Decellularized Human Stromal Lenticules Combine with Corneal Epithelial-Like Cells: A New Resource for Corneal Tissue Engineering by Shuai Qin, Shuai Zheng, Bing Qi, Rui Guo, Guanghui Hou

“…The lack of donor corneal tissue or the immunological rejection remains a challenge for individuals with limbal stem cell deficiency (LSCD) who are treated with keratoplasty. …”
Get full text

Analysis of Method Performance for Quantitative Assessment of Listeria monocytogenes in Queso Fresco Cheese by Neha Singh, Ravinder Reddy, Karina Hettwer, Kirstin Frost, Matthew Kmet, Steffen Uhlig

“…Statistical analysis was conducted to analyze test sample preparation and evaluate the performance of the quantitative method by utilizing participant’s data. Although individually inoculated, the samples were considered replicates based on the standard deviation values obtained from the Q/Hampel method. …”
Get full text

Bone Marrow Neutrophils of Multiple Myeloma Patients Exhibit Myeloid-Derived Suppressor Cell Activity by Julia Petersson, Sandra Askman, Åsa Pettersson, Stina Wichert, Thomas Hellmark, Åsa C. M. Johansson, Markus Hansson

“…Moreover, NDG isolated from the blood of both myeloma patients and healthy individuals could inhibit T-cell proliferation and IFN-γ production. …”
Get full text

Exploring the Effectiveness of Machine Learning and Deep Learning Techniques for EEG Signal Classification in Neurological Disorders by Souhaila Khalfallah, William Puech, Mehdi Tlija, Kais Bouallegue

“…Hence, our findings show impressive accuracy, with the random forest model achieving 99.85% accuracy in classifying autism vs. healthy subjects and 100% accuracy in distinguishing healthy individuals from those with dementia using Support Vector Machines (SVM). …”
Get full text

Genetic Variants of Neurotransmitter-Related Genes and miRNAs in Egyptian Autistic Patients by Ahmed M. Salem, Samira Ismail, Waheba A. Zarouk, Olwya Abdul Baky, Ahmed A. Sayed, Sawsan Abd El-Hamid, Sohair Salem

“…This work studied the association of autism with genetic variations in neurotransmitter-related genes, including MAOA uVNTR, MAOB rs1799836, and DRD2 TaqI A in 53 autistic patients and 30 healthy individuals. The study also analyzed sequence variations of miR-431 and miR-21. …”
Get full text

Alternative Expression Pattern of MALT1-A20-NF-κB in Patients with Rheumatoid Arthritis by Xu Wang, Lihua Zhu, Ziwei Liao, Fan Zhang, Ling Xu, Yan Xu, Shaohua Chen, Lijian Yang, Yi Zhou, Yangqiu Li

“…Real-time PCR was used to determine the expression level of MALT1, MALT-V1, A20, and NF-κB genes in RA and healthy individuals (HI). Significantly lower A20 expression was found in RA patients compared with those in the healthy group, while NF-κB overexpression could be detected in patients with RA. …”
Get full text

Food insecurity increases the risk of overweight and chronic diseases in adolescents: a systematic review and meta-analysis by Chong Zhou, Hongrui Miao, Yingjun Zhao, Xiaohong Wan

“…To investigate the relationship between food insecurity (FI) and overweight/obesity (OW/OB) or corresponding chronic diseases in adolescents, 33 studies with 181 135 individuals were included in this meta-analysis. Six studies and 10 studies, reported a higher risk of overweight and obesity in adolescents experiencing FI, respectively (OR 1.38, 95 % CI 1.201.58, P < 0.0001; OR 1.11, 95 % CI 1.011.22, P = 0.035, respectively). …”
Get full text

Relationship between personality traits and spontaneous coronary artery dissection risk: evidence from Mendelian randomization by Kun Zheng, Kun Zheng, Mengdi Wu, Junhua Wang, Junhua Wang, Jinjin Sun, Yuqian Li, Peng Wang, Zhiyue Zhang, Xiuming Pan, Yifeng Yang, Tianqi Li, Yujie Guo

“…BackgroundSpontaneous coronary artery dissection (SCAD) significantly contributes to myocardial infarction among young individuals. Despite the elusive nature of its etiology, empirical evidence indicates a substantial correlation between sociopsychological factors and the disorder. …”
Get full text

Multi-Scale Long- and Short-Range Structure Aggregation Learning for Low-Illumination Remote Sensing Imagery Enhancement by Yu Cao, Yuyuan Tian, Xiuqin Su, Meilin Xie, Wei Hao, Haitao Wang, Fan Wang

“…However, most existing methods can only individually exploit the general long-range or short-range structures shared across most images at a single scale, thus limiting their generalization performance in challenging cases. …”
Get full text

Dexamethasone Provides Effective Immunosuppression for Improved Survival of Retinal Organoids after Epiretinal Transplantation by Bikun Xian, Ziming Luo, Kaijing Li, Kang Li, Mingjun Tang, Runcai Yang, Shoutao Lu, Haijun Zhang, Jian Ge

“…Retinal organoids were then seeded onto poly(lactic-co-glycolic) acid (PLGA) scaffolds and implanted into rhesus monkey eyes (including a healthy individual and three monkeys with chronic ocular hypertension (OHT) induction) and subjected to different post-operative immunosuppressant treatments; 8 weeks after the experiment, histological examinations were carried out to assess the success of the different treatments. …”
Get full text

