Real-world clinical evidence of oral semaglutide on metabolic abnormalities in subjects with type 2 diabetes: a multicenter retrospective observational study (the Sapporo-Oral SEMA... by Sho Furusawa, Hiroshi Nomoto, Chiho Oba-Yamamoto, Jun Takeuchi, Miki Ito, Hiroyoshi Kurihara, Shin Aoki, Aika Miya, Hiraku Kameda, Akinobu Nakamura, Tatsuya Atsumi

“…Of 543 subjects who met the inclusion criteria, data for 434 subjects (age 55.5 ± 12.6 years; body mass index 29.6 ± 6.0 kg/m2) were analyzed. After a 6 months of observation period, semaglutide 3 mg, 7 mg, or 14 mg was used by 55 (12.7%), 241 (55.5%), and 138 (31.8%) of subjects, respectively. …”
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MUC5B regulates alterations in the immune microenvironment in nasopharyngeal carcinoma via the Wnt/β-catenin signaling pathway by Hongming Wang

“…With mucin 5B, oligomeric mucus/gel-forming as the focus, the correlation between its expression and immune indexes was analyzed by using the TIMER database. …”
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Allergic conditions and risk of rheumatoid arthritis: a Swedish case–control study by Johan Askling, Lars Klareskog, Lars Alfredsson, Marie Holmqvist, Helga Westerlind, Cynthia S Crowson, Vanessa L Kronzer

“…We used logistic regression and adjusted ORs (aOR) to assess the association between allergic conditions and risk of RA, adjusting for age, sex, residential area, body mass index, education, and smoking, and stratified by smoking and ACPA.Results A history of any reported allergy was equally common in RA (n=1047, 30%) as among population controls (n=1540, 29%), aOR 1.04, 95% CI 0.95 to 1.15. …”
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Mineralocorticoid axis activity and cardiac remodeling in patients with ACTH-dependent Cushing’s syndrome by Peter Wolf, Simon Travers, Oliver Domenig, Stephanie Baron, Anne Blanchard, Khaoula Bouazizi, Nadjia Kachenoura, Sylvie Salenave, Marko Poglitsch, Alban Redheuil, Severine Trabado, Jacques Young, Philippe Chanson, Peter Kamenický

“…Methods: In this ancillary study of our previous study prospectively investigating patients with ACTH-dependent Cushing’s syndrome by cardiac magnetic resonance imaging (NCT02202902), 11 patients without any interfering medication were cross-sectionally compared to 20 control subjects matched for age, sex and body mass index. Angiotensin metabolites and adrenal steroids were measured by liquid chromatography tandem mass spectrometry, and their relation to blood pressure and cardiac structure was evaluated. …”
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Identifying biomarkers for epilepsy after cerebral malaria in Zambian children: rationale and design of a prospective observational study by Bo Zhang, Archana A Patel, Gretchen L Birbeck, Maitreyi Mazumdar, Suzanna Mwanza, Rosemary Nyirongo, Dixon Berejena, Joseph Kasolo, Tina Mwale, Violet Nambeye, Kafula Lisa Nkole, Nfwama Kawatu, Alexander Rotenberg

“…Our goal is to develop a predictive PME index composed of EEG and clinical history metrics that are highly feasible to obtain in low-resourced regions.Methods and analyses This prospective observational study being conducted in Eastern Zambia will recruit 250 children aged 6 months to 11 years presenting with acute CM and follow them for two years. …”
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Curcumin Targeting NF-κB/Ubiquitin-Proteasome-System Axis Ameliorates Muscle Atrophy in Triple-Negative Breast Cancer Cachexia Mice by Jin Zhang, Jin Zheng, Haitao Chen, Xinrong Li, Chenxiao Ye, Fan Zhang, Zewei Zhang, Qinghua Yao, Yong Guo

“…The therapeutic effect of curcumin on breast cancer cachexia was characterized by tumor growth, changes in body mass and gastrocnemius mass, muscle function test, histopathology, and serum nutrition indexes. Mitochondrial function in muscle tissue was observed by transmission electron microscopy and ATP detection, muscle inflammatory factors were detected by ELISA, muscle differential metabolites were detected by 1HNMR metabolomics, and the muscle tissue ubiquitination levels and NF-KB expression were also analyzed by RT-qPCR and Western blot. …”
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Validation of a delirium predictive model in patients admitted to surgical intensive care units: a multicentre prospective observational cohort study by Kaweesak Chittawatanarat, Onuma Chaiwat, Sirirat Mueankwan, Sunthiti Morakul, Pitchaya Dilokpattanamongkol, Chayanan Thanakiattiwibun, Arunotai Siriussawakul

