Caerin 1.1/1.9-mediated antitumor immunity depends on IFNAR-Stat1 signalling of tumour infiltrating macrophage by autocrine IFNα and is enhanced by CD47 blockade by Junjie Li, Yuandong Luo, Quanlan Fu, Shuxian Tang, Pingping Zhang, Ian H. Frazer, Xiaosong Liu, Tianfang Wang, Guoying Ni

“…These results indicate that F1/F3 may be effective to improve the efficacy of ICB and therapeutic vaccine-based immunotherapy for human epithelial cancers and warrants consideration for clinical trials.…”
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Impact of antibody architecture and paratope valency on effector functions of bispecific NKp30 x EGFR natural killer cell engagers by Ammelie Svea Boje, Lukas Pekar, Katharina Koep, Britta Lipinski, Brian Rabinovich, Andreas Evers, Carina Lynn Gehlert, Steffen Krohn, Yanping Xiao, Simon Krah, Rinat Zaynagetdinov, Lars Toleikis, Sven Poetzsch, Matthias Peipp, Stefan Zielonka, Katja Klausz

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Outbreak of metabolic dysfunction-associated steatohepatitis pharmacotherapies in 2024: From resmetirom to tirzepatide by Rui Huang, Chunli Zhang, Xiaodong Mo, Huiying Rao, Rongman Jia

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WT1 Peptide Cancer Vaccine for Patients with Hematopoietic Malignancies and Solid Cancers by Yoshihiro Oka, Akihiro Tsuboi, Olga A. Elisseeva, Hiroko Nakajima, Fumihiro Fujiki, Manabu Kawakami, Toshiaki Shirakata, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Ichiro Kawase, Haruo Sugiyama

“…These results provided us with the rationale for elicitation of CTL responses targeting the WT1 product for cancer immunotherapy. On the basis of these findings, we performed a phase I clinical trial of a WT1 peptide cancer vaccine for the patients with malignant neoplasms. …”
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FABP6 Expression Correlates with Immune Infiltration and Immunogenicity in Colorectal Cancer Cells by Wenping Lian, Zhongquan Wang, Yajie Ma, Yalin Tong, Xinyu Zhang, Huifang Jin, Shuai Zhao, Ruijing Yu, Shaotan Ju, Xinyun Zhang, Xiaona Guo, Tao Huang, Xianfei Ding, Mengle Peng

“…Therefore, it is necessary to characterize TME immune infiltration and explore new targets to improve immunotherapy. Methods. The compositions of 64 types of infiltrating immune cells and their relationships with CRC patient clinical characteristics were assessed. …”
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Evaluation of Clinical and Immunological Responses: A 2-Year Follow-Up Study in Children with Allergic Rhinitis due to House Dust Mite by Heleen Moed, Roy Gerth van Wijk, Rudi W. Hendriks, J. C. van der Wouden

“…Whereas, comparable to immunotherapy, allergic complaints decrease, the immunological changes of specific T-cell activity (both effector cells and regulator cells) which are observed after immunotherapy, do not change.…”
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1,25-Vitamin D-mediated hypercalcaemia in the setting of immune therapy-related sarcoid-like reaction by R K Dharmaputra, N Sheriff, S Ravichandran

“…We presented a case of a 72-year-old male with severe hypercalcaemia of 3.84 mmol/L following the second cycle of immunotherapy with ipilimumab and nivolumab in the setting of metastatic melanoma with known bone metastases. …”
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Qualitative and Computational Analysis of a Mathematical Model for Tumor-Immune Interactions by F. A. Rihan, M. Safan, M. A. Abdeen, D. Abdel Rahman

“…We provide a family of ordinary and delay differential equations to model the dynamics of tumor-growth and immunotherapy interactions. We explore the effects of adoptive cellular immunotherapy on the model and describe under what circumstances the tumor can be eliminated. …”
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The Evolution of Radiation Therapy in Metastatic Breast Cancer: From Local Therapy to Systemic Agent by Jessica M. S. Jutzy, Jeffrey M. Lemons, Jason J. Luke, Steven J. Chmura

“…In this article, we will review the emerging role of radiation in the treatment of metastatic disease and discuss the current state of the science and clinical trials investigating the combination of radiation and immunotherapy.…”
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Identification of neoantigens derived from alternative splicing and RNA modification by Jiyeon Park, Yeun-Jun Chung

