Virulence factor discovery identifies associations between the Fic gene family and Fap2+ fusobacteria in colorectal cancer microbiomes by Geicho Nakatsu, Duhyun Ko, Monia Michaud, Eric A. Franzosa, Xochitl C. Morgan, Curtis Huttenhower, Wendy S. Garrett

“…Using a global data set of CRC shotgun metagenomes, we show that fusobacterial Fic and Fap2 genes frequently co-occur in the fecal microbiomes of individuals with late-stage CRC. We further characterize specific Fic gene families harbored by Fap2+ Fusobacterium animalis genomes and detect recombination events and elements of horizontal gene transfer via synteny analysis of Fic gene loci. …”
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“Unmasking the Uncommon”: A case series of multi-drug resistant Elizabethkingia meningoseptica causing late-onset sepsis and meningitis in preterm neonates [version 2; peer review:... by Anisha Maria Fernandes, Sinchana Bhat, Suchitra Shenoy M., Prajnha U.P.

“…Elizabethkingia meningoseptica is an uncommon nosocomial pathogen that causes meningitis, pneumonia, and sepsis in neonates and in immunocompromised individuals. It exhibits resistance to many commonly employed first-line antibiotics used to treat gram-negative pathogens. …”
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Correlation between depressive symptoms and cognitive function in middle-aged and elderly population in China: an analysis of CHARLS baseline data by Yuchao SUN, Jing FENG, Zihui LEI, Ge QU, Xinyan LI, Yong GAN

“…MethodsData on 17 705, 2 834, and 574 individuals aged ≥ 45 years were extracted from the 2011, 2013, and 2015 China Health and Retirement Longitudinal Study (CHARLS) enrollment surveys, which used the 10-item Center for the Epidemiological Studies of Depression Short Form (CES-D-10) to identify participants′ depression symptoms. …”
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Different expression of circulating microRNA profile in tibetan OSAHS with metabolic syndrome patients by Xue-feng Shi, Xiang He, Ze-rui Sun, Jie Duo, Hao Yang

“…Additionally, the target genes of differentially expressed miRNAs between Tibetan OSAHS patients with MetS and healthy individuals are regulated by transcription factors such as NR2C1, STAT3, STAT5a, HIF1a, ETV4, NANOG, RELA, SP1, E2F1, NFKB1, AR, and MYC. …”
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Association between sleep disorders and subsequent heart failure by Jamschid Sedighi, Mark Luedde, Julia Gaensbacher-Kunzendorf, Hans-Joerg Hippe, Pascal Bauer, Birgit Assmus, Samuel Sossalla, Karel Kostev

“…Data were available for 9,345,246 individuals, of which 406,265 had a history of HF. Results: The study analyzed data from 123,516 patients with HF and an equal number of matched controls. …”
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Public acceptance of microbiome management strategy in dairy calves: a European survey on colostrum, probiotic provision and prolonged cow-calf contact by A. Ait Sidhoum, A. Stygar, F. Bedoin, J.K. Niemi

“…Attitudinal and socio-economic variables were found to have a differential effect across the studied management strategies. For instance, individuals with greater familiarity with farming systems and microbiomes were more inclined to accept all four interventions, while women, compared to men, showed higher acceptance of prolonged cow-calf contact. …”
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Healthcare resource use of patients with transthyretin amyloid cardiomyopathy by Rosa Lauppe, Johan Liseth Hansen, Anna Fornwall, Katarina Johansson, Mark H. Rozenbaum, Anne Mette Strand, Merja Vakevainen, Johanna Kuusisto, Einar Gude, J. Gustav Smith, Finn Gustafsson

“…ATTR‐CM patients were defined as individuals diagnosed with amyloidosis and cardiomyopathy or HF between 2008 and 2018. …”
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Prevalence and correlates of symptoms of depression, anxiety, and psychological distress among women of reproductive age with delayed conception in urban and peri-urban low to mid-... by Barsha Gadapani Pathak, Gitau Mburu, Ndema Habib, Rita Kabra, Aiysha Malik, James Kiarie, Ranadip Chowdhury, Neeta Dhabhai, Sarmila Mazumder

