A single residue switch mediates the broad neutralization of Rotaviruses by Yang Huang, Feibo Song, Yuanjun Zeng, Hui Sun, Roufang Sheng, Xuechun Wang, Liqin Liu, Guoxing Luo, Yanan Jiang, Yaling Chen, Mengxuan Zhang, Shiyin Zhang, Ying Gu, Hai Yu, Shaowei Li, Tingdong Li, Qingbing Zheng, Shengxiang Ge, Jun Zhang, Ningshao Xia

“…A combination of time-resolved cryo-electron microscopy (cryo-EM) and in situ cryo-electron tomography (cryo-ET) analysis reveals a counterintuitive dynamic process of virus inactivation, in which 7H13 asymmetrically binds to a conserved epitope in the capsid-proximal aspect of VP4, triggers a conformational switch in a critical residue—F418—thereby disrupts the meta-stable conformation of VP4 essential for normal viral infection. …”
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Knockout of <i>dhx38</i> Causes Inner Ear Developmental Defects in Zebrafish by Mengmeng Ren, Xiang Chen, Liyan Dai, Jiayi Tu, Hualei Hu, Xiaohan Sun, Jiong Luo, Pei Li, Yiyang Fu, Yuejie Zhu, Weiqiang Sun, Zhaohui Tang, Mugen Liu, Xiang Ren, Qunwei Lu

“…<b>Methods</b>: Bright-field morphological analysis and in situ hybridization were performed to observe ear morphology changes. …”
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Loss of MTAP expression is strongly linked to homozygous 9p21 deletion, unfavorable tumor phenotype, and noninflamed microenvironment in urothelial bladder cancer by Natalia Gorbokon, Niklas Wößner, Viktoria Ahlburg, Henning Plage, Sebastian Hofbauer, Kira Furlano, Sarah Weinberger, Paul Giacomo Bruch, Simon Schallenberg, Florian Roßner, Sefer Elezkurtaj, Maximilian Lennartz, Niclas C Blessin, Andreas H Marx, Henrik Samtleben, Margit Fisch, Michael Rink, Marcin Slojewski, Krystian Kaczmarek, Thorsten Ecke, Tobias Klatte, Stefan Koch, Nico Adamini, Sarah Minner, Ronald Simon, Guido Sauter, Henrik Zecha, David Horst, Thorsten Schlomm, Lukas Bubendorf, Martina Kluth

“…A tissue microarray including 2,710 urothelial bladder carcinomas were analyzed for 9p21 deletion by fluorescence in situ hybridization and MTAP expression by IHC. Data were compared with data on tumor phenotype, patient survival, intratumoral lymphocyte subsets, and PD‐L1 expression. …”
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Identification and expression analysis of the heat shock proteins Hsp70, Hsp90, and Hsp90b in Litopenaeus vannamei under low-temperature stress by Min Peng, Hui Wang, Shuiping Wen, Zheng Liang, Zheng Huang, Bin Zhang, Tianchong Chen, Qingyun Liu, Qiangyong Li, Yuan Meng, Yuliu Huang, Chunling Yang, Digang Zeng, Manyuan Li, Weilin Zhu, Yongzhen Zhao

“…This study investigated the tissue-specific expression patterns of the heat shock protein genes hsp70, hsp90, and hsp90b in L. vannamei under low-temperature stress, and their correlation with cold tolerance. Fluorescence in situ hybridization revealed widespread expression of hsp70, hsp90, and hsp90b in the nucleus and cytoplasm of hepatopancreatic tubular cells. …”
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Modulating the sulfurization procedure to decrease by-product formation for one-step catalytic synthesis of sulfur-containing chemicals by ZhiZhi Xu, Jian Fang, Min Luo, Dedong He, Dingkai Chen, Jichang Lu, Yongming Luo

