Therapeutic effect and potential mechanism of Fufang Danshen dripping pills for stable coronary heart disease: a randomized controlled trial by Li-qin Meng, Li-qin Meng, Pei-ying Huang, Qing-min Li, Yu-chao Feng, Yu-chao Feng, Yu-chao Feng, Ding-jian Li, Guang-long Wu, Bo-wen Ao, Guo-chao Wu, Guo-xiong Zhang, Bo-jun Chen, Bo-jun Chen, Bo-jun Chen

“…By integrating these findings with network pharmacology targets, we highlighted the potential roles of LPL, CD36, FABPpm, L-FABP, LCAT, and CEPT in fat digestion, absorption, and metabolism pathways, suggesting their involvement in FFDS's treatment of SCHD by reducing triglycerides.ConclusionIn individuals with SCHD, the administration of FFDS has been shown to effectively reduce circulating triglyceride levels and decrease the frequency of angina episodes. …”
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DETERMINANTS OF GREEN FINANCING IMPLEMENTATION by Galih Suprapto

“…A sample size of seventy-five individuals was utilised for the purpose of data collection. …”
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MSC-sEVs exacerbate senescence by transferring bisecting GlcNAcylated GPNMB by Yihan Ma, Chongfu Zhao, Jingjing Feng, Junjie Gou, Enci Kang, Feng Guan, Qiong Wu, Xiang Li

“…Recent studies suggest that small extracellular vesicles (sEVs) derived from the serum of elderly individuals may play a pivotal role in promoting BMMSC senescence. …”
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Changes in PD-1 expression on T lymphocyte subsets and related immune indicators before and after definitive chemoradiotherapy for esophageal squamous cell carcinoma by Xueling Shi, Hongyu Zhao, Jiaqi Yu, Peng Cai, Shixiang Zhou, Ning Yang, Duojie Li

“…Peripheral blood from 10 healthy individuals was used as control.Results The percentages of CD3+ (p = 0.018), CD4+ (p < 0.001), and CD8+ T cells (p < 0.001); NK cells (p = 0.009); and the CD4+/CD8+ ratio (p < 0.001), as well as PD-1+CD3+ (p < 0.001), PD-1+CD4+ (p < 0.001), and PD-1+CD8+ (p < 0.001) T cells, before CRT significantly differed from those in the post-CRT group. …”
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International REACH forgiveness intervention: a multisite randomised controlled trial by Tyler J Vanderweele, Nicole Rodriguez, Richard G Cowden, Man Yee Ho, Everett L Worthington, Andrea Ortega Bechara, Zhuo Job Chen, Elly Yuliandari Gunatirin, Shaun Joynt, Viacheslav V Khalanskyi, Hennadii Korzhov, Ni Made Taganing Kurniati, Anastasiya Anastasiya Salnykova, Liudmyla Shtanko, Sergiy Tymchenko, Vitaliy L Voytenko, Anita Zulkaida, Maya B Mathur

“…Final follow-up occurred on 25 October 2021.Setting Participants were recruited from community-based samples in sites in Colombia, Hong Kong, Indonesia, South Africa, and Ukraine.Participants Individuals (n=7837) were screened for eligibility. …”
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GWAS of CRP response to statins further supports the role of APOE in statin response: A GIST consortium study by Emma F. Magavern, Harshal Deshmukh, Geraldine Asselin, Elizabeth Theusch, Stella Trompet, Xiaohui Li, Raymond Noordam, Y.-D. Ida Chen, Teresa E. Seeman, Kent D. Taylor, Wendy S. Post, Jean-Claude Tardif, Dirk S. Paul, Emelia J. Benjamin, Nancy L. Heard-Costa, Ramachandran S. Vasan, Jerome I. Rotter, Ronald M. Krauss, J.Wouter Jukema, Paul M. Ridker, Patricia B. Munroe, Mark J. Caulfield, Daniel I. Chasman, Marie-Pierre Dubé, Graham A. Hitman, Helen R. Warren

“…GWAS meta-analysis combined results from seven cohorts and clinical trials totalling 14,070 statin-treated individuals of European ancestry within the GIST consortium. …”
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Preoperative carcinoembryonic antigen to lymphocyte ratio serves as a prognostic predictor in elderly patients with colorectal cancer: a multicentre retrospective study by Lei Jiang, Ning Tan, Xiaonan Zhang, Jiayi Jiang, Xinyi Li, Gang Deng, Tao Liang, Haohan Ma, Weiping Deng, Lichang Guan, Kaijun Zhang, Xujie Cai, Lishu Xu

