CMEs and SEPs During November–December 2020: A Challenge for Real‐Time Space Weather Forecasting by Erika Palmerio, Christina O. Lee, M. Leila Mays, Janet G. Luhmann, David Lario, Beatriz Sánchez‐Cano, Ian G. Richardson, Rami Vainio, Michael L. Stevens, Christina M. S. Cohen, Konrad Steinvall, Christian Möstl, Andreas J. Weiss, Teresa Nieves‐Chinchilla, Yan Li, Davin E. Larson, Daniel Heyner, Stuart D. Bale, Antoinette B. Galvin, Mats Holmström, Yuri V. Khotyaintsev, Milan Maksimovic, Igor G. Mitrofanov

“…We validate our results using in situ observations at six locations, including Earth and Mars. …”
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Leveraging AI to automate detection and quantification of extrachromosomal DNA to decode drug responses by Kohen Goble, Aarav Mehta, Damien Guilbaud, Jacob Fessler, Jingting Chen, William Nenad, William Nenad, Christina G. Ford, Oliver Cope, Darby Cheng, William Dennis, Nithya Gurumurthy, Yue Wang, Kriti Shukla, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk

“…Extrachromosomal DNA (ecDNA), in contrast, represents a rapid, reversible, and predictable DNA alteration critical for cancer’s adaptive response.MethodsIn this study, we developed a novel post-processing pipeline for automated detection and quantification of ecDNA in metaphase Fluorescence in situ Hybridization (FISH) images, leveraging the Microscopy Image Analyzer (MIA) tool. …”
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Introducing the SMAP L4 Products and Investigating the Spatio-Temporal Variability of Soil Moisture in Iran by Ebrahim Asadi Oskouei, Leila Godarzy, Jalil Helali

“…Background and objectives: Although estimation of soil surface moisture plays an important role in soil and water resources management, unfortunately, there is currently no national soil moisture monitoring network in Iran and the distribution of in situ measurement stations is irregular and some provinces do not have any measuring station. …”
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Transcriptomic signatures of cold acclimated adipocytes reveal CXCL12 as a Brown autocrine and paracrine chemokine by Marina Agueda-Oyarzabal, Marie S. Isidor, Kaja Plucińska, Lars R. Ingerslev, Oksana Dmytriyeva, Patricia S.S. Petersen, Sara Laftih, Axel B. Pontoppidan, Jo B. Henningsen, Kaja Rupar, Erin L. Brown, Thue W. Schwartz, Romain Barrès, Zachary Gerhart-Hines, Camilla C. Schéele, Brice Emanuelli

“…Cxcl12 mRNA expression analysis by RT-qPCR and fluorescence in situ hybridization specified Cxcl12 distribution in various cell types, and indicated its enrichment in cold-acclimated brown adipocytes. …”
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A compilation of surface inherent optical properties and phytoplankton pigment concentrations from the Atlantic Meridional Transect by T. M. Jordan, G. Dall'Olmo, G. Tilstone, R. J. W. Brewin, F. Nencioli, R. Airs, C. S. Thomas, L. Schlüter

“…<p>In situ measurements of particulate inherent optical properties (IOPs) – absorption (<span class="inline-formula"><i>a</i>_p(<i>λ</i>)</span>), scattering (<span class="inline-formula"><i>b</i>_p(<i>λ</i>)</span>), and beam attenuation (<span class="inline-formula"><i>c</i>_p(<i>λ</i>)</span>) – are crucial for the development of optical algorithms that retrieve biogeochemical quantities such as chlorophyll <span class="inline-formula"><i>a</i></span>, particulate organic carbon (POC), and total suspended matter (TSM). …”
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Tunning valence state of cobalt centers in Cu/Co-CoO1-x for significantly boosting water-gas shift reaction by Xing-Chi Li, Jun-Hao Wang, Tao-Tao Huang, Yang Hu, Xin Li, De-Jiu Wang, Wei-Wei Wang, Kai Xu, Chun-Jiang Jia, Hao Dong, Guangshe Li, Chen Li, Ya-Wen Zhang

“…A synergistic mechanism is proposed that Coδ+ species can be easily reduced by CO adsorbed on Cu and Co0 can be oxidized by H2O. Systematic in situ characterization results reveal that the addition of Cu can regulate the redox properties of Co species and thus modulate the adsorption properties of catalysts. …”
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Pressure‐Enhanced Superconductivity and Structural Phase Transition in Layered Sn4P3 by Hao Ding, Jingyu Hou, Kun Zhai, Xin Gao, Junquan Huang, Feng Ke, Bingchao Yang, Congpu Mu, Fusheng Wen, Jianyong Xiang, Bochong Wang, Tianyu Xue, Anmin Nie, Xiaobing Liu, Lin Wang, Xiang‐Feng Zhou, Zhongyuan Liu

