PrEP15-19 Choices: an implementation study protocol of HIV prevention with oral and long-acting injectable cabotegravir PrEP in real-world settings among sexual and gender minority... by Inês Dourado, Eliana Miura Zucchi, Laio Magno, Alexandre D Grangeiro, Márcia Thereza Couto, Mateus Westin, Eduardo Oliveira, Maria Mercedes Escuder, Dirceu Greco, Thais Regis Aranha Rossi, Fabiane Soares, Lorenza Dezanet, Paula Massa, Priscilla Caires, Ricardo de Paula Vasconcelos, Unaí Tupinambas, Beo Leite, Joilson Nascimento Paim, Guilherme Barreto Campos, Lucas Miranda Marques, Nathalia Suzart, Suilan Pedreira, DulceAurélia deSouza Ferraz, Dyemison Pinheiro, Eliane Sala, Raphaella Goulart, Ana Paula Silva, Erica Dumont Pena, Gabriella Jomara daSilva, Marília Greco, Matheus dePaula Alves

“…The study will include a sample of 550 HIV-negative adolescent men who have sex with men, non-binary individuals assigned male at birth, transgender men and women, aged 15–19 years, in three Brazilian capital cities. …”
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Clinical and cost-effectiveness of Knee Arthroplasty versus Joint Distraction for Osteoarthritis (KARDS): protocol for a multicentre, phase III, randomised control trial by Deborah D Stocken, Dennis G McGonagle, David Murray, Catherine Reynolds, Catherine Fernandez, David R Ellard, Andrew Metcalfe, Hemant Sharma, Paul Harwood, Hamish Simpson, Hemant Pandit, Susanne Arnold, Cerys Joyce Tassinari, Ruchi Higham, Isabelle Louise Smith, Ruben Mujica-Mota, Thomas William Hamilton, Julie Croft

“…The KARDS trial will investigate whether KJD is non-inferior to KR in terms of patient-reported postoperative pain 12 months post-surgery.Methods and analysis KARDS is a phase III, multicentre, pragmatic, open-label, individually randomised controlled non-inferiority trial comparing KJD with KR in patients with severe knee OA, employing a hybrid-expertise design, with internal pilot phase and process evaluation. 344 participants will be randomised (1:1) to KJD or KR. …”
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The efficacy of sodium-glucose transporter 2 inhibitors in patients with nonalcoholic fatty liver disease: A systematic review and meta-analysis by Hongsheng Li, Yanli Hou, Wenyong Xin, Lina Ding, Ying Yang, Yikun Zhang, Wenqi Wu, Zhibin Wang, Wenyu Ding

“…The meta-analysis revealed a beneficial effect of SGLT-2 inhibitors on liver functions and body weight, BMI, TG, HDL-C, and glucose homeostasis in patients with NAFLD, indicating that SGLT-2 inhibitors might be a clinical therapeutic strategy for these patients, especially individuals with concurrent type 2 diabetes mellitus (T2DM).…”
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Intravesical BCG in patients with non-muscle invasive bladder cancer induces trained immunity and decreases respiratory infections by J Alfred Witjes, Alina Vrieling, Mihai G Netea, Leo A B Joosten, Katja K H Aben, Sita H Vermeulen, Joost L Boormans, Antoine G van der Heijden, Boris Novakovic, Jelmer H van Puffelen, Liesbeth van Emst, Denise Kooper, Tahlita C M Zuiverloon, Ursula T H Oldenhof, Tessel E Galesloot, Lambertus A L M Kiemeney, Egbert Oosterwijk

“…An epigenomics approach combining chromatin immuno precipitation-sequencing and RNA-sequencing with in vitro trained immunity experiments identified enhanced inflammasome activity in BCG-treated individuals. Finally, germline variation in genes that affect trained immunity was associated with recurrence and progression after BCG therapy in NMIBC.Conclusion We conclude that BCG immunotherapy induces trained immunity in NMIBC patients and this may account for the protective effects against respiratory infections. …”
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Advancing early detection of organ damage and cardiovascular risk prevention: the Suzhou cardiometabolic health study protocol - exploring the role of oral microbiome and metabolic... by Mengmeng Zhu, Mengmeng Zhu, Yiwen Li, Wenting Wang, Longkun Liu, Wenwu Liu, Jiayu Yu, Qian Xu, Jing Cui, Yanfei Liu, Keji Chen, Yue Liu, Yue Liu

