Intermittent fasting boosts antitumor immunity by restricting CD11b+Ly6Clow Ly6Glow cell viability through glucose metabolism in murine breast tumor model by Chenghao Fu, Zhehao Liang, Zemiao Niu, Ning Chen, Yuemin Li, Zhenhua Liang, Yanwei Huo, Hao Xi, Rong Wang, Yonghuan Yan, Xiaoru Gano, Mengtian Wang, Yun Huang, Yan Zhang, Mingming Gao, Pin Lü

“…During this process, both the immunosuppressive monocytic- (M-) and granulocytic- (G-) myeloid-derived suppressor cell (MDSC) decreased, accompanied by an increase in interleukin (IL) 7R+ and granzyme B+ T cells in the tumor microenvironment. …”
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Management of Bladder Cancer following Solid Organ Transplantation by Jeffrey J. Tomaszewski, Jeffrey A. Larson, Marc C. Smaldone, Matthew H. Hayn, Stephen V. Jackman

“…The use of intravesical BCG is possible in select immunosuppressed patients.…”
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SMAD4 Protein Expression Is Downregulated in Ileal Epithelial Cells from Patients with Crohn’s Disease with Significant Inverse Correlation to Disease Activity by Pia Klausen, John Gásdal Karstensen, Mehmet Coskun, Adrian Săftoiu, Peter Vilmann, Jack Bernard Cowland, Lene Buhl Riis

“…Small mothers against decapentaplegic (SMAD)4 and SMAD7 are key regulatory components in the immunosuppressive transforming growth factor- (TGF-) β signaling pathway, which is defective in inflammatory bowel disease (IBD). …”
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Machine Learning-Devised Immune-Related lncRNA Signature Panel Predicts the Prognosis and Immune Landscape in Breast Cancer Novel IRLP Signature in BRCA by Jun-Yu Zhu, An-Qi Lyu, Zhang-Ting Wang, Wai-Yee Chan, Tao Qin, Kai-Kei Miu, He-Rui Yao

“…Immune infiltrating analyses found that the low-risk group has a lower expression level of macrophage M2 and a higher expression level of immunosuppressed biomarkers than the high-risk group. DEirlncRNAs were further proven to be significantly related to the MAPK signaling, Jak-STAT signaling, and ErbB signaling pathways in BRCA. …”
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Immunoprotective Effect of Seabuckthorn (Hippophae rhamnoides) and Glucomannan on T-2 Toxin-Induced Immunodepression in Poultry by T. Ramasamy, C. Varshneya, V. C. Katoch

“…The present investigation revealed that the seabuckthorn alone protected the immunosuppressant action of T-2 toxin, but seabuckthorn and glucomannan in combination provided an additive protection against T-2 toxicity.…”
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Time in therapeutic range of tacrolimus in allogeneic hematopoietic stem cell transplant recipients is associated with acute graft-versus-host disease prophylaxis by Naoki Yoshikawa, Yukina Ehara, Yusei Yamada, Yuki Matsusaki, Kazuya Shimoda, Ryuji Ikeda

“…Abstract Intra-patient variability in immunosuppressive blood drug concentrations is a potential biomarker in managing organ transplant patients. …”
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Retroperitoneal Soft Tissue Sarcoma and Kidney Autotransplantation: A Case Report by S. N. Hakkesteegt, C. A. J. Oudmaijer, L. J. Jeletich, J. Sprakel, H. J. A. N. Kimenai, D. J. Grünhagen

“…Kidney autotransplantation offers a unique solution by preserving renal function in these cases, avoiding the need for dialysis and immunosuppressive therapy. This case report presents a 61‐year‐old female with a large RPS encasing her only functioning kidney. …”
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Heterochromatic gene silencing controls CD4+ T cell susceptibility to regulatory T cell-mediated suppression in a murine allograft model by Julie Noguerol, Karl Laviolette, Margot Zahm, Adeline Chaubet, Ambrine Sahal, Claire Détraves, Romain Torres, Clothilde Demont, Véronique Adoue, Carine Joffre, Florence Cammas, Joost PM van Meerwijk, Olivier P. Joffre

“…While HP1α converts immunosuppressive signals into heterochromatin-dependent gene silencing mechanisms, HP1γ adjusts Tconv sensitivity to inhibitory environmental signals.…”
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Cardiovascular disease risk in Korean patients with systemic lupus erythematosus compared to diabetes mellitus and the general population by Jung-Yong Han, Soo-Kyung Cho, Yena Jeon, Gaeun Kang, Sun-Young Jung, Eun Jin Jang, Yoon-Kyoung Sung

“…Advanced age, male gender, and current use of glucocorticoids, immunosuppressive, and anti-platelet agents were associated with increased CVD risk in SLE patients. …”
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Repurposing Drugs for Synergistic Combination Therapies to Counteract Monkeypox Virus Tecovirimat Resistance by Haydar Witwit, Beatrice Cubitt, Roaa Khafaji, Esteban M. Castro, Miguel Goicoechea, Maria M. Lorenzo, Rafael Blasco, Luis Martinez-Sobrido, Juan C. de la Torre

