In vivo confocal microscopic study of cornea verticillata and limbus deposits in patients with Fabry disease by Xuecong Zhou, Yawen Zhao, Yingsi Li, Yujing Yuan, Xiaoming Yan, Wei Zhang, Yuan Wu

“…Patients with FD demonstrated a profound bilateral increase in corneal epithelial deposits and limbal hyperreflective cells compared to controls, with more prominent pathological changes observed in classical phenotype individuals. The high prevalence of epithelial deposits observed through IVCM in the cardiac variant highlights the essential ability of IVCM as an effective diagnostic tool.…”
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Ki-67 and CDK1 control the dynamic association of nuclear lipids with mitotic chromosomes by Hsiao-Tang Hu, Ueh-Ting Tim Wang, Bi-Chang Chen, Yi-Ping Hsueh, Ting-Fang Wang

“…Given that Ki-67 has been proposed to promote chromosome individualization and establish chromosome-cytoplasmic compartmentalization during open mitosis in vertebrates, our results reveal that nuclear lipid enrichment at the perichromosomal layer enhances the ability of Ki-67 to form a protective perichromosomal barrier (chromosome envelope), which is critical for correct chromosome segregation and maintenance of genome integrity during mitosis.…”
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Voice analysis and deep learning for detecting mental disorders in pregnant women: a cross-sectional study by Hikaru Ooba, Jota Maki, Hisashi Masuyama

“…Discussion The voice-based model showed higher sensitivity and recall, suggesting that it may be more effective in identifying at-risk individuals than the EPDS. Machine learning and voice analysis are promising objective screening methods for mental disorders during pregnancy, potentially improving early detection. …”
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Distribution of Pupil Size and Associated Factors: Results from the Population-Based Gutenberg Health Study by Marian Kiel, Stephanie D. Grabitz, Susanne Hopf, Thomas Koeck, Philipp S. Wild, Irene Schmidtmann, Karl J. Lackner, Thomas Münzel, Manfred E. Beutel, Norbert Pfeiffer, Alexander K. Schuster

“…Socioeconomic status and smoking were not associated with pupil size. Conclusion. Individuals of older age, after cataract surgery, under therapy with ACE inhibitors and with diabetes have a smaller pupil. …”
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Comparative analysis of real-world data on the efficacy and safety of and adherence to ICS/LABA combinations in asthma management by Hee Sun Park, Jungkuk Lee, Hasung Kim, Seong-Dae Woo

“…These results provide valuable insights for clinicians in selecting appropriate and individually tailored inhaler therapies in real-world settings. …”
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Overwintering of Thrips (Thysanoptera) Under the Bark of the Plane Tree (<i>Platanus</i> x <i>hispanica</i> Mill. ex Münchh.) in Southeastern Poland by Halina Kucharczyk, Marek Kucharczyk, Tomasz Olbrycht

“…A total of 494 thrips individuals were collected, with 84% representing the suborder Terebrantia. …”
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TWIN-10: protocol for a 10-year longitudinal twin study of the neuroscience of mental well-being and resilience by Robin M Turner, Haeme R P Park, Leanne M Williams, Justine M Gatt

“…However, we lack an understanding of the neural mechanisms that contribute to individual variation in the trajectories of well-being and resilience relative to risk. …”
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CFD analysis of heat transfer enhancement in impinging jet array by varying number of jets and spacing by Zakia Rachdi, Nidhal Hnaien, Aboulbaba Eladeb, Badr M. Alshammari, Lioua Kolsi, Hacen Dhahri

“…Our study examines the combined effect of the number of jets (N) and the jet–jet spacing (S) on flow mechanisms and heat transfer performance, which is unique compared to previous research that frequently focuses on the individual effects of parameters. Through the investigation of the turbulent kinetic energy, friction coefficient, velocity contours, streamlines, pressure contours, and local and mean Nusselt numbers, we provide important information about how these parameters impact flow dynamics. …”
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Inhaled corticosteroids in asthma and chronic obstructive pulmonary disease combined phenotype: when to use and what to expect? by Srishankar Bairy, Tarun Tiwari, Himanshu Mittal, Neeraj Gupta, Meghana M

“…These parameters were compared with baseline values obtained prior to the initiation of ICS to evaluate the impact of the intervention. Among the 43 individuals in the study population, the majority fell within the age group of 60-69 years. …”
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Gastrointestinal Bleeding in COVID-19 Patients: A Systematic Review with Meta-Analysis by Giovanni Marasco, Marcello Maida, Gaetano Cristian Morreale, Massimo Licata, Matteo Renzulli, Cesare Cremon, Vincenzo Stanghellini, Giovanni Barbara

“…In this meta-analysis of published studies, individuals with COVID-19 were found to be at risk for gastrointestinal bleeding, especially upper gastrointestinal bleeding.…”
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Development and validation of a high-throughput qPCR platform for the detection of soil-transmitted helminth infections. by Nils Pilotte, Victor Omballa, Monica Voss, Leah Padgett, Malathi Manuel, Jeanne L Goodman, Tim Littlewood, Zayina Zondervenni Manoharan, Lisette van Lieshout, Jaco J Verweij, Manigandan Sekar, Ajith Kumar Muthukumar, Gretchen Walch, Abriana Warren, Mariyam Sheikh, Andrew Gonzalez, Sean R Galagan, Sitara Swarna Rao Ajjampur, Moudachirou Ibikounlé, Steven A Williams, Doug Rains, Ushashi Dadwal, Judd L Walson

