Opioidergic tuning of social attachment: reciprocal relationship between social deprivation and opioid abuse by Julia A. Galiza Soares, Samantha N. Sutley-Koury, Matthew B. Pomrenze, Matthew B. Pomrenze, Jason M. Tucciarone

“…Individuals misusing opioids often report heightened feelings of loneliness and decreased ability to maintain social connections. …”
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Evaluation of Antioxidant Properties of Residual Hemp Leaves Following Optimized Pressurized Liquid Extraction by Vassilis Athanasiadis, Martha Mantiniotou, Dimitrios Kalompatsios, Ioannis Makrygiannis, Aggeliki Alibade, Stavros I. Lalas

“…The results showed that after three 5 min PLE cycles, the recovered individual polyphenols were comparable (<i>p</i> > 0.05) to a 45 min STE (19.34 and 20.84 mg/g, respectively), as well as in antioxidant capacity assays and other bioactive compounds. …”
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Large-scale data mining of four billion human antibody variable regions reveals convergence between therapeutic and natural antibodies that constrains search space for biologics dr... by Pawel Dudzic, Dawid Chomicz, Jarosław Kończak, Tadeusz Satława, Bartosz Janusz, Sonia Wrobel, Tomasz Gawłowski, Igor Jaszczyszyn, Weronika Bielska, Samuel Demharter, Roberto Spreafico, Lukas Schulte, Kyle Martin, Stephen R. Comeau, Konrad Krawczyk

“…It was previously demonstrated that, despite the immense sequence space, different individuals can produce the same antibodies. It was also shown that therapeutic antibodies, which typically follow seemingly unnatural development processes, can arise independently naturally. …”
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Longitudinal relationship between baseline Weight-Adjusted Waist Index and stroke risk over 8 years in Chinese adults aged 45 and older: a prospective cohort study by Xiaoqiang Li, Xiangmao Zhou, Hui Du, Hui Wang, Zhijian Tan, Yaqing Zeng, Zhibin Song, Guifeng Zhang

“…BackgroundThis study explores the longitudinal relationship between the Weight-Adjusted Waist Index (WWI), an innovative obesity metric, and stroke incidence in aged 45 and older Chinese adults.MethodsData from 9,725 individuals aged 45 years and older were analyzed from the China Health and Retirement Longitudinal Study (2011–2020). …”
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Patient Complications after Interscalene Block: A Retrospective Comparison of Liposomal Bupivacaine to Nonliposomal Bupivacaine by Jacob L. Hutchins, Jason Habeck, Zac Novaczyk, Richard Campbell, Christopher Creedon, Ellen Spartz, Michael Richter, Jeremy Wolter, Gaurav Suryawanshi, Alexander Kaizer, Aaron A. Berg

“…Medical records were individually reviewed for surgical procedure, block medications, complications related to the block or surgical procedure, phone calls to the healthcare system for issues related to opioids or pain within 3 and within 30 days, readmissions within 30 days, and emergency room visits for complications within 3 and 30 days. …”
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Digital connection, real bonding: Brief online chats boost interpersonal closeness regardless of the conversational topic by Chiara Fini, Vanessa Era, Giovanna Cuomo, Ilenia Falcinelli, Mattia A. Gervasi, Matteo Candidi, Claudia Mazzuca, Marco Tullio Liuzza, Bodo Winter, Anna M. Borghi

“…The results of the first experiment were replicated, reinforcing the idea that the quality of the virtual exchange—rather than the topic itself—plays a crucial role in fostering feelings of closeness between individuals.…”
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NF-κB-94ins/del ATTG Genotype Contributes to the Susceptibility and Imbalanced Th17 Cells in Patients with Immune Thrombocytopenia by Jie Yu, Mingqiang Hua, Xueyun Zhao, Rui Wang, Chaoqing Zhong, Chen Zhang, Ruiqing Wang, Guosheng Li, Na He, Ming Hou, Daoxin Ma

“…Compared with controls, NF-κB gene expression was significantly decreased and WW or WD genotype ITP patients displayed higher mRNA expression than DD individuals. Similarly, the mRNA expression of NLRP3 was also increased in the WW genotype. …”
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Dietary Glycemic Index, Dietary Glycemic Load, Blood Lipids, and Coronary Heart Disease by Edgar Denova-Gutiérrez, Gerardo Huitrón-Bravo, Juan O. Talavera, Susana Castañón, Katia Gallegos-Carrillo, Yvonne Flores, Jorge Salmerón

“…Results. IIn the 5,830 individuals aged 20 to 70 who were evaluated, dietary GI and GL were significantly associated with HDL-C, LDL-C, LDL-C/HDL-C ratio, and triglycerides serum levels. …”
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Staphylococcus aureus carriage is associated with microbiome composition in the nares and oropharynx, not the hand, of monozygotic twins by Mark R. Dalman, W. Brian Simison, Danny Nielsen, Sabana Bhatta, Noor Ramahi, Clair Yee, Dipendra Thapaliya, Jhalka Kadariya, Shanice Cheatham, Hailee Olson, Tara C. Smith

“…BackgroundStaphylococcus aureus is a gram-positive bacterium commonly found in the nares and oropharynx of one in three individuals and has the potential to cause significant health problems. …”
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Cuckoo Hosts Fine‐Tune Their Egg Rejection After Experiencing a Parasitism Event by Bin Li, Longwu Wang, Jianping Liu, Wei Liang

