Orthoweb: a software package for evolutionary analysis of gene networks by R. A. Ivanov, A. M. Mukhin, F. V. Kazantsev, Z. S. Mustafin, D. A. Afonnikov, Y. G. Matushkin, S. A. Lashin

“…This article introduces Orthoweb (https://orthoweb.sysbio.cytogen.ru/), a software package developed for the calculation of evolutionary indices, including phylostratigraphic indices and divergence indices (Ka/Ks) for individual genes as well as for gene networks. The phylostratigraphic age index (PAI) allows the evolutionary stage of a gene’s emergence (and thus indirectly the approximate time of its origin, known as “evolutionary age”) to be assessed based on the analysis of orthologous genes across closely and distantly related taxa. …”
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Peering into the Black Box: Forward Modeling of the Uncertainty Budget of High-resolution Spectroscopy of Exoplanet Atmospheres by Arjun B. Savel, Megan Bedell, Eliza M.-R. Kempton, Peter C. B. Smith, Jacob L. Bean, Lily L. Zhao, Kaze W. K. Wong, Jorge A. Sanchez, Michael R. Line

“…Ground-based high-resolution cross-correlation spectroscopy (HRCCS; R  ≳ 15,000) is a powerful complement to space-based studies of exoplanet atmospheres. By resolving individual spectral lines, HRCCS can precisely measure chemical abundance ratios, directly constrain atmospheric dynamics, and robustly probe multidimensional physics. …”
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A review of parameter settings for galvanic vestibular stimulation in clinical applications by Yishai Valter, Yishai Valter, Linda Vataksi, Aaron R. Allred, Jeffrey R. Hebert, Tad T. Brunyé, Tad T. Brunyé, Torin K. Clark, Jorge Serrador, Abhishek Datta, Abhishek Datta

“…Based on our findings, we recommend that future GVS research include at least one sham condition, the use of individualized current intensity, and the comparison of multiple GVS parameters within the same trial.…”
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Rationale, Design, and Baseline Characteristics of Beijing Prediabetes Reversion Program: A Randomized Controlled Clinical Trial to Evaluate the Efficacy of Lifestyle Intervention... by Yingying Luo, Sanjoy K. Paul, Xianghai Zhou, Cuiqing Chang, Wei Chen, Xiaohui Guo, Jinkui Yang, Linong Ji, Hongyuan Wang

“…Between March 2007 and March 2011, 1945 participants were randomized. At baseline, the individuals were 53±10 years old, with median BMI 26.0 (23.9, 28.2) kg/m2 and HbA1c 5.8 (5.6, 6.1)%. 85% of the participants had IGT and 15% had IFG. …”
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Systemic Therapy of Neuroendocrine Neoplasia: Single Center Experience from a Cohort of 110 Consecutive Cases by Karin Mayer, Selina Kiry, Anna Yordanova, Hojjat Ahmadzadehfar, Florian C. Gaertner, Ralph A. Bundschuh, Markus Essler, Maria A. Gonzalez-Carmona, Christian P. Strassburg, Hanno Matthaei, Philipp Lingohr, Savita Bisht, Peter Brossart, Georg Feldmann

“…Treatment of NEN patients remains challenging due to lack of prospective evidence on the choice of ideal therapeutic sequence and therapeutic efficacy in specific individual scenarios. Methods. Clinical data on 110 consecutive patients suffering from NEN treated at a single German university center were analyzed, therapeutic regimens applied were assessed, and the outcome was evaluated. …”
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Association of serum magnesium and calcium with metabolic syndrome: a cross-sectional study from the Qatar-biobank by Raneem Alsheikh, Haneen Aldulaimi, Rami Hinawi, Fatima Al-Sadi, Alanoud Al-Baker, Aldana Alkuwari, Muhammad Sameer, Ghalya Al-Abdulla, Zumin Shi, Giridhara Rathnaiah Babu

