Impact of pharmacist-prescriber partnerships to track antibiotic prescribing in publicly funded primary care in the Cape Town metropole, South Africa: An implementation study by O Van Hecke, Y Adegoke, M Allwood, K von Pressentin, M Namane, C Butler, M Mendelson, R Coetzee

“…At each clinic, a prescriber-pharmacist team gathered prospective antibiotic prescribing data for ‘acute cough’, linked to clinical indication, and provided individual prescribing feedback through each clinic’s WhatsApp messaging platform about their prescribing quality (antibiotic dose, duration, frequency). …”
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Assessment of awareness of keratoconus and its relation to eye rubbing among Saudi Arabia population by Nuwayyir Abdullah Alqasimi, Lujain Hatim Aljohani, Renato Ambrósio, Renato Ambrósio, Renato Ambrósio, Renato Ambrósio, Renato Ambrósio, Bader Saad AlQahtani, Bader Saad AlQahtani, Nasser Saleh Al Haydar, Bdour Raja Alanazi, Danah Tariq Alfurayhan, Lina Sami Hussain Saber, Fatemah Saleh Alsalem, Nawaf Abdullah Alqahtani, Jose Manuel Vargas

“…KC affects 1.38 per 1,000 individuals globally, with a higher prevalence in Asian and Middle Eastern populations. …”
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Current and future burden of breast cancer in Asia: A GLOBOCAN data analysis for 2022 and 2050 by Mengxia Fu, Zhiming Peng, Min Wu, Dapeng Lv, Yanping Li, Shuzhen Lyu

“…Both incidence and mortality rates were notably higher among older individuals, especially in countries with high human development index. …”
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Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease by Thomas F Baumert, Charlotte Bach, Patrick Pessaux, Catherine Schuster, Frank Jühling, Sarah C Durand, Yujin Hoshida, Fabien Zoulim, Atish Mukherji, Naoto Fujiwara, Marine A Oudot, Armando Andres Roca Suarez, Michel L Tremblay, Barbara Testoni, Joachim Lupberger, Romain Parent, Laurent Mailly, Nassim Dali-Youcef, Emanuele Felli, Maria Saez-Palma, Julien Moehlin, Alessia Virzì, Nicolas Brignon, Eugenie Schaeffer, Romain Martin, Laura Meiss-Heydmann, Zakaria Boulahtouf, Lea Girard, Emma Osswald, Carole Jamey, Daniel Brumaru, Bhuvaneswari Koneru

“…The clinical relevance was further explored in a cohort with metabolic disease by ranking patients according to PTPRD expression and analysing its association with metabolic disease markers.Results The analysis of individuals ranked according to PTPRD expression and Ptprd-deficient mice, showed that PTPRD levels were associated with hepatic glucose/lipid signalling and peroxisome function. …”
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The association between TyG index and cardiovascular mortality is modified by antidiabetic or lipid-lowering agent: a prospective cohort study by Changchang Fang, Nanqin Peng, Jiang Cheng, Xiyu Zhang, Wenli Gu, Zicheng Zhu, Xiaoping Yin, Zhiwei Yan, Jing Zhang, Peng Yu, Xiao Liu

“…Results A total of 5,046 adults (representing 42,753,806 individuals, weighted mean age 61.08 years [SE: 0.24]; 49.35% female) were analyzed. …”
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Dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) in patients with chronic coronary artery disease (CAD) - current state of knowledge and perspective... by Hubert Bochenek, Anna Bielicka, Michał Bzoma, Julia Gugulska, Irmina Czerepak, Marcin Kapij, Karolina Niewczas, Adrianna Brzozowska

“…Current European Society of Cardiology (ESC) guidelines recommend tailoring DAPT duration and composition based on individual patient risk factors for bleeding and ischemia. …”
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Protocol of a randomised trial of teriparatide followed by zoledronic acid to reduce fracture risk in adults with osteogenesis imperfecta by Jennifer Walsh, Catriona Keerie, Stuart H Ralston, Christopher J Weir, Muhammad K Javaid, WAYNE LAM, Bente L Langdahl, Jannie D Hald, Patricia Osborne

