MicroRNA-150-3p enhances the antitumour effects of CGP57380 and is associated with a favourable prognosis in non-small cell lung cancer by Hongmei Zheng, Songqing Fan, Jiadi Luo, Qiuyuan Wen, Hongjing Zang

“…High miR-150-3p expression may enhance the response to immunotherapy, cisplatin and gemcitabine. In summary, this study underscores the promising therapeutic implications of combining miR-150-3p and CGP57380 for NSCLC treatment. …”
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High Expression of Ten Eleven Translocation 1 Is Associated with Poor Prognosis in Hepatocellular Carcinoma by Haopeng Wen, Tengfei Ji, Liteng Lin, Nan Cheng, Kangshun Zhu, Liangqi Cao

“…High and low TET1 expression groups had distinct immune cell infiltration and response to immunotherapy and chemotherapy. We identified 90 DEGs related to DNA demethylation in high vs. low TET1 expression groups. …”
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DNA methylation and immune evasion in triple-negative breast cancer: challenges and therapeutic opportunities by Wen-yu Cai, Xin-xian Cai, Yi-ran Fei, Rui Ye, Ding-ming Song, Dan Hu, Wan-wan Zhang, Ming-fei Xia, Xiao-xiao Yang

“…The integration of epigenetic therapies and immunotherapy offers a promising avenue for improving survival in TNBC patients.…”
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Evaluation of Epstein-Barr Virus Latent Membrane Protein 2 Specific T-Cell Receptors Driven by T-Cell Specific Promoters Using Lentiviral Vector by Dongchang Yang, Qing Shao, Hua Sun, Xiaoxin Mu, Yun Gao, Runqiu Jiang, Jiajie Hou, Kun Yao, Yun Chen, Beicheng Sun

“…Transduction of latent membrane protein 2 (LMP2)-specific T-cell receptors into activated T lymphocytes may provide a universal, MHC-restricted mean to treat EBV-associated tumors in adoptive immunotherapy. We compared TCR-specific promoters of distinct origin in lentiviral vectors, that is, Vβ6.7, delta, luria, and Vβ5.1 to evaluate TCR gene expression in human primary peripheral blood monocytes and T cell line HSB2. …”
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Real-world use of tafasitamab preceding CD19-directed chimeric antigen receptor T-cell therapy for relapsed or refractory diffuse large B-cell lymphoma by Narendranath Epperla, Loretta J. Nastoupil, Bruce Feinberg, John Galvin, Prathamesh Pathak, Theresa Amoloja, Danielle Gentile, Kim Saverno

“…Tafasitamab, a CD19-targeting immunotherapy, combined with lenalidomide, is approved for relapsed or refractory diffuse large B-cell lymphoma (R/R DLBCL) treatment in adults ineligible for autologous stem cell transplantation. …”
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Perturbations in gut microbiota composition in patients with autoimmune neurological diseases: a systematic review and meta-analysis by Xiaolin Deng, Xiaolin Deng, Xue Gong, Xue Gong, Dong Zhou, Zhen Hong, Zhen Hong

“…Subgroup analyses assessed the confounding effects of geography and immunotherapy use. These findings suggest that disturbances of the gut flora are associated with autoimmune neurological diseases, primarily manifesting as non-specific and shared microbial alterations, including a reduction in SCFA-producing bacteria and an increase in pathogenic or opportunistic pathogens.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42023410215.…”
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LINC01355 Contributes to Malignant Phenotype of Oral Squamous Cell Carcinoma and Cytotoxic T Cell Infiltration via Activating Notch Signaling Pathway by Chen Zou, Siyuan Wu, Haigang Wei, Hailing Luo, Zhe Tang, Xia Li, Xiaozhi Lv, Yilong Ai

“…Knockdown of LINC01355 repressed OSCC cell proliferation, migration, and invasion. Recently, immunotherapy is a significant method for the treatment of cancers, in which CD8+ T cells exhibit a significant role. …”
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Flow Cytometric Detection of p38 MAPK Phosphorylation and Intracellular Cytokine Expression in Peripheral Blood Subpopulations from Patients with Autoimmune Rheumatic Diseases by Athanasios Mavropoulos, Dimitrios P. Bogdanos, Christos Liaskos, Timoklia Orfanidou, Theodora Simopoulou, Efterpi Zafiriou, Lazaros I. Sakkas, Eirini I. Rigopoulou

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Subtype-specific human endogenous retrovirus K102 envelope protein is a novel serum immunosuppressive biomarker of cancer by Qinyuan Gong, Qinyuan Gong, Rongzhen Xu, Rongzhen Xu

“…Immune dysfunction is one of the hallmarks of cancer and plays critical roles in immunotherapy resistance, but there is no serum biomarker that can be used to evaluate immune-dysfunction status of cancer patients. …”
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Next-generation sequencing and immuno-informatics for designing a multi-epitope vaccine against HSV-1-induced uveitis by He Cao, Zhi Cao, Yue Han, Jing Shan

