Real world study on combining local interventions with systemic therapy in unresectable hepatocellular carcinoma by Zhaosong Xue, Ming Yao, Kang Chen, Taiyun Huang, Jianjun Li, Jian Chen, Fei Huang, Yubin Huang, Xiaoyong Cai, Yihe Yan

“…The study cohort comprised 79 patients, among whom 20 individuals (25.3%) underwent R0 resection subsequent to the initiation of triple therapy. …”
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Diversity and seasonal variation of zooplankton community in a large deep-water reservoir of Eastern China using eDNA and morphological methods by Lei Hao, Lei Hao, Xinting Xu, Xinting Xu, Yan Zhou, Yan Zhou, Dan Liu, Dan Liu, Jianqiang Shao, Jiayong Pan, Guangxi He, Zhongjun Hu, Zhongjun Hu, Qigen Liu, Qigen Liu

“…Furthermore, combining morphological abundance and biomass as predictor variables for eDNA reads moderately enhanced the explanatory power compared to using them individually. Although eDNA cannot yet replace morphological methods, its efficiency and sensitivity make it a valuable complementary tool for zooplankton monitoring, with considerable potential for future applications.…”
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Pathomorphological features of the proximal femur in crowe IV hips and their implication on stem selection during total hip arthroplasty by Kaveh Gharanizadeh, Elham Mohammadyahya, Mohammad Reza Bahaeddini, Shayan Amiri, Sajad Noori Gravand, Sepideh Pezeshki, Amir Aminian, Arvin Eslami, Hamed Tayyebi, Mansour Abolghasemian

“…Our goal is to identify and define the differences in the anatomy of the proximal femur between patients with Crowe type IV DDH and normal individuals, in order to determine the appropriate neck cut location in these patients to increase the chances of successfully using a wedge femoral stem. …”
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Prevalence of diabetes-related sarcopenia and its defining components within primary care: A cross-sectional study by Rubén Silva-Tinoco, Lilia Castillo-Martínez, Berenice Cabrera-Victoria, Eileen Guzmán-Olvera, Christian Hinojosa-Segura, Alejandro Avalos-Bracho, Cira Santillán-Díaz

“…This study aimed to assess the prevalence of sarcopenia and at-risk morphofunctional (MF) phenotypes and to identify the factors associated in patients with type 2 diabetes (T2D), including non-elderly adults, in primary care settings Methods: This cross-sectional study included 261 individuals managed in primary care units in Mexico City, between July 2022 and May 2024. …”
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Pleiotropic Effects of a KCNQ1 Variant on Lipid Profiles and Type 2 Diabetes: A Family-Based Study in China by Xiaowen Wang, Junhui Wu, Yao Wu, Mengying Wang, Zijing Wang, Tao Wu, Dafang Chen, Xun Tang, Xueying Qin, Yiqun Wu, Yonghua Hu

“…Methods. In total, 5839 individuals (2220 were T2DM patients) across 2885 families were included. …”
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Efficacy and Safety of an Aflibercept Treat-and-Extend Regimen in Treatment-Naïve Patients with Macular Oedema Secondary to Central Retinal Vein Occlusion (CRVO): A Prospective 12-... by Jose Garcia-Arumi, Francisco Gómez-Ulla, Navea Amparo, Enrique Cervera, Alex Fonollosa, Luis Arias, Javier Araiz, Juan Donate, Marta Suárez de Figueroa, Lucia Manzanas, Jaume Crespí, Roberto Gallego

“…Intravitreal aflibercept 2 mg monthly (3 months) followed by proactive individualized dosing. Main Outcomes. Mean change in BCVA after 12 months. …”
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The Impact of Ageing on Diaphragm Function and Maximal Inspiratory Pressure: A Cross-Sectional Ultrasound Study by Toru Yamada, Taro Minami, Takahiro Shinohara, Shuji Ouchi, Suguru Mabuchi, Shunpei Yoshino, Ken Emoto, Kazuharu Nakagawa, Kanako Yoshimi, Mitsuko Saito, Ayane Horike, Kenji Toyoshima, Yoshiaki Tamura, Atsushi Araki, Ryoichi Hanazawa, Akihiro Hirakawa, Takeshi Ishida, Takuma Kimura, Haruka Tohara, Masayoshi Hashimoto