“…The Treatment of Osteogenesis Imperfecta with Parathyroid Hormone and Zoledronic Acid trial will determine if therapy with teriparatide (TPTD) followed by zoledronic acid (ZA) can reduce the risk of clinical fractures in OI.Methods and analysis Individuals aged ≥18 years with a clinical diagnosis of OI are eligible to take part. …”
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Healthy dietary patterns and the incidence of chronic kidney disease: results from a prospective cohort study by Yong-Ping Lu, Bin Xia, Xiao-Hua Wang, Qiang-Sheng He, Chang-Bo Qu, Ying-Ying Xie, Tian-Jiao Cui, Si-Qing Wu, Jin-Yu Zhao, Zhi-Hua Zheng, Ting Zhu, Jin-Qiu Yuan, Chun Tang

“…Results A total of 207,268 British individuals who completed at least one online 24-hour dietary recall assessment were included in this study. …”
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Longitudinal Survey of Astrovirus infection in different bat species in Zimbabwe: Evidence of high genetic Astrovirus diversity by Chidoti, Vimbiso, De Nys, Hélène, Abdi, Malika, Mashura, Getrude, Pinarello, Valérie, Chiweshe, Ngoni, Matope, Gift, Guerrini, Laure, Pfukenyi, Davies, Cappelle, Julien, Mwandiringana, Ellen, Missé, Dorothée, Gori, Elizabeth, Bourgarel, Mathieu, Liégeois, Florian

“…A study on Astrovirus circulation and diversity in different insectivorous and frugivorous chiropteran species roosting in trees, caves and building basements was carried out at 11 different sites across Zimbabwe. Pooled and individual faecal sampling methods were used for this study, with collection dates ranging from June 2016 to July 2021. …”
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Establishing primary care physician commitment in Canadian long-term care homes: a protocol for a modified e-Delphi study by Andrew P Costa, Aaron Jones, Darly Dash, Paula Rochon, Patrick Quail, Rachel D Savage, Henry Yu-Hin Siu, Lisa M McCarthy, Nathan Stall, Dee Tripp, Maya Potter, Paul Katz, Samantha Peck

“…The PCP’s commitment to LTC practice is theorised as the proportion of a physician’s practice dedicated to LTC, the number of residents for whom they provide care and the time spent on individual resident encounters. We aim to establish consensus on expectations concerning PCP commitment in Canadian LTC homes.Methods and analysis We describe a protocol for a two-round modified e-Delphi study assessing the consensus of an expert panel, guided by the RAND methodological guidance for conducting Delphi panels and the ACcurate COnsensus Reporting Document (ACCORD) guideline for healthcare-based consensus studies. …”
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Risk factors for Clostridioides difficile infection among patients diagnosed with inflammatory intestinal and rheumatological diseases in the biologic era by Helena Martínez-Lozano, Paula Saralegui-Gonzalez, Elena Reigadas, Pablo Ramón Fueyo-Peláez, Aurea García-García, José Miranda-Bautista, Luis Alcalá, Juan Carlos Nieto, María Elena Lobato-Matilla, Ignacio Marín-Jiménez, Patricia Muñoz, Luis Menchén

“…Conclusions IBD significantly increases the risk of CDI among patients treated with biologic therapy; although such treatments do not seem to individually increase the risk, the number of biologics received may be a new predictor of CDI.…”
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Case report: an unusual long-term evolution of a diffuse midline glioma, H3K27 altered by Michael Griessmair, Michael Griessmair, Claire Delbridge, Claus Zimmer, Eva Mayr, Arthur Wagner, Julian Canisius, Marie-Christin Metz, Benedikt Wiestler, Benedikt Wiestler

“…Better understanding this molecular cascade might help to identify novel targets for individualized therapies.…”
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Clinical efficacy of low‐dose Perampanel correlates with neurophysiological changes in familial adult myoclonus epilepsy 2 by Antonietta Coppola, Claudia Cuccurullo, Gianmaria Senerchia, Marica Rubino, Liana Veneziano, Francesco Brancati, Luigi Baratto, Valentina Virginia Iuzzolino, Leonilda Bilo, Pasquale Striano, Raffaele Dubbioso

“…Plain Language Summary: This study investigated the effects of low‐dose perampanel in individuals with Familial Adult Myoclonus Epilepsy2 (FAME2), a hereditary condition characterized by epilepsy and tremors. …”
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Neutralizing antibody responses to three XBB protein vaccines in older adults by Guo-Jian Yang, Mei Lu, Rui-Rui Chen, Shuang-Qing Wang, Sheng Wan, Xue-Dong Song, Guo-Ping Cao, Lei Lv, Xue-Juan He, Bing-Dong Zhan, Mai-Juan Ma