“…Molecular docking simulations showed strong binding interactions between the vaccine and TLR-9, suggesting enhanced antigen presentation capabilities.ConclusionThis comprehensive immuno-informatics approach provides a precision immunotherapy strategy for uveitis by leveraging computational modeling and predictive analytics to design a multi-epitope vaccine for HSV-1. …”
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Different immunological characteristics of asymptomatic and symptomatic COVID-19 patients without vaccination in the acute and convalescence stages by Li Li, Xin Zhang, Huimin Yan, Muwei Dai, Huixia Gao, Yuling Wang, Ping Jiang, Erhei Dai

“…These findings may provide new insights into COVID-19 immunotherapy and immune intervention.…”
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LAMB1 promotes proliferation and metastasis in nasopharyngeal carcinoma and shapes the immune-suppressive tumor microenvironment by Enzi Feng, Xinyu Yang, Jie Yang, Qianqian Qu, Xiaojiang Li

“…Tumors with high LAMB1 level had weak responses to immunotherapy. In vitro experiment, LAMB1 significantly suppressed HLA-1 and enhanced the proliferation, migration, and invasion capabilities of NPC cells. …”
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Case Report: The Versatile Art of Reconstruction: A Decade‐Long Journey With Recurrent Facial Basal Cell Carcinoma by T. H. Pathirana, V. Bandaranayake, A. P. Nellihela, S. Nikeshala, T. Saranga, A. Abegunasekara, S. Gunathilake, N. J. Asanthi

“…Although no chemotherapy and immunotherapy were given, the functional and aesthetic result were satisfactory. …”
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Circulating CD3+HLA-DR+ Extracellular Vesicles as a Marker for Th1/Tc1-Type Immune Responses by Ryutaro Oba, Motomichi Isomura, Akira Igarashi, Kinya Nagata

“…The results suggest that these EV subpopulations reflect in vivo activation status of total CD4+, total CD8+, and Th1/Tc1-type T cells, respectively, and may be helpful in T cell-related clinical settings, such as cancer immunotherapy and treatment of chronic infection, autoimmune diseases, and graft-versus-host disease.…”
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Activating CD137 Signaling Promotes Sprouting Angiogenesis via Increased VEGFA Secretion and the VEGFR2/Akt/eNOS Pathway by Bo Li, Yue Zhang, Runting Yin, Wei Zhong, Rui Chen, Jinchuan Yan

“…Combination of antiangiogenesis and immunotherapy may be an effective strategy for treatment of solid tumors. …”
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DeepDrug as an expert guided and AI driven drug repurposing methodology for selecting the lead combination of drugs for Alzheimer’s disease by Victor O. K. Li, Yang Han, Tushar Kaistha, Qi Zhang, Jocelyn Downey, Illana Gozes, Jacqueline C. K. Lam

“…While newly approved amyloid immunotherapy has been reported, effective AD drugs remain to be identified. …”
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Investigation of Scutellaria Barbata’s immunological mechanism against thyroid cancer using network pharmacology and experimental validation by Gen Ouyang, Yuangui Zhu, Zhehao Ouyang

“…This study combines database predictions with experimental validation to reveal the potential mechanisms of SBH against TC, providing effective strategies for the immunotherapy of TC.…”
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Transcriptome profiling revealed multiple circadian rhythm-related genes associated with common gynecological cancers by Lan Peng, Meiping Jiang, Kangming Li, Shuhui Yu, Chunfang Zhao, Lan Zhang, Lan Li

“…It is notable that multiple immune-related signaling pathways were associated with the clinical risk of CC, and the immunotherapy sensitivity was worse in the high-risk group. …”
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EXO1 is a key gene for lung-resident memory T cells and has diagnostic and predictive values for lung adenocarcinoma by Zhuoqi Li, Xiaoyan Lin, Yuanhui Yang, Mei Tian, Lu Zhang, Fujing Huang, Xiao Wen, Zhigang Wei, Yuan Tian

“…EXO1 expression was correlated with the infiltration of immune cells, and high expression of EXO1 was an adverse effect on LUAD patients receiving anti-PD-1/PD-L1 immunotherapy. Moreover, patients with EXO1 mutation had worse DSS, DFI and PFI.…”
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Transcriptome analysis of novel B16 melanoma metastatic variants generated by serial intracarotid artery injection by Jenny C. Kienzler, Erick M. Contreras, Janet Treger, Linda M. Liau, Geoffrey C. Owens, Robert M. Prins

“…Treatment strategies including surgical resection, stereotactic radiation, and immunotherapy have improved clinical response rates and overall survival, but the changes that occur in circulating melanoma cells to promote invasion of the brain are not fully understood. …”
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