Peripheral nerve injury induces dystonia-like movements and dysregulation in the energy metabolism: A multi-omics descriptive study in Thap1+/− mice by Colette Reinhold, Susanne Knorr, Rhonda L. McFleder, Lisa Harder-Rauschenberger, Tom Gräfenhan, Andreas Schlosser, Michael Sendtner, Jens Volkmann, Chi Wang Ip

“…The incomplete penetrance of DYT-THAP1 dystonia, estimated at 40 to 60 %, suggests that an environmental trigger may be required for the manifestation of the disease in genetically predisposed individuals. To investigate the gene-environment interaction in the development of dystonic features, we performed a sciatic nerve crush injury in a genetically predisposed DYT-THAP1 heterozygous knockout mouse model (Thap1+/−). …”
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APOEε4 alters ApoE and Fabp7 in frontal cortex white matter in prodromal Alzheimer's disease by Marta Moreno-Rodriguez, Sylvia E. Perez, Michael Malek-Ahmadi, Elliott J. Mufson

“…To evaluate the effects of APOEε4 on ApoE, Fabp7 and myelin in the WM of the frontal cortex (FC), we examined individuals carrying one ε4 allele that came to autopsy with a premortem clinical diagnosis of no cognitive impairment (NCI), mild cognitive impairment (MCI) and mild to moderate AD compared with non-carrier counterparts. …”
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Use of Stiripentol in Patients with Dravet Syndrome: Common Practice Among Experts in Spain by Juan José García-Peñas, Rocío Calvo-Medina, Adrián García-Ron, Antonio Gil-Nagel, Vicente Villanueva, Rocío Sánchez-Carpintero

“…Results According to these recommendations, stiripentol can be administered to patients with DS of any age, although its initiation and titration vary according to age group. Individualized adjustment of concomitant ASMs, such as valproic acid and clobazam or drugs specifically for DS (i.e., fenfluramine), at initiation and during stiripentol treatment, can mitigate drug interactions, thereby increasing the long-term tolerability of stiripentol treatment. …”
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Association between urinary metallothionein concentration and causes of death among cadmium-exposed residents in Japan: a 35-year follow-up study by Lianen Li, Rie Okamoto, Xian Liang Sun, Teruhiko Kido, Kazuhiro Nogawa, Yasushi Suwazono, Hideaki Nakagawa, Masaru Sakurai

“…Background: As research progresses, there is a growing body of evidence indicating that urinary metallothionein (MT) levels may be elevated in individuals exposed to cadmium (Cd). This study aimed to investigate the potential association between urinary MT levels and causes of mortality among residents of the Kakehashi River Basin who have been exposed to Cd. …”
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CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation. by John T Loffredo, Thomas C Friedrich, Enrique J León, Jason J Stephany, Denise S Rodrigues, Sean P Spencer, Alex T Bean, Dominic R Beal, Benjamin J Burwitz, Richard A Rudersdorf, Lyle T Wallace, Shari M Piaskowski, Gemma E May, John Sidney, Emma Gostick, Nancy A Wilson, David A Price, Esper G Kallas, Helen Piontkivska, Austin L Hughes, Alessandro Sette, David I Watkins

“…However, specific correlates of viral control in individuals expressing these alleles have been difficult to define. …”
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Identification of Potential Type II Diabetes in a Large-Scale Chinese Population Using a Systematic Machine Learning Framework by Mingyue Xue, Yinxia Su, Chen Li, Shuxia Wang, Hua Yao

“…Combined with the risk factors selected by LR, we used a decision tree, a random forest, AdaBoost with a decision tree (AdaBoost), and an extreme gradient boosting decision tree (XGBoost) to identify individuals with T2DM, compared the performance of the four machine learning classifiers, and used the best-performing classifier to output the degree of variables’ importance scores of T2DM. …”
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An increased proportion of transgenic plants in the progeny of rapeseed (<i>Brassica napus</i> L.) transformants by G. N. Raldugina, T. Z. Hoang, H. B. Ngoc, I. V. Karpichev

“…We also found that in individual transformants gfp is randomly inherited throughout the central peduncle; its presence in the genome of seedlings does not depend on the location of the pod. …”
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HISTOLOGICAL ANALYSIS OF LYMPHOID MASSES OF THE STOMACH AND SMALL INTESTINE IN THE CLINICAL AND PATHOGENETIC PROFILE OF BABESIOSIS by I. I. Torianyk

“…A focal version of the nosological prototype was observed in individual specimens occasionally, presented as single cells (most often in the terminal parts of the organ). …”
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Cervical cancer screening utilization among HIV-positive women in Edo State, Nigeria by Ngozi R. Osunde, Mercy N. Anayo, Ona Patience, Favour E. Omoregie

“…One hundred ninety-one individuals (51.6%) reported awareness of screening, while 65 (17.6%) had undergone screening. …”
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Impacts of a multipronged initiative with community HIV clinics to support retention and re-engagement in HIV care by Ellen Eaton, Claudia T. Martorell, Jewel Sawyer, Tanya S. Schreibman, Gregory S. Felzien, Jenniffer Meza Jimenez, Chelsie Anderson Chadha, Jeffrey Carter, Chris Napolitan, Laura Simone, Leah Molloy, Bonnie Douglas