“…<h4>Conclusion</h4>This study demonstrates the high mental health burden faced by women with delayed conception in low- to mid-socioeconomic neighbourhoods of North India including high levels of anxiety and depression. To better support individuals and couples achieve their reproductive goals, we advocate for the integration of psychosocial interventions to improve mental health outcomes and promote the well-being of those facing delays in achieving pregnancy. …”
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Preterm Birth and Cardiometabolic Health Trajectories From Birth to Adulthood: The Avon Longitudinal Study of Parents and Children by Gemma L. Clayton, Laura D. Howe, Linda M. O'Keeffe, Adam J. Lewandowski, Deborah A. Lawlor, Abigail Fraser

“…Methods and Results Multilevel models were used to compare trajectories from early childhood (<9 years) to age 25 years of body mass index, fat and lean mass, systolic and diastolic blood pressure, lipids, glucose, and insulin, between individuals born preterm (N=311–676; range, 25–36 weeks’ gestation) and term (N=4973–10 534) in a UK birth cohort study. …”
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Making Maoshan Great Again: Religious Rhetoric and Popular Mobilisation from Late Qing to Republican China (1864–1937) by Qijun Zheng

“…Additionally, this study also highlights the crucial role of social networks, particularly the efforts of key individuals such as Zhang Hefeng 張鶴峰 (fl. 1860–1864), Long Zehou 龍澤厚 (1860–1945), Jiang Daomin 江導岷 (1867–1939), Wang Yiting 王一亭 (1867–1938) and Teng Ruizhi 滕瑞芝 (fl. 1920–1947) who facilitated the reconstruction, reprinting and dissemination of these texts. …”
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Prevalence and risk factors associated with prehypertension in Shunde District, southern China by Yuli Huang, Yunzhao Hu, Xiaoyan Cai, Wenke Qiu, Changhua Liu, Dingji Zhu, Jinghai Hua, Yanxian Wu, Dingli Xu

“…Multivariate logistic regression analysis showed that overweight (OR=2.84, 95% CI 1.55 to 5.20), male sex (OR=2.19, 95% CI 1.39 to 3.45), age (per 10 years, OR=1.21, 95% CI 1.02 to 1.44, p=0.03) and hyperuricaemia (OR=1.70, 95% CI 1.14 to 2.54) were independent risk factors of prehypertension.Conclusions Prehypertension is highly prevalent in southern China. Prehypertensive individuals presented with many other cardiovascular risk factors. …”
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Asthma and obesity increase inflammatory markers in children by Harshita Shailesh, Safa Noor, Lena Hayati, Antonisamy Belavendra, Nicholas Van Panhuys, Abdul Badi Abou-Samra, Stefan Worgall, Ibrahim Janahi, Ibrahim Janahi

“…These findings challenge the previous view that obesity enhances inflammation in individuals with asthma and highlight the importance of considering both conditions while treating obesity-associated asthma in children. …”
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Risk factors for growth retardation in children with juvenile idiopathic arthritis: a case-control study by Ying Zhang, Liping Song, Weihu Ma, Ye Wang, Peipei Wang, Xiaolin Zhang, Zhe Zhang, Yuan Zhang, Qianhui Yu, Yang Yu, Lin Zhang

“…While each of these factors demonstrates moderate predictive value individually, their combined consideration significantly improves predictive accuracy. …”
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Network pharmacology and experimental verification to investigate the mechanism of isoliquiritigenin for the treatment of Alzheimer’s disease by Waimao Gao, Guang Yang, Xinjuan Liu, Kaifan Hu, Jie Pan, Xingyu Wang, Yan Zhao, Ying Xu

“…Subsequently, the receiver operating characteristic (ROC) curve analysis and the assessment of hub gene expression levels between AD and healthy individuals were used to estimate a possible link between target genes in AD. …”
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The correlations between demographic factors, self-efficacy, and quality of life among Indonesian patients with ischemic stroke: A cross-sectional study by Nabila Azzahra, Fitria Handayani, Wahyu Hidayati

