Development and validation of predictive models of early immune effector cell–associated hematotoxicity by Emily C. Liang, Jennifer J. Huang, Andrew J. Portuguese, Valentín Ortiz-Maldonado, Aya Albittar, Natalie Wuliji, Ryan Basom, Yein Jeon, Qian Wu, Aiko Torkelson, Delaney Kirchmeier, Abigail Chutnik, Barbara Pender, Mohamed Sorror, Joshua A. Hill, Noam E. Kopmar, Rahul Banerjee, Andrew J. Cowan, Damian Green, Ajay K. Gopal, Christina Poh, Mazyar Shadman, Alexandre V. Hirayama, Brian G. Till, Erik L. Kimble, Lorenzo Iovino, Aude G. Chapuis, Folashade Otegbeye, Ryan D. Cassaday, Filippo Milano, Cameron J. Turtle, David G. Maloney, Jordan Gauthier

“…Both models generated calibrated predictions and high discrimination (area under the receiver operating characteristic curve in test set, 0.87 for eIPMPre and 0.88 for eIPMPost), with higher net benefit in decision curve analysis for eIPMPost. Individualized predictions of severe eICAHT can be generated from both eIPMs using our online tool (available at https://eipm.fredhutch.org).…”
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Long-Term Voluntary Physical Exercise Exerts Neuroprotective Effects and Motor Disturbance Alleviation in a Rat Model of Parkinson’s Disease by Wan-Ling Tsai, Hsin-Yung Chen, Ying-Zu Huang, Yuan-Hao Chen, Chi-Wei Kuo, Kai-Yun Chen, Tsung-Hsun Hsieh

“…Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder affecting 7–10 million individuals. The pathologic hallmark of PD is nigrostriatal dopaminergic neuron loss, leading to several motor and nonmotor disturbances, such as akinesia, gait disturbance, depression, and anxiety. …”
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Cell-free DNA: a metabolic byproduct with diagnostic and prognostic potential in rheumatic disorders by Fancheng Liu, Fancheng Liu, Yazhen Su, Yazhen Su, Xinling Liu, Li Zhao, Li Zhao, Zewen Wu, Zewen Wu, Yang Liu, Yang Liu, Liyun Zhang, Liyun Zhang

“…Within a healthy organism, cfDNA undergoes swift elimination and filtration upon release, ensuring a persistently low concentration in the bloodstream. Conversely, individuals suffering from diverse illnesses like stroke, trauma, myocardial infarction, and various cancers show markedly higher levels of cfDNA in their blood plasma or serum. …”
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The Role of Technical Car Features in Managing and Promoting New Peer-to-Peer Car-Sharing Systems: Insights from Potential Users and Strategic Implications for Service Providers by Katarzyna Turoń, Andrzej Kubik, Piotr Folęga, Andrzej Wilk, Peter Bindzar, Truong M. N. Bui

“…Addressing this gap, and in the context of launching a new peer-to-peer car-sharing service in Katowice, Poland, this article investigates the technical features influencing the choice of vehicles in peer-to-peer car-sharing systems, particularly from the perspective of individuals who currently do not use such platforms. …”
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Colorectal cancer in Lynch syndrome families: consequences of gene germline mutations and the gut microbiota by Xuexin Wang, Zhijun Zheng, Dongliang Yu, Xiaojue Qiu, Ting Yang, Ruoran Li, Jing Liu, Xin Wang, Peng Jin, Jianqiu Sheng, Nan Qin, Na Li, Junfeng Xu

“…Methods This prospective, observational study was performed from December 2020 to March 2023. We enrolled 72 individuals from 9 LS families across six provinces in China and employed 16S rRNA gene amplicon sequencing to analyze the fecal microbiota components among LS-related CRC patients (AS group), their spouses (BS group), mutation carriers without CRC (CS group), and non-mutation carriers (DS group) using alpha and beta diversity indices. …”
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Harnessing new mHealth technologies to Strengthen the Management of Multidrug-Resistant Tuberculosis in Vietnam (V-SMART trial): a protocol for a randomised controlled trial by Ben J Marais, Joel Negin, James Johnston, Virginia Wiseman, Greg J Fox, Thu Anh Nguyen, Binh Hoa Nguyen, Viet Nhung Nguyen, Justin Beardsley, Guy Barrington Marks, Kavindhran Velen, Tho Dang, Hoang Anh Nguyen, Dinh Hoa Vu, Thu Thuong Do, Cuong Pham Duc, Huu Lan Nguyen, Huu Thuong Pham, Warwick Britton