“…Background Despite advances in HIV treatment, gaps in care retention threaten the individual health of people with HIV (people) and public health efforts to end the HIV epidemic. …”
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In silico methods for immunogenicity risk assessment and human homology screening for therapeutic antibodies by Aimee E. Mattei, Andres H. Gutierrez, Soorya Seshadri, Jacob Tivin, Matt Ardito, Amy S. Rosenberg, William D. Martin, Anne S. De Groot

“…This toolkit has evolved and now contains an array of algorithms that can be used individually and/or consecutively for immunogenicity assessment and protein engineering. …”
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Comparative indicators of morphology and seed productivity in rare <i>Iris</i> L. spp. within their natural habitats and under cultivation in the Southern Urals by A. V. Kryukova, A. N. Mustafina, L. M. Abramova

“…., I. scariosa Wild. ex Link, and I. humilis Georgi, were studied in 2012–2017 in 23 natural and 4 introduced cenopopulations. Individual parameters were compared for 25 medium-age plants from each cenopopulation in their mass-flowering and fruiting phase according to 11 biometric parameters using conventional methods. …”
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Impact of Admission Blood Glucose on Coronary Collateral Flow in Patients with ST-Elevation Myocardial Infarction by Ozge Kurmus, Turgay Aslan, Berkay Ekici, Sezen Baglan Uzunget, Sukru Karaarslan, Asli Tanindi, Aycan Fahri Erkan, Ebru Akgul Ercan, Celal Kervancıoglu

“…The development of coronary collateral is heterogeneous among individuals with coronary artery disease. In this study, we aimed to investigate whether glucose value on admission is associated with collateral flow in ST-elevation myocardial infarction (STEMI) patients. …”
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Investigating papillary thyroid cancer risk factors among women living at the central region of Iran: a case–control study by Hamed Ghoshouni, Saeed Hosseini, Akram Ghadiri-Anari, Reyhaneh Azizi, Masoud Rahmanian, Narjes Hazar

“…Results In present study, 77 individuals participated in the case group, 76 in the relative control group and 72 in the non-relative control group. …”
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Transgenerational epigenetic heritability for growth, body composition, and reproductive traits in Landrace pigs by Andre C. Araujo, Jay S. Johnson, Jason R. Graham, Jeremy Howard, Yijian Huang, Hinayah R. Oliveira, Luiz F. Brito

“…Epigenetics is an important source of variation in complex traits that is not due to changes in DNA sequences, and is dependent on the environment the individuals are exposed to. Therefore, we aimed to estimate transgenerational epigenetic heritability, percentage of resetting epigenetic marks, genetic parameters, and predicting breeding values using genetic and epigenetic models for growth, body composition, and reproductive traits in Landrace pigs using routinely recorded datasets. …”
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Examines The Impact of Product And Service Quality On Customer Satisfaction at PT. BMTP With Personal Branding by Andi Nadirah M., Indrawan, Suparman Parintak, Anne Attas, Burhanuddin Harahap

“…Personal branding refers to the perception and reputation of the bank's employees or representatives as individuals. However, there has been no concrete research on the effect of all three of these factors affects customer satisfaction. …”
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Cytokines in Liver Cirrhosis (Their Importance in Assessing Activity and Decompensation) by G. K. Mirodzhov, S. D. Pulatova

“…The study of the content of pro-inflammatory and anti-inflammatory cytokines in the blood serum of patients with Class A liver cirrhosis showed, that levels of tumour necrosis factor alpha (TNF-α), interleukin-2, interleukin-6 were statistically higher compared to healthy individuals, while the concentration of anti-inflammatory interleukin-10 was lower (30.7 ± 4.7 pg/mL) in comparison with the control group. …”
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Penambahan Kinesiotaping pada Intervensi Ultrasound, Transcutaneous Electrical Nerve Stimulation, dan Massage lebih Meningkatkan Kemampuan Fungsional pada Pasien Osteoarthritis Gen... by Made Widnyana, I Putu Yudi Pramana Putra, Anak Agung Gede Eka Septian Utama, I Dewa Gede Alit Kamayoga

“…OA genu dapat terjadi pada setiap individu, angka kejadian lebih tinggi pada perempuan dan menjadi penyebab gangguan fungsional tertinggi pada orang dengan usia di atas 65 tahun. …”
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Successful management of refractory epilepsy in creatine transporter deficiency with cannabidiol and clobazam: A case report by Maria Borrell‐Pichot, Carmen Fons, Susana Boronat, Alba Sierra‐Marcos

“…To date, fewer than 200 individuals with CRTR‐D have been reported. As a result, there is little evidence for effective treatment. …”
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Adherencia terapéutica en pacientes con hipertensión arterial by Ahmed José Pomares Avalos, Marian Amanda Vázquez Núñez, Erika Solange Ruíz Domínguez

“…Se aplicaron dichas herramientas de forma individual a cada paciente. El análisis estadístico de la información se realizó en la base de datos del paquete estadístico Statistical Package for the Social Sciences.…”
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