“…The study will be conducted in Suzhou City, Jiangsu Province, China, planning to include 5000-6000 eligible subjects, with inclusion criteria of age ≥18 years, excluding individuals with a history of CVD and other serious diseases. …”
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Delineation of reduced CTV2 on the basis of the characteristics and distribution of cervical lymph node metastasis in nasopharyngeal carcinoma by Zhiqiang Wang, Yi Yang, Chunlei Ge, Rui Tian, Sheng Cheng, Jingyu Gao, Yan Wang, Qi Yue, Zhiwei Wang, Qingqing He, Yuchuan Xu, Yan Li, Xudong Feng, Yanli Yang, Yong Zhang

“…We used image registration techniques to map patients’ neck metastatic lymph nodes onto a template CT of healthy individuals. Using MIM software, we integrated all patients’ lymph node images onto the template CT images and conducted an in-depth analysis of their distribution characteristics and metastatic patterns. …”
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Association between migraine severity and sleep quality: a nationwide cross-sectional study by Nura A. Almansour, Nura A. Almansour, Seham S. Alsalamah, Seham S. Alsalamah, Razan S. Alsubaie, Razan S. Alsubaie, Nada N. Alshathri, Nada N. Alshathri, Yasmeen A. Alhedyan, Yasmeen A. Alhedyan, Faisal Y. Althekair’s, Faisal Y. Althekair’s, Faisal Y. Althekair’s

“…BackgroundMigraine is a primary headache disorder that affects more than 1 billion individuals globally and imposes a significant disability burden on society. …”
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Monitoring poultry social dynamics using colored tags: Avian visual perception, behavioral effects, and artificial intelligence precision by Florencia B. Rossi, Nicola Rossi, Gabriel Orso, Lucas Barberis, Raul H. Marin, Jackelyn M. Kembro

“…However, maintaining the identity of individuals over time, especially in homogeneous poultry flocks, remains challenging for algorithms. …”
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Exploring the impact and mechanisms of behavioral activation on sleep disorders in colorectal cancer: a randomized controlled trial by Anlong Li, Runze Huang, Han Ge, Dajie Liu, Shaochun Liu, Yingxue Jia, Jiaying Chai, Xinyi Zheng, Lijun Liu, Chen Gan, Jian Xu, Ling Cheng, Mingjun Zhang, Huaidong Cheng

“…BA highlights the importance of activation, a strategy that encourages active participation in positive, meaningful activities to boost positive experiences and reduce negative emotions, which may have potential benefits for individuals with sleep disorders. This study explores the effects of BA on sleep disturbances, quality of life, and psychological distress in CRC patients and investigates potential underlying mechanisms. …”
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Revealing the heterogeneity of treatment resistance in less‐defined subtype diffuse large B cell lymphoma patients by integrating programmed cell death patterns and liquid biopsy by Wei Hua, Jie Liu, Yue Li, Hua Yin, Hao‐Rui Shen, Jia‐Zhu Wu, Yi‐Lin Kong, Bi‐Hui Pan, Jun‐Heng Liang, Li Wang, Jian‐Yong Li, Rui Gao, Jin‐Hua Liang, Wei Xu

“…Programmed cell death (PCD) pathways are crucial in the advancement of lymphoma and serve as significant prognostic markers for individuals afflicted with lymphoid cancers. To identify robust prognostic biomarkers that can guide personalized management for less‐defined subtype DLBCL patients, we integrated multi‐omics data derived from 339 standard R‐CHOP‐treated patients diagnosed with less‐defined subtype DLBCL from three independent cohorts. …”
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Designing a Policy Making Model in Iran' Sport with the Approach of Sport for All Development by Behdad Sadeghi, Rahmatollah Gholipour, Mojtaba Amiri, Marjan Saffari

“…Results After an in-depth examination of the interviews and the data obtained, each interview was analyzed individually to extract initial codes. Subsequently, concepts and categories were developed. …”
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Remote Monitoring of Chemotherapy-Induced Peripheral Neuropathy by the NeuroDetect iOS App: Observational Cohort Study of Patients With Cancer by Ciao-Sin Chen, Michael P Dorsch, Sarah Alsomairy, Jennifer J Griggs, Reshma Jagsi, Michael Sabel, Amro Stino, Brian Callaghan, Daniel L Hertz