“…Participants will be individually randomised to an intervention arm, comprising use of an mHealth application for treatment support, or a ‘standard care’ arm. …”
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Investigating dynamic brain functional redundancy as a mechanism of cognitive reserve by Julia Schwarz, Franziska Zistler, Adriana Usheva, Anika Fix, Sebastian Zinn, Juliana Zimmermann, Franziska Knolle, Franziska Knolle, Gerhard Schneider, Rachel Nuttall

“…IntroductionIndividuals with higher cognitive reserve (CR) are thought to be more resilient to the effects of age-related brain changes on cognitive performance. …”
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Genomic insights into the specialisation and selection of the Jinding duck by H. Chen, Y. Huang, J. Xue, K. luo, H. Tang, S. Zheng, Y. Xiong, Y. Wu, J. Li, R. Xuan, R. Xiong, Y. Gong, X. Fang, L. Wang, J. Miao, J. Zhou, H. Tan, Y. Wang, L. Wu, J. Ouyang, Y. Shen, X. Yan

“…Employing whole-genome resequencing data from 325 individuals across five Chinese indigenous duck breeds, we aimed to dissect the unique population structure and assess the genetic diversity within the JDD cohort. …”
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Akkermansia muciniphila and its metabolite propionic acid maintains neuronal mitochondrial division and autophagy homeostasis during Alzheimer’s disease pathologic process via GPR4... by Zifan Wang, Cai Wang, Boyu Yuan, Li Liu, Haoming Zhang, Mingqiang Zhu, Hongxia Chai, Jie Peng, Yanhua Huang, Shuo Zhou, Juxiong Liu, Liyong Wu, Wei Wang

“…Results In this study, we present distinctions in blood and fecal SCFA levels and microbiota composition between healthy individuals and those diagnosed with AD. We found that AD patients showed a decrease in the abundance of Akkermansia muciniphila and a decrease in propionic acid both in fecal and in blood. …”
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Knowledge, attitudes and practices regarding pulmonary rehabilitation among patients with chronic respiratory diseases: a cross-sectional questionnaire-based study in a tertiary ho... by Xueli Bai, Yuan Chen, Xiansheng Liu, Lingling Wang, Xiaohong Zhang, Jie Ding, Lin Su, Ruiying Wang, Shuang Wei

“…Participants were aged 18 or older, able to complete the questionnaire independently or with assistance and included individuals from diverse demographic backgrounds.Primary and secondary outcome measures Primary outcomes included KAP scores related to pulmonary rehabilitation. …”
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Attributing heatwave-related mortality to climate change: a case study of the 2009 Victorian heatwave in Australia by Sarah E Perkins-Kirkpatrick, Linda Selvey, Philipp Aglas-Leitner, Nina Lansbury, Samuel Hundessa, Dáithí Stone, Kristie L Ebi, Nicholas John Osborne

“…Moreover, on average, around 6 ± 3–4 extra individuals out of 31 (an increase of 20%) died as a direct result of extreme temperatures due to anthropogenic influence on the climate. …”
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Dissecting the role of single nucleotide polymorphism of lymphotoxin beta gene during pig domestication using bioinformatic and experimental approaches by R. B. Aitnazarov, E. V. Ignatieva, N. E. Bazarova, V. G. Levitsky, S. P. Knyazev, Y. Gon, N. S. Yudin

“…Therefore, it is likely that domestication favored selection of individuals with high reproductive performance but low immunity. …”
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Discovery of the microbiota-gut-brain axis mechanisms of acupuncture for amnestic mild cognitive impairment based on multi-omics analyses: A pilot study by Zi-Han Yin, Qiong-Nan Bao, Ya-Qin Li, Yi-Wei Liu, Zi-Qi Wang, Fang Ye, Xia He, Xin-Yue Zhang, Wan-Qi Zhong, Ke-Xin Wu, Jin Yao, Zi-Wen Chen, Ling Zhao, Fan-Rong Liang

“…However, little is known about whether and how acupuncture change the MGB axis of aMCI individuals. Methods: This was a randomized, controlled, clinical trial. …”
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Assessment of prognosis and responsiveness to immunotherapy in colorectal cancer patients based on the level of immune cell infiltration by Kaili Liao, Minqi Zhu, Lei Guo, Zijun Gao, Jinting Cheng, Bing Sun, Yihui Qian, Bingying Lin, Jingyan Zhang, Tingyi Qian, Yixin Jiang, Yanmei Xu, Qionghui Zhong, Xiaozhong Wang

