Cyclosporine and Herbal Supplement Interactions by D. Colombo, L. Lunardon, G. Bellia

“…Cyclosporine (CyA) is a well-known immunosuppressant with a narrow therapeutic window. Its bioavailability is affected by many other traditional drugs and herbal extracts. …”
Get full text

Abdominal Cocoon Syndrome: Two Cases of an Anatomical Abnormality by Apostolos Sovatzidis, Eirini Nikolaidou, Anastasios Katsourakis, Iosif Chatzis, George Noussios

“…Although conservative management with immunosuppressants and steroids has been described, surgical treatment is the gold standard. …”
Get full text

Graft-versus-Host Disease after Living-Unrelated Kidney Transplantation by N. Zacharias, M. H. Gallichio, D. J. Conti

“…Biopsy findings were consistent with GVHD. Aggressive immunosuppressive therapy was instituted with a good response. …”
Get full text

Diagnostic and Treatment Options to the Patients Presenting with Neurological Symptoms Caused by Celiac Disease by Domantas Jakubauskas, Rūta Mameniškienė

“…The primary treatment for neurological manifestations of gluten-related disorders is a strict gluten-free diet, although a small number of patients may require additional immunosuppressive therapy, typically using mycophenolate or intravenous immunoglobulins. …”
Get full text

Drug-induced bone disorders: A systematic review by Anshita Aggarwal, Meha Sharma, Indira Maisnam, Soumitra Ghosh, Sameer Aggarwal, Saptarshi Bhattacharya, Deep Dutta

“…Anti-epileptics, proton pump inhibitors, glucocorticoids, immunosuppressants (calcineurin inhibitors), anticoagulants, glitazones, SGLT2 inhibitors, somatostatin analogs, anticancer medications, and protein kinase inhibitors are some of the commonly used medications associated with bone mineral loss. …”
Get full text

Catalysts of change: Immunotherapy's frontier in oral oncology by Shyamaladevi Babu, Madhan Krishnan

“…The article explores the difficulties posed by the immunosuppressive tumour microenvironment and the need for patient-specific biomarkers to assess therapy response. …”
Get full text

Crescentic Glomerulonephritis and Membranous Nephropathy: A Rare Overlap by Mohamedanwar Ghandour, Heba Osman, Samer Alkassis, Alix Charles, Kristina Zalewski, Jarrett Weinberger, Yahya Malik-Osman, Zeenat Y. Bhat

“…Membranous nephropathy complicated by crescentic glomerulonephritis has a more aggressive clinical course and decline in renal function compared to MN alone which can lead to initiating renal replacement therapy. However, immunosuppressive drugs can result in significant improvement of renal function if started early enough.…”
Get full text

RHINITIS: A SHORT REVIEW by Felix Daniel Lucaci, Sorin Marian Mârza, Radu Lăcătuș, Robert Cristian Purdoiu

“…Advanced diagnostic tools, including rhinoscopy, computed tomography (CT), and cytology, have greatly improved the ability to differentiate between infectious, allergic, and neoplastic causes, leading to targeted treatment strategies such as antimicrobial therapy, antifungal agents, and immunosuppressive therapies. Environmental factors, including poor air quality and inadequate husbandry practices, play a critical role in chronic rhinitis, particularly in overcrowded environments. …”
Get full text

Tolerogenic Splenic IDO+ Dendritic Cells from the Mice Treated with Induced-Treg Cells Suppress Collagen-Induced Arthritis by Jie Yang, Yiming Yang, Huahua Fan, Hejian Zou

“…In this study, we found that after treatment with iTregs, splenic CD11c+DCs, termed “DCiTreg,” expressed tolerogenic phenotypes, secreted high levels of IL-10, TGF-β, and IDO, and showed potent immunosuppressive activity in vitro. After reinfusion with DCiTreg, marked antiarthritic activity improved clinical scores and histological end-points were observed. …”
Get full text

Inhibiting HnRNP L-mediated alternative splicing of EIF4G1 counteracts immune checkpoint blockade resistance in Castration-resistant prostate Cancer by Xumin Zhou, Shilong Cheng, Zhongjie Chen, Jinming Zhang, Jiaqi Wang, Qiang Li, Xumin Zhou

“…In vivo, inhibition of EIF4G1 by the inhibitor, SBI-0640756, attenuated HnRNP l-induced tumor progression and immunosuppressive activity. And most of all, therapeutic synergy between HnRNP L knockdown and Anti-PD-1 could significantly suppress xenograft prostate cancer growth. …”
Get full text

Not Always Asthma: Clinical and Legal Consequences of Delayed Diagnosis of Laryngotracheal Stenosis by Adam C. Nunn, S. Ali R. Nouraei, P. Jeremy George, Guri S. Sandhu, S. A. Reza Nouraei

“…After an admission with respiratory symptoms that worsened to the extent that she required intubation, a previously well 14-year-old girl was diagnosed with GPA. Following immunosuppressive therapy, she made a good recovery and was discharged after 22 days. …”
Get full text

<i>Сlostridium difficile</i> Infection in a COVID-19 Patient by A. A. Timofeeva, Yu. O. Shulpekova, V. M. Nechaev, M. R. Skhirtladze