“…Multivariate Cox proportional hazard models indicated that CLR ≤2.53 was significantly associated with reduced mortality risk in the derivation (HR: 0.405, p&lt;0.001), external validation (HR: 0.519, p=0.039) and localised validation cohorts (HR: 0.167, p&lt;0.001).Conclusions Preoperative CLR serves as a reliable predictor of all-cause death following curative resection in elderly patients with CRC. Individuals with CLR exceeding 2.53 are inclined to a lower overall survival probability.…”
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Backtranslation of human RNA biosignatures of tuberculosis disease risk into the preclinical pipeline is condition dependent by Hannah Painter, Sasha E. Larsen, Brittany D. Williams, Hazem F. M. Abdelaal, Susan L. Baldwin, Helen A. Fletcher, Andrew Fiore-Gartland, Rhea N. Coler

“…Human-derived correlate of risk (COR) gene signatures, which identify an individual’s risk of progressing to active TB disease, provide an opportunity for evaluating new therapies for TB with clear and defined endpoints. …”
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Otologic Manifestations in Patients with Achondroplasia: A Multicenter Study by Dohee Kim, Joonsik Yoon, Myung-Whan Suh, Jun Ho Lee, Moo Kyun Park

“…This study aimed to explore the prevalence and treatment outcomes of otologic disease in individuals with achondroplasia. Methods: A retrospective review of medical records was conducted for 70 patients who visited the otolaryngology clinic at 3 institutions in South Korea from 1999 to 2023. …”
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Species Composition and Growth Pattern of a Multi-Species Grouper in Kwandang Bay, Sulawesi Sea, Indonesia by Dewi Shinta Achmad, Muh Saleh Nurdin, Fauziah Azmi, Merita Ayu Indrianti, Evi Hulukati, Jamaluddin Jompa, Teuku Fadlon Haser, Novianita Achmad

“…The number of specimens identified during January - December 2021 was 1,571 individuals. Research showed that those samples consisted of 26 species under eight genera. …”
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Exploration of the quantitative-effectiveness association between acupuncture temporal parameters and chemotherapy-induced peripheral neuropathy in cancer patients: a dose-response... by Hao Tian, Qin Luo, Liuyang Huang, Liuyang Huang, Liuyang Huang, Guang Chen, Mingsheng Sun, Fanrong Liang

“…Sensitivity analysis confirmed the robustness of these findings.ConclusionAcupuncture demonstrates significant potential in managing CIPN, particularly through individualized treatment regimens. The identified time-dose-response relationship suggests that tailoring acupuncture frequency and duration can to optimize pain relief in CIPN patients. …”
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Relationship of serum total cholesterol and triglyceride with risk of mortality in maintenance hemodialysis patients: a multicenter prospective cohort study by Yan Huang, Qiuxia Zhong, Junzhi Chen, Xianhui Qin, Yaya Yang, Yanhuan He, Zizhen Lin, Yumin Li, Shenglin Yang, Yongxin Lu, Yanhong Zhao, Yaozhong Kong, Qijun Wan, Qi Wang, Sheng Huang, Yan Liu, Aiqun Liu, Fanna Liu, Fanfan Hou, Min Liang

“…We aimed to explore the individual and combined association of TC and TG levels with the risk of mortality in Chinese MHD patients.Methods 1036 MHD patients were enrolled in this multicenter, prospective cohort study. …”
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Genomic scans for selection and runs of homozygosity in southern Italian turkey populations by Medhat S. Saleh, Vincenzo Landi, Martijn F.L. Derks, Gerardo Centoducati, Martien A.M. Groenen, Pasquale De Palo, Elena Ciani, Nicola Pugliese, Elena Circella, Antonio Camarda

“…We identified 27 genomic regions that harbor 61 candidate genes in ROH islands in which single nucleotide polymorphisms (SNPs) occur in more than 90 % of individuals. In addition, we detected 608 genomic regions under positive selection using the iHS method being 104, 98, 130, 102, and 174 for BAS, APU_C, APU_M, APU_PN, and APU_PS, respectively. …”
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Oligogenic effect is associated with the clinical heterogeneity of autosomal dominant deafness-15 by Jianyan Pan, Hua Teng, Fang Liu, Siyi Chen, Yaning Liu, Yanling Teng, Desheng Liang, Zhuo Li, Lingqian Wu