“…In this study we have used vaccinia virus (VACV) as a surrogate of MPXV to assess the antiviral efficacy of combination therapy of TPOXX together with mycophenolate mofetil (MMF), an FDA-approved immunosuppressive agent that we have shown to inhibit VACV and MPXV, or the N-myristoyltransferase (NMT) inhibitor IMP-1088. …”
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In-depth proteomic profiling identifies potentiation of the LPS response by 7-ketocholesterol by Iain R. Phair, Magdalena Sovakova, Noor Alqurashi, Raid B. Nisr, Alison D. McNeilly, Douglas Lamont, Graham Rena

“…In this context, our findings suggest that drugs targeting atherogenic markers induced by 7-KC might be well tolerated, as they will not necessarily be expected to be immunosuppressive.…”
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Isolated Pauci-Immune Pulmonary Capillaritis Associated with Hydrocarbon Inhalation and Marijuana Smoking: An Unusual Case of Severe Hypoxemia by Jason S. Oh, Uni Wong, Divyansh Bajaj, Stella E. Hines

“…He was diagnosed with IPIPC and initiated on immunosuppressive therapy. He was soon liberated from mechanical ventilation and improved to hospital discharge. …”
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Mean Platelet Volume in Ocular Behçet’s Disease by Fatih Mehmet Türkcü, Abdullah Kürşat Cingü, Harun Yüksel, Yasin Çınar, Meltem Akkurt, Muhammed Şahin, Zeynep Özkurt, Alparslan Şahin, İhsan Çaça

“…MPV measurement in ocular BD is not a predictive laboratory test to determine the clinical improvement in early stages following classical immunosuppressive treatment.…”
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Serology of Viral Infections and Tuberculosis Screening in an IBD Population Referred to a Tertiary Centre of Southern Italy by Marco Ardesia, Giuseppe Costantino, Placido Mondello, Angela Alibrandi, Walter Fries

“…With the introduction of more potent immunosuppressive agents in inflammatory bowel disease, prevention of opportunistic infections has become necessary by introducing screening programs. …”
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Phosphodiesterase Inhibitors Suppress Lactobacillus casei Cell-Wall-Induced NF-κB and MAPK Activations and Cell Proliferation through Protein Kinase A—or Exchange Protein Activated... by Takekatsu Saito, Naotoshi Sugimoto, Kunio Ohta, Tohru Shimizu, Kaori Ohtani, Yuko Nakayama, Taichi Nakamura, Yashiaki Hitomi, Hiroyuki Nakamura, Shoichi Koizumi, Akihiro Yachie

“…However, a high mortality rate results from underlying immunosuppressive conditions in patients with Lactobacillus casei bacteremia. …”
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Targeting lipid metabolism: novel insights and therapeutic advances in pancreatic cancer treatment by Yanyan Zhang, Zhichao Yang, Yuchen Liu, Jinjin Pei, Ruojie Li, Yanhui Yang

“…Their accumulation fosters an immunosuppressive tumor microenvironment that supports cancer cell proliferation and metastasis. …”
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Cervical Bone Graft Candida albicans Osteomyelitis: Management Strategies for an Uncommon Infection by Carlo Brembilla, Luigi Andrea Lanterna, Andrea Risso, Giuseppe Bonaldi, Paolo Gritti, Bruno Resmini, Andrea Viscone

“…The factors contributing to its emergence include a growing population of immunosuppressed patients, invasive surgeries, broad-spectrum antibiotics, injection drug users, and alcohol abuse. …”
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A new strategy for the treatment of advanced ovarian cancer: utilizing nanotechnology to regulate the tumor microenvironment by Zixuan Xiong, Yichun Huang, Shulong Cao, Xuqun Huang, Haiyuan Zhang

“…In the immune TME, the immune effector cells such as dendritic cells (DCs), M1-like tumor-associated macrophages (M1-TAMs), and T cells are inhibited. In contrast, immunosuppressive cells such as M2-like tumor-associated macrophages (M2-TAMs), myeloid-derived suppressor cells (MDSCs), and regulatory T cells (Tregs) are activated. …”
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CAR T cells for treating autoimmune diseases by Dimitrios Mougiakakos, Ulrike Koehl, Stephan Fricke, Ulrich Blache, Sandy Tretbar

“…Currently, autoimmune disorders are largely treated by broad immunosuppressive agents and blocking antibodies, which can manage the diseases but often are not curative. …”
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Carbonic anhydrase 2-derived drug-responsive domain regulates membrane-bound cytokine expression and function in engineered T cells by Mara C. Inniss, Sean G. Smith, Dan Jun Li, Benjamin Primack, Dexue Sun, Grace Y. Olinger, Kerri-Lynn Sheahan, Theresa Ross, Meghan Langley, Violet Young, Andres Alvarado, Shabnam Davoodi, Jiefei Geng, Michael Schebesta, Michelle L. Ols, Jeremy Tchaicha, Jan ter Meulen, Dhruv K. Sethi

“…Abstract Adoptive cell therapies (ACT) have shown reduced efficacy against solid tumor malignancies compared to hematologic malignancies, partly due to the immunosuppressive nature of the tumor microenvironment (TME). …”
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