“…A background antibiotic and putative-immunosuppressive therapy proceeded with watery diarrhoea to 7–8 times a day and C. difficile toxins A and B detected in stool. …”
Get full text

Severe Aplastic Anemia following Acute Hepatitis from Toxic Liver Injury: Literature Review and Case Report of a Successful Outcome by Kamran Qureshi, Usman Sarwar, Hicham Khallafi

“…The findings of immune related myeloid injury implied the use of immunosuppressive therapy (IST) and led to improved survival from HAAA. …”
Get full text

Mechanisms Underlying the Osteo- and Adipo-Differentiation of Human Mesenchymal Stem Cells by Yu Zhang, Dilaware Khan, Julia Delling, Edda Tobiasch

“…In addition, even in allogenic origin-derived donor cells, hMSCs generate a local immunosuppressive microenvironment, causing only a weak immune reaction. …”
Get full text

Kidney Transplantation: The Challenge of Human Leukocyte Antigen and Its Therapeutic Strategies by Tilahun Alelign, Momina M. Ahmed, Kidist Bobosha, Yewondwossen Tadesse, Rawleigh Howe, Beyene Petros

“…Therefore, the purpose of this review is to highlight facts about HLA and its sensitization, various mechanisms of allograft rejection, the current immunosuppressive approaches, and the directions for future therapy.…”
Get full text

Effect of exercise training on modulating the TH17/TREG imbalance in individuals with severe COPD: A randomized controlled trial by Juliana Tiyaki Ito, Luan Henrique Vasconcelos Alves, Luana de Mendonça Oliveira, Rafaella Fagundes Xavier, Regina Maria Carvalho-Pinto, Iolanda de Fátima Lopes Calvo Tibério, Maria Notomi Sato, Celso R. F. Carvalho, Fernanda Degobbi Tenorio Quirino dos Santos Lopes

“…Additionally, Th17/Treg responses were moderately correlated with improvements in the six-minute walking test, muscle strength of the upper and lower limbs, and daily life physical activity levels.Conclusion Exercise training improved functional exercise capacity, muscle strength, and physical fitness, which was associated with a decrease in the Th17 inflammatory response and an increase in Treg cell phenotypes immunosuppressive activity.…”
Get full text

Seronegative Arthritis and Whipple Disease: Risk of Misdiagnosis in the Era of Biologic Agents by Luca Quartuccio, Ivan Giovannini, Stefano Pizzolitto, Maurizio Scarpa, Salvatore De Vita

“…We report 2 cases of Whipple disease (WD), previously diagnosed as seronegative polyarthritis and treated for several years with immunosuppressive agents, accordingly. Both cases had been treated over years with cDMARDs and bDMARDs. …”
Get full text

Attitudes to Medication after Kidney Transplantation and Their Association with Medication Adherence and Graft Survival: A 2-Year Follow-Up Study by Mirjam Tielen, Job van Exel, Mirjam Laging, Denise K. Beck, Roshni Khemai, Teun van Gelder, Michiel G. H. Betjes, Willem Weimar, Emma K. Massey

“…As a measure of medication adherence, respondents completed the Basel Assessment of Adherence to Immunosuppressive Medications Scale (BAASIS©-interview). …”
Get full text

Improving ferroptosis-mediated immunotherapy for colorectal cancer through lysosome-targeted photodynamic therapy by Zhian Chen, Yutong Wang, Zhenhao Li, Meijuan Chen, Yingshi Li, Chuyue Lu, Zhenyu Lin, Hua Zheng, Lujia Chen, Qianbing Zhang

“…Subsequently, the cancer cells were suffered from ferroptosis through triggering cell-intrinsic Fenton chemistry and mitochondrial dysfunction, which would release damage-associated molecular pattern molecules (DAMPs) to induce immunogenic cell death and remodel immunosuppressive tumor microenvironment. Notably, combined with PD-L1 antibody and TLA could greatly potentiate the immune response and exhibit highest anti-tumor effects. …”
Get full text

Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response in pancreatic cancer by Lukas Klein, Mengyu Tu, Niklas Krebs, Laura Urbach, Daniela Grimm, Muhammad Umair Latif, Frederike Penz, Anna Blandau, Xueyan Wu, Rebecca Diya Samuel, Stefan Küffer, Florian Wegwitz, Nathan Chan, Kazeera Aliar, Foram Vyas, Uday Kishore, Elisabeth Hessmann, Andreas Trumpp, Elisa Espinet, Argyris Papantonis, Rama Khokha, Volker Ellenrieder, Barbara T. Grünwald, Shiv K. Singh

“…Here, by combining preclinical models, multi-center clinical, transcriptomic, proteomic, and patient bioimaging data, we identify an interplay between neoplastic intrinsic AP1 transcription factor dichotomy and extrinsic macrophages driving subtype co-existence and an immunosuppressive microenvironment. ATAC-, ChIP-, and RNA-seq analyses reveal that JUNB/AP1- and HDAC-mediated epigenetic programs repress pro-inflammatory signatures in tumor cells, antagonizing cJUN/AP1 signaling, favoring a therapy-responsive classical neoplastic state. …”
Get full text