“…Since the immune system recognizes tumor-specific peptides, they are potential targets for personalized neoantigen-based immunotherapy. However, the discovery of druggable neoantigens remains challenging, suggesting that a deeper understanding of the mechanism of neoantigen generation and better strategies to identify them will be required to realize the promise of neoantigen-based immunotherapy. …”
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Immunotherapeutic Potential of Mollusk Hemocyanins in Combination with Human Vaccine Adjuvants in Murine Models of Oral Cancer by Juan José Mora Román, Miguel Del Campo, Javiera Villar, Francesca Paolini, Gianfranca Curzio, Aldo Venuti, Lilian Jara, Jorge Ferreira, Paola Murgas, Alvaro Lladser, Augusto Manubens, María Inés Becker

“…Overall, our study opens a new door to further investigation of the use of hemocyanins plus adjuvants for the development of immunotherapies against oral carcinoma.…”
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Regulatory T Cells in Allogeneic Stem Cell Transplantation by Maria Michael, Avichai Shimoni, Arnon Nagler

“…Growing evidence suggests that cellular adoptive immunotherapy is becoming an attractive though challenging approach in regulating tumor immunity and alloresponses in clinical transplantation. …”
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The Informed Consent in Allergology from a Scientific, Technological and Social Perspective by Marisela Luisa Pérez Pacaréu, Yanet Morejón del Rosario, Gloria Arlenys Suárez Rodríguez, Aleima Rodríguez Carbajal

“…It is demonstrated that when applying the informed consent in this specialty, the humanistic social precepts are respected by directing health actions to respect the integrity of the patients against possible risks, offering the option to use immunotherapy and respecting their autonomy in research. …”
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Revolutionizing acute myeloid leukemia treatment: a systematic review of immune-based therapies by Ugochi Ebinama, Binsah George

“…In response to the necessity for more efficacious therapeutic modalities, targeted immunotherapy has emerged as a promising advancement in AML treatment. …”
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Superficial Bladder Cancer Therapy by Emmanuel Schenkman, Donald L. Lamm

“…Presently, BCG immunotherapy remains the most effective treatment and prophylaxis for TCC (Ta, T1, CIS) and reduces tumor recurrence, disease progression, and mortality. …”
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Aseptic Meningitis as an Immune-Related Adverse Event after Pembrolizumab by Gian Lima, Adriana Kahn, Shashank Sama, Jacqueline Savage

“…The management of patients with advanced malignancies is challenging, although recent advances with immunotherapy have shown better outcomes. Pembrolizumab has been associated with a variety of immune-related side effects, but the occurrence of aseptic meningitis is rare. …”
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An Episode of Pseudothrombocytopenia during Pembrolizumab Therapy in NSCLC Patient by Kinga Krukowska, Robert Kieszko, Katarzyna Kurek, Izabela Chmielewska, Paweł Krawczyk, Janusz Milanowski

“…Immunotherapy with immune checkpoint inhibitors (ICI) is a new option of treatment in a growing range of neoplasms. …”
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Inhibiting HnRNP L-mediated alternative splicing of EIF4G1 counteracts immune checkpoint blockade resistance in Castration-resistant prostate Cancer by Xumin Zhou, Shilong Cheng, Zhongjie Chen, Jinming Zhang, Jiaqi Wang, Qiang Li, Xumin Zhou

“…Immunotherapy with checkpoint inhibitors produced significant clinical responses in a subset of cancer patients who were resistant to prior therapies. …”
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Integrating multiomics analysis and machine learning to refine the molecular subtyping and prognostic analysis of stomach adenocarcinoma by Miaodong Wang, Qin He, Zeshan Chen, Yijue Qin

“…Patients in the high-CMLS group had a significantly poorer prognosis and were less sensitive to immunotherapy but were likely to benefit more from chemotherapy and targeted therapy. …”
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The Increase of Circulating PD-1- and PD-L1-Expressing Lymphocytes in Endometriosis: Correlation with Clinical and Laboratory Parameters by Monika Walankiewicz, Ewelina Grywalska, Grzegorz Polak, Izabela Korona-Glowniak, Elzbieta Witt, Agata Surdacka, Jan Kotarski, Jacek Rolinski

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