“…The activity tests, the characterization results and in situ DRIFTS technique demonstrate that a slower sulfurization heating rate and abundant-reduced sulfurization atmosphere facilitate the formation of K-intercalated 1 T-MoS2 phase, which possesses a weaker Mo-S(O) bond than that of CO bond in CO molecules. …”
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Preindustrial-to-present-day changes in atmospheric carbon monoxide: agreement and gaps between ice archives and global model reconstructions by X. Faïn, S. Szopa, V. Naïk, P. Martinerie, D. M. Etheridge, D. M. Etheridge, R. H. Rhodes, C. M. Trudinger, C. M. Trudinger, V. V. Petrenko, K. Fourteau, P. Place, P. Place

“…However, a divergence in the [CO] growth rate emerges in the NH between models and observations over the 1920–1980 period, attributed to uncertainties in CO emission factors (EFs), particularly EFs for the RCO (residential, commercial, and other) and transportation sectors, although we cannot totally rule out the possibility that the CO record based on the Greenland ice archives may be biased high by CO chemical production processes occurring in the ice prior<span id="page1106"/> to the measurements (i.e. in situ CO production). In the Southern Hemisphere, AerChemMIP models simulate an increase in atmospheric [CO] from 1850 to 1980 that closely reproduces the observations (22 <span class="inline-formula">±</span> 10 ppb and 13 <span class="inline-formula">±</span> 7 ppb, respectively). …”
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Revealing the biological features of the axolotl pancreas as a new research model by Hui Ma, Hui Ma, Hui Ma, Guangcong Peng, Yan Hu, Binbin Lu, Binbin Lu, Yiying Zheng, Yingxian Wu, Weimin Feng, Yu Shi, Xiangyu Pan, Li Song, Ina Stützer, Yanmei Liu, Jifeng Fei, Jifeng Fei, Jifeng Fei

“…Pancreatic development was observed using in situ hybridization and immunostaining for key pancreatic markers. …”
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Études comportementales pour la conservation du singe laineux de Poeppig (Lagothrix l. poeppigii) by Justine Philippon

“…En partenariat avec le centre de réhabilitation de l’association Ikamaperu situé en Amazonie péruvienne aux portes de la Réserve Nationale Pacaya-Samiria, ce projet représente l’opportunité unique d’approfondir les connaissances sur le comportement du singe laineux par l’observation comportementale de 47 individus de la sous-espèce Lagothrix l. poeppigii vivant en semi-liberté. …”
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Research Progress on Stem Cell Therapies for Articular Cartilage Regeneration by Shuangpeng Jiang, Guangzhao Tian, Xu Li, Zhen Yang, Fuxin Wang, Zhuang Tian, Bo Huang, Fu Wei, Kangkang Zha, Zhiqiang Sun, Xiang Sui, Shuyun Liu, Weimin Guo, Quanyi Guo

“…Endogenous stem cell homing and in situ regeneration strategies have received extensive attention. …”
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Macrofaunal biopores: Diversity and regeneration rates across diverse pedoclimatic conditions studied with repacked soil cores by Charlotte Védère, Hanane Aroui Boukbida, Yvan Capowiez, Sougueh Cheik, Guillaume Coulouma, Rinh Pham Dinh, Séraphine Grellier, Claude Hammecker, Thierry Henry Des Tureaux, Ajay Harit, Jean Louis Janeau, Pascal Jouquet, Jean Luc Maeght, Pascal Podwojewski, Cornelia Rumpel, Stéphane Sammartino, Norbert Silvera, Siwaporn Siltecho, Lotfi Smaili, Bounsamay Soulileuth, Nicolas Bottinelli

“…In this study we investigated the diversity of biopores and their regeneration rates in situ in various pedoclimatic conditions. Our approach involved field incubation of repacked soil cores with lateral openings across nine study sites in five countries (France, Vietnam, India, Laos and Thailand). …”
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Assessment framework to predict sensitivity of marine calcifiers to ocean alkalinity enhancement – identification of biological thresholds and importance of precautionary principle... by N. Bednaršek, H. van de Mortel, G. Pelletier, G. Pelletier, M. García-Reyes, R. A. Feely, A. G. Dickson, A. G. Dickson