“…This cut-off offered the highest value for Youden’s index (0.50), the best AUROC, and the optimum values for sensitivity (78.9%) and specificity (70.9%).Conclusions The model developed by the previous study was able to predict the occurrence of postoperative delirium in critically ill surgical patients admitted to SICUs.Trial registration number Thai Clinical Trail Registry (TCTR20180105001).…”
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The Influence of the Farming System and Forecrop on the Yield and Chemical and Health-Promoting Composition of Spring Wheat Grain by Elżbieta Harasim, Cezary A. Kwiatkowski, Jan Buczek

“…Among the forecrops, red clover and sugar beet had the most beneficial effect on grain quality (including the amino acid composition and EAAI index), followed by oat (especially under organic farming conditions). …”
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Growth and Productivity Assessment of Short-Duration Rice (Oryza sativa L. and Upland NERICA) Genotypes in Semiarid North-Central Namibia by Simon K. Awala, Kudakwashe Hove, Vistorina Shivute, Johanna S. Valombola, Pamwenafye I. Nanhapo, Yoshihiro Hirooka, Osmund D. Mwandemele, Morio Iijima

“…The results showed significant genotype by year interaction for days to heading, plant height, the number of tillers per m2, shoot biomass, the number of panicles per m2, 1000-grain weight, harvest index, and grain yield. The IRRI genotypes produced a higher number of tillers, shoot biomass, and grain yield than the NERICA ones, which were early maturing, were taller, and had higher 1000-grain weight across the years. …”
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Study on Pressure Relief Zone Formed Inside Roadway Rib by Rotary Cutting with Pressurized Water Jet for Preventing Rock Burst by Zeng-Qiang Yang, Chang Liu, Hui-Wu Jin

“…Based on the engineering geological conditions of mining area 2502 in Yanbei coal mine as a background, the comprehensive index method is used to evaluate the rock burst risk of mining area 2502, and the burst tendency of coal seam 5# under natural and water-saturated conditions is also tested in laboratory. …”
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Oxidative Stability at Different Storage Conditions and Adulteration Detection of Prickly Pear Seeds Oil by Fatima Ettalibi, Abderraouf El Antari, Chemseddoha Gadhi, Hasnaâ Harrak

“…The present study investigates the control of two commercial quality aspects of prickly pear seeds oil (PPSO): oxidative stability during storage and detection of adulteration. Peroxide index, specific extinction coefficients K232 and K270, free acidity, and fatty acids composition were evaluated during different periods of incubation (6, 12, and 18 months) at various temperatures (4°C, 25°C, 40°C, and uncontrolled room temperature ranging between 4°C and 40°C) with different packaging (protected and unprotected from sunlight, with and without nitrogen gas bubbling). …”
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Structural validity and internal consistency of the Patient Centred Assessment Method in a primary care setting in a Japanese island area: a cross-sectional study by Masato Matsushima, Shuhei Yoshida, Rieko Mutai, Yoshifumi Sugiyama, Ryoko Horiguchi, Hisashi Yoshimoto

“…Confirmatory factor analysis found that the previously reported two-factor and three-factor structures did not show a good fit (root mean square error of approximation 0.18 and 0.16, comparative fit index 0.83 and 0.89 and standardised root mean square residual 0.14 and 0.11, respectively). …”
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Evaluation of the association between lymph node ratio and long-term survival in patients after surgery for lymph node-positive bladder cancer: a SEER population-based study with e... by Tao Chen, Xinchang Zou, Yihe Li, Lifen Peng, Zhen Song, Haichao Chao, Bin Fu, Tao Zeng

“…The Kaplan-Meier method and Cox regression model were utilized to evaluate the association between LNR and overall survival (OS) and cancer-specific survival (CSS). Based on the LNR index, two nomograms were constructed to estimate the prognosis of patients with lymph node-positive bladder cancer. …”
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Physicochemical Characterisation and Potential Uses of Oils From the Entrails of Nile Tilapia From Different Farming Sites in Ghana by Ekow Quansar, Marcel Tunkumgnen Bayor, Janet Anchirinah, Stephen Yao Gbedema, Frederick William Akuffo Owusu, Desmond Asamoah Bruce Otu, Prince George Jnr Acquah, Kawsar Adam Baninie

