Islet organoids: a new hope for islet transplantation in diabetes by Xuemei Yu, Chengkong Liu, Zheng Kuang, Siyuan Song, Limin Tian, Yi Wang, Yi Wang

Subjects: “…chemically induced pluripotent stem cells (CiPSCs)…”
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iPSC Technology Revolutionizes CAR-T Cell Therapy for Cancer Treatment by Jiepu Zong, Yan-Ruide Li

Subjects: “…induced pluripotent stem cell (iPSC)…”
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Investigating the utilization of biomaterials and bioengineering methods in developing functional cardiac tissue for heart repair by Omar Elsaka

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Novel, low-cost bioreactor for in vitro electrical stimulation of cardiac cells by Joseph P. Licata, Jonathan A. Gerstenhaber, Peter I. Lelkes

“…However, there are discrepancies in the literature as to best practices for promoting cardiac differentiation using ES.MethodsThis study presents a novel, 3D printed bioreactor that delivers in vitro ES to human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), promoting cell maturity and functional readiness for implantation. …”
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Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism by Kelley C. Larson, Frederick W. Gergits, Abigail J. Renoux, Elizabeth J. Weisman, Borislav Dejanovic, Liyue Huang, Bhaumik Pandya, Donald G. McLaren, Berkley A. Lynch, Richard Fisher, Evan Thackaberry, David Gray, Francois Gaudreault, Christian Mirescu

“…Iluzanebart treatment rescued viability of human monocyte-derived macrophages (hMDM) and induced pluripotent stem cell-derived human microglia (iMGL) in multiple in vitro models of CSF1R-ALSP, including in induced pluripotent stem cell (iPSC) differentiated microglia carrying the heterozygous I794T mutation found in CSF1R-ALSP patients. …”
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Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming by Androniki Kretsovali, Christiana Hadjimichael, Nikolaos Charmpilas

“…They have been used to facilitate embryo development following somatic cell nuclear transfer and induced pluripotent stem cell derivation by ectopic expression of pluripotency factors. …”
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Generation of an isogenic series of genome-edited hiPSC lines with the BAG3P209L-mutation for modeling myofibrillar myopathy 6 by Isabelle Riße, Kerstin Filippi, Martin Wiemann, Bernd K. Fleischmann, Michael Hesse

“…We generated an isogenic series of heterozygous and homozygous genome-edited human induced pluripotent stem cell (hiPSC) lines with the BAG3P209L-mutation and its control. …”
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Protocol for live imaging of axonal transport in iPSC-derived iNeurons by Dan Dou, Erika L.F. Holzbaur, C. Alexander Boecker

“…Summary: Studies of human induced pluripotent stem cell (iPSC)-derived neurons promise important insights into neurodegenerative diseases. …”
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Proteomic profiling of iPSC and tissue-derived MSC secretomes reveal a global signature of inflammatory licensing by Margeaux Hodgson-Garms, Matthew J. Moore, Mikaël M. Martino, Kilian Kelly, Jessica E. Frith

“…This study analysed the secretomes of bone-marrow (BM.MSCs), umbilical-cord (UC.MSCs), adipose-tissue (AT.MSCs) and clinical/commercial-grade induced pluripotent stem cell-derived MSCs (iMSCs), under resting and inflammatory licenced conditions. iMSCs recapitulated the inflammatory licensing process, validating their comparability to tissue-derived MSCs. …”
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Generation of hiPSCs lines from three sporadic Parkinson’s disease patients by Giorgia Benedetto, Clara Zannino, Desirée Valente, Raffaele Covello, Stefania Scalise, Valeria Lucchino, Andrea Quattrone, Elvira I. Parrotta, Aldo Quattrone, Giovanni Cuda

“…Here, we described the generation of human induced pluripotent stem cell lines (hiPSCs) from three sporadic Parkinson’s disease (sPD) patients by reprogramming of their peripheral blood mononuclear cells (PBMC).…”
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Development and characterization of in vitro inducible immortalization of a murine microglia cell line for high throughput studies by Hana Yeh, Matthew A. De Cruz, Yang You, Seiko Ikezu, Tsuneya Ikezu

“…Recent approaches include the human induced pluripotent stem cell model, but these can be challenging for large-scale assays and may lead to batch variability. …”
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Living biobank: Standardization of organoid construction and challenges by Ruixin Yang, Yao Qi, Xiaoyan Zhang, Hengjun Gao, Yingyan Yu, Yuanyuan Ji

