Computational pathology assessments of cardiac stromal remodeling: Clinical correlates and prognostic implications in heart transplantation by Eliot G. Peyster, MD, MSc, Cai Yuan, PhD, Sara Arabyarmohammadi, PhD, Priti Lal, MD, Michael D. Feldman, MD, PhD, Pingfu Fu, PhD, Kenneth B. Margulies, MD, MS, Anant Madabhushi, PhD, FAIMBE, FIEEE, FNAI

“…Background: The hostile immune environment created by allotransplantation can accelerate pathologic tissue remodeling. Both overt and indolent inflammatory insults propel this remodeling, but there is a paucity of tools for monitoring the speed and severity of remodeling over time. …”
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Microenvironment-Centred Dynamics in Aggressive B-Cell Lymphomas by Matilde Cacciatore, Carla Guarnotta, Marco Calvaruso, Sabina Sangaletti, Ada Maria Florena, Vito Franco, Mario Paolo Colombo, Claudio Tripodo

“…The immunological and stromal microenvironments have been classically regarded as essential partners of indolent lymphomas, while considered mainly negligible in the setting of aggressive B-cell lymphomas that, by their nature, are less reliant on external stimuli. …”
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A Gastrointestinal Stromal Tumor of the Stomach Demonstrating a Stepwise Progression from Low- to High-Grade Malignancy by Takahiko Nakajima, Tomonori Ushijima, Atsushi Kihara, Kenichiro Murata, Toshiro Sugiyama, Koichi Tsuneyama, Johji Imura, Junichi Fukushima, Hajime Horiuchi

“…The patient had been followed for a small gastric submucosal tumor that had turned malignant after 8 years of indolence, manifested by tarry stools. The tumor was enucleated, and gastric GIST was diagnosed. …”
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A 75-Year-Old Female with Hemoptysis and Recurrent Respiratory Infections by Mary S. Baker, Khalil Diab

“…This is a very interesting case of indolent actinomycosis which we suspect had a very slow progressive course secondary to the multiple courses of antibiotics that the patient was treated with.…”
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Gut Microbiota Secondary Metabolites: Key Roles in GI Tract Cancers and Infectious Diseases by Eman K. E. Anwer, Muhammad Ajagbe, Moustafa Sherif, Abobaker S. Musaibah, Shuaib Mahmoud, Ali ElBanbi, Anwar Abdelnaser

“…Recent research has highlighted the significant role of these metabolites, particularly short-chain fatty acids, indoles, and bile acids, in modulating immune responses, impacting epigenetic mechanisms, and contributing to disease processes. …”
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Clear Cell Papillary Renal Cell Carcinoma in the Bilateral Native Kidneys after 2 Years of Renal Transplantation: Report of a Case and Review of the Literature by Zhanyong Bing, John E. Tomaszewski

“…Clear cell papillary renal cell carcinoma commonly presents with low pathologic stage and lower Fuhrman grade and is clinically indolent. Additional cases are needed to evaluate the clinical behavior of this type of tumor in renal transplant recipients.…”
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Deep Neck Infection: A Typical Presentation of Papillary Thyroid Cancer by Apichana Mahattanapreut, Rangsima Aroonroch, Chalermchai Chintrakarn, Chutintorn Sriphrapradang

“…Papillary thyroid cancer has a naturally indolent course, and most patients present with a thyroid nodule. …”
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Primary Nasal Tuberculosis by Varun Jerath, Bipin Kishore Prasad, Yamuna Ranganathan, Sunil Goyal

“…Tuberculosis primarily occurring in the nose, poses a diagnostic challenge, as the clinical presentations of other important pathologies such as infective and inflammatory diseases, granulomatous disorders and neoplastic conditions are similar, have an indolent course and are non-specific. Moreover, due to its rarity, it is often missed and not considered in differential diagnosis. …”
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PHYSIOLOGICAL EFFICACY OF MELANIN AS A FOOD INGREDIENT by N. Cherno, A. Kapustian, K. Naumenko, L. Gural, S. Osolina

“…Melanin is a biological pigment formed by indoles and phenolic compounds that is widespread in nature. …”
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« I am the Resurrection and the Life » : Sydney Carton, ou les modalités du retour d’une figure familière dans A Tale of Two Cities by Isabelle Hervouet-Farrar

“…Yet Sydney Carton appears as an altogether different type of hero, a falsely passive and indolent one. His ambiguous characterization shows a constant combination of the motifs of exclusion from and integration within a group, both at the diegetic and narrative levels. …”
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Fibrolamellar Carcinoma: 2012 Update by Michael Torbenson