“…Thus, we emphasize the importance of including much lower additions of alkalinity in experimental trials to realistically evaluate in situ biological responses. However, it is important to note our results do not consider equilibration with the atmosphere and are thus only applicable to short-term and near-field application. …”
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Retrospective, Non-Interventional, Multicenter Study on the Effectiveness and Safety of Intravesical Bacillus Calmette–Guerin in Patients with Non-Muscle-Invasive Bladder Cancer: R... by Panagiotis Angelopoulos, Titos Markopoulos, Lazaros Lazarou, Andreas Skolarikos, Panagiotis Stamatakos, Georgios I. Papadopoulos, Charalampos Fragkoulis, Konstantinos Ntoumas, Napoleon Moulavasilis, Panagiotis Levis, Dimitrios Papanikolaou, Ioannis Sokolakis, Konstantinos Hatzimouratidis, Charalampos Tzanetakos, Marina Psarra, George Mavridoglou, Konstantinos Skriapas, Dimitra Akrivou, Dimitrios Karagiannis, Christos Noutsos, Andreas Georgiou, Konstantinos Hastazeris, George Gourzoulidis, Dionysios Mitropoulos

“…Methods: From January 2016 to December 2023, medical records from six hospital centers were reviewed for adult patients with histologically confirmed stage Ta or T1 NMIBC (with or without carcinoma in situ [CIS]) who received at least one maintenance course of SII-ONCO-BCG after induction. …”
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Unraveling the depth-dependent causal dynamics of methanogenesis and methanotrophy in a high-latitude fen peatland by Shuai Yang, Jinyun Tang, Zhen Li, Kunxiaojia Yuan, Qiong Wu, Kuang-Yu Chang, Suzanne B Hodgkins, Rachel M Wilson, Qing Zhu, Robert F Grant, William J Riley, Scott R Saleska, Virginia I Rich, Ruth K Varner

“…Additionally, long-term in situ measurements within soil columns are limited and associated with large uncertainties in microbial substrates (e.g. dissolved organic carbon, acetate, hydrogen). …”
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An Overview of Solar Orbiter Observations of Interplanetary Shocks in Solar Cycle 25 by Domenico Trotta, Andrew Dimmock, Heli Hietala, Xochitl Blanco-Cano, Timothy S. Horbury, Rami Vainio, Nina Dresing, Immanuel Christopher Jebaraj, Francisco Espinosa Lara, Raúl Gómez-Herrero, Javier Rodriguez-Pacheco, Yulia Kartavykh, David Lario, Jan Gieseler, Miho Janvier, Milan Maksimovic, Nasrin Talebpour Sheshvan, Christopher J. Owen, Emilia K. J. Kilpua, Robert F. Wimmer-Schweingruber

“…We use previously unavailable measurements of IP shocks in the inner heliosphere provided by Solar Orbiter, and present a survey of the first 100 shocks observed in situ at different heliocentric distances during the rising phase of solar cycle 25. …”
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Multi-omics analysis reveals the interplay between intratumoral bacteria and glioma by Ting Li, Zhanyi Zhao, Meichang Peng, Lu Zhang, Cheng Wang, Feiyang Luo, Meiqin Zeng, Kaijian Sun, Zhencheng Fang, Yunhao Luo, Yugu Xie, Cui Lv, Jiaxuan Wang, Jian-Dong Huang, Hongwei Zhou, Haitao Sun

“…We employed immunohistochemistry, multicolor immunofluorescence, and fluorescence in situ hybridization (FISH) staining to observe the presence and location of bacteria. …”
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Une pompe hydraulique romaine en bois en contexte d’incendie à Reims/Durocortorum by Cyril Driard

“…The pistons were found in situ inside and they are of different design. The one discovered in the right cylinder consists of circular pieces of leather nailed to the end of the wooden sleeve using a single, large iron nail. …”
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Cambios hidrográficos estacionales a lo largo de la costa del Golfo de Arauco (37º S) by Odette A. Vergara, Josse Contreras-Rojas, Richard Muñoz, Luis Bermedo, Marcus Sobarzo, Gonzalo S. Saldías, Cristian Chandía, Aldo Hernández, Marco Salamanca, Eduardo Hernández-Miranda

