Targeting Cancer Stem Cells and Their Niche: Current Therapeutic Implications and Challenges in Pancreatic Cancer by Jiangang Zhao, Jiahui Li, Hans A. Schlößer, Felix Popp, Marie Christine Popp, Hakan Alakus, Karl-Walter Jauch, Christiane J. Bruns, Yue Zhao

“…In this review, we summarize the characteristics of pancreatic CSCs and discuss the mechanisms involved in resistance to chemotherapy, the interactions with the niche, and the potential role in cancer immunoediting. We propose that immunotherapy targeting pancreatic CSCs, in combination with targeting the niche components, may provide a novel treatment strategy to eradicate pancreatic CSCs and hence improve outcomes in pancreatic cancer.…”
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Intratumoral microbiota, fatty acid metabolism, and tumor microenvironment constitute an unresolved trinity in colon adenocarcinoma by Guangyi Liu, Kun Liu, Lei Ji, Yang Li

“…More importantly, the crosstalk between the three can have a significant impact on prognosis, response to immunotherapy, and drug sensitivity of patients. Pathological image profiling showed that changes in the TME originating from intratumoral microbiota disturbance could be reflected in pathological image features. …”
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Convalescent plasma therapy in severe coronavirus disease-2019: A narrative review by Rasmi Ranjan Sahoo, Kasturi Hazarika, Prashant Bafna, Manesh Manoj, Anupam Wakhlu

“…Passive immunotherapy using whole blood or plasma from recovered patients is a potential therapeutic strategy for infections with no known drug therapy or prophylactic vaccines. …”
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Mitochondria-Targeted Biomaterials-Regulating Macrophage Polarization Opens New Perspectives for Disease Treatment by Tian Z, Wang X, Chen S, Guo Z, Di J, Xiang C

“…Zui Tian,* Xudong Wang,* Shuai Chen,* Zijian Guo, Jingkai Di, Chuan Xiang Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chuan Xiang, Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China, Email chuanxiang@sxmu.edu.cnAbstract: Macrophage immunotherapy is an emerging therapeutic approach designed for modulating the immune response to alleviate disease symptoms. …”
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Dynamics analysis and optimal control of a fractional-order lung cancer model by Xingxiao Wu, Lidong Huang, Shan Zhang, Wenjie Qin

“…Next, by considering surgery and immunotherapy as control measures, we discussed the existence of an optimal solution and derived its expression using the Pontryagin maximum principle. …”
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Organ preservation strategies for rectal cancer treatment: tarts or trap? by ZHOU Yihang, ZENG Ziwei, KANG Liang

“…In recent years, with advancements in neoadjuvant chemoradiotherapy and the implementation of immunotherapy, the pathological complete response (pCR) rate following neoadjuvant therapy for rectal cancer has significantly increased. …”
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Role of Farnesoid X Receptor in the Pathogenesis of Respiratory Diseases by Jin-nan Wu, Jian-rong Chen, Jin-liang Chen

“…For example, FXR can regulate the tumor microenvironment by regulating the balance of inflammatory and immune responses in the body to promote the occurrence and development of non-small-cell lung cancer (NSCLC), thereby being considered a potential target for immunotherapy of NSCLC. In this article, we provide an overview of the internal relationship between FXR and respiratory diseases to track the progress that has been achieved thus far in this direction and suggest potential therapeutic prospects of FXR in respiratory diseases.…”
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Advanced anaplastic thyroid carcinoma with positive expression of PD-L1 response to immune checkpoint inhibitors: A case report by Shanmin Fan, Yang Yuan, Yanfang Su, Die Sang

“…Our review highlights the need for further studies investigating the role of PD-L1 status as biomarker to predict the prognosis of immunotherapy in the treatment of ATC.…”
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Efficacy of Nivolumab in a Patient with Metastatic Renal Cell Carcinoma and End-Stage Renal Disease on Dialysis: Case Report and Literature Review by Jawaher Ansari, Muhammad Ali, Ashraf Farrag, Arwa M. Ali, Abdulaziz Alhamad

“…In addition, there is uncertainty regarding drug dosing/pharmacokinetics, lack of safety and efficacy data, and potential for increased toxicity when using targeted therapy or immunotherapy for the management of patients with mRCC on dialysis. …”
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tRNA-derived small RNAs: their role in the mechanisms, biomarkers, and therapeutic strategies of colorectal cancer by Bo Zhang, Yanru Pan, Zhe Li, Kefeng Hu

“…Consequently, future research should focus on elucidating the clinical significance of tsRNAs concerning base modifications, TIME regulation, cancer immunotherapy, and NPs delivery systems to facilitate their clinical translation.…”
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Helicobacter pylori and gastric cancer: mechanisms and new perspectives by Yantao Duan, Yonghu Xu, Yi Dou, Dazhi Xu