“…Fibrolamellar carcinomas are not indolent tumors, but have an overall better prognosis than typical hepatocellular carcinomas, in part because of the younger age at presentation and the lack of cirrhosis. …”
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Evaluation of Task Shifting in Community-Based DOTS Program as an Effective Control Strategy for Tuberculosis by André P. Gabriel, Charles P. Mercado

“…While the course of the disease is indolent with years of latency, the reactivation of the disease can pose serious pulmonary and systemic infections that compromise multiple organ functions which lead to respiratory failure or end-organ damage. …”
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Probable Hydrochlorothiazide-Induced Myopericarditis: First Case Reported by Toufik Mahfood Haddad, Muhammad Sarfraz Nawaz, Ahmed S. Abuzaid, Smrithy Upadhyay, Pallavi Bellamkonda, Aryan N. Mooss

“…An African American female, with past history of hypertension, coronary artery disease, and sulfa allergy, presented with indolent onset and retrosternal chest pain which was positional, pleuritic, and unresponsive to sublingual nitroglycerin. …”
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Primary Dural Lymphoma Mimicking En Plaque Cerebellopontine Angle Meningioma by Mei Xu, Ashish Bains, Yuan Rong

“…No recurrence was found at 15-month follow-up. PDLs are mostly indolent and have a good prognosis. There is no doubt that the most important differential diagnosis is meningioma. …”
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A Rare Case of Metastatic Primary Peritoneal Ependymoma: A Case Report and Literature Review by Ben Man Fei Cheung, Johnny Kin Sang Lau, Anthony W. I. Lo, Mai-Yee Luk, Kwok Keung Yuen

“…It typically follows an indolent disease course. We describe a rare case of metastatic primary peritoneal ependymoma which was treated with chemotherapy and radiotherapy resulting in prolonged survival to date for 10 years. …”
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Current Challenges in Prostate Cancer Management and the Rationale behind Targeted Focal Therapy by Al B. Barqawi, Kevin J. Krughoff, Khadijah Eid

“…Prostate-specific antigen (PSA) screening has increased prostate cancer awareness since its implementation as a screening tool almost 25 years ago, but, due to the largely indolent course of this disease and the unspecific nature of the PSA test, increased incidence has largely been associated with cancers that would not go on to cause death (clinically insignificant), leading to an overdiagnosis challenge and an ensuing overtreatment consequences. …”
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UJI ZPT HANTU TERHADAP PERTUMBUHAN DAN PRODUKSI SELADA MERAH (Lactuca sativa) by Seprita Lidar, Enny Mutryarny

“…Hantu PGR containing gibberellic acid, Indol Acetic Acid, Kinetin and Zeatin. The research objective was to determine the effect and get the best Hantu PGR concentration on the growth and production of red lettuce. …”
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Utility of Bruton’s Tyrosine Kinase Inhibitors in Light Chain Amyloidosis Caused by Lymphoplasmacytic Lymphoma (Waldenström’s Macroglobulinemia) by Maroun Bou Zerdan, Jason Valent, Maria Julia Diacovo, Karl Theil, Chakra P. Chaulagain

“…Ibrutinib, acalabrutinib, and zanubrutinib are Bruton tyrosine kinase (BTK) inhibitors approved for certain indolent B cell non-Hodgkin’s lymphoma (NHL). BTK is a nonreceptor kinase involved in B-cell survival, proliferation, and interaction with the microenvironment. …”
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Runaway Train: A Leaky Radiosensitive SCID with Skin Lesions and Multiple Lymphomas by Børre Fevang, Unn Merete Fagerli, Hanne Sorte, Harald Aarset, Håkon Hov, Marit Langmyr, Thomas Morten Keil, Ellen Bjørge, Pål Aukrust, Asbjørg Stray-Pedersen, Tobias Gedde-Dahl

“…Hypomorphic mutations in the Artemis gene can lead to a functional, but reduced, T-cell and B-cell repertoire with a more indolent clinical course called “leaky” SCID. Here, we present the case of a young man who had increasingly aggressive lymphoproliferative skin lesions from 2 years of age which developed into multiple EBV+ B-cell lymphomas, where a hypomorphic mutation in the Artemis gene was found in a diagnostic race against time using whole exome sequencing. …”
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A Case of Chemotherapy-Refractory “THRLBCL like Transformation of NLPHL” Successfully Treated with Lenalidomide by Mamatha Siricilla, Lydia Irwin, Andres Ferber

“…NLPHL typically has an indolent course, and THRLBCL has an aggressive course. …”
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