“…These findings offer valuable insights for accurate prognostication and comprehensive management of individuals diagnosed with colon cancer.…”
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Gastrointestinal symptoms and bowel habits in 53 046 healthy Danish blood donors: a nationwide cross-sectional study by Christian Erikstrup, Ole Birger Pedersen, Henrik Hjalgrim, Erik Sørensen, Jens Frederik Dahlerup, Klaus Rostgaard, Mikkel Steen Petersen, Sisse Rye Ostrowski, Susan Mikkelsen, Khoa Manh Dinh, Thorsten Brodersen, Janna Nissen, Anne Karmisholt Grosen, Jens Kjærgaard Boldsen, Simon Mark Dahl Baunwall, Mie Topholm Bruun, Bitten Aagaard, Christina Mikkelsen, Christian Lodberg Hvas

“…The acid regurgitation and/or heartburn only phenotype associated with obesity, and the remaining symptomatic phenotypes were associated with female sex, decreasing age, and an irregular defaecation pattern, even after excluding individuals with self-reported irritable bowel syndrome, lactose intolerance, or gluten intolerance.Conclusion Most healthy adults, especially women younger than 50 years, experience gastrointestinal symptoms. …”
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The Late Orchid Catches the Bee: Frost Damage and Pollination Success in the Face of Global Warming in a European Terrestrial Orchid by Florian P. Schiestl, Beat A. Wartmann, Ruth Bänziger, Brigitte Györög‐Kobi, Klaus Hess, Jürg Luder, Edith Merz, Beat Peter, Max Reutlinger, Tobias Richter, Heinz Senn, Thomas Ulrich, Beate Waldeck, Claudia Wartmann, Roland Wüest, Walter Wüest, Quint Rusman

“…We measured flowering time, frost damage, and fruiting success in 1250 individually marked plants during 3 years, and documented spring temperatures. …”
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Peripapillary atrophy area predicts the decrease of macular choroidal thickness in young adults during myopia progression by Xun Xu, Jianfeng Zhu, Ying Fan, Luyao Ye, Ya Shi, Menghan Li, Qiuying Chen, Guangyi Hu, Jiamin Xie, Jiangnan He

“…Objective This study aimed to investigate the influence of peripapillary atrophy (PPA) area and axial elongation on the longitudinal changes in macular choroidal thickness (ChT) in young individuals with myopia.Methods and analysis In this longitudinal investigation, 431 eyes—342 categorised as non-high myopia (non-HM) and 89 as HM—were examined for 2 years. …”
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Omics-Based Comparison of Fungal Virulence Genes, Biosynthetic Gene Clusters, and Small Molecules in <i>Penicillium expansum</i> and <i>Penicillium chrysogenum</i> by Holly P. Bartholomew, Christopher Gottschalk, Bret Cooper, Michael R. Bukowski, Ronghui Yang, Verneta L. Gaskins, Dianiris Luciano-Rosario, Jorge M. Fonseca, Wayne M. Jurick

“…While these two fungi have been investigated individually, a recent discovery revealed that <i>P. chrysogenum</i> can block <i>P. expansum-</i>mediated decay of apple fruit. …”
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Global, regional, and national burden of very early-onset colorectal cancer and its risk factors from 1990 to 2019: A systematic analysis for the global burden of disease study 201... by Zhen Junhai, Meng Yang, Tan Zongbiao, Yan Wenxuan, Li Tiange, Wu Yanrui, Liu Chuan, Dong Weiguo

“…Conclusions: The increase in CRC burden among populations younger than 35 years globally requires vigilance from policy makers, physicians, and young individuals themselves, especially those regions experiencing faster growth burden of very EOCRC.…”
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Evaluation of exo-long noncoding RNA MALAT1 in OSCC in comparison to dysplastic and normal: A cross-sectional study by Ramya Sekar, Selvaraj Jayaraman, VishnuPriya Veeraraghavan, Kalaiselvi Krishnamoorthy, Shubhra Chauhan Aramanai, Sathan Raj Natarajan

“…There was no significant change in expression pattern of MALAT1 between dysplastic patients and normal, yet, significant association was found on corelation analysis between expression pattern of MALAT1 and PI3K/AKT/PTEN (p 0.001∗) among individuals of dysplasia and OSCC. As well pairwise comparisons of MALAT1 expression levels between all three stages of dysplasia showed significant association (p < 0.001∗). …”
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