“…<b>Results</b>: The study involved 230 individuals with a mean age of 55.5 years (older adults (65 years and over), <i>n</i> = 117; non-older adults, <i>n</i> = 113). …”
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A Study on the Induction of Multi-Type Immune Responses in Mice via an mRNA Vaccine Based on Hemagglutinin and Neuraminidase Antigen by Mengyuan Liu, Yixuan Liu, Shaohui Song, Qiurong Qiao, Jing Liu, Yun Xie, Jian Zhou, Guoyang Liao

“…Comparative analyses were performed with mice immunized individually with the IAV HA mRNA vaccine, IAV NA mRNA vaccine, and inactivated vaccine. …”
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Association between the levels of urinary cell cycle biomarkers and non-recovery of renal function among critically ill geriatric patients with acute kidney injury by Li Cheng, Hui-Miao Jia, Xi Zheng, Yi-Jia Jiang, Xin Xin, Wen-Xiong Li

“…However, no reliable prognostic biomarker is available for identifying individuals at risk of renal non-recovery or mortality in older adults. …”
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Helicobacter pylori infection at long-term treatment by proton pump inhibitors for acid-related diseases (Literature review and resolution of Advisory council, March 22, 2018) by V. T. Ivashkin, I. V. Mayev, R. A. Abdulkhakov, O. P. Alekseyeva, S. A. Alekseyenko, A. Yu. Baranovsky, Ye. K. Baranskaya, I. L. Klyaritskaya, N. V. Korochanskaya, Yu. A. Kucheryavy, T. L. Lapina, M. F. Osipenko, V. I. Simanenkov, G. N. Tarasova, A. S. Trukhmanov, I. B. Khlynov, A. A. Sheptulin

“…The choice of specific PPI for treatment of patients with GERD and other acid-related diseases, carrying out H. pylori eradication therapy or substitution of one PPI agent to another are individualized and depend on the indications registered in the drugs administration instructions, features of its pharmacokinetics and pharmacodynamics, possible drug-to-drug interactions. …”
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Prednisolone versus antihistamine for allergic rhinitis: No significant difference found in randomized trial by Carl Skröder, Laila Hellkvist, Ulla Westin, Pernilla Sahlstrand‐Johnsson, Kerstin Hansson, Agneta Karlsson, Åslög Dahl, Leif Bjermer, Lars Olaf Cardell

“…These results suggest that systemic corticosteroids may not provide additional benefits over antihistamines, and clinicians should prioritize individualized treatment based on patient preferences and tolerability.…”
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Comparative survival outcomes of neoadjuvant and adjuvant therapy in patients with T1c, node-negative, triple-negative breast cancer: A population-based analysis by Yi-Zi Zheng, Jia-Qi Ying, Ting-Ting Wu, Yong-Hui Su, Ou-Chen Wang

“…Background: Ongoing discussions persist concerning the precedence of neoadjuvant therapy (NAT) relative to adjuvant therapy (AT) for patients with T1c, node-negative, triple-negative breast cancer (TNBC), and pertinent guidelines for these individuals are absent. Methods: Women diagnosed with T1cN0M0-stage TNBC who received chemotherapy and surgery were selected from the Surveillance, Epidemiology and End Results database (2010–2020). …”
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Comprehensive Hematological and molecular Characterization of hemoglobin Hekinan [α27(B8)Glu→Asp(α1), HBA1:c.84G > T] in a Large Thai cohort by Amornchai Suksusut, Jidapa Jaitheang, Manussavee Prapphal, Pranee Sutcharitchan, Ponlapat Rojnuckarin, Noppacharn Uaprasert

“…Additional genetic determinants, including α-thalassemia, β-thalassemia and other variants, were detected using multiplex GAP-PCR, ARMS-PCR or direct DNA sequencing as appropriate.Results: Among 61,997 Hb typing samples, 149 cases of Hb Hekinan were identified in Thai individuals and classified into 8 genotypic groups. …”
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Effect of Combination Therapy of Canagliflozin Added to Teneligliptin Monotherapy in Japanese Subjects with Type 2 Diabetes Mellitus: A Retrospective Study by Yoshiro Fushimi, Atsushi Obata, Junpei Sanada, Yuichiro Iwamoto, Akiko Mashiko, Megumi Horiya, Akiko Mizoguchi-Tomita, Momoyo Nishioka, Yuki Kan, Tomoe Kinoshita, Seizo Okauchi, Hidenori Hirukawa, Kenji Kohara, Fuminori Tatsumi, Masashi Shimoda, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto

