Upregulation of α3β1-Integrin in Podocytes in Early-Stage Diabetic Nephropathy by Kaichiro Sawada, Masao Toyoda, Noriko Kaneyama, Sawako Shiraiwa, Hitomi Moriya, Han Miyatake, Eitaro Tanaka, Naoyuki Yamamoto, Masaaki Miyauchi, Moritsugu Kimura, Takehiko Wada, Masafumi Fukagawa

“…Surgical specimens from DN patients were examined by in situ hybridization, and the expression levels of α3- and β1-integrin subunits in glomeruli of early (n=6) and advanced (n=8) stages were compared with those of normal glomeruli (n=5). …”
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Study on the Effect of Isotropic Initial Stress on the Anchoring Performance of Self-Expanding Bolts by Jie Liu, Hongya Li, Yunzhou Li, Yunan Yang, Tao Sun, Rui Song, Rongqi Sun

“…In order to study the anchoring performance of a new type of self-expanding, high-strength, precompression anchoring technology with a large amount of expansion agent (ω ≥ 5) cement slurry as anchoring solids under confined surrounding rock conditions, a rock mass anchoring device and methods that simulate in situ stress are developed, and real-time monitoring of expansion stress and anchor pull-out tests are carried out. …”
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Anti-TNBC effects of Lappaol F by targeting epithelial-mesenchymal transition via regulation of GSK-3β/YAP/β-catenin and PI3K/AKT pathways by Qiqi Meng, Qiqi Meng, Zhiping Li, Xiaofeng He, Yuanhao Hu, Guiyun Wu, Jiawen Huang, Zhuohui Luo, Zhuohui Luo, Yingjie Hu, Xiaoling Shen

“…The present study aimed to reveal the potential mechanism of LAF against TNBC by in vivo and in vitro experiments.MethodsIn situ, transplantation-induced MDA-MB-231 solid tumor model in NCG mice and cultured MDA-MB-231 and Hs-578T cells were used to evaluate the anti-TNBC effect of LAF. …”
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Assimilating ESA CCI land surface temperature into the ORCHIDEE land surface model: insights from a multi-site study across Europe by L.-E. Olivera-Guerra, C. Ottlé, N. Raoult, P. Peylin

“…This improvement, assessed against CCI-LST and in situ observations, reaches up to a 60 % reduction in the root-mean-square deviation, with a median decrease of 20 % over the entire validation period (2009–2020). …”
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ADAMTS13 Improves Endothelial Function and Reduces Inflammation in Diabetic Retinopathy by Ahmed M. Abu El-Asrar, Mohd I. Nawaz, Ajmal Ahmad, Mairaj Siddiquei, Eef Allegaert, Lowie Adyns, Lotte Vanbrabant, Priscilla W. Gikandi, Gert De Hertogh, Sofie Struyf, Ghislain Opdenakker

“…Our findings suggest that enhancing ADAMTS13 levels in situ ameliorates diabetes-induced retinal inflammation and vascular dysfunction.…”
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CeRNA profiling and the role in regulating gonadal development in gold pompano by Changcan Yang, Yijun Zhao, Wendong Zhao, Hai Huang, Quanqi Zhang, Jinxiang Liu

“…Dual-luciferase gene reporter system and fluorescence in situ hybridization analyses preliminary verified the regulation relationship between Rspo1 and oni-let-7d-1-p3, as well as lnc-TGFβR and oni-let-7d-1-p3 in the cytoplasm of sertoli cells. …”
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MFBTFF-Net: A Novel Multi-Frequency Brightness Temperature Feature Fusion Network for Global Lunar Surface Oxides Abundance Estimation With Chang'e-2 Lunar Microwave Sounder... by Yu Li, Zifeng Yuan, Sarah Mazhar, Zhiguo Meng, Yuanzhi Zhang, Jinsong Ping, Ferdinando Nunziata

“…First, the majority of these studies rely on spectral data and used in situ (drilled) ground truth samples collected by satellite missions. …”
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Single Exposure to Low-Intensity Focused Ultrasound Causes Biphasic Opening of the Blood-Brain Barrier Through Secondary Mechanisms by Tasneem A. Arsiwala, Kathryn E. Blethen, Cullen P. Wolford, Geoffrey L. Pecar, Dhruvi M. Panchal, Brooke N. Kielkowski, Peng Wang, Manish Ranjan, Jeffrey S. Carpenter, Victor Finomore, Ali Rezai, Paul R. Lockman

“…<b>Methods:</b> We employed in situ brain perfusion to assess alterations in BBB integrity and transporter function, as well as multiplex cytokine analysis to quantify the inflammatory response. …”
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Geochemical signatures and nanomechanical properties of echinoid tests from nearshore habitats of Florida: environmental and physiological controls on echinoid biomineralization by Przemysław Gorzelak, Luis Torres Jr., Dorota Kołbuk, Tobias B. Grun, Michał Kowalewski

“…In this study, we (1) contrast geochemical signatures of specimens collected across multiple taxa and environmental settings to assess in situ the effects of environmental and physiological factors on skeletal biomineralogy; and (2) analyze the nanomechanical properties of the echinoid skeleton to assess potential linkages between magnesium/calcium (Mg/Ca) ratios and skeletal nanohardness. …”
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Efficacy and safety of edoxaban in patients with chronic thromboembolic pulmonary hypertension: protocol for a multicentre, randomised, warfarin-controlled, parallel group trial -... by Keiichi Fukuda, Satoshi Yasuda, Hiroyuki Tsutsui, Toyoaki Murohara, Kohtaro Abe, Koichiro Tatsumi, Junji Kishimoto, Yu Taniguchi, Yuichi Tamura, Koji Todaka, Shun Minatsuki, Kazuya Hosokawa, Yuko Kobayakawa, Takumi Inami, Nobutaka Ikeda