“…Although Magnesium (Mg) and Calcium (Ca) have been individually linked to MetS, the impact of the calcium-to-magnesium ratio (Ca: Mg) on MetS remains unclear, especially in the adult population of Qatar. …”
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A qualitative exploration of owner experiences following dog adoption by Bethany Joy Moyer, Helen Zulch, Beth Ann Ventura, Oliver Burman

“…Future research should incorporate a longer time-frame to better understand how and when dogs adjust to a home, and as there is variation in dog behaviour during adjustment, it must also account for individual differences. As we develop a better understanding of how to characterise this period, adopters can be better prepared for the initial months of dog ownership, and interventions can be individualised to improve owner experience and dog welfare.…”
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Dyadic examination of rumination and depressive symptoms in Chinese heterogeneous young couples: the differential role of gender by Xiaoyu Liu, Anji Zhou, Zhuyun Jin, Zhuo Rachel Han, Jing Qian, Hui Wang

“…Couples completed self-reported questionnaires assessing rumination and depressive symptoms separately, using the Ruminative Response Scale (RRS) and the Center for Epidemiologic Studies Depression Scale (CES-D).ResultsThe results of a series of actor-partner interdependence models (APIM) showed that, on the intrapersonal level, rumination was positively and significantly associated with an individual’s own depressed affect, somatic and retarded activity, and interpersonal distress. …”
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Wild Boar Attacks on Hunting Dogs in Czechia: The Length of the Hunting Season Matters by Jana Adámková, Karolína Lazárková, Jan Cukor, Hana Brinkeová, Jitka Bartošová, Luděk Bartoš, Kateřina Benediktová

“…This study investigated the impact of increased hunting pressure—both across the hunting season and within individual hunting events—on the risk of wild boar attacks on hunting dogs, i.e., the length of the hunting season (2.68 ± 0.76 months, mean ± standard deviation), the number of driven hunts per season (3.99 ± 0.43), the intervals between hunts (17.85 ± 4.83 days), the number of wild boars harvested per season (14.46 ± 13.10), and the number of participants (23.8 ± 10.69) and dogs (4.56 ± 2.66) involved per hunt. …”
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A data driven approach for soft tissue biomarker identification linked to Chiari-like malformation and syringomyelia by Jake Cumber, Jake Cumber, Emma Scales-Theobald, Emma Scales-Theobald, Clare Rusbridge, Clare Rusbridge, Clare Rusbridge, Kevin Wells, Kevin Wells

“…The associated neuro-disability in affected individuals compromises quality of life. CM is characterized by overcrowding of the brain and cervical spinal cord and is predisposed by skull-base shortening and miniaturization with brachycephalic toy dogs overwhelmingly represented. …”
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Glucagon-like peptide 1 receptor agonists in obesity treatment - a literature review by Aleksander Jentkiewicz, Esmail Haj Obeid, Jakub Ulrych, Jan Krupa, Maciej Malinowski, Michał Krasowski, Alicja Kalinowska, Wiktoria Pietras, Adrian Kozieł, Zofia Kurek

“…Introduction and Purpose: Obesity is an escalating global health challenge, affecting over 2 billion individuals worldwide, contributing to many challenges for healthcare providers such as cardiovascular disorders, cancers, and type 2 diabetes mellitus. …”
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Rap1 and mTOR signaling pathways drive opposing immunotoxic effects of structurally similar aryl-OPFRs, TPHP and TOCP by Bilin Zhao, Shuang Zheng, Gaoxiang Yang, Zhijun He, Jiewei Deng, Lijuan Luo, Xinyan Li, Tiangang Luan

“…This study sought to address the knowledge gap by integrating transcriptomic and metabolomic analyses to elucidate the intricate mechanisms. During individual omics analyses, we unfortunately only obtained highly similar results for both TPHP and TOCP, failing to identify the key reasons for their differences. …”
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Machine learning algorithm for predict the in-hospital mortality in critically ill patients with congestive heart failure combined with chronic kidney disease by Xunliang Li, Zhijuan Wang, Wenman Zhao, Rui Shi, Yuyu Zhu, Haifeng Pan, Deguang Wang

