Promising New Treatments for Psoriasis by Sarah Dubois Declercq, Roxane Pouliot

“…However, the available treatments are only able to relieve the symptoms and lives of individuals. The discovery of new immunological factors and a better understanding of psoriasis have turned to the use of immunological pathways and could develop new biological drugs against specific immunological elements that cause psoriasis. …”
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Therapeutics of bitter plants from Northeast region of India and their pharmacological and phytochemical perspectives by Bhaskar Das, Bharat Gopalrao Somkuwar, Sushil Kumar Chaudhary, Evanylla Kharlyngdoh, Careen Liza Pakyntein, Kishor Basor, Jitendra Kumar Shukla, Pardeep Kumar Bhardwaj, Pulok Kumar Mukherjee

“…Natural resources have been used for food and medicine since the beginning of human civilization, and they have always been a low-cost, easily accessible source for individuals. Northeast region of India (NER) represents a significant portion of India's flora and fauna. …”
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Beneficial microbiome and diet interplay in early-onset colorectal cancer by Zhengyuan Zhou, Linda Kleis, Ana Depetris-Chauvin, Stefanie Jaskulski, Victoria Damerell, Karin B Michels, Biljana Gigic, Ute Nöthlings, Gianni Panagiotou

“…Although the risk of developing CRC increases with age, approximately 10% of newly diagnosed cases occur in individuals under the age of 50. Significant changes in dietary habits in young adults since industrialization create a favorable microenvironment for colorectal carcinogenesis. …”
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Helioseismic inference of the solar radiative opacity by Gaël Buldgen, Jean-Christophe Pain, Philippe Cossé, Christophe Blancard, Franck Gilleron, Anil K. Pradhan, Christopher J. Fontes, James Colgan, Arlette Noels, Jørgen Christensen-Dalsgaard, Morgan Deal, Sergey V. Ayukov, Vladimir A. Baturin, Anna V. Oreshina, Richard Scuflaire, Charly Pinçon, Yveline Lebreton, Thierry Corbard, Patrick Eggenberger, Peter Hakel, David P. Kilcrease

“…We present opacity profiles derived from helioseismic inferences and compare them with detailed theoretical computations of individual element contributions using three different opacity computation codes, in a complementary way to experimental results. …”
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Wing Morphometry and Acoustic Signals in Sterile and Wild Males: Implications for Mating Success in Ceratitis capitata by João Maria Gomes Alencar de Souza, Paulo Augusto de Lima-Filho, Wagner Franco Molina, Lúcia Maria de Almeida, Milson Bezerra de Gouveia, Francisco Pepino de Macêdo, Raul Alberto Laumann, Beatriz Aguiar Jordão Paranhos

“…Among males that emit buzz signals, wild males obtained copulation more frequently than males in Groups 2 and 3. The individuals of Group 3 achieved more matings than those in Group 2. …”
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Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures by Stolarczyk Mariusz, Apola Anna, Maślanka Anna, Kwiecień Anna, Opoka Włodzimierz

“…The precision of the method was high with RSD from 0.1 to 2.5 % and recovery of individual components was within the range of 100 ± 5 %. …”
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Assessment of the Sphericity of Submicrometer Particles Using a Single-particle Polar Nephelometer at an Urban Site in Japan by Maho Nakagawa, Tomoki Nakayama, Hiroshi Sasago, Yuki Kuruma, Hikari Yai, Shuhei Ogawa, Yange Deng, Michihiro Mochida, Yutaka Matsumi

“…Thus, to examine this property and its controlling factors, this study measured the scattering angular distributions of both thermodenuded and non-thermodenuded individual particles with a diameter of 500 nm in real time using a home-made polar nephelometer in Nagoya, Japan. …”
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Deciphering consciousness: The role of corticothalamocortical interactions in general anesthesia by Yuxi Zhou, Shiqian Huang, Tianhao Zhang, Daling Deng, Li Huang, Xiangdong Chen

“…General anesthesia is administered to millions of individuals each year, however, the precise mechanism by which it induces unconsciousness remains unclear. …”
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Effects of a 12-Week Exercise Training Program on Physical Function in Institutionalized Frail Elderly by Cristiane Batisti Ferreira, Pâmela dos Santos Teixeira, Geiane Alves dos Santos, Athila Teles Dantas Maya, Paula Americano do Brasil, Vinícius Carolino Souza, Cláudio Córdova, Aparecido Pimentel Ferreira, Ricardo Moreno Lima, Otávio de Toledo Nóbrega

“…The sample consisted of 37 elderly people of both genders, aged 76.1 ± 7.7 years, who were randomly allocated into 2 groups: 13 individuals in the exercise group (EG) and 24 in the control group (CG). …”
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Genomic characterization of chronic lymphocytic leukemia in patients of African ancestry by Cecilia Bonolo de Campos, Chantal E. McCabe, Laura A. Bruins, Daniel R. O’Brien, Sochilt Brown, Renee C. Tschumper, Cristine Allmer, Yuan Xiao Zhu, Kari G. Rabe, Sameer A. Parikh, Neil E. Kay, Huihuang Yan, James R. Cerhan, John N. Allan, Richard R. Furman, J. Brice Weinberg, Danielle M. Brander, Diane F. Jelinek, Marta Chesi, Susan L. Slager, Esteban Braggio