Sample size calculations based on day-to-day variability of stress biomarkers in persons with dementia and their family caregivers by Azita Emami, Jeehye Jun, Gabriella Engström, Lars Berglund, Töres Theorell

“…Introduction: Accurate estimates of intra-individual variability are necessary for proper design of clinical trials and epidemiological studies where the stress biomarkers cortisol and dehydroepiandrosterone sulfate (DHEA-S) are measured for dyads of persons with dementia (PWDs) and their family caregivers (FCGs). …”
Get full text

A soft tick vector of Babesia sp. YLG in Yellow-legged gull (Larus michahellis) nests by Bonsergent, Claire, Vittecoq, Marion, Leray, Carole, Jouglin, Maggy, Buysse, Marie, McCoy, Karen D., Malandrin, Laurence

“…We collected ticks over four years, maintained certain individuals through moulting or oviposition, and dissected fresh ticks to isolate different organs and test for the presence of the parasite using molecular assays. …”
Get full text

Beyond age: Decoding the investment DNA of generations Z and Y in Indonesia by Debbi Chyntia Ovami, Henny Zurika Lubis, Esa Setiana, Ita Mustika, Sari Wulandari

“…Investment decisions are a matter of how individuals should allocate funds into investment forms that provide future benefits. …”
Get full text

Thermodynamic Properties of γ- and δ-Lactones: Exploring Alkyl Chain Length Effect and Ring-Opening Reactions for Green Chemistry Applications by Ana L. R. Silva, Gastón P. León, Vladimír Lukeš, Erik Klein, Maria D. M. C. Ribeiro da Silva

“…Finally, the thermochemistry of individual steps of lactone ring opening and successive decarboxylation mechanism, including the identification of transition states, was studied using the M06-2X/6-311++G(d,p) approach.…”
Get full text

Mapping dynamic regulation of gene expression using single-cell transcriptomics and application to complex disease genetics by Hanna Abe, Phillip Lin, Dan Zhou, Douglas M. Ruderfer, Eric R. Gamazon

“…However, the identification of gene-level associations in distinct cell types faces several challenges, including the limited reference resources from population-scale studies, data sparsity in single-cell RNA sequencing, and the complex cell state pattern of expression within individual cell types. Here, we develop genetic models of cell-type-specific and cell-state-adjusted gene expression in mid-brain neurons undergoing differentiation from induced pluripotent stem cells. …”
Get full text

Videofluoroscopic swallowing study predicts clinical outcomes in critically Ill children with dysphagia: a retrospective observational study by Yoonju Na, Jaeyoung Choi, Jihong Choi, Su Mi Oh, Hyuna Jang, Suein Choi, Joongbum Cho, Jeong-Yi Kwon

“…Any occurrence of aspiration throughout the examination was deemed as aspiration. All individuals displaying aspiration were found to have silent aspiration. …”
Get full text

Morale in Old Age and Its Association with Sociodemographic, Social, and Health-Related Factors in Different Age Groups by Marina Näsman, Johan Niklasson, Jan Saarela, Mikael Nygård, Birgitta Olofsson, Yngve Gustafson, Fredrica Nyqvist

“…The sample consisted of 9,047 individuals aged between 65 and 86 years from Ostrobothnia and Southern Ostrobothnia in Finland, and Västerbotten in Sweden. …”
Get full text

A case study in statistical software development for advanced evidence synthesis: the combined value of analysts and research software engineers by Naomi Bradbury, Tom Morris, Clareece Nevill, Janion Nevill, Ryan Field, Suzanne Freeman, Nicola Cooper, Alex Sutton

“…Aim Here, we present our experience of developing production grade web-apps from the point-of-view of individuals trained primarily as statisticians rather than software developers in the hopes of encouraging and inspiring other groups to develop valuable open-source statistical software whilst also learning from our experiences. …”
Get full text

A concise practical clinical guide to identifying spasticity in neurological shoulder dysfunction by Damon Hoad, Stephen Ashford, Stephen Ashford, Ganesh Bavikatte, Rachel Farrell, Rachel Farrell, Adrian Robertson, Jörg Wissel, Jörg Wissel

“…However, there is a current discrepancy between the diagnosis of arm spasticity and the subsequent assessment and treatment of spasticity in people with shoulder involvement.ObjectiveAn expert panel aimed to establish a consensus and provide a simple structured approach to identifying and assessing people with spasticity of the hemiplegic shoulder.MethodsA consensus group of six spasticity experts were interviewed individually via 1-h video calls to ascertain how they assess people with arm spasticity for shoulder involvement. …”
Get full text

Nursing of a patient with gout of damp-heat stagnation syndrome combined with erosive gastritis treated with auricular acupoint therapy combine with pricking and cupping therapy (耳... by ZHU Jianmei (朱建妹), CHEN Hui (陈慧), ZHANG Xiaolin (张小林), LIAO Xuefeng (廖雪锋)

“…In addition to routine nursing, individualized auricular acupoint treatment including auricular bloodletting and pressing combined with pricking and cupping therapy were carried out, aiming at relieving heat and detoxification at early stage of disease, promoting blood circulation, dredging collaterals and regulating qi at midterm and invigorating spleen and warming kidney Yang and end stage of treatment. …”
Get full text