“…The Combined Model numerically, though not statistically, outperformed either assessment strategy individually, indicating that the combination of functional and patient-reported assessment within a smartphone may be optimal to CIPN detection. …”
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Medication adherence and blood pressure control in treated hypertensive patients: first follow-up findings from the PREDIcT-HTN study in Northern Bangladesh by Ahmed Hossain, Gias Uddin Ahsan, Mohammad Zakir Hossain, Mohammad Anwar Hossain, Probal Sutradhar, Sarowar-E. Alam, Zeeba Zahra Sultana, Heba Hijazi, Syed Azizur Rahman, Mohamad Alameddine

“…Addressing medication adherence is essential for better BP control, with particular attention needed for women, rural residents, and newly diagnosed individuals. A comprehensive approach is warranted, including strategies to enhance adherence, early diagnosis, personalized treatment, and simplified medication regimens. …”
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Optimizing the Construction Supply Chain Network Considering the Flow of Materials, Equipment, Manpower, Drawings and Technical Documents by Seyed Saeid Helli, Hadi Mokhtari, Saeed Dehnavi

“…In the classic supply chain, the flow of materials and output at the end of the chain includes the manufactured product, while in the construction supply chain, the final output includes a building or a structure. Individuals, industries and even countries incur a lot of construction costs to meet their needs in the field of construction. …”
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Incidence and predictors of seizure-related injuries among epileptic patients undergoing follow-up treatment at public hospitals in Central Ethiopia by Selamawit Wondale Begizew, Bethelhem Birhanu Muluneh, Taye Mezgebu Ashine, Asnakech Zekiwos Heliso, Getachew Ossabo Babore, Elias Ezo Ereta, Sentayehu Admasu Saliya, Awoke Girma Hailu, Elias Nigusu Abdisa

“…Abstract Seizure-related injuries represent a significant concern for both individuals with epilepsy and their caregivers. Compared to the general population, those diagnosed with epilepsy face a heightened risk of sustaining injuries. …”
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Dairy cows' responses to 2 separation methods after 3 months of cow-calf contact by Anina Vogt, Susanne Waiblinger, Rupert Palme, Uta König von Borstel, Kerstin Barth

“…Taken together, results showed that cows experienced distress during separation with the GR method, when implemented over 3 wk in 3 steps, as well as with the NF method, but differences between individuals were considerable.…”
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Assessment of upper respiratory and gut bacterial microbiomes during COVID-19 infection in adults: potential aerodigestive transmission by Hafez Al-Momani, Andrew Nelson, Hadeel Al Balawi, Dua’a Al Balawi, Iman Aolymat, Ashraf I. Khasawneh, Hala Tabl, Ayman Alsheikh, AbdelRahman M. Zueter, Jeffrey Pearson, Christopher Ward

“…The respiratory microbiota from individuals with COVID-19 demonstrated a statistically significant reduction in Shannon diversity and bacterial richness alongside an overall reduction in the prevalence of organisms from a typical healthy respiratory microbiome. …”
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United by Sports? Key Factors affecting Sports Participation in a Sports-based Initiative to Promote Social Integration in Segregated Communities by Anna Boemmel, Matthias Buser, Thomas Persson

“…Regular participation is essential for achieving these goals, making it crucial to understand why individuals participate or not in such initiatives and develop social capital (Flensner et al., 2021). …”
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Post-COVID-19 Syndrome and Related Dysautonomia: Reduced Quality of Life, Increased Anxiety and Manifestation of Depressive Symptoms: Evidence from Greece by Petros Galanis, Aglaia Katsiroumpa, Irene Vraka, Katerina Kosiara, Olga Siskou, Olympia Konstantakopoulou, Theodoros Katsoulas, Parisis Gallos, Daphne Kaitelidou

“… Background: Post-COVID-19 syndrome affects a significant number of SARS-CoV-2 infected individuals, even in asymptomatic cases causing several neurological and neuropsychiatric symptoms and signs. …”
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