“…The tilapia fish oil (TFO) was extracted by the wet rendering method. The refractive index, fatty acid profile, colour and cholesterol content of the TFO samples (TFS1, TFS2, TFS3 and TFS4) were determined using a refractometer, GC–MS, chromameter and UV spectrophotometer, respectively. …”
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Dicoumarol sensitizes hepatocellular carcinoma cells to ferroptosis induced by imidazole ketone erastin by Ziwei Yang, Ziwei Yang, Tixin Han, Ruibin Yang, Ruibin Yang, Yinuo Zhang, Yinuo Zhang, Yifei Qin, Yifei Qin, Yifei Qin, Jialu Hou, Jialu Hou, Fei Huo, Fei Huo, Zhuan Feng, Zhuan Feng, Yaxin Ding, Yaxin Ding, Jiali Yang, Jiali Yang, Gang Zhou, Gang Zhou, Shijie Wang, Shijie Wang, Xiaohang Xie, Xiaohang Xie, Peng Lin, Peng Lin, Zhi-Nan Chen, Zhi-Nan Chen, Jiao Wu, Jiao Wu

“…Differentially expressed genes were identified and intersected with the ferroptosis-related genes (FRGs) listed in the FerrDb database, yielding the identification of 13 distinct FRGs.ResultsA ferroptosis signature index model (Risk Score) was developed to predict HCC prognosis. …”
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Prevalence of piriformis syndrome and its associated risk factors among university students in Pakistan: a cross-sectional study by Hassan N Moafa, Nusrat Batool, Naila Azam, Azka Hafeez, Humaira Mehmood, Nimbal Imtiaz, Waqas A Shehzad, Asaad Saleem Malik, Ajiad Alhazmi, Manal Almalki, Almutasim B Moafa, Jobran M Moshi

“…Secondary outcome measures included the severity of PS.Results Of the total, 119 (62.6%) were female, 114 (60.0%) were between 22 and 25 years old, and 125 (65.8%) had standard body mass index. The prevalence of PS was (61.1%), whereas half suffered from severe PS, and the remaining half had mild and moderate PS. …”
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Protocol for the impact of CBT for insomnia on pain symptoms and central sensitisation in fibromyalgia: a randomised controlled trial by Michael Robinson, Chokkalingam Siva, Christina S McCrae, Ashley F Curtis, Jason Craggs, Chelsea Deroche, Pradeep Sahota, Roland Staud

“…The following assessments will be completed: 2 weeks of daily diaries measuring sleep and pain, daily actigraphy, insomnia severity index, pain-related disability, single night of polysomnography recording, arousal (heart rate variability, cognitive affective arousal), structural and functional MRI to examine pain-related neural activity and plasticity and mood (depression, anxiety).Ethics and dissemination Ethics approval was obtained in July 2018 from the University of Missouri. …”
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Role of ixodid ticks in tick-borne pathogen spread and circulation in the Belarusian Lakeland by A. A. Osmolovsky, I. A. Subotsina

“…The following epidemically and epizootically significant ticks contributing to transmissible infection and invasion spread were found in the Belarusian Lakeland: ticks of Ixodes and Dermacentor genera; their frequency index was 70.1 and 29.9%, respectively. Tick-transmitted pathogen prevalence rate in the examined territories of the Vitebsk Raion was as follows: 61.7% for Borrelia spp., 25.8% for Anaplasma spp. …”
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Evaluation of Growth Performance, Carcass Characteristics, Digestibility and Ileum Histomorphology of Broiler Chickens fed Two Forms of Diets Supplemented with Exogenous Proteases by RA Alhotan, HH Al-Baadani, EOS Hussein

“…The results showed that birds in the C and D groups in pelleted form had a higher body weight, production and performance index, and better feed conversion ratio. Chickens fed a pelleted diet with protease C, followed by proteases B and D, and chickens fed a diet mashed with protease C had a higher digestibility of dry matter and crude protein. …”
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Metabolic and Hepatic Effects of Energy-Reduced Anti-Inflammatory Diet in Younger Adults with Obesity by Gordana Kenđel Jovanović, Ines Mrakovcic-Sutic, Sandra Pavičić Žeželj, Indira Benjak Horvat, Lucia Šuša, Dario Rahelić, Sanja Klobučar Majanović

“…The inflammatory potential of the diet was assessed by the Dietary Inflammatory Index, DII®. Results. Energy-restricted anti-inflammatory diet resulted in significant weight loss (−7.1%, p < 0.001), in reducing the visceral adiposity (−22.3%, p < 0.001), metabolic (HOMA-IR, −15.5%; total cholesterol, −5.3%; LDL-C, −4.6%; triglycerides, −12.2%), and inflammatory biomarkers (hs-CRP, −29.5%; IL-6, −18.2%; TNF-α, −34.2%), with significant improvement of liver parameters (NAFLD-FLS, −143.4%; FLI, −14.3%; FIB-4, −2.5%). …”
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