Red flags to suspect inborn errors of immunity in patients with autoimmune diseases by Natalia Vélez, Juliette De Ávila, Jaime Cortés, Nelson Barrero, Leosirlay Rojas, Juan Manuel Bello, Consuelo Romero-Sánchez

“…The principal red flags in autoimmune cytopenias are chronic, recurrent, and refractory cytopenias, recurrent infection, severe infectious complications associated with immunosuppressive treatment, and chronic lymphoproliferation. …”
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Immunogenic properties of nickel-doped maghemite nanoparticles and the implication for cancer immunotherapy by Lenka Rajsiglova, Michal Babic, Katerina Krausova, Pavol Lukac, Katerina Kalkusova, Pavla Taborska, Ludek Sojka, Jirina Bartunkova, Dmitry Stakheev, Luca Vannucci, Daniel Smrz

“…In conclusion, this study shows that FN NP could be a valuable platform for targeting cancer cells without causing immunosuppressive effects on the subsequent anticancer immune response.…”
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The Association of TNF-Alpha Inhibitors and Development of IgA Nephropathy in Patients with Rheumatoid Arthritis and Diabetes by Vedran Premužić, Ivan Padjen, Mislav Cerovec, Marijana Ćorić, Bojan Jelaković, Branimir Anić

“…Discontinuation of anti-TNF-alpha therapy and initiation of immunosuppressive therapy led to improvement in serologic abnormalities and renal function in two patients, while the third patient’s 24-hour proteinuria was only partially reduced, which supports previous reports on TNF-alpha inhibitor induced autoimmunity. …”
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The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy by Zhaocheng Dong, Zhiyuan Liu, Haoran Dai, Wenbin Liu, Zhendong Feng, Qihan Zhao, Yu Gao, Fei Liu, Na Zhang, Xuan Dong, Xiaoshan Zhou, Jieli Du, Guangrui Huang, Xuefei Tian, Baoli Liu

“…Regulatory B cells (Breg) are widely regarded as immunomodulatory cells which play an immunosuppressive role. Breg inhibits pathological autoimmune response by secreting interleukin-10 (IL-10), transforming growth factor-β (TGF-β), and adenosine and through other ways to prevent T cells and other immune cells from expanding. …”
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Novel Modifications and Delivery Modes of Cyclic Dinucleotides for STING Activation in Cancer Treatment by Lu Y, Li Z, Zhu X, Zeng Q, Liu S, Guan W

“…Yanjun Lu,1,* Zhiyan Li,2,* Xudong Zhu,1 Qingwei Zeng,1 Song Liu,1 Wenxian Guan1 1Division of Gastric Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, People’s Republic of China; 2Division of Thoracic Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Song Liu; Wenxian Guan, Email liusong@nju.edu.cn; guan_wenxian@sina.comAbstract: The microenvironment tends to be immunosuppressive during tumor growth and proliferation. …”
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Oral Manifestations in Organ Transplant Patients: A Literature Review by Willy Muñoz-Gallardo, Fran Espinoza-Carhuancho, Julia Medina, Lucia Quispe-Tasayco, Cesar Mauricio-Vilchez, Diego Galarza-Valencia, Frank Mayta-Tovalino

“…Neoplastic disease, specifically oral cancer, was a significant concern, with factors, such as immunosuppressive therapy and previous skin cancer, increasing the risk. …”
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Role of Cyclosporine in Crohn's Disease by CN Williams

“…There is a steroid-sparing effect with this drug, as with other immunosuppressives used in Crohn's disease - a valuable side effect of this therapy. …”
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Evaluation of the Effects of systemic Therapy on Inflammatory Markers and Disease Severity in Patients With Pemphigus by Mehmet Enes Güner, Perihan Ozturk, Mine müjde Kuş

“…Objective: In this study, our objective was to investigate changes in the inflammatory markers NLR, PLR, MPV, LMR, CRP and ESR, which are inflammatory markers, before treatment and during follow-up, and the correlation of disease severity with these markers in patients with pemphigus receiving IVIG and/or systemic immunosuppressant agents. Method: 76 pemphigus patients who received systemic treatment, and used these treatments for at least 6 months were included. …”
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The relationship between Helicobacter pylori and pityriasis versicolor by May H. El Samahy, Raafat Z. Abdelrahman, Hossam O. Ibrahim, Azza E. Mostafa

“…Accordingly, its role as a systemic immunosuppressive cytokine predisposing for PVC was unverified in this study.…”
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HER2 Negative Mammary Paget’s Disease or In Situ Melanoma? A Case Report and Review of the Literature by Luana-Andreea Boșoteanu, Mariana Așchie, Cristian Ionuţ Orǎșanu, Mădălina Boșoteanu