“…Emerging evidence also suggests the effect of H. pylori on the tumor microenvironment and its possible implications for cancer immunotherapy. This review synthesizes the current knowledge and identifies gaps that warrant further investigation. …”
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Real-world studies of crizotinib in patients with ROS1-positive non-small-cell lung cancer: experience from China by Hua Zhong, Jun Lu, Mengzhao Wang, Baohui Han

“…The treatment of non-small-cell lung cancer (NSCLC) has progressed from histology-oriented cytotoxic therapy to the era of molecular biology-oriented targeted therapy and immunotherapy. As the first tyrosine kinase inhibitor (TKI) targeting the ROS1 pathway, crizotinib is widely used as a first-line regimen for ROS1-rearranged NSCLC. …”

Downregulated Copper Homeostasis-Related Gene FOXO1 as a Novel Indicator for the Prognosis and Immune Response of Breast Cancer by Rong Zeng, Bi Peng, Emin Peng

“…Overall, these findings would deepen our understanding of FOXO1 in BRCA prognosis and immunotherapy response, representing a promising therapeutic strategy for BRCA patients.…”
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Female urethral diverticular carcinoma: a case report and review of the literature by Dan Li, Fan Hua Meng, Xu Yang

“…For patients with distant metastasis, a combination of surgery, chemotherapy, and radiotherapy may be considered.Genetic testing and targeted immunotherapy offer new approaches for future treatment.…”
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A Potential Role of MicroRNA in the Renal Cancer and Its Tumor Microenvironment by Daniel Chikere Ali, Siva Bharath Merugu

“…Additionally, the expression patterns of certain miRNAs have been linked to patient responses to chemotherapy, immunotherapy, and targeted treatments such as sunitinib. …”
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γδ T Cell and Other Immune Cells Crosstalk in Cellular Immunity by Ying He, Kangni Wu, Yongxian Hu, Lixia Sheng, Ruxiu Tie, Binsheng Wang, He Huang

“…Here we will discuss the interactivities among them and the perspective on γδ T cells for their use in immunotherapy could be imagined. The understanding of the crosstalk among the immune cells in immunopathology might be beneficial for the clinical application of γδ T cell.…”
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Bioinformatic Analysis of PTTG Family and Prognosis and Immune Cell Infiltration in Gastric Cancer by Xiao Li, Yanghao Tai, Shuying Liu, Yating Gao, Kaining Zhang, Jierong Yin, Huijuan Zhang, Xia Wang, Xiaofei Li, Dongfeng Zhang

“…Difficulties and future prospects of immunotherapy in cancer treatment. Adaptive cell therapy, cancer vaccines, gene therapy, and monoclonal antibody therapy have all been used in gastric cancer with some initial success. …”
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Nanoparticles Modulating the Immune Microenvironment in Breast Cancer Treatment by Guo LJ, Wu J, Lu W, Li J, Wang Y, Yang H, Wang TZ

“…Finally, we outline future research directions and the potential advancements in nanoparticle-based immunotherapy, emphasizing their transformative impact on breast cancer treatment.Keywords: nanoparticle, breast cancer, immune cells…”
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Paraneoplastic Dermatomyositis Associated with Metastatic Seminoma by Hidekazu Yoshie, Ryuto Nakazawa, Wataru Usuba, Hiroya Kudo, Yuichi Sato, Hideo Sasaki, Tatsuya Chikaraishi

“…We initially performed orchiectomy along with conventional immunotherapy. However, muscle weakness gradually worsened, and he eventually showed dysphagia and forced respiration and became bedridden. …”
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Multicentre Harmonisation of a Six-Colour Flow Cytometry Panel for Naïve/Memory T Cell Immunomonitoring by Iole Macchia, Valentina La Sorsa, Irene Ruspantini, Massimo Sanchez, Valentina Tirelli, Maria Carollo, Giorgio Fedele, Pasqualina Leone, Giovanna Schiavoni, Carla Buccione, Paola Rizza, Paola Nisticò, Belinda Palermo, Stefania Morrone, Helena Stabile, Aurelia Rughetti, Marianna Nuti, Ilaria Grazia Zizzari, Cinzia Fionda, Roberta Maggio, Cristina Capuano, Concetta Quintarelli, Matilde Sinibaldi, Chiara Agrati, Rita Casetti, Andrea Rozo Gonzalez, Floriana Iacobone, Angela Gismondi, Filippo Belardelli, Mauro Biffoni, Francesca Urbani

“…The panel was based on a backbone mixture of dried antibodies (anti-CD3, anti-CD4, anti-CD8, anti-CD45RA, and anti-CCR7) to detect naïve/memory T cells, recognised as potential prognostic/predictive immunological biomarkers in cancer immunotherapies. The coordinating centre distributed frozen peripheral blood mononuclear cells (PBMCs) and fresh whole blood (WB) samples from healthy donors, reagents, and Standard Operating Procedures (SOPs) to participants who performed experiments by their own equipment, in order to mimic a real-life scenario. …”
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