“…In addition, we found that two individuals with earlier age of onset and more rapid progression of hearing loss carry additional pathogenic variants in other deafness genes (III-7, STRC:c.4057 C > T; IV-1, GJB2:c.109G > A; CDC14A:c.935G > A). …”
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Real-world enrollment for a prospective clinico-genomic database using a pragmatic technology-enabled platform by Alexia Exarchos, Ariel B. Bourla, Maneet Kaur, Katja Schulze, Sophia Maund, Yi Cao, Yihua Zhao, Elizabeth H. Williams, Sarah C. Gaffey, Richard Zuniga, Shaily Lakhanpal, Vladan Antic, Michelle Doral, Johanna Sy, Neal J. Meropol, Anne C. Chiang

“…Enrollment rates were estimated from eligible populations at individual centers. Clinical data from routinely collected EHR documentation were centrally processed and normalized for quality control. …”
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Enhanced AC/DC optimal power flow via nested distributed optimization for AC/VSC-MTDC hybrid power systems by Haixiao Li, Pedro P. Vergara, Robert Dimitrovski, Hongjin Du, Aleksandra Lekić

“…In the inner iteration, the master problem is continuously decomposed into multiple sub-MPs associated with individual VSCs. The alternating direction method of multipliers (ADMM) is employed to solve these sub-MPs iteratively. …”
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Mechanism of Threshold Voltage Instability in Double Gate &#x03B1;-IGZO Nanosheet TFT Under Bias and Temperature Stress by Muhammad Aslam, Shu-Wei Chang, Yi-Ho Chen, Yao-Jen Lee, Yiming Li, Wen-Hsi Lee

“…The spectroscopic analysis is performed to establish evidence for the assumed mechanisms, and the role of individual gates is investigated in the context of performance variance under temperature-bias stress. …”
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Efficacy of double filtration plasmapheresis in hyperlipidemia acute pancreatitis: a retrospective observational study by Rong Qin, Yibei Liu, Rui Ding, Minhui Yang, Yun Huang, Xujia Chen, Feng Zhang, Yanting Liu, Hongping Jia, Yiyao Duan, Lifang Zhou, Hui Wang

“…The DFPP group exhibited greater reductions in TG levels and more individual variability. In terms of complications, the rate of systemic inflammatory response syndrome (SIRS) differed significantly between the groups (P < 0.05). …”
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Modelling height to crown base using non-parametric methods for mixed forests in China by Zeyu Zhou, Huiru Zhang, Ram P. Sharma, Xiaohong Zhang, Linyan Feng, Manyi Du, Lianjin Zhang, Huanying Feng, Xuefan Hu, Yang Yu

“…The relative importance was higher for individual tree variables (77.54 %, 31.02 %, 31.12 %, and 73.69 % for coniferous, spruce-fir, hard broadleaved, and soft broadleaved groups, respectively) and stand variables (5.00 %, 20.34 %, 11.03 %, and 8.71 % for coniferous, spruce-fir, hard broadleaved, and soft broadleaved groups, respectively) compared with stand spatial structure variables (4.57 %, 12.14 %, 21.91 %, and 5.89 % for coniferous, spruce-fir, hard broadleaved, and soft broadleaved groups, respectively), density indexes variables (2.17 %, 1.28 %, 4.05 %, and 2.87 % for coniferous, spruce-fir, hard broadleaved, and soft broadleaved groups, respectively), and tree species variables (10.79 %, 35.20 %, 31.90 %, and 8.84 % for coniferous, spruce-fir, hard broadleaved, and soft broadleaved groups, respectively). …”
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Unusual congenital polydactyly in mini-pigs from the breeding group of the Institute of Cytology and Genetics (Novosibirsk, Russia) by S. V. Nikitin, S. P. Knyazev, V. A. Trifonov, A. A. Proskuryakova, Yu. D. Shmidt, K. S. Shatokhin, V. I. Zaporozhets, D. S. Bashur, E. V. Korshunova, V. I. Ermolaev

“…The polydactyly in mini-pigs is a stand-alone trait and is not part of any syndromes. Individuals with polydactyly may have extra digits either on pectoral or on pectoral and pelvic limbs. …”
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