CD154 Induces Interleukin-6 Secretion by Kidney Tubular Epithelial Cells under Hypoxic Conditions: Inhibition by Chloroquine by Antoine Dewitte, Julien Villeneuve, Sébastien Lepreux, Marion Bouchecareilh, Xavier Gauthereau, Claire Rigothier, Christian Combe, Alexandre Ouattara, Jean Ripoche

“…Searching for inhibitors of CD154-mediated IL-6 production by HK-2 cells in hypoxic conditions, we observed that chloroquine, a drug that has been repurposed as an anti-inflammatory agent, alleviated this induction. Therefore, CD154 is a potent early stimulus for IL-6 secretion by TECs in O2 deprivation conditions, a mechanism likely to take part in the deleterious inflammatory consequences of platelet activation in kidney tubular injury. …”
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Perspectives of healthcare stakeholders in Nigeria on the impact of COVID-19 on health services by Adeponle O. Adeoye, Yewande T. Nejo, Chinwe L. Ochu, Josephine Bayigga, Rodgers R. Ayebare, Adedayo O. Faneye, Charles O. Adewemimo, Oluwaseun Emmanuel Falayi, Adeniyi Francis Fagbamigbe, Prosper Okonkwo, Adewale Victor Opayele, Gloria Ogochukwu Nwiyi, Sunday Obiajunwa Eziechina, Ikemefule Rex Uzoma, Priscilla Ibekwe, Tamrat Shaweno, Nebiyu Dereje, Francis Kakooza, Mosoka Papa Fallah, Georgina Njideka Odaibo

“…Recorded interviews were transcribed verbatim, and analysed using an inductive qualitative data analysis method to generate themes. …”
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Magnetic Vestibular Stimulation (MVS). A research tool with possible implementation in rehabilitation of stroke-affected athletes – a review by Monika Olszanecka, Tomasz Olszanecki, Anna Hanslik, Agata Białek, Agnieszka Walczak, Magdalena Mendak

“…This effect is a result of vestibular stimulation of the inner ear, the mechanism being a magnetohydrodynamic force (Lorentz force) which is generated by the interaction between normal ionic currents in the endolymph of the inner ear and the strong magnetic fields of the static MRI devices. The result of the induction is magnetic vestibular stimulation (MVS). …”
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Does Cisapride, as a 5HT4 Receptor Agonist, Aggravate the Severity of TNBS-Induced Colitis in Rat? by Azadeh Motavallian, Mohsen Minaiyan, Mohammad Rabbani, Parvin Mahzouni, Sasan Andalib, Alireza Abed, Mohammad Reza Babavalian

“…Two hours subsequent to induction of colitis using TNBS in rats, cisapride (2 mg/kg, intraperitoneally (i.p); 4 mg/kg, orally (p.o)) and dexamethasone (1 mg/kg, i.p; 2 mg/kg, p.o) were administrated for 6 days. …”
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Targeting murine metastatic cancers with cholera toxin A1-adjuvanted peptide vaccines by Sanchari Paul, Mustafa Kaya, Olivia Johnsson, Hanna Grauers Wiktorin, Andreas Törnell, Mohammad Arabpour, Kristoffer Hellstrand, Anna Martner

“…Both mucosal (intranasal) and systemic (intraperitoneal) vaccine administration provided effective protection against intravenously injected tumor cells, with intranasal administration leading to superior induction of CD4+ T cells at metastatic sites. When comparing antigens admixed with CTA1-DD to those fused with a CTA1-based adjuvant, the fusion construct elicited the strongest immunogenicity. …”
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Design and experimental validation of the action of small molecule-based inhibitors of the FADD protein by N. V. Ivanisenko, L. Hillert, V. A. Ivanisenko, I. N. Lavrik

“…Activation of CD95 leads to the induction of the cell death programme, apoptosis, via formation of the death-inducing signaling complex (DISC). …”
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Optimal Pore Size of Honeycomb Polylactic Acid Films for In Vitro Cartilage Formation by Synovial Mesenchymal Stem Cells by Misaki Yagi, Mitsuru Mizuno, Ryota Fujisawa, Hisako Katano, Kentaro Endo, Nobutake Ozeki, Yuriko Sakamaki, Hideyuki Koga, Ichiro Sekiya

“…One day after plating, the medium was switched to chondrogenic induction medium, and the films were time-lapse imaged and observed histologically. …”
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HLA-G Expression on Blasts and Tolerogenic Cells in Patients Affected by Acute Myeloid Leukemia by Grazia Locafaro, Giada Amodio, Daniela Tomasoni, Cristina Tresoldi, Fabio Ciceri, Silvia Gregori

“…DC-10 are present in the peripheral blood and are essential in promoting and maintaining tolerance via the induction of adaptive T regulatory (Treg) cells. We investigated HLA-G expression on blasts and the presence of HLA-G-expressing DC-10 and CD4+ T cells in the peripheral blood of AML patients at diagnosis. …”
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Mitochondrial Mayhem: How cigarette smoke induces placental dysfunction through MMS19 degradation by Pei Zhou, Feng Jin, Shenshen Yao, Ben Sun, Ni Sun, Hongbo Guan, Xiaomei Liu

“…Additionally, MMS19 deficiency resulted in mitochondrial fragmentation, ROS accumulation, and the induction of autosis and apoptosis. Transcriptome analysis indicated that dysregulation of the SMAD pathway mediates mitochondrial damage induced by MMS19 KD. …”
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Specific Immune Responses and Oncolytic Effects Induced by EBV LMP2A-Armed Modified Ankara-Vaccinia Virus Vectored Vaccines in Nasopharyngeal Cancer by Liying Sun, Chao Liu, Junping Peng