“…Comprehensive measurements using in situ synchrotron X‐Ray diffraction and Raman spectroscopy reveal a structural phase transition with mild distortion of SnP3 building blocks and interlayer shrinkage under high pressure. …”
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Reductive acetogenesis is a dominant process in the ruminant hindgut by Qiushuang Li, Jiabin Huo, Gaofeng Ni, Fan Zhang, Shizhe Zhang, Xiumin Zhang, Rong Wang, Jinzhen Jiao, Zhongtang Yu, Xuanxuan Pu, Yipeng Yue, Emilio M. Ungerfeld, Xiaoli Zhang, Jian Wu, Zhiliang Tan, Chris Greening, Min Wang

“…Results To address this gap, we comparatively investigated the composition, capabilities, and activities of the rumen and the cecum microbiome using goats as an experimental ruminant model. In situ measurements showed significantly higher levels of dissolved hydrogen and acetate in the cecum than in the rumen. …”
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Localization and expression of C1QTNF6 in chicken follicles and its regulatory effect on follicular granulosa cells by Chong Li, Qi Li, Xing Wu, Zihao Zhang, Jing Li, Ruirui Jiang, Guoxi Li, Xiaojun Liu, Xiangtao Kang, Zhuanjian Li, Donghua Li, Yadong Tian

“…Using quantitative real-time PCR (qRT-PCR) and fluorescence in situ hybridization (FISH), we observed that C1QTNF6 is widely expressed in adult chicken follicle tissues, predominantly in granulosa cells (GCs). …”
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CircTTC13 promotes sorafenib resistance in hepatocellular carcinoma through the inhibition of ferroptosis by targeting the miR-513a-5p/SLC7A11 axis by Ying Zhang, Ruiwei Yao, Mingyi Li, Chongkai Fang, Kunliang Feng, Xiuru Chen, Jinan Wang, Rui Luo, Hanqian Shi, Xinqiu Chen, Xilin Zhao, Hanlin Huang, Shuwei Liu, Bing Yin, Chong Zhong

“…In silico analysis, luciferase assays, and fluorescence in situ hybridization collectively demonstrated that circTTC13 directly targets and reduces miR-513a-5p expression, which in turn leads to the upregulation of the negative ferroptosis regulator SLC7A11. …”
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Analytical methods for nanomaterials investigation in food and food-related materials by Daniele Passeri, Pierfrancesco Atanasio, Anacleto Proietti, Chiara Mancini, Flavio Cognigni, Giancarlo La Penna, Luca Buccini, Marco Rossi, Anna Chiara Turco, Marilena D'Amato, Angela Sorbo, Simone Dinarelli, Giulia D'Ettorre, Federica Aureli

“…Thus, the characterization of the nanomaterials ‘in situ’, e.g., directly inside the biological matrix, is of paramount importance, to measure the real concentration of the nanomaterials as well as their distribution and unwanted local modification of the biological matrix. …”
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Achalasia—An Autoimmune Inflammatory Disease: A Cross-Sectional Study by J. Furuzawa-Carballeda, D. Aguilar-León, A. Gamboa-Domínguez, M. A. Valdovinos, C. Nuñez-Álvarez, L. A. Martín-del-Campo, A. B. Enríquez, E. Coss-Adame, A. E. Svarch, A. Flores-Nájera, A. Villa-Baños, J. C. Ceballos, G. Torres-Villalobos

“…Herpes simplex virus-1 (HSV-1) infection was determined by in situ hybridization, RT-PCR, and immunohistochemistry. …”
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Surface water and flood-based agricultural systems: Mapping and modelling long-term variability in the Senegal river floodplain by Andrew Ogilvie, Cheickh Sadibou Fall, Ansoumana Bodian, Didier Martin, Laurent Bruckmann, Djiby Dia, Issa Leye, Papa Malick Ndiaye, Donissongou Dimitri Soro, Jean Homian Danumah, Jean-Claude Bader, Jean-Christophe Poussin

“…Combining the advances in earth observations with hydrological modelling and extensive in situ fieldwork, this research seeks to improve our understanding of surface water dynamics and associated agricultural practices in the Senegal river floodplain. 2813 mosaics from Landsat, MODIS and Sentinel-2 earth observations are created to map and monitor surface water variations using a site specific MNDWI classification adapted to complex, wetland environments. …”
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Comparison of shortwave radiation dynamics between boreal forest and open peatland pairs in southern and northern Finland by O. Peräkylä, E. Rinne, E. Ezhova, A. Lintunen, A. Lintunen, A. Lohila, A. Lohila, J. Aalto, J. Aalto, M. Aurela, P. Kolari, M. Kulmala

