M. Godara, H. L. Trivedi

“…We analyzed 132 HCV-positive RTx patients (group A) transplanted under tolerance induction protocol (TIP) and compared them with 79 controls (group B) transplanted using standard triple drugs. …”
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Hypoxia Promotes Vascular Smooth Muscle Cell (VSMC) Differentiation of Adipose-Derived Stem Cell (ADSC) by Regulating Mettl3 and Paracrine Factors by Jiaying Lin, Qianqian Zhu, Jialyu Huang, Renfei Cai, Yanping Kuang

“…Herein, we investigated the expression of N6-adenosine methyltransferases (Mettl3) and demethylases (Fto and Alkbh5) and found that Mettl3 was upregulated in ADSCs undergoing vascular smooth muscle differentiation induction. Moreover, silence of Mettle3 reduced the expression level of VSMC-specific markers, including α-SMA, SM22α, calponin, and SM-MHC. …”
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Effectiveness of Phytomining of Vanadium (V) and Chromium (Cr) Using Cymbopogon citratus and Portulaca grandiflora in Red Mud with Manure Addition by Fitranto Irwan, Voijant Tangahu Bieby, Yulikasari Andriyan, Mashudi, Sulistyaning Titah Harmin, Najib Rizal Moh., Salsabilla Faiza, Ming Lam Yeng, Wang Yamin, In Hurun, Maryanawati Soesilo Mery

“…The phytomining capacity of the plants was determined by measuring the concentration of vanadium (V) and chromium (Cr) in the plant extractions using inductively coupled plasma-optical emission spectroscopy (ICP-OES) equipment. …”
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