“…When a single pure white egg of the white‐rumped munia (Lonchura striata) or a blue model egg was individually added to the nest of the grey bushchat, the rejection rate for the white‐rumped munia eggs was as high as 93.3%, whereas the rejection rate for the blue model egg was minimal (5.56%). …”
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The status of care for youth with type 1 diabetes within and coming from humanitarian crises settings: a narrative review by Steven James, Samira B. Jabakhanji, Roopa Mehta, John McCaffrey, Maisoon Mairghani, Dominika Bhatia, Olive James, Sylvia Kehlenbrink, Philippa Boulle, Kiran Mejia Mehta, David Simmons, Edward W. Gregg

“…Results Glycaemic management was consistently suboptimal in HCS. However, among individuals coming from HCS, glycaemia varied. Across both groups, data relating to blood pressure, lipids, severe hypoglycaemia or diabetic ketoacidosis were either unavailable or limited. …”
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Religiosity as a potential mediator for violence in childhood and adulthood: results from a Brazilian nationally representative survey by Homero Vallada, Ronaldo Laranjeira, Juliane Piasseschi de Bernardin Gonçalves, Giancarlo Lucchetti, Maria do Rosario Dias Latorre

“…However, while there was a significant association between suffering violence during childhood and suffering and/or perpetrating violence in adulthood, religiosity did not mediate this relationship.Conclusions Although religious individuals self-reported less violence suffered in childhood, religiosity did not show evidence of being a potential mediator for childhood and adulthood violence (experienced and/or perpetrated). …”
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Screening for transcriptomic associations with Swine Inflammation and Necrosis Syndrome by Katharina Gerhards, Sabrina Becker, Josef Kuehling, Mirjam Lechner, Hermann Willems, Robert Ringseis, Gerald Reiner

“…Abstract Background The recently identified swine inflammation and necrosis syndrome (SINS) affects tail, ears, teats, coronary bands, claws and heels of affected individuals. The primarily endogenous syndrome is based on vasculitis, thrombosis, and intimal proliferation, involving defence cells, interleukins, chemokines, and acute phase proteins and accompanied by alterations in clinical chemistry, metabolome, and liver transcriptome. …”
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Automation-aided construction and characterization of Bacillus subtilis PrsA strains for the secretion of amylases by Felix Hamburger, Niels Schlichting, Michael Eichenlaub, Paul Igor Costea, Christopher Sauer, Stefan Jenewein, Johannes Kabisch, Johannes Kabisch

“…Following strain selection and deletion of major extracellular proteases, several hundred individual strains were created and screened using a stepwise and modular automation approach combined with amplicon sequencing. …”
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Intravenous esketamine in pediatric Rett syndrome: An open-label, early phase 1 pilot study by Huiping Li, Shu Liu, Caimei Lin, Yuchao Wu, Xiuping Wu, Yukun Huang, Yajun Wu, Xiubin Tong, Xiu Xu

“…Three participants showed minimal improvements in their Clinical Global Impression Scale-Improvement, Rett Syndrome Behavior Questionnaire, and Revised Motor Behaviors Assessment Scale scores. However, individual differences were observed in the efficacy measures. …”
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Social Justice and Health Equity in the Teaching and Learning Environment: Perspectives of Academic Leaders in Health Profession Education Programmes by Benita Cohen, Debra Beach Ducharme, Moni Fricke, Alan Katz, Laura MacDonald, Donna Martin, Christen Rachul, Gayle Restall, Dana Turcotte

“…The objective of this study was to explore the perspectives of health profession education leaders about their individual and collective vision for a TLE that promotes SJ/HE and its actualization. …”
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Synergistic action between a synthetic cannabinoid compound and tramadol in neuropathic pain rats by Quiñonez-Bastidas Geovanna Nallely, Osuna-Martínez Ulises, Reda-Licea Ana Laura, López-Ortíz Manuel, Regla Ignacio, Navarrete Andrés

“…A plasma acute toxicity study was carried out to assess the hepatic, renal, and heart functions after an individual or combined administration of the drugs, as well as histology using the hematoxylin-eosin or Masson-trichome method. …”
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Effects of Core Stability and Mckenzie Exercises in Low Back Pain with Extension Preference by Hamidreza Nemati, Hoda Niknam, Khosro Khademi Kalantari, Alireza Akbarzadeh Baghban, Negin Jalili

“…Materials and Methods: In this clinical trial, 22 patients received core stability exercises, and 22 received McKenzie exercises based on individual mechanical assessments. Before treatment, each patient underwent mechanical assessment via the McKenzie mechanical assessment form, pain assessment using the visual analog scale, disability evaluation with the Oswestry disability index questionnaire, muscle control, as well as function assessment with unilateral single limb stance, and range of motion evaluation using fingertip-to-floor distance measurements. …”
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Evaluation of the effects of short-term PM2.5 exposure on triglyceride-glucose metrics in a population in eastern China by Zhenpeng Guo, Chenchen Yang, Qiang Zhang, Xinling Shi, Xiaona Li, Qun Zhang, Jianming Wang

“…Methods We conducted an ecological study on a cohort comprising 39,011 individuals who had undergone at least two physical examinations between 2017 and 2019 at the First Affiliated Hospital of Nanjing Medical University, China. …”
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Circulating Angiogenic Growth Factors in Diabetes Patients with Peripheral Arterial Disease and Exertional Leg Pain in Ghana by Kwame Yeboah, Jennifer A. Agyekum, Eric Kyei Baafour, Daniel A. Antwi, Afua B. Adjei, Vincent Boima, Ben Gyan

“…In this cross-sectional study, ankle-brachial index was measured with oscillometrically and exertional leg symptoms were screened with Edinburgh claudication questionnaire in 140 diabetes patients and 110 nondiabetes individuals. Circulating levels of Ang-1, Ang-2, and VEGF were measured with immunosorbent assay. …”
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