“…In addition, the LIME algorithm explains the individualized predictions.Conclusions In conclusion, our study accomplished the successful development and validation of ML models for predicting in-hospital mortality in critically ill patients with CHF combined with CKD. …”
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A novel ubiquitination-related gene signature for overall survival prediction in patients with liver hepatocellular carcinoma by Xiuyun Chen, SenLin Li, Lixue Cao, Shaoxian Chen, Qiuxiong Lin, Shilong Zhong

“…Abstract Liver hepatocellular carcinoma (LIHC) is a highly heterogeneous disease, necessitating the discovery of novel biomarkers to enhance individualized treatment approaches. Recent research has shown the significant involvement of ubiquitin-related genes (UbRGs) in the progression of LIHC. …”
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True cancer stem cells exhibit relative degrees of dormancy and genomic stability by Sanford H. Barsky, Krista Mcphail, Justin Wang, Jordan Dillard, Crystal J. Beard, Yin Ye

“…Methods: Using a human PDX, Mary-X, that overall expressed a strong cancer stem cell phenotype, the study conducted both GPP-labelled retroviral transfection and fluorescent microsphere uptake studies to distinguish proliferating from dormant cells and array CGH to identify regions of amplifications (gains) and deletions (losses) on the overall Mary-X population and then applied derived probes by FISH on individual cells to identify a genomically stable subpopulation. …”
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Residual transmission of schistosomiasis in Ndikinimeki Health District (Centre Region, Cameroon) despite implementation of complementary control strategies: Prospects for eliminat... by Hervé Kengne Fogang, Hugues C. Nana Djeunga, Alvine C. Kengne-Fokam, Murielle C. Tchami Mbagnia, Flobert Njiokou, Dickson S. Nsagha, Emmanuel Yenshu, Joseph Kamgno

“…The assessment of the impact of this package of interventions revealed that only a few individuals were still infected with Schistosoma mansoni. …”
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Telephone coaching supports exercise in people with prediabetes and diabetes: A mixed-methods study by Ana Paula Delgado Bomtempo, Gabriela Lima de Melo Ghisi, Mariana Balbi Seixas, Adriano Luiz Pereira, Paul Oh, Danielle Aparecida Gomes Pereira, Lilian Pinto da Silva

“…Results: Thirty-one individuals (20 to 74 years old, 55% male, 71% type 2 diabetes) answered, on average, 4.0 ± 1.4 phone calls. …”
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MetALD: Clinical aspects, pathophysiology and treatmentKeypoints by Jordi Gratacós-Ginès, Silvia Ariño, Pau Sancho-Bru, Ramon Bataller, Elisa Pose

“…Furthermore, metabolic risk factors and alcohol often co-exist in the same individuals and have recently been shown to act synergistically to markedly increase the risk of liver disease. …”
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The success rate of infrazygomatic mini-implants placed with and without surgical guides: a historical control study by Lixian Yuan, Ruifeng Zhao, Jingjing Liu, Rui Tang, Shizhu Bai, Xin Liu

“…In this study, we introduced a two-trajectories surgical guide and investigated the success rate of infrazygomatic mini-implants under the guidance of the template. Methods An individualized surgical guide was fabricated based on the cone-beam computed tomography images, digital intraoral scanning images and the predesigned insertion plans. …”
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Plantar Temperature Response to Walking in Diabetes with and without Acute Charcot: The Charcot Activity Response Test by Bijan Najafi, James S. Wrobel, Gurtej Grewal, Robert A. Menzies, Talal K. Talal, Mahmoud Zirie, David G. Armstrong

“…We examined dynamic changes in plantar temperature (PT) as a function of graduated walking activity to quantify thermal responses during the first 200 steps. Methods. Fifteen individuals with Acute Charcot neuroarthropathy (CN) and 17 non-CN participants with type 2 diabetes and peripheral neuropathy were recruited. …”
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