“…In patients with CTEPH, lifelong anticoagulation is mandatory to prevent recurrence of PE and secondary in situ thrombus formation. Warfarin, a vitamin K antagonist, is commonly used for anticoagulation in CTEPH based on historical experience and evidence. …”
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Aux origines gauloises de Tours (Indre-et-Loire) : état des connaissances by Sandrine Linger-Riquier

“…The objects were observed in situ or in a secondary position and were spread over approximately 500 m from north to south (spanning the Place de la Victoire to the Clocheville Hospital), and approximately 500 m from east to west (from the Place de la Résistance to the Place des Halles), i.e. over a maximum area of approximately 25 ha. …”
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Direct calibration using atmospheric particles and performance evaluation of Particle Size Magnifier (PSM) 2.0 for sub-10&thinsp;nm particle measurements by Y. Liu, Y. Liu, A. Yli-Kujala, F. Schmidt-Ott, S. Holm, L. Ahonen, T. Chan, J. Enroth, J. Vanhanen, R. Cai, T. Petäjä, M. Kulmala, Y. Chen, J. Kangasluoma

“…This suggests that chemical composition differences introduce measurement uncertainties and highlights the importance of in situ calibration. The size resolution of PSM 2.0 was characterized using metal particles. …”
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A sedimentological oxymoron: highly evolved glauconite of earliest diagenetic origin by Tribovillard, Nicolas, Bout-Roumazeilles, Viviane, Guillot, François, Baudin, François, Deconinck, Jean-François, Abraham, Romain, Ventalon, Sandra

“…Glauconite formation allegedly requires protracted episodes of ion capture from the water column, which is no longer possible when glauconite gets trapped within authigenic carbonates. Therefore, in-situ glauconite formation preceded carbonate authigenesis. …”
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Co–In Bimetallic Hydroxide Nanosheet Arrays With Coexisting Hydroxyl and Metal Vacancies Anchored on Rod‐Like MOF Template for Enhanced Photocatalytic CO2 Reduction by Jingjuan Feng, Weiwei Li, Tianxia Chen, Zhaopeng Zeng, Meng Tian, Wenxin Ji, Yan Guo, Shixiong Min, Xiangyu Liu

“…The metal‐organic framework (MOF) template‐grown LDHs demonstrate excellent promise for exploiting the strengths of both MOFs and LDHs. Herein, the in situ growth of MIL‐68(In)‐NH2 MOF‐templated Co–In bimetallic catalyst (CoIn‐LDH/MOF) having an ultrathin nanosheet morphology on the preserved rod‐like MOF template is demonstrated. …”
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Bursera graveolens en matorral desértico con fines de desarrollo forestal sostenible: Volumetría, peso, inventario forestal y regeneración natural by Miguel Antonio Puescas Chully, Eber Leopoldo Herrera Palacios, José Antonio Moscol Ortiz, Hidalgo Sandoval Eder E., William Huaman Huaman

“…El objetivo fue determinar el peso de madera seca de palo santo en 1 m3 por hectárea in situ en el bosque matorral desértico comprendido en el plan operativo anual (1 POA) de 100 ha del plan general de manejo forestal (PGMF) de 500 ha. …”
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Comparative Evaluation of AI-Based Multi-Spectral Imaging and PCR-Based Assays for Early Detection of <i>Botrytis cinerea</i> Infection on Pepper Plants by Dimitrios Kapetas, Eleni Kalogeropoulou, Panagiotis Christakakis, Christos Klaridopoulos, Eleftheria Maria Pechlivani

“…This approach marks a significant step forward in the detection and management of crop diseases, highlighting the potential to integrate such methods into <i>in situ</i> systems like mobile apps or robots.…”
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Co-obligate symbioses have repeatedly evolved across aphids, but partner identity and nutritional contributions vary across lineages by Manzano-Marín, Alejandro, Coeur d’acier, Armelle, Clamens, Anne-Laure, Cruaud, Corinne, Barbe, Valérie, Jousselin, Emmanuelle

“…Genome-based metabolic inference confirms interdependencies between Buchnera and its partners for the production of essential nutrients but shows contributions vary across pairs of co-obligate associates. Fluorescent in situ hybridisation microscopy shows a common bacteriocyte localisation of two newly acquired symbionts. …”
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Sox Genes Show Spatiotemporal Expression during Murine Tongue and Eyelid Development by Ryuichi Ishikawa, Maiko Kawasaki, Katsushige Kawasaki, Akane Yamada, Supaluk Trakanant, Fumiya Meguro, Atsushi Kitamura, Takehisa Kudo, Takeyasu Maeda, Atsushi Ohazama

“…We therefore performed a comparative in situ hybridization analysis of 17 Sox genes (Sox1–14, 17, 18, and 21) during murine tongue development. …”
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Development of nucleus-targeted histone-tail-based photoaffinity probes to profile the epigenetic interactome in native cells by Yu Wang, Jian Fan, Xianbin Meng, Qingyao Shu, Yincui Wu, Guo-Chao Chu, Rong Ji, Yinshan Ye, Xiangwei Wu, Jing Shi, Haiteng Deng, Lei Liu, Yi-Ming Li

“…Peptide- or protein-based histone photoaffinity tools expanded the ability to probe the epigenetic interactome, but in situ profiling in native cells remains challenging. …”
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Exploring the upper ocean characteristics of a bay using coastal and regional ocean community model by D. Jaishree, P.T. Ravichandran

“…The simulations were validated against the existing satellite, reanalysis, and in situ data.CONCLUSIONS: The innovativeness of this study lies in its successful demonstration of the seasonal variability of temperature and salinity in the Bay of Bengal. …”
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