“…Bowen’s disease was invalidated by its rare presentation in the breast cutaneous tissue and the absence of individual risk factors suggestive of an existing immunosuppressive status. In the case of similar morphoimmunohistochemical aspects, significant expression of Ki-67 signals MPD, an immunoreactivity that helped distinguish the cellular population from Toker cells. …”
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Effect of Shogaol on the Expression of Intestinal Stem Cell Markers in Experimentally Induced Colitis in BALB/c Mice by Snur M. A. Hassan, Ali Hussein Hassan

“…The results of this study indicated that oral treatment with the ginger-derived substance Shogaol could be better than the conventional immunosuppressive chemotherapeutic remedy 6-TG in treatment of DSS-induced UC.…”
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Silent Human Trypanosoma brucei gambiense Infections around the Old Gboko Sleeping Sickness Focus in Nigeria by Karshima Solomon Ngutor, Lawal A. Idris, Okubanjo Oluseyi Oluyinka

“…We isolated 7 (33.3%) trypanosomes from the 21 seropositive samples using immunosuppressed mice which were identified as T. b. gambiense group 1 by TgsGP-PCR. …”
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The Burden of Cost in Bronchiolitis Obliterans Syndrome: Predictions for the Next Decade by Christopher A. Jones, David G. Chapman, Peter Weimersheimer, Luca Fernandez, Oscar Alejandro Mesa, Christian Peters, Bart M. Vanaudenaerde, Mitchell C. Norotsky, Robin Vos

“…The lost workforce resulting from BOS-related infirmity will cost society more than $3.7 Billion over the next decade, a figure that is more than double the estimated 10-year cost of treating BOS ($1.4B), including diagnostics, immunosuppressives, and additional complications. As such, BOS is estimated to present a burden of cost that must be evaluated in a new light to include the wider societal perspective.…”
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Long COVID in patients with rheumatologic disease: A single center observational study by Horacio Quinones-Moya, Armando Ocampo-Del Valle, Adolfo Camargo-Coronel, Francisco Javier Jimenez-Balderas, Miriam Berenice Bernal-Enriquez, Pedro Madinabeitia-Rodríguez, Kenia Nahomi Morales-Medino, Cynthia Roque-Ibanez, Mario Raúl Hernandez-Zavala

“…As these patients have immunosuppressive therapy and this syndrome has inflammatory characteristics, we postulate that these patients will have a lower prevalence of sequelae. …”
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Serum-Free Manufacturing of Mesenchymal Stem Cell Tissue Rings Using Human-Induced Pluripotent Stem Cells by Tackla S. Winston, Kantaphon Suddhapas, Chenyan Wang, Rafael Ramos, Pranav Soman, Zhen Ma

“…Mesenchymal stem cells (MSCs) have been widely used for regenerative medicine applications because of their immunosuppressive properties and multipotent potentials. …”
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Immunotherapies to Nano-Immunotherapies: Advances in Immune Targeting in Bladder Cancer by Beatriz Ramos, Dakota Rogers

“…Upregulation of checkpoint molecules like PD-L1 and recruitment of immunosuppressive cells, contribute to immune evasion and treatment resistance. …”
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Musculoskeletal Corticosteroid Injection during COVID-19 Pandemic in Sabah: Is It Safe? by Mohamad Azwan Aziz, Redzal Abu Hanifah, Azmi Mohamed Mohd Nahar

“…In this current COVID-19 pandemic, many clinicians would differ from this treatment as steroid is considered an immunosuppressive drug and could risk the patient of developing severe adverse effects if contracting COVID-19. …”
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An autopsy case with tubular obstruction by impacted swollen blebs due to ischemic acute kidney injury by Yukako Akiyama, Mitsuhiro Sato, Yoshio Taguma

“…Because of the existence of hematuria with red blood cell casts and rapid deterioration of renal function and severe systemic symptoms such as loss of appetite and general fatigue, we started immunosuppressive therapy with steroids, considering a vasculitis-like condition with NS, and hemodialysis was also started for oliguria. …”
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Our Unique Experience with Low-Dose Alemtuzumab as an Induction Agent for Renal Transplantation: A Case Series by Cherin Josi, Arjun Parthasarathy, Divya Sundar, Milly Matthew, Premkumar Rajendran, Georgi Abraham

“…Tacrolimus, mycophenolate mofetil, and steroids were the maintenance immunosuppressive agents. Postoperatively, white blood cell and differential count and renal function were monitored daily. …”
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Integrative bioinformatics and immunohistochemical analysis unravel the prognostic significance and immunological implication of LIMCH1 in breast cancer: a retrospective study by Xin Yu, Bei Li, Wenge Li, Jingping Yuan, Shengrong Sun, Juanjuan Li

“…Additionally, LIMCH1 expression was correlated with an immunosuppressive TIME characterized by increased numbers of M2 macrophages and reduced numbers of CD8 + T cells and NK cells. …”
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