“…Here, we constructed a novel MVA-LMP2A recombinant virus and investigated its specific immune response induction and oncolytic effect. Results: An immunization dose of 2 × 10⁷ PFU induced the highest specific immune response, which was no longer increased by boost injections after four doses. …”
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Total Intravenous Anaesthesia with High-Dose Remifentanil Does Not Aggravate Postoperative Nausea and Vomiting and Pain, Compared with Low-Dose Remifentanil: A Double-Blind and Ran... by Seong-Hyop Kim, Chung-Sik Oh, Tae-Gyoon Yoon, Min Jeng Cho, Jung-Hyun Yang, Hye Ran Yi

“…Propofol and remifentanil 5 ng·mL−1 (L group) or 10 ng·mL−1 (H group) were administered for anaesthesia induction and maintenance. Propofol was titrated within range of 0.1 μg·mL−1 to maintain bispectral index (BIS) values between 40 and 60. …”
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Association between alkali and alkaline earth elements in chorionic villus and risk for spontaneous abortion by Meng Lin, Yutong Wang, Xiaoye Wang, Lailai Yan, Linlin Wang, Chan Tian

“…The concentrations of six alkali and alkaline earth elements in chorionic villi were measured using inductively coupled plasma mass spectrometry (ICP-MS). …”
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Hemorrhagic Shock Induces a Rapid Transcriptomic Shift of the Immune Balance in Leukocytes after Experimental Multiple Injury by Lisa Debler, Annette Palmer, Sonja Braumüller, Bettina Klohs, Tom Eirik Mollnes, Karlheinz Holzmann, Markus Huber-Lang, Rebecca Halbgebauer

“…Four hours after trauma, corresponding to three hours after induction of hemorrhage, RNA was isolated from all peripheral blood leukocytes, and a microarray analysis was performed. …”
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Limited Vitrectomy versus Complete Vitrectomy for Epiretinal Membranes: A Comparative Multicenter Trial by Matteo Forlini, Purva Date, Domenico D’Eliseo, Paolo Rossini, Adriana Bratu, Andrea Volinia, Giovanni Neri, Tommaso Verdina, Maria Rosaria Carbotti, Gian Maria Cavallini, Luigi Sborgia, Alessandra Galeone, Aurelio Imburgia, Alessandro Mularoni, Alessandro Meduri

“…In the limited vitrectomy group, a posterior vitreous detachment (PVD) was induced up till the equator as opposed to complete PVD induction till the vitreous base in the comparison group. …”
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Evaluation of Plaque Stability of Advanced Atherosclerotic Lesions in Apo E-Deficient Mice after Treatment with the Oral Factor Xa Inhibitor Rivaroxaban by Qianxing Zhou, Florian Bea, Michael Preusch, Hongjie Wang, Berend Isermann, Khurrum Shahzad, Hugo A. Katus, Erwin Blessing

“…Thrombin not only plays a central role in thrombus formation and platelet activation, but also in induction of inflammatory processes. Activated factor X (FXa) is traditionally known as an important player in the coagulation cascade responsible for thrombin generation. …”
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Gene Expression Profiling of IL-17A-Treated Synovial Fibroblasts from the Human Temporomandibular Joint by Toshio Hattori, Naomi Ogura, Miwa Akutsu, Mutsumi Kawashima, Suguru Watanabe, Ko Ito, Toshirou Kondoh

“…Furthermore, signal inhibitor experiments indicated that IL-17-mediated induction of IL-6 was transduced via activation of NFκB and phosphatidylinositol 3-kinase/Akt. …”
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Differential expression and localization of expansins in Arabidopsis shoots: implications for cell wall dynamics and drought tolerance by Darina Balkova, Katerina Mala, Jan Hejatko, Jan Hejatko, Klara Panzarova, Lamis Abdelhakim, Barbora Pleskacova, Marketa Samalova, Marketa Samalova

“…Overexpression of EXPA1 resulted in pronounced changes in CW-related gene expression, particularly during early stages of induction, including the upregulation of other expansins and CW-modifying enzymes. …”
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Social Justice and Health Equity in the Teaching and Learning Environment: Perspectives of Academic Leaders in Health Profession Education Programmes by Benita Cohen, Debra Beach Ducharme, Moni Fricke, Alan Katz, Laura MacDonald, Donna Martin, Christen Rachul, Gayle Restall, Dana Turcotte

“…Using semi-structured interviews, participants (n=14) representing five different colleges including medicine, nursing, oral health, pharmacy, and rehabilitation sciences, were interviewed in-person in the academic setting. Following inductive thematic analysis, one overarching theme resulted, “We Need to Walk the Talk.” …”
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Evaluation of the Tyrosine and Dopamine Serum Levels in Experimental Infected BALB/c Mice with Chronic Toxoplasmosis by Mehdi Mirzaeipour, Fattaneh Mikaeili, Qasem Asgari, Mohammad Nohtani, Sajad Rashidi, Mohammad Saleh Bahreini

“…Modified agglutination test (MAT), polymerase chain reaction (PCR), and microscopic methods were conducted to confirm the induction of chronic toxoplasmosis. The infected mouse sera were separated at days 40, 50, 60, 70, and 80 for evaluation of tyrosine and dopamine serum levels using high-performance liquid chromatography (HPLC). …”
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p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment by Darya Yanushko, Beatriz German Falcon, Rana El Bizri, Despoina Pervizou, Robin Dolgos, Céline Keime, Tao Ye, Christelle Thibault-Carpentier, Clementine Le Magnen, Sandrine Henri, Gilles Laverny, Daniel Metzger

“…Importantly, our single-cell transcriptomic and chromatin accessibility analyses combined with histological examinations uncovered an epithelial cell population characterized by an induction of Jak/Stat3 signaling and displaying mesenchymal features. …”
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