“…Therefore, we aimed to elucidate in which type of individuals and/or under which conditions canagliflozin as add-on therapy to teneligliptin could exert more beneficial effects on glycemic control and/or renal protection. …”
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Nano-delivery platform with strong protection and efficient delivery: preparation of self-assembled RNA pesticide with dual RNAi targets against Apolygus lucorum by Heng Qiao, Qinhong Jiang, Jing Zhao, Liubin Xiao, Keyan Zhu-Salzman, Dejin Xu, Guangchun Xu, Jie Shen, Aiguo Gu, Dejun Hao, Shuo Yan, Yongan Tan

“…Then, dsECR-A and dsTre-1 fragments were individually screened, and the dsECR-A and dsTre-1 fragments with good control effects were co-expressed in pET28-BL21 (DE3) RNase III − system to prepare the dsECR-A + Tre-1/SPc complex. …”
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Combined biochemical profiling and DNA sequencing in the expanded newborn screening for inherited metabolic diseases: the experience in an Italian reference center by Simona Fecarotta, Lorenzo Vaccaro, Alessandra Verde, Marianna Alagia, Alessandro Rossi, Chiara Colantuono, Maria Teresa Cacciapuoti, Patrizia Annunziata, Sara Riccardo, Antonio Grimaldi, Tonya Fusco, Rosa De Santis, Fernando Barretta, Lucia Albano, Daniela Crisci, Fabiana Vallone, Antonietta Tarallo, Marcella Cesana, Nicola Brunetti-Pierri, Giulia Frisso, Margherita Ruoppolo, Davide Cacchiarelli, Giancarlo Parenti

“…In total, we could identify 17 affected, 34 false positives, 12 individuals referred to us for maternal conditions. …”
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Effectiveness of educational interventions to promote safe handling of pesticides: protocol for a systematic review and meta-analysis by Anne Cockcroft, Neil Andersson, Sergio Paredes-Solís, José Legorreta-Soberanis, Belén Madeline Sánchez-Gervacio, Víctor Manuel Alvarado-Castro, Miguel Flores-Moreno, Claudia Erika Rios-Rivera, Janet Saldaña-Almazán

“…Subgroup analyses will examine the impact of different kinds of educational interventions.Ethics and dissemination Ethics approval is not required as no information from individuals are collected. The results will be published in a peer-reviewed journal or disseminated at relevant conferences.PROSPERO registration number CRD42023413028.…”
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Identification of therapeutic target genes for age-related hearing loss through systematic genome-wide mendelian randomization of druggable genes by Kun Zhang, Bo Hou, Tao Yan, Ruru Qiao, Peng Qu, Xinbo Xu, Hanbing Zhang

“…Therefore, we performed a systematic genome-wide MR of drug-eligible individuals to explore potential therapeutic targets for ARHL. …”
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Uric acid to albumin ratio is a novel predictive marker for all-cause and cardiovascular death in diabetic patients: a prospective cohort study by Shengnan Chen, Shengnan Chen, Ming Zhang, Shouye Hu, Xiaolong Shao, Lin Liu, Zhi Yang, Kai Nan

“…The clinical utility of UAR and nomogram based on age and UAR can help physicians identify individuals at higher risk and therefore promote prevention strategies.…”
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Comparative Proteomic Analysis of Visceral Adipose Tissue in Morbidly Obese and Normal Weight Chinese Women by Chen Shang, Wei Sun, Chunlin Wang, Xiangqing Wang, Huijuan Zhu, Linjie Wang, Hongbo Yang, Xue Wang, Fengying Gong, Hui Pan

“…Forty-one proteins were upregulated, and 83 proteins were downregulated in obese individuals. These altered VAT proteins were involved in the attenuation of the liver X receptor/retinoid X receptor (LXR/RXR) signaling pathway and the activation of the acute-phase response process. …”
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