“…Comparison of this platform with singleplex reference assays for the detection of these same pathogens has demonstrated comparable performance metrics, with index assay accuracy measuring at or above 99.5% and 98.1% for each target species at the level of the technical replicate and individual extraction respectively. Through the implementation of a rigorous validation program, we have developed a diagnostic platform capable of providing the necessary throughput and performance required to meet the needs of the DeWorm3 cluster randomized trial and other large-scale operational research efforts for STH.…”
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From one size fits all to a tailored approach: integrating precision medicine into medical education by Lana Sbitan, Noor Alzraikat, Haneen Tanous, Abdelrahman M. Saad, Mohanad Odeh

“…Results Participants in the present study were 607 individuals, 55.5% were males. 29.6% of participants had low knowledge scores (marks between − 12 and 0). …”
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Association between impaired brachial flow-mediated dilation and early neurological deterioration in acute ischemic stroke: a retrospective analysis by Sang Hee Ha, Bo Hye Yoon, Bon Gook Koo, Dong Hoon Shin, Yeong-Bae Lee, Bum Joon Kim

“…Abstract Background Early neurological deterioration (END) occurs in individuals who had experienced acute ischemic stroke (AIS), impacting long-term functional outcomes. …”
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A Cross-Sectional Analysis of Dietary Intake and Nutritional Status of Patients on Haemodialysis Maintenance Therapy in a Country of Sub-Saharan Africa by Nyangi A. Gityamwi, Kathryn H. Hart, Barbara Engel

“…Patients will benefit from improved nutritional services that deliver individually tailored and culturally practical dietary advice to enable them to make informed food choices whilst optimizing disease management.…”
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Association of a novel nutritional index with cognitive impairment in middle-aged and elderly Chinese adults: a cross-sectional analysis from the China Health and Retirement Longit... by Guotao Liu, Jianyuan Zhang

“…Subgroup analysis indicated that the association was stronger among participants aged ≥60 years (OR = 0.655, 95% CI: 0.438–0.979), non-current drinkers (OR = 0.643, 95% CI: 0.451–0.917), and those who engaged in socializing (OR = 0.568, 95% CI: 0.371–0.871).ConclusionTCBI was significantly and negatively associated with cognitive impairment in Chinese middle-aged and elderly individuals, with the effect more pronounced in those aged ≥60 years, non-current drinkers, and socially active participants.…”
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Histogram of Apparent Diffusion Coefficient to Evaluate the Activity of Thyroid‐Associated Ophthalmopathy by Defu Li, Tingting Zhu, Yujin Wang

“…The area under the curve (AUC) of the 10th percentile of the ADC histogram and the median distinguishing between active and inactive TAOs were both 0.791 (both p < 0.05), and the AUCs of the combined model of age, sex, smoking, and the 10th percentile in the ADC histogram were better than those of their individual models and the combined model of age, sex, and smoking (all p < 0.05). …”
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Reduction in Surgical Wound Infection Rates Associated with Reporting Data to Surgeons by GD Taylor, M Buchanan-Chell, T Kirkland, M McKenzie, B Sutherland, R Wiens

“…Since 1987, the authors have been performing concurrent surveillance of surgical patients and confidentially reporting surgeon-specific ssi rates to individual surgeons and their clinical directors, and providing surgeons with the mean rates of their peers. …”
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Reliability and Validity of Visual Estimation in Determining Thorax Rotation Mobility using the Quadruped Lumbar-Locked Position by Katelyn S Whetstone, Kyle A Matsel, Andrew S Patton, Sarah E Gehres, Kate Schwartzkopf-Phifer

“…The quadruped lumbar-locked thorax rotation test can accurately discriminate between individuals with active and passive physiological deficits regardless of rater experience using visual estimation…”
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Anthropogenic Disturbance and Climate Change Impacts on the Suitable Habitat of Sphenomorphus incognitus in China by Kai Chen, Li Ma, Weijun Jiang, Lijin Wang, Li Wei, Hongji Zhang, Ruhao Yang

“…The mean true skill statistic (TSS) and the area under the receiver operating characteristic curve (AUC) suggested that the ensemble model yield more precise predictions than those of individual models. Rainfall and slope were identified as the most important factors influencing S. incognitus distribution. …”
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Clinical, biochemical and molecular characteristics of classic homocystinuria in Saudi Arabia and the impact of newborn screening on prevention of the complications: A tertiary cen... by Ahmed Sarar Mohamed, Talal AlAnzi, Amal Alhashem, Hadeel Alrukban, Fahad Al Harbi, Sarar Mohamed

“…This suggests that specific mutation testing may be cost‐effective for individuals from certain ethnicities.…”
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