“…Occupational status significantly influenced self-efficacy, with employed individuals being 6.333 times more likely (95% CI = 3.134–16.599; p <0.001) to achieve high self-efficacy. …”
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Association between mixed exposure of non-persistent pesticides and liver fibrosis in the general US population: NHANES 2013–2016 by Shuge Shu, Yuan Li, Xiangyu Yu, Xinting Chen, Ummara Abdullah, Yongquan Yu

“…To examine the relationship between mixed non-persistent pesticides exposure and liver fibrosis, and to identify the potential pesticides of significant importance, this study enrolled the representative individuals from the NHANES 2013–2016 survey cycles, in which urinary non-persistent pesticides were measured. …”
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The impact of dietary patterns on gut microbiota for the primary and secondary prevention of cardiovascular disease: a systematic review by Junwen Yu, Yue Wu, Zheng Zhu, Hongzhou Lu

“…However, conflicting findings have been reported on how dietary patterns impact gut microbiota in individuals either established or at risk of cardiovascular disease (CVD). …”
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Detection Methods for Asparagine and Glutamine Contents in Fruits and Vegetables and Recommendations for Dietary Intake of Fruits and Vegetables in Patients with Urea Cycle Disorde... by YE Xinyu, LI Ziying, TANG Shujun, SUN Liping, ZHAO Yunxia, XIAO Weimin, GU Yaping, KUANG Huiying, CHEN Xin, YANG Guowu, HUANG Yali

“…These findings suggested that individuals with urea cycle disorders should eat more nut fruits and green leafy vegetables, with less asparagine and glutamine, in daily life, especially vegetables and fruits with higher ratio of branched-chain amino acids to Asn plus Gln such as Chinese cabbage, Auricularia auricula, green onion, coconut juice, longan, and pomelo, and should eat less vegetables and fruits with lower ratio of branched-chain amino acids to Asn plus Gln such as potato, pumpkin, green bean, cantaloupe, red plum and yellow peach.…”
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Hp eradication decreased the expression level of PG II in patients of Hp negative with gastric intestinal metaplasia: a retrospective cross-sectional study by Yanhong Wang, Xixiang Cao, Baodong Shan, Song Chen, Shengnan Li, Sujuan Fei, Xunlei Pang

“…Among patients without Hp eradication history, those with low PG II levels had a higher proportion of individuals with a history of Hp eradication than those with high PG II levels (29.31% VS 3.13%, p = 0.003). …”
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Dose-Weighted Network Pharmacology: Evaluating Traditional Chinese Medicine Formulations for Lumbar Disc Herniation by Zhou C, Xiang T, Yu Y, Ma H, Liu C, Yang F, Yang L

“…Changwen Zhou,1 Ting Xiang,2 Yu Yu,3 Hongzhong Ma,1 Ce Liu,1 Feng Yang,1,4,&ast; Lixue Yang1,4,&ast; 1The First Clinical Medical College, Shaanxi University of Chinese Medicine, Shaanxi, People’s Republic of China; 2Rehabilitation Department, Xiang Xi Autonomous Prefecture National Hospital, Hunan, People’s Republic of China; 3Department of Chinese Medicine, Minda Hospital of Hubei Minzu University, Hubei, People’s Republic of China; 4Department of Orthopedic Hospital, The Affiliated Hospital of Shaanxi University of Chinese Medicine, Shaanxi, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Lixue Yang; Feng Yang, The First Clinical Medical College, Shaanxi University of Chinese Medicine, Vice No. 2, West Weiyang Road, Qindu District, Shaanxi, 712000, People’s Republic of China, Email ylx18391076233@163.com; yangfengdudu@163.comBackground and Purpose: Lumbar disc herniation (LDH) significantly impacts individuals, particularly those aged 40– 45. Traditional Chinese Medicine (TCM) formulations such as Taohong Siwu Decoction (TSD), Yaotong Jizheng Decoction (YJD), and Panlong Qi Tablet (PQT) are widely used for treatment. …”
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