“…Organoids cover two mainstream fields: Adult stem cell-derived organoids (also known as patient-derived organoids) and induced pluripotent stem cell-derived and/or embryonic stem cell-derived organoids. …”
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Synthetic embryology of the human heart by Maria Belen Paredes-Espinosa, Janet L. Paluh

“…The evolution of stem cell-based heart models from cells and tissues to organoids and assembloids and recently synthetic embryology gastruloids, is poised to revolutionize our understanding of cardiac development, congenital to adult diseases, and patient customized therapies. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have already been integrated into transplantable patches and are in preclinical efforts to reverse fibrotic scarring from myocardial infarctions. …”
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Gut microbiota modulation in cardiac cell therapy with immunosuppression in a nonhuman primate ischemia/reperfusion model by Hung-Chih Chen, Yu-Che Cheng, Marvin L. Hsieh, Po-Ju Lin, Emily F. Wissel, Theodore Steward, Cindy M. C. Chang, Jennifer Coonen, Timothy A. Hacker, Timothy J. Kamp, Patrick C. H. Hsieh

“…We investigated gut microbiota dynamics in a nonhuman primate (NHP) cardiac ischemia/reperfusion model while under immunosuppression and receiving cell therapy with human induced pluripotent stem cell (hiPSC)-derived endothelial cells (EC) and cardiomyocytes (CM). …”
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Rapid iPSC-derived neuromuscular junction model uncovers motor neuron dominance in amyotrophic lateral sclerosis cytopathy by Hsiao-Chien Ting, Yun-Ting Guo, Hong-Lin Su, Yu-Shuan Chen, Shinn-Zong Lin, Horng-Jyh Harn, Chia-Yu Chang

“…Although human induced pluripotent stem cell (iPSC)-derived models have advanced NMJ research, their application is constrained by challenges such as limited differentiation efficiency, lengthy generation times, and cryopreservation difficulties. …”
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Ion channel traffic jams: the significance of trafficking deficiency in long QT syndrome by Gema Mondéjar-Parreño, Ana I. Moreno-Manuel, Juan Manuel Ruiz-Robles, José Jalife

“…Finally, we discuss how using human induced pluripotent stem cell technology to model ion channel trafficking and its defects may help accelerate drug discovery toward preventing life-threatening arrhythmias. …”
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Antiarrhythmic Effects of Carvedilol and Flecainide in Cardiomyocytes Derived from Catecholaminergic Polymorphic Ventricular Tachycardia Patients by R. P. Pölönen, K. Penttinen, H. Swan, K. Aalto-Setälä

“…In this study, we evaluated antiarrhythmic efficacy of carvedilol and flecainide in CPVT patient-specific induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) carrying different mutations in RYR2. iPSC-CMs were generated from skin biopsies of CPVT patients carrying exon 3 deletion and L4115 or V4653F mutation in RYR2 and of a healthy individual. …”
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Advances in Stem Cell Therapy for Huntington’s Disease: A Comprehensive Literature Review by Siddharth Shah, Hadeel M. Mansour, Brandon Lucke-Wold

“…PubMed was systematically searched using three search strings: ‘“Huntington disease” + “stem cell”’, ‘”Huntington disease” + Mesenchymal stromal cell’, and ‘”Huntington disease” + “induced pluripotent stem cell”’. For each string, the search results were categorized based on cell type, and papers that included a clinical analysis were categorized as well. …”
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Axodendritic targeting of TAU and MAP2 and microtubule polarization in iPSC-derived versus SH-SY5Y-derived human neurons by Breuer Helen, Bell-Simons Michael, Zempel Hans

“…To study MT dynamics in human neurons, we compared two cell culture systems: SH-SY5Y-derived neurons (SHN) and induced pluripotent stem cell-derived neurons (iN). Using immunostaining and EB3-tdTomato time-lapse imaging, we found AnkG absent in SHN but present in iN, while TRIM46 was present in both. …”
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Downregulation of an Evolutionary Young miR-1290 in an iPSC-Derived Neural Stem Cell Model of Autism Spectrum Disorder by Dalia Moore, Brittney M. Meays, Lepakshe S. V. Madduri, Farah Shahjin, Subhash Chand, Meng Niu, Abrar Albahrani, Chittibabu Guda, Gurudutt Pendyala, Howard S. Fox, Sowmya V. Yelamanchili

“…Here, we show that miR-1290 is significantly downregulated during neuronal differentiation in reprogrammed induced pluripotent stem cell- (iPSC-) derived neurons obtained from idiopathic autism spectrum disorder (ASD) patients. …”
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