“…This study was therefore undertaken to investigate and compare neutralizing antibody responses to three XBB-containing protein-based vaccines (trivalent XBB.1.5 vaccine, bivalent Omicron XBB vaccine, and tetravalent XBB.1 vaccine) head-to-head in 90 individuals aged >65 years. The results showed that all three XBB-containing vaccines substantially enhanced the neutralizing antibody response, with 100% of vaccinees having detectable antibody titers against ancestral D614G and variants BA.5, XBB.1.5, JN.1, KP.2, and KP.3 after booster immunization. …”
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Relationship between prenatal metals exposure and neurodevelopment in one-year-old infants in the CLIMB study by Xiao-Yuan Fan, Xian-Shu Lin, Bing-Rui Yang, Han-Wen Zhang, Feng Tang, Jia-Jia Tang, He-Bin Chi, Toby Mansell, Noora Kartiosuo, Yin-Yin Xia, Ting-Li Han, Hua Zhang, Philip Baker, Richard Saffery

“…However, most studies focus on individual metals, neglecting combined effects. Objectives: We aimed to assess the effects of both single and combined prenatal metals exposure on one-year-old infants’ neurodevelopment. …”
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Altered O-Glycans in stimulated whole saliva from patients with primary Sjögren’s syndrome and non-pSS sicca by Sarah Kamounah, Kristina A. Thomsson, Christiane Elisabeth Sørensen, Eric Paul Bennett, Niclas G. Karlsson, Anne Marie Lynge Pedersen

“…The 50 most abundant glycans were identified and their intensity compared for each sample, reflecting the relative abundance of individual monosaccharide residues. Comparison of the compositions of O-glycans in SWS samples revealed higher relative levels of sialic acid (NeuAc) and lower levels of neutral amino-monosaccharides (HexNAc) in pSS and non-pSS sicca patients than in the healthy controls. …”
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Effect of probiotics on the growth, blood profile, and nutritional-metabolic profile of feedlot cattle by Flavia I. Mansilla, María C. Aristimuño Ficoseco, María H. Miranda, Marcela D’Urso Villar, Graciela M. Vignolo, María E. F. Nader-Macías

“…The suspensions consisted of (A) Lactobacillus acidophilus CRL2074, (B) Limosilactobacillus fermentum CRL2085, or (C) multistrain CRL2074 + CRL2085 + Limosilactobacillus mucosae CRL2069 formulations, against the control group. Individual samples were taken from each animal thrice throughout the assay (0, 45, and 105 days). …”
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A high fat, high sugar diet exacerbates persistent post-surgical pain and modifies the brain-microbiota-gut axis in adolescent rats by Sabrina Salberg, Matthew Macowan, Angela Doshen, Glenn R. Yamakawa, Marissa Sgro, Benjamin Marsland, Luke A. Henderson, Richelle Mychasiuk

“…Spearman correlation analyses were performed between individual microbial abundance and MRI diffusivity to determine if specific bacterial species were associated with PPSP-induced brain changes. …”
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Application of ATR-FTIR spectroscopy and multivariate statistical analysis in cancer diagnosis by Ao Song, Wanli Yang, Jun Wang, Yisa Cai, Lizheng Cai, Nan Pang, Ruihua Yu, Zhikun Liu, Chao Yang, Feng Jiang

“…The analysis of the receiver operating characteristic (ROC) curve demonstrated that the area under the curve (AUC) exceeded 0.95 for all models, with the LDA model achieving an accuracy rate of 99.4% in identifying lung cancer patients compared to healthy individuals. The findings suggest that the integration of ATR-FTIR spectroscopy with multiple machine learning models represents a promising auxiliary diagnostic method for clinical lung cancer diagnosis, enabling detection at the molecular level.…”
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Beyond the storms: Exploring predictors of posttraumatic stress and posttraumatic growth among survivors of hurricanes Irma and Maria in Puerto Rico by Marie-Claire Meadows, Noelle Serino, Dahianira M. Camacho-Monclova, Kaumudi Joshipura, Sarah R. Lowe

“…This analysis focused on 484 individuals who completed structured interviews 20 to 34 months after the hurricanes. …”
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