“…To begin to address this gap, we evaluated whether differences exist in the genetic and transcriptomic features of 157 AA and 440 EA individuals diagnosed with CLL. We sequenced 59 putative driver genes and found an increased frequency of high-impact mutations in AA CLL, including genes of the DNA damage repair (DDR) pathway. …”
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Comprehensive Overview of Ketone Bodies in Cancer Metabolism: Mechanisms and Application by Ziyuan Liang, Lixian Deng, Xiaoying Zhou, Zhe Zhang, Weilin Zhao

“…Nonetheless, numerous questions remain regarding the expression of key metabolic genes across different tumors, the regulation of their activities, and the impact of individual KBs on various tumor types. Further investigation is imperative to resolve the conflicting data concerning KB synthesis and functionality within tumors. …”
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When Things Are Not as They Appear: Assessing the Adequacy of Cluster Randomization When Outcome Events Are Rare at Baseline by Veronica Dinaj-Koci, Nanika Brathwaite, Lynette Deveaux, Sonya Lunn, Lesley Cottrell, Carole Harris, Bonita Stanton, Xiaoming Li, Sharon Marshall, Perry Gomez, Xinguang Chen

“…Not considering such individual differences could impact the integrity of trial outcomes.…”
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Passive Monitoring of Parkinson Tremor in Daily Life: A Prototypical Network Approach by Luc J. W. Evers, Yordan P. Raykov, Tom M. Heskes, Jesse H. Krijthe, Bastiaan R. Bloem, Max A. Little

“…Objective and continuous monitoring of Parkinson’s disease (PD) tremor in free-living conditions could benefit both individual patient care and clinical trials, by overcoming the snapshot nature of clinical assessments. …”
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Climate change, air pollution and chronic respiratory diseases: understanding risk factors and the need for adaptive strategies by Jiayu Xu, Zekang Su, Chenchen Liu, Yuxuan Nie, Liangliang Cui

“…Furthermore, this association can be modified by factors such as socioeconomic status, adaptability, individual behavior, medical services. Potential pathophysiological mechanisms linking climate change and increased risk of CRD involved pulmonary inflammation, immune disorders, oxidative stress. …”
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Exploring the Landscape of Digital Entrepreneurship among Disabled People: A Bibliometric Analysis by Rahmawati Rahmawati, Rochmat Aldy Purnomo, Ari Kuncara Widagdo, Noor Ismawati Jaafar, Farzana Parveen Tajudeen, Endang Dwi Amperawati, Sri Hartoko, Agus Dwianto

“…The research unveils trends, prominent contributors, leading publication outlets, and prevalent themes in digital entrepreneurship among individuals with disabilities. Furthermore, employing cartographic analyses with VOSviewer, the study maps out the interconnectedness and collaboration networks among authors, nations, and keywords, offering insights into the global research landscape in this critical area. …”
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Effects of Catastrophic Insect Outbreaks on the Harvesting Solutions of Dahurian Larch Plantations by Qi Jin, Lauri Valsta, Kari Heliövaara, Jing Li, Youqing Luo, Juan Shi

“…Stand simulation is based on an individual-tree growth system. A scenario approach is applied when simulating the effects of catastrophic pest outbreaks. …”
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A network analysis of postpartum depression and mother-to-infant bonding shows common and unique symptom-level connections across three postpartum periods by Norihiro Harasawa, Chong Chen, Sumiyo Okawa, Ryo Okubo, Toshio Matsubara, Shin Nakagawa, Takahiro Tabuchi

“…Our study aims to dissect their complex relationship through a graphical LASSO network analysis of individual symptoms in 5594 Japanese postpartum women, whose geographical distribution was nationally representative. …”
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Analysis of Gene Expression in an Inbred Line of Soft-Shell Clams (Mya arenaria) Displaying Growth Heterosis: Regulation of Structural Genes and the NOD2 Pathway by John J. Wilson, Janelle Grendler, Azaline Dunlap-Smith, Brian F. Beal, Shallee T. Page

“…To assess the biological basis of this growth heterosis, we characterized the complete transcriptomes of six individuals and identified differentially expressed genes by RNAseq. …”
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Comparisons of Tensile Fracturing Behaviors of Hydraulic Fully Graded and Wet-Screened Concretes: A Mesoscale Study by Lei Xu, Yongmiao Jin, Shuaizhao Jing, Jie Liu, Yefei Huang, Changqiao Zhou

“…To this end, a two-dimensional mesoscale modeling methodology is developed for simulating the tensile fracturing behaviors of hydraulic fully graded and wet-screened concretes, and extensive Monte Carlo simulations are performed. The individual effects of specimen size variation, variation of gradation and volume fraction of coarse aggregates, and the weaker interfacial transition zones surrounding the large coarse aggregates to be removed by wet-screening are detailed followed by the discussion on the combined effect of these three main factors. …”
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Case Report: Severe acute pancreatitis accompanied by gastric mucosal exfoliation hemorrhage: clinical alerts and novel insights by Yanquan Liu, Hehui Zhang, Minjuan Zeng, Jian Luo, Yun Lai, He Huang, Qinglin Xu, Yuan Liu

“…Acute pancreatitis (AP), a condition marked by its swift progression, substantial individual discrepancies, and profound concealment, poses a formidable challenge. …”
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