“…At seasonally snow-covered high latitudes, this lowering of the albedo has been suggested to offset some or all of the climate cooling effect of the carbon stored by forests. We used long-term in situ measurements to study the albedo and shortwave radiation balance of two pairs of sites, each consisting of an open peatland and a forest. …”
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Delay of Near-relativistic Electrons with Respect to Type III Radio Bursts throughout the Inner Heliosphere by J. G. Mitchell, E. R. Christian, G. A. de Nolfo, C. M. S. Cohen, M. E. Hill, A. Kouloumvakos, A. W. Labrador, R. A. Leske, D. J. McComas, R. L. McNutt Jr., D. G. Mitchell, M. Shen, N. A. Schwadron, M. E. Wiedenbeck, S. D. Bale, M. Pulupa

“…This is noteworthy because type III radio emission is produced by streaming suprathermal electrons, and thus this observed delay implies either a delayed injection/release of higher-energy electrons, compared with the suprathermal population, and/or a delay of the electrons observed in situ in transit through the interplanetary medium. …”
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An aquaria set‐up for long‐term, multiple‐stressor research in marine organisms by Cristina Gutiérrez‐Zárate, Alfredo Veiga, Andrea Gori, Fabián Gerpe, Leo Domínguez, Alberto Rodríguez, Noelia Arias, Marta Álvarez, Rubén Acerbi, Lucía Vázquez, Juancho Movilla, Marta M. Varela, Rodrigo Alba‐Salgueiro, Joaquín Valencia‐Vila, Covadonga Orejas

“…To prove the efficacy of the set‐up, we provide an assessment over a nine‐month experiment on a deep‐sea coral species, combining values from current in situ and IPCC AR5 RCP 8.5 scenarios for the aforementioned parameters. …”
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Field-based evidence for the prevalence of soil antibiotic resistomes under long-term antibiotic-free fertilization by Yuhao Fu, Fang Hu, Fang Wang, Min Xu, Zhongjun Jia, Wulf Amelung, Zhi Mei, Xiaozeng Han, Marko Virta, Xin Jiang, James M. Tiedje

“…This study aimed to quantify the assembly patterns of the antibiotic resistome by in situ probing bacterial community and environmental variations in field soils that have been subjected to long-term exposure to chemical fertilizer and/or manure from animals without antibiotic amendments. …”
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Cancer Cell‐Derived Exosomal miR‐500a‐3p Modulates Hepatic Stellate Cell Activation and the Immunosuppressive Microenvironment by Yu Zhang, Xin Li, Huiyan Chen, Jiawei Li, Xiaohuan Guo, Yilin Fang, Linjie Chen, Kaiqiang Li, Yi Zhang, Fei Kong, Aodong Chen, Jianxin Lyu, Wei Zhang, Zhen Wang

“…Moreover, miR‐500a‐3p is associated with CD4+ T‐cell exhaustion and Treg differentiation and is significantly associated with increased tumorigenicity in in situ mouse HCC models. Mechanistically, HCC‐derived exosomal miR‐500a‐3p directly influences SOCS2 to regulate the JAK3/STAT5A/STAT5B signaling pathway. …”
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CeO2−δ as Electron Donor in Co0.07Ce0.93O2−δ Solid Solution Boosts Alkaline Water Splitting by Gege Su, Yichao Hou, Jie Yin, Jiayi Yang, Zhenglong Li, Xin Du, Xin Zhang, Pinxian Xi, Chun‐Hua Yan

“….), in which Co0.07Ce0.93O2−δ shows optimized band structure because of electron transition in the reaction, namely Co3+ (3d64s0) + Ce3+ (4f15d 06s0) → Co2+ (3d74s0) + Ce4+ (4f05d06s0), with more stable electronic configuration. The in situ Raman spectra show a stable F2g peak at ≈452 cm−1 of Co0.07Ce0.93O2−δ, while the F2g peak in CeO2−δ almost disappeared during HER progress, demonstrating the charge distribution of *H adsorbed on Co0.07Ce0.93O2−δ is more stable than *H adsorbed on CeO2−δ. …”
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Mixing-enthalpy modulation on phase transformation in the gradient chemical core/shell high-entropy shape-memory alloys by E-Wen Huang, Tu-Ngoc Lam, Zachary H. Aitken, Mao-Yuan Luo, Nien-En Chiang, Yuh Sun, Jo-Chi Tseng, Ching-Yu Chiang, Wan-Zhen Hsieh, Wen-Jay Lee, Yong-Wei Zhang, Peter K. Liaw, Che-Wei Tsai

“…In this study, selected benchmark phenomena revealed by in-situ synchrotron X-ray mapping demonstrates how local chemical gradients control temperature-dependent behaviors in HEAs. …”
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