“…Adicionalmente, datos satelitales provenientes del sensor MODIS-aqua de temperatura superficial del mar, clorofila-a y Rrs645 fueron utilizados para complementar la información in situ. Nuestros resultados muestran una marcada estacionalidad en la hidrografía del golfo de Arauco, principalmente en la temperatura superficial del mar. …”
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Bioinspired hierarchical porous tough adhesive to promote sealing of high-pressure bleeding by Yinghao Li, Dongling Xiao, Weixi Yan, Meilin Jiang, Ju Tan, Zhongliang Qin, Jingting Zhou, Yue Sun, Mingcan Yang, Guanyuan Yang, Yawei Gu, Yong Liu, Chuhong Zhu

“…This hierarchical matrix is fabricated through a phase separation process, which involves the in-situ formation of nanoporous aggregates within a microporous double-network (DN) matrix. …”
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Uptake and 4-week outcomes of an ‘opt-out’ smoking cessation referral strategy in a London-based lung cancer screening setting by Anthony Edey, Neal Navani, Kitty Chan, Graham Robinson, Janine Zylstra, Paul Robinson, Laura Green, Anand Devaraj, Jane Rowlands, Allan Hackshaw, Carolyn Horst, Arjun Nair, Sam M Janes, Kate Davies, Jeannie Eng, Mamta Ruparel, Samantha L Quaife, Jennifer L Dickson, Magali Taylor, Angshu Bhowmik, Hasti Robbie, Joseph Jacob, Laura Farrelly, Sophie Tisi, Tanya Patrick, Andrew Creamer, Helen Hall, Samanjit Hare, Jon Teague, Samuel M Janes, Esther Arthur-Darkwa, Thea Buchan, Stephen Ellis, Thomas Callender, Rachael Sarpong, John McCabe, Zaheer Mangera, Ethaar El-Emir, Terry O'Shaughnessy, Geoff Bellingan, Nick Screaton, Priyam Verghese, William M Ricketts, Vicky Bowyer, Kylie Gyertson, Fanta Bojang, Claire Levermore, Tania Anastasiadis, Ruth Prendecki, Amyn Bhamani, Malavika Suresh, Judy Airebamen, Alice Cotton, Kaylene Phua, Elodie Murali, Simranjit Mehta, Karen Parry-Billings, Columbus Ife, April Neville, Zahra Hanif, Helen Kiconco, Ricardo McEwen, Dominique Arancon, Nicholas Beech, Derya Ovayolu, Christine Hosein, Sylvia Patricia Enes, Qin April Neville, Aashna Samson, Urja Patel, Fahmida Hoque, Hina Pervez, Sofia Nnorom, Moksud Miah, Julian McKee, Mark Clark, Anant Patel, Sara Lock, Rajesh Banka, Ugo Ekeowa, Charlotte Cash, Tunku Aziz, Alberto Villanueva, Elena Stefan, Charlie Sayer, Navinah Nundlall, Andrew Crossingham, Tanita Limani, Kate Gowers, Andrew Perugia, James Rusius, Anne-Marie Hacker, Monica L Mullin, Evangelos Katsampouris, Chuen R Khaw, Chuen Khaw, Sheetal Karavadra, Alan Shaw, Chris Valerio, Ali Mohammed, Lynsey Gallagher, Mehran Azimbagirad, Burcu Ozaltin, Maureen Browne, Eleanor Hellier, Catherine Nestor

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Charles Lévesque, entre les genres by Luc Bonenfant

“…Lue à partir de ses jeux formels et rythmiques tout autant que depuis la singularité de sa voix, l’œuvre de Lévesque montre en effet son originalité pleine, alors qu’elle se situe entre les genres (ce mot étant entendu tout autant au sens de « catégorie littéraire » que du « genre sexué »). …”
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