-
1041
African animal trypanocide resistance: A systematic review and meta-analysis
Published 2024“…Major markers of resistance explored include TbAT1, P1/P2 transporters, folate transporters, such as F-I, F-II, F-III, and polyamine biosynthesis inhibitors. In addition, immunosuppressed hosts favor the development of AATr.…”
Get full text
Article -
1042
Enhanced Suppressive Activity of Regulatory T Cells in the Microenvironment of Malignant Pleural Effusions
Published 2018-01-01“…Understanding of relations between cellular and cytokine immunosuppressive factors in tumor microenvironment may determine success of anticancer response.…”
Get full text
Article -
1043
Exploring the Mechanism of Skeletal Muscle in a Tacrolimus-Induced Posttransplantation Diabetes Mellitus Model on Gene Expression Profiles
Published 2020-01-01“…Tacrolimus (Tac or FK506) is a widely used immunosuppressant that has been reported to be a risk factor for PTDM and to further induce complications in heart and skeletal muscles, but the mechanism is still largely unknown. …”
Get full text
Article -
1044
Lipid nanoparticles deliver DNA-encoded biologics and induce potent protective immunity
Published 2025-01-01“…Single-cell RNA sequencing (scRNA-seq) analysis revealed that the LNP-M/pSpike vaccine enhanced CD80 activation signaling in CD8+ T cells, NK cells, macrophages, and DCs, while reducing the immunosuppressive signals. The enrichment of TCR and BCR by LNP-M/pSpike suggested an increase in immune response specificity and diversity. …”
Get full text
Article -
1045
Development of Fulminant Type 1 Diabetes Mellitus in a Patient with DRESS Syndrome
Published 2020-01-01“…She had numerous complications including significant facial edema, seizures, bacterial pneumonia, sepsis, hypovolemic shock, acute respiratory distress syndrome, diabetic ketoacidosis, nonalcoholic steatohepatitis, liver failure, and recurring DRESS rashes despite treatment with high-dose intravenous steroids and immunosuppressants. During this time, the patient developed a rare form of uncontrolled type 1 diabetes mellitus not explained by autoantibody production or continued high-dose steroid use. …”
Get full text
Article -
1046
Development of chimeric Nanobody-Granzyme B functionalized ferritin nanoparticles for precise tumor therapy
Published 2025-03-01“…The efficacy of traditional T-cell therapies, including chimeric antigen receptor (CAR) T cells, is often constrained by immunosuppressive factors and the tumor microenvironment. …”
Get full text
Article -
1047
The Different Effects of IFN-β and IFN-γ on the Tumor-Suppressive Activity of Human Amniotic Fluid-Derived Mesenchymal Stem Cells
Published 2019-01-01“…AFMSCs primed with IFN-γ highly expressed immunosuppressive molecule IDO1, but IFN-β counteracted the IFN-γ-initiated IDO1 expression. 1-MT (IDO1 inhibitor) decreased TRAIL, but increased IDO1 expression in AFMSCs primed with interferon. …”
Get full text
Article -
1048
Possibility of using a mouse SCID as a model animal to variola virus for evaluating anti-smallpox drug efficacy
Published 2015-12-01“…This opens up the prospect of using SCID mice as an animal model for smallpox to develop antiviral drugs intended for people with severe immunosuppressive states.…”
Get full text
Article -
1049
Evaluating the use of Uromune® autovaccine in recurrent urinary tract infections: a pilot unicenter retrospective study in Reus, Spain
Published 2025-01-01“…Regression analysis identified having had a urostomy, chronic kidney disease, and being immunosuppressed as predictors of recurrence. Conclusion Uromune® autovaccine was associated with a significant reduction in the frequency of recurrent UTIs and related hospitalizations, offering substantial relief to patients. …”
Get full text
Article -
1050
Fabry cardiomyopathy: Gb3‐induced auto‐reactive panmyocarditis requiring heart transplantation
Published 2020-06-01“…Immune‐mediated inflammation of systemic Fabry cells may coexist and be controlled by implemental immunosuppressive therapy.…”
Get full text
Article -
1051
Fetal Cartilage Progenitor Cells in the Repair of Osteochondral Defects
Published 2025-03-01“…Osteochondral defects were created in the knee of immunosuppressed rats and were grafted with cell pellets from either equine fetal IZN, equine fetal ANL, adult fibroblasts, or adult chondrocytes, or they were left untreated. …”
Get full text
Article -
1052
Intestinal obstruction caused by disseminated mycobacterium avium complex disease following solid organ transplantation: a case report
Published 2025-01-01“…The patient’s outcome emphasizes the need for vigilance in managing long-term immunosuppressed patients, particularly when they present with atypical infections.…”
Get full text
Article -
1053
Sinomenine attenuates uremia vascular calcification by miR-143-5p
Published 2025-01-01“…Sinomenine exhibited anti-inflammatory and immunosuppressive effects. Objective of this study was to investigate the effect of sinomenine in vascular calcification and its potential molecular mechanism. …”
Get full text
Article -
1054
Classification of Nanomaterial Drug Delivery Systems for Inflammatory Bowel Disease
Published 2025-02-01“…Lifelong maintenance therapy may thus be needed to manage these symptoms; however, traditional IBD drugs, such as 5-aminosalicylic acid, glucocorticoids, immunosuppressants, and biological agents, are often associated with problems including poor solubility, instability, and ineffective targeting, as well as causing serious side effects in non-target tissues. …”
Get full text
Article -
1055
Familial Adenomatous Polyposis and Desmoid Tumor Treated with Multivisceral Transplantation and Kidney Autotransplantation: Case Report and Literature Review
Published 2019-01-01“…The patient received immunosuppressive, antithrombotic, and antibiotic treatment. …”
Get full text
Article -
1056
Early, Noninvasive Clinical Indicators of Kidney Prognosis in Primary Nephrotic Syndrome: A Retrospective Exploratory Study
Published 2022-01-01“…Univariate Cox proportional hazards regression analysis identified clinical parameters in the 2-month period after initiating immunosuppressive therapy (IST); it predicted 40% reduction in the estimated glomerular filtration rate (eGFR) in 36 patients with primary NS. …”
Get full text
Article -
1057
Identification of tacrolimus-related genes in familial combined hyperlipidemia and development of a diagnostic model using bioinformatics analysis
Published 2025-02-01“…Given tacrolimus's immunosuppressive impact, the gene expression matrix data obtained from dataset GSE1010 was submitted to CIBERSORT to assess immune cell infiltration outcomes. …”
Get full text
Article -
1058
Impact of Cyclosporine A on Cognitive Functions and Neuronal Oxidative Stress, Apoptosis and Inflammatory Markers in Rats
Published 2024-07-01“… Cyclosporine A (CYP-A), a potent immunosuppressive agent, significantly impacts organ transplantation and the treatment of autoimmune disorders, and its ability to control autoimmune reactions and prevent organ rejection has made it indispensable in contemporary medicine. …”
Get full text
Article -
1059
Composite submental flaps in facial reconstructive surgery involving the zygoma and orbit
Published 2020-10-01“…A third case was a 75-year-old immunosuppressed male with a 6.5 cm SCC of the right cheek with invasion of the orbit and zygoma following prior resection as well as high dose radiotherapy. …”
Get full text
Article -
1060
COVID-19 in the years 2020 to 2022 in Germany: effects of comorbidities and co-medications based on a large-scale database analysis
Published 2025-02-01“…Immunodeficiencies and use of immunosuppressives were strongest risk modifying factors for hospitalization in both study populations. …”
Get full text
Article